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List of works by Tim Hales

A Structural Rationale for N-Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand-Gated Ion Channels

scientific article published on 20 December 2019

A conditionally immortalized glial cell line that expresses mature myelin proteins and functional GABA(A) receptors.

scientific article

A novel class of ligand-gated ion channel is activated by Zn2+

scientific article

A role for loop G in the β1 strand in GABAA receptor activation.

scientific article

Activation of μ opioid receptors by MT-45 and its fluorinated derivatives

scientific article published on 04 April 2020

Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors.

scientific article

Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat.

scientific article

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

scientific article published on 13 December 2018

Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2

scientific article

Arresting the development of morphine tolerance and dependence ⬇️

scientific article published on November 1, 2011

Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons.

scientific article

Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.

scientific article published on May 1995

Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory.

scientific article

Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors.

scientific article published on 3 January 2006

Consensus statement from the BJA Workshop on Cancer and Anaesthesia

scientific article published on 7 August 2014

Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines.

scientific article published on September 1994

Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells

scientific article published on 01 July 1988

Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor

scientific article published on 02 January 2007

Few cell lines with GABAA mRNAs have functional receptors.

scientific article published on September 1994

Fluorophore assisted light inactivation (FALI) of recombinant 5-HT₃A receptor constitutive internalization and function.

scientific article

From inhibition to excitation: functional effects of interaction between opioid receptors.

scientific article

Functional analysis of cloned opioid receptors in transfected cell lines.

scientific article published on November 1996

Functional properties of Cav1.3 (alpha1D) L-type Ca2+ channel splice variants expressed by rat brain and neuroendocrine GH3 cells.

scientific article

GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons.

scientific article

GABA(A) receptors mediate inhibition of T cell responses.

scientific article published on April 1999

Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors ⬇️

scientific article published on August 1, 1992

Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons.

scientific article published on 31 August 2005

Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization.

scientific article

Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

scientific article

Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor.

scientific article published on November 2005

L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells.

scientific article published on March 1999

Loop G in the GABAA receptor α1 subunit influences gating efficacy.

scientific article published on 16 December 2016

Mechanisms of spontaneous calcium oscillations and action potentials in immortalized hypothalamic (GT1-7) neurons

scientific article published on 01 January 1995

Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells.

scientific article

Modulation of GABAA and glycine receptors by chlormethiazole

scientific article published on 01 January 1992

Modulation of the GABAA receptor by propofol is independent of the gamma subunit.

scientific article published in August 1995

Molecular determinants of single-channel conductance and ion selectivity in the Cys-loop family: insights from the 5-HT3 receptor.

scientific article

Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor.

scientific article published on 12 September 2013

Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors

scientific article

Novel structural determinants of single-channel conductance in nicotinic acetylcholine and 5-hydroxytryptamine type-3 receptors

scientific article published on 01 November 2006

Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit.

scientific article published in September 2002

Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function

scientific article

Potentiation, activation and blockade of GABAA receptors of clonal murine hypothalamic GT1-7 neurones by propofol.

scientific article published in July 1995

Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor.

scientific article published on 12 May 2008

The 5-HT3 receptor--the relationship between structure and function

scientific article

The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine

scientific article published in February 2012

The 5-HT3B subunit is a major determinant of serotonin-receptor function

scientific article

The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance.

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The Minimum M3-M4 Loop Length of Neurotransmitter-activated Pentameric Receptors Is Critical for the Structural Integrity of Cytoplasmic Portals ⬇️

scientific article published on 05 June 2013

The actions of endogenous and synthetic pregnane steroids on GABAA receptors

scientific article published on January 1, 1992

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones ⬇️

scientific article published on November 1, 1991

The promiscuous role of the epsilon subunit in GABAA receptor biogenesis.

scientific article published on 15 December 2007

Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating.

scientific article published on 7 November 2006

Traumatic needle damage to nerves during regional anesthesia: presentation of a novel mechanotransduction hypothesis

scientific article published in 2022

Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors.

scientific article published on October 1996

Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

scientific article published on 22 June 2015

Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion

scientific article

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