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List of works by M. Methawasin

Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)

scientific article published on 28 July 2016

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

scientific article published on 01 April 2019

Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

scientific article

Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction.

scientific article published on 14 September 2016

Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.

scientific article

Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm (20ΔRRM) Mice.

scientific article published on 29 July 2016

Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

scientific article published on 19 December 2018

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

scientific article published on 01 June 2019

Response by Methawasin and Granzier to Letter Regarding Article, "Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function in a Mouse Model of Heart Failure With Preserved Ejection

scientific article published in March 2017

Sarcomere length-dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin

scientific article published on 06 December 2018

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction

scientific article published on 24 May 2013

Softening the Stressed Giant Titin in Diabetes Mellitus

scientific article published on 01 July 2018

The giant protein titin regulates the length of the striated muscle thick filament.

scientific article published on 19 October 2017

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.

scientific article published on 5 December 2012

Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin

scientific article published on 30 April 2016

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