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List of works by Keiji Miyazawa

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

scientific article

A comparative analysis of Smad-responsive motifs identifies multiple regulatory inputs for TGF-β transcriptional activation

scientific article published on 03 September 2019

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP

scientific article (publication date: December 2000)

A negative regulator or just an unconcerned passerby: phosphoinositide 3-kinase signalling in IL-12 production

scientific article published on 16 October 2012

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

scientific article published on 28 March 2003

Activation of MET receptor tyrosine kinase in ulcer surface epithelial cells undergoing restitution.

scientific article published in July 2008

Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator

scientific article published on 01 April 1995

Activation of hepatocyte growth factor in monkey stomach following gastric mucosal injury.

scientific article published in January 2004

Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator.

scientific article

An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling

scientific article

An alternatively processed mRNA generated from human hepatocyte growth factor gene.

scientific article published on April 1991

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

scientific article

Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.

scientific article published on 21 October 2010

Arkadia enhances BMP signalling through ubiquitylation and degradation of Smad6

scientific article published on 11 March 2015

Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.

scientific article published in November 2009

Basolateral BMP Signaling in Polarized Epithelial Cells ⬇️

scientific article published on May 13, 2013

Characterization of hepatocyte-growth-factor receptors on Meth A cells

scientific article published on 01 March 1992

Characterization of the promoter region of the rat hepatocyte-growth-factor/scatter-factor gene.

scientific article published in April 1993

Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.

scientific article published on 27 October 2008

Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.

scientific article

Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator.

scientific article published on 25 December 2008

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells

scientific article published on 12 March 2020

Dissociation of c-fos induction and mitogen-activated-protein kinase activation from the hepatocyte-growth-factor-induced motility response in human gastric carcinoma cells.

scientific article

Dissociation of the AhR-ARNT complex by TGF-β-Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity

scientific article published on 14 May 2020

Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression

scientific article published on 12 July 2016

Encountering unpredicted off-target effects of pharmacological inhibitors ⬇️

scientific article published on 09 May 2011

Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.

scientific article published on 20 August 2014

Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells

scientific article published on March 2017

Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF.

scientific article published in January 2002

Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade.

scientific article published on 31 May 2018

Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1.

scientific article published on 22 January 2002

Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains

scientific article published on October 13, 1992

Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells.

scientific article published on 3 August 2009

Glioma-initiating cells retain their tumorigenicity through integration of the Sox axis and Oct4 protein

scientific article published on 10 October 2011

Hepatocyte growth factor (HGF)-induced cell migration is negatively modulated by epidermal growth factor through tyrosine phosphorylation of the HGF receptor

scientific article published on 01 March 1996

Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor.

scientific article published on 02 April 2010

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta

scientific journal article

Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment

scientific article (publication date: 22 December 2000)

Hepatocyte growth factor and transforming growth factor-beta stimulate both cell growth and migration of human gastric adenocarcinoma cells

scientific article published on 01 June 1992

Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy

scientific article published on 01 April 1995

Identification of a 190-kDa vascular endothelial growth factor 165 cell surface binding protein on a human glioma cell line.

scientific article published on September 1997

Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes

scientific article

Identification of integrin α3 as a molecular marker of cells undergoing epithelial–mesenchymal transition and of cancer cells with aggressive phenotypes ⬇️

scientific article published on July 20, 2013

Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis.

scientific article

Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation

scientific article published on 01 January 1997

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski

scientific article

Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2.

scientific article

Maid is a negative regulator of transforming growth factor-β-induced cell migration.

scientific article published on 22 May 2015

Molecular cloning and characterization of a novel protein serine/threonine kinase highly expressed in mouse embryo.

scientific article published in December 1998

Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract.

scientific article

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

scientific article

Nuclear and cytoplasmic c-Ski differently modulate cellular functions

scientific article

Oligodendrocyte transcription factor 1 (Olig1) is a Smad cofactor involved in cell motility induced by transforming growth factor-β.

scientific article published on 17 May 2013

Phosphoinositide 5-phosphatases: How do they affect tumourigenesis?

scientific article published on 26 September 2012

Phosphorylation in the activation loop as the finishing touch in c-Kit activation ⬇️

scientific article published on March 20, 2012

Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins

scientific article

Production and activation of hepatocyte growth factor during the healing of rat gastric ulcers

scientific article published on 01 January 1997

RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity ⬇️

scientific article published on July 27, 2011

Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells.

scientific article published on April 2008

Reciprocal expression of Slug and Snail in human oral cancer cells

scientific article published on 03 July 2018

Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice.

scientific article published in November 2004

Regulation of TGF-β Family Signaling by Inhibitory Smads.

scientific article published on 5 December 2016

Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.

scientific article published on 20 January 2017

Role of immunoglobulin-like domains 2-4 of the platelet-derived growth factor alpha-receptor in ligand-receptor complex assembly

scientific article published on 01 September 1998

SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells

scientific article

STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression

scientific article published on 11 May 2015

SUMO amplifies TGF-beta signalling

scientific article published on 01 June 2008

Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors

scientific article published on 10 May 2007

Smad3-STAT3 crosstalk in pathophysiological contexts.

scientific article published on 13 November 2017

Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.

scientific article published on 27 July 2010

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells

scientific article

Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion

scientific article published on 11 September 2017

Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.

scientific article published on 25 June 2008

Stimulation of prostaglandin production by hepatocyte growth factor in human gastric carcinoma cells

scientific article published on 01 November 1993

Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain

scientific article

Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator.

scientific article

Structural organization and the transcription initiation site of the human hepatocyte growth factor gene ⬇️

scientific article published on September 24, 1991

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

scientific article

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.

scientific article

TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition

scientific journal article

The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.

scientific article published on 27 January 2016

Transcriptional and post-transcriptional regulation in TGF-β-mediated epithelial-mesenchymal transition.

scientific article published on 23 April 2012

Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1

scientific article published on 01 October 2007

Two major Smad pathways in TGF-beta superfamily signalling.

scientific article

Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN

scientific article (publication date: 3 January 2003)

VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells.

scientific article published on 25 August 2009

ZEB1 and oncogenic Ras constitute a regulatory switch for stimulus-dependent E-cadherin downregulation

scientific article published on 17 October 2020

c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis.

scientific article published on 24 April 2007

c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases

scientific journal article

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements

scientific article

δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells

scientific article

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