List of works - F. Xavier Gomis-Rüth

1.8‐Å Crystal Structure of the Catalytic Domain of Human Neutrophil Collagenase (Matrix Metalloproteinase‐8) Complexed with a Peptidomimetic Hydroxamate Primed‐Side Inhibitor with a Distinct Selectivity Profile ⬇️

scientific article published on July 1, 1997

2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode

scientific article published in December 1997

A Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane Metallopeptidases

scientific article

A different look for AB5 toxins.

scientific article

A novel mechanism of latency in matrix metalloproteinases

scientific article published on 2 January 2015

A novel strategy for inhibition of α-amylases: yellow meal worm α-amylase in complex with the Ragi bifunctional inhibitor at 2.5 å resolution ⬇️

scientific article published on July 15, 1998

A standard orientation for metallopeptidases ⬇️

scientific article published on April 30, 2011

A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome

scientific article

Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease.

scientific article

Architecture and function of metallopeptidase catalytic domains

scientific article published on February 2014

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'

scientific article

Catalytic domain architecture of metzincin metalloproteases.

scientific article published on 05 February 2009

Caught after the Act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide

scientific article

Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution

scientific article published on August 20, 1992

Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation 1 1Edited by I. A. Wilson

article

Crystal structure of yellow meal worm α-amylase at 1.64 Å resolution ⬇️

scientific article published on May 8, 1998

Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity

scientific article published on 24 June 1994

Crystallization and preliminary X-ray analysis of the ternary complex of procarboxypeptidase A from bovine pancreas

scientific article published on 01 July 1995

Crystallization and preliminary X-ray diffraction analysis of eukaryotic α2 -macroglobulin family members modified by methylamine, proteases and glycosidases

scientific article published on 01 October 2014

Crystallization and preliminary X-ray diffraction analysis of proline iminopeptidase from Xanthomonas campestris pv. citri

scientific article published on 01 January 1997

Cut and move: protein machinery for DNA processing in bacterial conjugation.

scientific article

Cutting at the right place. The importance of selective limited proteolysis in the activation of proproteinase E

article

De novo design of immunoglobulin-like domains

scientific article published in 2022

Detailed architecture of a DNA translocating machine: the high-resolution structure of the bacteriophage phi29 connector particle

scientific article

Determination of hemihedral twinning and initial structural analysis of crystals of the procarboxypeptidase A ternary complex

scientific article published on 01 September 1995

Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.

scientific article published on December 2015

Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization ⬇️

scientific article published on December 1, 1992

Expression and purification of integral membrane metallopeptidase HtpX.

scientific article published on 24 April 2014

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases

scientific article

Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI)

scientific article

Inhibition of carboxypeptidase A by excess zinc: analysis of the structural determinants by X-ray crystallography

article

Insights into MMP-TIMP interactions.

scientific article

Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor

scientific article

Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite

scientific article

Matrix metalloproteinases outside vertebrates

scientific article published on 6 April 2017

Matrix metalloproteinases: fold and function of their catalytic domains

scientific article (publication date: 2010)

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1 ⬇️

scientific article published on September 4, 1997

Multiple Architectures and Mechanisms of Latency in Metallopeptidase Zymogens.

scientific article

Multiple stable conformations account for reversible concentration-dependent oligomerization and autoinhibition of a metamorphic metallopeptidase

scientific article

On the Relevance of the Met-turn Methionine in Metzincins

scientific article

Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the pMV158-encoded plasmid transcriptional repressor protein CopG

scientific article published on 20 March 1998

Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the receiver domain of PhoB

scientific article published on 01 November 1998

Pancreatic procarboxypeptidases: oligomeric structures and activation processes revisited.

scientific article published on March 1997

Papaya glutamine cyclotransferase shows a singular five-fold beta-propeller architecture that suggests a novel reaction mechanism.

scientific article published on October 2006

Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

scientific article

Plasmid transcriptional repressor CopG oligomerises to render helical superstructures unbound and in complexes with oligonucleotides

scientific article

Purification, crystallization and preliminary X-ray diffraction of wild-type and mutant recombinant human transforming growth factor beta-induced protein (TGFBIp).

scientific article published on 26 February 2009

Recombinant production of human α2-macroglobulin variants and interaction studies with recombinant G-related α2-macroglobulin binding protein and latent transforming growth factor-β2

scientific article published on 24 June 2019

Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation.

scientific article published on 17 June 2019

Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin

scientific article published on 01 June 1994

Solving a 300 kDa multimeric protein by low-resolution MAD phasing and averaging/phase extension.

scientific article published on 25 May 2001

Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome

scientific article

Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase

scientific article

Structural and Functional Implications of Human Transforming Growth Factor β-Induced Protein, TGFBIp, in Corneal Dystrophies

scientific article

Structural and functional insight into pan-endopeptidase inhibition by α2-macroglobulins

scientific article published on 2 March 2017

Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition

scientific article published on 22 June 2015

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

scientific article

Structural aspects of the metzincin clan of metalloendopeptidases.

scientific article

Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.

scientific article

Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome

scientific article

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase

scientific article published on July 2015

Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.

scientific article

Structure and mechanism of metallocarboxypeptidases

scientific article published on 01 September 2008

Structure and role of coupling proteins in conjugal DNA transfer.

scientific article

Structure of TrwB, a gatekeeper in bacterial conjugation

scientific article published on 01 September 2001

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

scientific article

Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition

scientific article published on 28 February 2019

Structure of proline iminopeptidase from Xanthomonas campestris pv. citri: a prototype for the prolyl oligopeptidase family.

scientific article published on January 1998

Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog

scientific article

Structure-Function Studies of the Staphylococcal Methicillin Resistance Antirepressor MecR2

scientific article

Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor α convertase inhibitors ⬇️

scientific article published on February 1, 1998

Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex

scientific article published in January 2007

Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator

scientific article

The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases

scientific article published on 11 October 2019

The alpha-amylase from the yellow meal worm: complete primary structure, crystallization and preliminary X-ray analysis.

scientific article published on June 1997

The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase

scientific article

The cofactor-induced pre-active conformation in PhoB.

scientific article

The crystal structure of human α2-macroglobulin reveals a unique molecular cage

scientific article

The eight-cysteine motif, a versatile structure in plant proteins.

scientific article

The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties

scientific article (publication date: April 2003)

The metzincin-superfamily of zinc-peptidases.

scientific article published on January 1996

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases ⬇️

scientific article published on May 1, 1995

The molecular analysis of Trypanosoma cruzi metallocarboxypeptidase 1 provides insight into fold and substrate specificity

scientific article

The pCri System: a vector collection for recombinant protein expression and purification

scientific article

The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity

scientific article published on 01 March 2001

The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family

scientific article

The structure of the catalytic domain of Tannerella forsythia karilysin reveals it is a bacterial xenologue of animal matrix metalloproteinases

scientific article

Third time lucky? Getting a grip on matrix metalloproteinases.

scientific article published in October 2017

Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution

scientific article published in July 2000

Three-dimensional crystal structure of the transcription factor PhoB receiver domain

scientific article

Two-wavelength MAD phasing: in search of the optimal choice of wavelengths

scientific article published in August 1999

Unbound and acylated structures of the MecR1 extracellular antibiotic-sensor domain provide insights into the signal-transduction system that triggers methicillin resistance

scientific article published on 07 July 2006

α2-Macroglobulins: Structure and Function

scientific article published on January 2017

List of works by F. Xavier Gomis-Rüth

1.8‐Å Crystal Structure of the Catalytic Domain of Human Neutrophil Collagenase (Matrix Metalloproteinase‐8) Complexed with a Peptidomimetic Hydroxamate Primed‐Side Inhibitor with a Distinct Selectivity Profile ⬇️

2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode

A Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane Metallopeptidases

A different look for AB5 toxins.

A novel mechanism of latency in matrix metalloproteinases

A novel strategy for inhibition of α-amylases: yellow meal worm α-amylase in complex with the Ragi bifunctional inhibitor at 2.5 å resolution ⬇️

A standard orientation for metallopeptidases ⬇️

A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome

Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease.

Architecture and function of metallopeptidase catalytic domains

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'

Catalytic domain architecture of metzincin metalloproteases.

Caught after the Act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide

Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution

Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation 1 1Edited by I. A. Wilson

Crystal structure of yellow meal worm α-amylase at 1.64 Å resolution ⬇️

Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity

Crystallization and preliminary X-ray analysis of the ternary complex of procarboxypeptidase A from bovine pancreas

Crystallization and preliminary X-ray diffraction analysis of eukaryotic α2 -macroglobulin family members modified by methylamine, proteases and glycosidases

Crystallization and preliminary X-ray diffraction analysis of proline iminopeptidase from Xanthomonas campestris pv. citri

Cut and move: protein machinery for DNA processing in bacterial conjugation.

Cutting at the right place. The importance of selective limited proteolysis in the activation of proproteinase E

De novo design of immunoglobulin-like domains

Detailed architecture of a DNA translocating machine: the high-resolution structure of the bacteriophage phi29 connector particle

Determination of hemihedral twinning and initial structural analysis of crystals of the procarboxypeptidase A ternary complex

Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.

Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization ⬇️

Expression and purification of integral membrane metallopeptidase HtpX.

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases

Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI)

Inhibition of carboxypeptidase A by excess zinc: analysis of the structural determinants by X-ray crystallography

Insights into MMP-TIMP interactions.

Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor

Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite

Matrix metalloproteinases outside vertebrates

Matrix metalloproteinases: fold and function of their catalytic domains

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1 ⬇️

Multiple Architectures and Mechanisms of Latency in Metallopeptidase Zymogens.

Multiple stable conformations account for reversible concentration-dependent oligomerization and autoinhibition of a metamorphic metallopeptidase

On the Relevance of the Met-turn Methionine in Metzincins

Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the pMV158-encoded plasmid transcriptional repressor protein CopG

Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the receiver domain of PhoB

Pancreatic procarboxypeptidases: oligomeric structures and activation processes revisited.

Papaya glutamine cyclotransferase shows a singular five-fold beta-propeller architecture that suggests a novel reaction mechanism.

Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

Plasmid transcriptional repressor CopG oligomerises to render helical superstructures unbound and in complexes with oligonucleotides

Purification, crystallization and preliminary X-ray diffraction of wild-type and mutant recombinant human transforming growth factor beta-induced protein (TGFBIp).

Recombinant production of human α2-macroglobulin variants and interaction studies with recombinant G-related α2-macroglobulin binding protein and latent transforming growth factor-β2

Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation.

Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin

Solving a 300 kDa multimeric protein by low-resolution MAD phasing and averaging/phase extension.

Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome

Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase

Structural and Functional Implications of Human Transforming Growth Factor β-Induced Protein, TGFBIp, in Corneal Dystrophies

Structural and functional insight into pan-endopeptidase inhibition by α2-macroglobulins

Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

Structural aspects of the metzincin clan of metalloendopeptidases.

Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.

Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome

Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase

Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.

Structure and mechanism of metallocarboxypeptidases

Structure and role of coupling proteins in conjugal DNA transfer.

Structure of TrwB, a gatekeeper in bacterial conjugation

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition

Structure of proline iminopeptidase from Xanthomonas campestris pv. citri: a prototype for the prolyl oligopeptidase family.

Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog

Structure-Function Studies of the Staphylococcal Methicillin Resistance Antirepressor MecR2

Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor α convertase inhibitors ⬇️

Substrate specificity of a metalloprotease of the pappalysin family revealed by an inhibitor and a product complex

Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator

The C-terminal region of human plasma fetuin-B is dispensable for the raised-elephant-trunk mechanism of inhibition of astacin metallopeptidases

The alpha-amylase from the yellow meal worm: complete primary structure, crystallization and preliminary X-ray analysis.

The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase

The cofactor-induced pre-active conformation in PhoB.

The crystal structure of human α2-macroglobulin reveals a unique molecular cage

The eight-cysteine motif, a versatile structure in plant proteins.