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List of works by R.H. Porter

ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology

scientific article published on 01 January 1996

An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application

scientific article published in September 2005

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives

scientific article

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

scientific article published on 24 January 2006

Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion.

scientific article published on February 1995

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.

scientific article published on July 2006

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors

scientific article

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series

scientific article published on 4 August 2009

Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity

scientific article

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

scientific article published in January 2011

GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation

scientific article published on 01 March 2000

Glutamate and Parkinson's disease

scientific article

Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist

scientific article published on March 2003

Inhibition of autoradiographic MK-801 binding by an endogenous factor.

scientific article

Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum

scientific article published on 01 September 1993

Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series

scientific article published in January 2008

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine ⬇️

scientific article published on October 1, 2003

NMDA and AMPA receptors in transgenic mice expressing human beta-amyloid protein.

scientific article published on December 1993

Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion.

scientific article

Regional variations in the pharmacology of AMPA receptors as revealed by receptor autoradiography

scientific article published on 01 November 1994

Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential

scientific article published on 01 February 1995

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease ⬇️

scientific article published on 02 July 2011

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