List of works - Carlos Hermenegildo

A C >T polymorphism located at position -1 of the Kozak sequence of CD40 gene is associated with low bone mass in Spanish postmenopausal women

scientific article published on 21 December 2007

Activation of N-methyl-D-aspartate receptors in rat brain in vivo following acute ammonia intoxication: characterization by in vivo brain microdialysis

scientific article published on 01 March 2000

Aging enhances contraction to thromboxane A2 in aorta from female senescence-accelerated mice

scientific article published on 19 November 2011

Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.

scientific article

Aging-related endothelial dysfunction in the aorta from female senescence-accelerated mice is associated with decreased nitric oxide synthase expression.

scientific article published on 13 August 2013

Alterations in the antioxidant defense of peripheral nervous tissue following acute ethanol administration

scientific article published on 01 May 1993

Alterations in the phenotype and function of immune cells in ovariectomy-induced osteopenic mice

scientific article published on 03 February 2006

An affordable method to obtain cultured endothelial cells from peripheral blood.

scientific article

Are the serum levels of sCD40L modified by raloxifene in postmenopausal women?

scientific article published on 25 June 2008

Association of female aging with decreased parthenogenetic activation, raised MPF, and MAPKs activities and reduced levels of glutathione S-transferases activity and thiols in mouse oocytes.

scientific article published in December 2004

Beneficial effects of dithiothreitol on relative levels of glutathione S-transferase activity and thiols in oocytes, and cell number, DNA fragmentation and allocation at the blastocyst stage in the mouse.

scientific article

Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons

scientific article published on 01 October 1996

Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles.

scientific article

Chronic exposure to aluminium impairs the glutamate-nitric oxide-cyclic GMP pathway in the rat in vivo.

scientific article published in March 1999

Chronic exposure to aluminum impairs neuronal glutamate-nitric oxide-cyclic GMP pathway

scientific article published on 01 April 1998

Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity

scientific article published in September 2015

Circulating miRNA Fingerprint and Endothelial Function in Myocardial Infarction: Comparison at Acute Event and One-Year Follow-Up

scientific article published on 02 June 2022

Combined sub-optimal doses of rosuvastatin and bexarotene impair angiotensin II-induced arterial mononuclear cell adhesion through inhibition of Nox5 signaling pathways and increased RXR/PPARα and RXR/PPARγ interactions.

scientific article

Common polymorphisms rather than rare genetic variants of the Runx2 gene are associated with femoral neck BMD in Spanish women

scientific article published on 21 April 2010

Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice.

scientific article published in June 2008

Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice

scientific article published on 11 September 2006

Cyclooxygenases regulation by estradiol on endothelium

scientific article (publication date: 2006)

Decreased bioavailability of nitric oxide in aorta from ovariectomized senescent mice. Role of cyclooxygenase.

scientific article published on 13 January 2016

Decreased glutathione peroxidase activity in sciatic nerve of alloxan-induced diabetic mice and its correlation with blood glucose levels

scientific article published on 01 August 1993

Delayed fatherhood in mice decreases reproductive fitness and longevity of offspring.

scientific article published on 15 October 2008

Delayed motherhood decreases life expectancy of mouse offspring.

scientific article

Drug targeting of estrogen receptor signaling in the cardiovascular system: preclinical and clinical studies.

scientific article published in April 2004

Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial infarction.

scientific article published on 14 November 2013

Effects of administration of hormone therapy or raloxifene on the immune system and on biochemical markers of bone remodeling.

scientific article published in March 2012

Endocrinology and physiology of pseudocyesis

scientific article

Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

scientific article published on 2 September 2015

Endothelial and neural factors functionally involved in the modulation of noradrenergic vasoconstriction in healthy pig internal mammary artery

scientific article published on 11 January 2012

Endothelial transcriptomic changes induced by oxidized low density lipoprotein disclose an up-regulation of Jak-Stat pathway.

scientific article published on 29 May 2015

Estradiol counteracts oxidized LDL-induced asymmetric dimethylarginine production by cultured human endothelial cells

scientific article published on 30 September 2006

Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells.

scientific article

Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production

scientific article published on 11 November 2015

Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells

scientific article published on 07 September 2012

Estrogens inhibit angiotensin II-induced leukocyte-endothelial cell interactions in vivo via rapid endothelial nitric oxide synthase and cyclooxygenase activation.

scientific article published in December 2002

Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells

scientific article published on 11 July 2018

Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells.

scientific article

Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome

scientific article published on 30 July 2014

Gathering of aging and estrogen withdrawal in vascular dysfunction of senescent accelerated mice.

scientific article published on 12 August 2010

Gene expression profile induced by ovariectomy in bone marrow of mice: a functional approach to identify new candidate genes associated to osteoporosis risk in women

scientific article published on 9 May 2014

Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.

scientific article

Glutamate and muscarinic receptors in the molecular mechanisms of acute ammonia toxicity and of its prevention.

scientific article published on January 1997

Inhibition of low-density lipoprotein oxidation by the pure antiestrogens ICI 182780 and EM-652 (SCH 57068).

scientific article published in November 2002

Inhibition of protein kinase C restores Na+,K(+)-ATPase activity in sciatic nerve of diabetic mice

scientific article published on 01 April 1992

Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line.

scientific article

Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring.

scientific article published on 15 October 2008

Long-term effects of delayed motherhood in mice on postnatal development and behavioural traits of offspring.

scientific article published in August 2003

Long-term effects of postovulatory aging of mouse oocytes on offspring: a two-generational study.

scientific article published in November 1999

Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation

scientific article published on 25 January 2017

Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women

scientific article published on 26 August 2019

Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.

scientific article

MicroRNA as Crucial Regulators of Gene Expression in Estradiol-Treated Human Endothelial Cells.

scientific article published on 28 February 2018

Microparticles harbouring Sonic hedgehog morphogen improve the vasculogenesis capacity of endothelial progenitor cells derived from myocardial infarction patients

scientific article published on 01 February 2019

Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: Time-course after acute myocardial infarction and stroke

article

Modulation of glutamine synthesis in cultured astrocytes by nitric oxide.

scientific article published in August 1997

Modulation of the oestrogen receptor: a process with distinct susceptible steps.

scientific article published in May 2000

NMDA receptor antagonists prevent acute ammonia toxicity in mice

scientific article published on 01 October 1996

Neurotoxicity of ammonia and glutamate: molecular mechanisms and prevention.

scientific article published in August 1998

No effect of Cimicifuga racemosa extract on serum interleukin-6 levels and prostacyclin production by human endothelial cells.

scientific article published on 23 February 2009

Prevention of the acute neurotoxic effects of phenytoin on rat peripheral nerve by H7, an inhibitor of protein kinase C

scientific article published on 01 November 1992

Progestogens reduce thromboxane production by cultured human endothelial cells.

scientific article published on 5 May 2010

Progestogens stimulate prostacyclin production by human endothelial cells.

scientific article published on 25 February 2005

Pure anti-oestrogens.

scientific article published in May 2000

Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1.

scientific article published on 18 April 2007

Raloxifene increases the capacity of serum to promote prostacyclin release in human endothelial cells: implication of COX-1 and COX-2.

scientific article published in July 2004

Raloxifene promotes prostacyclin release in human endothelial cells through a mechanism that involves cyclooxygenase-1 and -2.

scientific article published in June 2005

Regulatory Mechanisms of Estrogen on Vascular Ageing.

scientific article published on 28 April 2019

Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing

scientific article published on 20 December 2018

Selective estrogen receptor modulators and risk for coronary heart disease.

scientific article published on April 2007

Some aspects of cardiac antioxidant defence: Ebselen (PZ 51) treatment increases glutathione peroxidase activity in the rat heart.

scientific article published in December 1990

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

scientific article

Sustained recovery of Na(+)-K(+)-ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC

scientific article published on 01 February 1993

The activity of glutathione S-transferase in hepatopancreas of Procambarus clarkii: seasonal variations and the influence of environmental pollutants.

scientific article published in January 1991

The effect of hormone replacement therapy on Ca2+ mobilization and P-selectin (CD62P) expression in platelets examined under flow cytometry.

scientific article

The effect of oral hormone replacement therapy on lipoprotein profile, resistance of LDL to oxidation and LDL particle size.

scientific article published in May 2001

Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.

scientific article published on 13 August 2010

Transdermal estradiol reduces F2alpha-isoprostane levels in postmenopausal women.

scientific article published in July 2008

Transdermal estradiol reduces plasma myeloperoxidase levels without affecting the LDL resistance to oxidation or the LDL particle size.

scientific article published in March 2002

Unpredicted ovulations and conceptions during early pregnancy: an explanatory mechanism of human superfetation

scientific article

Usefulness of Clinical Data and Biomarkers for the Identification of Frailty After Acute Coronary Syndromes.

scientific article

miRNA as a New Regulatory Mechanism of Estrogen Vascular Action.

scientific article published on 6 February 2018

List of works by Carlos Hermenegildo

A C >T polymorphism located at position -1 of the Kozak sequence of CD40 gene is associated with low bone mass in Spanish postmenopausal women

Activation of N-methyl-D-aspartate receptors in rat brain in vivo following acute ammonia intoxication: characterization by in vivo brain microdialysis

Aging enhances contraction to thromboxane A2 in aorta from female senescence-accelerated mice

Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ERα/ERβ balance in female mice.

Aging-related endothelial dysfunction in the aorta from female senescence-accelerated mice is associated with decreased nitric oxide synthase expression.

Alterations in the antioxidant defense of peripheral nervous tissue following acute ethanol administration

Alterations in the phenotype and function of immune cells in ovariectomy-induced osteopenic mice

An affordable method to obtain cultured endothelial cells from peripheral blood.

Are the serum levels of sCD40L modified by raloxifene in postmenopausal women?

Association of female aging with decreased parthenogenetic activation, raised MPF, and MAPKs activities and reduced levels of glutathione S-transferases activity and thiols in mouse oocytes.

Beneficial effects of dithiothreitol on relative levels of glutathione S-transferase activity and thiols in oocytes, and cell number, DNA fragmentation and allocation at the blastocyst stage in the mouse.

Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons

Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles.

Chronic exposure to aluminium impairs the glutamate-nitric oxide-cyclic GMP pathway in the rat in vivo.

Chronic exposure to aluminum impairs neuronal glutamate-nitric oxide-cyclic GMP pathway

Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity

Circulating miRNA Fingerprint and Endothelial Function in Myocardial Infarction: Comparison at Acute Event and One-Year Follow-Up

Combined sub-optimal doses of rosuvastatin and bexarotene impair angiotensin II-induced arterial mononuclear cell adhesion through inhibition of Nox5 signaling pathways and increased RXR/PPARα and RXR/PPARγ interactions.

Common polymorphisms rather than rare genetic variants of the Runx2 gene are associated with femoral neck BMD in Spanish women

Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice.

Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice

Cyclooxygenases regulation by estradiol on endothelium

Decreased bioavailability of nitric oxide in aorta from ovariectomized senescent mice. Role of cyclooxygenase.

Decreased glutathione peroxidase activity in sciatic nerve of alloxan-induced diabetic mice and its correlation with blood glucose levels

Delayed fatherhood in mice decreases reproductive fitness and longevity of offspring.

Delayed motherhood decreases life expectancy of mouse offspring.

Drug targeting of estrogen receptor signaling in the cardiovascular system: preclinical and clinical studies.

Dynamics of serum-induced endothelial cell apoptosis in patients with myocardial infarction.

Effects of administration of hormone therapy or raloxifene on the immune system and on biochemical markers of bone remodeling.

Endocrinology and physiology of pseudocyesis

Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

Endothelial and neural factors functionally involved in the modulation of noradrenergic vasoconstriction in healthy pig internal mammary artery

Endothelial transcriptomic changes induced by oxidized low density lipoprotein disclose an up-regulation of Jak-Stat pathway.

Estradiol counteracts oxidized LDL-induced asymmetric dimethylarginine production by cultured human endothelial cells

Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells.

Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production

Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells

Estrogens inhibit angiotensin II-induced leukocyte-endothelial cell interactions in vivo via rapid endothelial nitric oxide synthase and cyclooxygenase activation.

Extracellular histones activate autophagy and apoptosis via mTOR signaling in human endothelial cells

Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells.

Frailty and other geriatric conditions for risk stratification of older patients with acute coronary syndrome

Gathering of aging and estrogen withdrawal in vascular dysfunction of senescent accelerated mice.

Gene expression profile induced by ovariectomy in bone marrow of mice: a functional approach to identify new candidate genes associated to osteoporosis risk in women

Gene-gene interaction between CD40 and CD40L reduces bone mineral density and increases osteoporosis risk in women.

Glutamate and muscarinic receptors in the molecular mechanisms of acute ammonia toxicity and of its prevention.

Inhibition of low-density lipoprotein oxidation by the pure antiestrogens ICI 182780 and EM-652 (SCH 57068).

Inhibition of protein kinase C restores Na+,K(+)-ATPase activity in sciatic nerve of diabetic mice

Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line.

Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring.

Long-term effects of delayed motherhood in mice on postnatal development and behavioural traits of offspring.

Long-term effects of postovulatory aging of mouse oocytes on offspring: a two-generational study.

Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation

Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women

Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.

MicroRNA as Crucial Regulators of Gene Expression in Estradiol-Treated Human Endothelial Cells.

Microparticles harbouring Sonic hedgehog morphogen improve the vasculogenesis capacity of endothelial progenitor cells derived from myocardial infarction patients

Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: Time-course after acute myocardial infarction and stroke

Modulation of glutamine synthesis in cultured astrocytes by nitric oxide.

Modulation of the oestrogen receptor: a process with distinct susceptible steps.

NMDA receptor antagonists prevent acute ammonia toxicity in mice

Neurotoxicity of ammonia and glutamate: molecular mechanisms and prevention.

No effect of Cimicifuga racemosa extract on serum interleukin-6 levels and prostacyclin production by human endothelial cells.

Prevention of the acute neurotoxic effects of phenytoin on rat peripheral nerve by H7, an inhibitor of protein kinase C

Progestogens reduce thromboxane production by cultured human endothelial cells.

Progestogens stimulate prostacyclin production by human endothelial cells.

Pure anti-oestrogens.

Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1.

Raloxifene increases the capacity of serum to promote prostacyclin release in human endothelial cells: implication of COX-1 and COX-2.

Raloxifene promotes prostacyclin release in human endothelial cells through a mechanism that involves cyclooxygenase-1 and -2.

Regulatory Mechanisms of Estrogen on Vascular Ageing.

Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing

Selective estrogen receptor modulators and risk for coronary heart disease.

Some aspects of cardiac antioxidant defence: Ebselen (PZ 51) treatment increases glutathione peroxidase activity in the rat heart.

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

Sustained recovery of Na(+)-K(+)-ATPase activity in sciatic nerve of diabetic mice by administration of H7 or calphostin C, inhibitors of PKC

The activity of glutathione S-transferase in hepatopancreas of Procambarus clarkii: seasonal variations and the influence of environmental pollutants.

The effect of hormone replacement therapy on Ca2+ mobilization and P-selectin (CD62P) expression in platelets examined under flow cytometry.

The effect of oral hormone replacement therapy on lipoprotein profile, resistance of LDL to oxidation and LDL particle size.

Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.