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List of works by Roberto Cosimo Melcangi

Actions of progesterone and its 5alpha-reduced metabolites on the major proteins of the myelin of the peripheral nervous system.

scientific article published on November 2003

Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels.

scientific article published on 20 September 2009

Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know?

scientific article published on 23 August 2015

Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives ⬇️

scientific article published on July 1, 1998

Age-related changes in neuroactive steroid levels in 3xTg-AD mice.

scientific article published on 2 November 2012

Aging in peripheral nerves: regulation of myelin protein genes by steroid hormones.

scientific article

Allopregnanolone: state of the art.

scientific article published on 10 October 2013

Alterations of gut microbiota composition in post-finasteride patients: a pilot study

scientific article published on 19 September 2020

Androgen Metabolism in Different Target Tissues ⬇️

scientific article published on January 1, 1990

Androgen and progesterone metabolism in the central and peripheral nervous system.

scientific article

Aromatase: a neuroprotective enzyme ⬇️

scientific article published on September 1, 2003

Astrocyte-neuron interactions in vitro: role of growth factors and steroids on LHRH dynamics.

scientific article published on January 1997

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.

scientific article published on 19 January 2018

Comparison of plasma and cerebrospinal fluid levels of neuroactive steroids with their brain, spinal cord and peripheral nerve levels in male and female rats.

scientific article published on 21 May 2013

Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice.

scientific article published on 3 March 2015

Corticosteroid Effects on Gene Expression of Myelin Basic Protein in Oligodendrocytes and of Glial Fibrillary Acidic Protein in Type 1 Astrocytes ⬇️

scientific article published on October 1, 1997

Corticosteroids protect oligodendrocytes from cytokine-induced cell death

scientific article published on 01 December 2000

Corticosteroids regulate the gene expression of FGF-1 and FGF-2 in cultured rat astrocytes

scientific article published on 01 August 2000

Crosstalk between normal and tumoral brain cells. Effect on sex steroid metabolism.

scientific article published on February 1998

Cyclophenil, a non-steroidal compound with a higher central than peripheral oestrogenic activity: study of its effects on uterine growth and on some central parameters in castrated female rats

scientific article published on 01 November 1984

Diabetes alters myelin lipid profile in rat cerebral cortex: Protective effects of dihydroprogesterone.

scientific article

Diabetic neuropathic pain: a role for testosterone metabolites

scientific article published on 07 March 2014

Differential localization of the 5 alpha-reductase and the 3 alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures.

scientific article published in March 1993

Dihydrotestosterone as a Protective Agent in Chronic Experimental Autoimmune Encephalomyelitis.

scientific article published on 26 February 2015

Distribution of aromatase activity in cultured neurons and glia cells

scientific article published on 01 March 1993

Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model.

scientific article

Editorial

scientific article published on 02 March 2016

Editorial - New perspectives for the action of steroids in the brain.

scientific article published on 31 January 2018

Effect of progesterone, testosterone and their 5 alpha-reduced metabolites on GFAP gene expression in type 1 astrocytes.

scientific article

Effect of short-and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats.

scientific article published in November 2010

Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain.

scientific article published on 9 December 2015

Effects of steroid hormones on gene expression of glial markers in the central and peripheral nervous system: variations induced by aging.

scientific article published in November 1998

Endocrine modulation of gamma-aminobutyric acidergic innervation in the rat fallopian tube.

scientific article published in January 1986

Estrogen receptor is expressed in different types of glial cells in culture.

scientific article published on December 1994

Evaluation of neuroactive steroid levels by liquid chromatography–tandem mass spectrometry in central and peripheral nervous system: Effect of diabetes

scientific article published on 19 June 2007

Evidences for Antinociceptive Effect of 17-Alpha-Hydroxyprogesterone Caproate in Carpal Tunnel Syndrome ⬇️

scientific article published on November 24, 2011

Experimental epothilone B neurotoxicity: results of in vitro and in vivo studies.

scientific article published on 21 May 2009

Expression of androgen-activating enzymes in cultured cells of developing rat brain.

scientific article

Formation and effects of neuroactive steroids in the central and peripheral nervous system.

scientific article

GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids.

scientific article

GABAB receptors in Schwann cells influence proliferation and myelin protein expression

scientific journal article

Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis

scientific article

Gender influence on neurodegenerative and psychiatric disorders.

scientific article published on 3 May 2016

Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones

scientific article published on 15 January 2005

Glial cells: a target for steroid hormones.

scientific article

Growth factors and steroid hormones: a complex interplay in the hypothalamic control of reproductive functions.

scientific article

Hypothalamic transforming growth factor beta1 and basic fibroblast growth factor mRNA expression is modified during the rat oestrous cycle.

scientific article published in June 2001

Identification of the glial cell types containing carnosine-related peptides in the rat brain.

scientific article published in November 1997

Impaired Expression of Ciliary Neurotrophic Factor in Charcot-Marie-Tooth Type 1A Neuropathy

scientific article published in May 2009

Interactions between growth factors and steroids in the control of LHRH-secreting neurons

scientific article published in November 2001

Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival.

scientific article published on 10 July 2009

Intracellular signalling systems controlling the 5 alpha-reductase in glial cell cultures

scientific article published on July 10, 1992

Is the 5 alpha-reductase of the hypothalamus and of the anterior pituitary neurally regulated? Effects of hypothalamic deafferentations and of centrally acting drugs.

scientific article

Is the 5 alpha-reductase-3 alpha-hydroxysteroid dehydrogenase complex associated with the myelin in the peripheral nervous system of young and old male rats?

scientific article published on 01 September 1992

LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals

scientific article published on 03 March 2012

Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy

scientific article published on 26 March 2015

Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features

scientific article

Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions.

scientific article published on 16 August 2013

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease

scientific article

Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology.

scientific article

Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds

scientific article published on 08 August 2019

Liver X receptors, nervous system, and lipid metabolism.

scientific article published on 18 April 2013

Mifepristone (RU 38486) influences expression of glycoprotein Po and morphological parameters at the level of rat sciatic nerve: in vivo observations.

scientific article published in December 2003

Milestones on Steroids and the Nervous System: 10 years of basic and translational research.

scientific article

Modifications of neuroactive steroid levels in an experimental model of nigrostriatal degeneration: potential relevance to the pathophysiology of Parkinson's disease

scientific article published on 14 June 2011

Modulation of fibroblast growth factor-2 by stress and corticosteroids: from developmental events to adult brain plasticity

scientific article published on 01 November 2001

Multimodal analysis in acute and chronic experimental autoimmune encephalomyelitis.

scientific article

Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy.

scientific article

Neuroactive Steroids and Sex-Dimorphic Nervous Damage Induced by Diabetes Mellitus

scientific article published on 14 August 2018

Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients

scientific article published on 10 April 2017

Neuroactive steroid levels in plasma and cerebrospinal fluid of male multiple sclerosis patients

scientific article published on 28 May 2014

Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy

scientific article published on 04 March 2014

Neuroactive steroids and diabetic complications in the nervous system.

scientific article

Neuroactive steroids and peripheral myelin proteins

article

Neuroactive steroids and peripheral neuropathy.

scientific article published on 6 May 2007

Neuroactive steroids and the nervous system: further observations on an incomplete tricky puzzle.

scientific article

Neuroactive steroids and the new decade

scientific article published on 22 January 2020

Neuroactive steroids and the peripheral nervous system: An update.

scientific article published on 28 March 2015

Neuroactive steroids influence peripheral myelination: a promising opportunity for preventing or treating age-dependent dysfunctions of peripheral nerves.

scientific article published on September 2003

Neuroactive steroids prevent peripheral myelin alterations induced by diabetes

scientific article published on 19 April 2006

Neuroactive steroids: A therapeutic approach to maintain peripheral nerve integrity during neurodegenerative events.

scientific article

Neuroactive steroids: an update of their roles in central and peripheral nervous system.

scientific article published on December 2009

Neuroactive steroids: focus on human brain

scientific article (publication date: 15 September 2011)

Neuroactive steroids: old players in a new game.

scientific article

Neuroactive steroids: state of the art and new perspectives.

scientific article published on March 2008

Neuroprotective Effects of Neuroactive Steroids in the Spinal Cord and Peripheral Nerves

scientific article published on 01 January 2006

Neuroprotective Effects of Progesterone in Chronic Experimental Autoimmune Encephalomyelitis

scientific article published on 01 June 2012

Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.

scientific article

Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury

scientific journal article

Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy

scientific article published on 26 April 2017

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

scientific article published on 17 December 2015

Neurosteroids: measurement and pathophysiologic relevance.

scientific article published on 26 September 2007

New steps forward in the neuroactive steroid field.

scientific article published on 19 March 2015

Oestradiol synthesized by female neurons generates sex differences in neuritogenesis.

scientific article published on 24 August 2016

Ontogenetic development of the 5 alpha-reductase in the rat brain: cerebral cortex, hypothalamus, purified myelin and isolated oligodendrocytes

scientific article published on 01 December 1988

Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma.

scientific article

Peripheral nerves: a target for the action of neuroactive steroids

scientific article published on 28 January 2005

Physiopathological Role of Neuroactive Steroids in the Peripheral Nervous System

scientific article published on 26 November 2020

Po gene expression is modulated by androgens in the sciatic nerve of adult male rats.

scientific article

Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?

scientific article published on 19 April 2018

Profiling Neuroactive Steroid Levels After Traumatic Brain Injury in Male Mice.

scientific article published on 22 August 2016

Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes

scientific article

Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats.

scientific article published in October 2003

Progesterone derivatives are able to influence peripheral myelin protein 22 and P0 gene expression: possible mechanisms of action.

scientific article published in May 1999

Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells.

scientific article

SRC-1 is involved in the control of the gene expression of myelin protein Po.

scientific article published on January 2004

Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy

scientific article published on February 2017

Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats.

scientific article

Sex differences in the brain expression of steroidogenic molecules under basal conditions and after gonadectomy

scientific article published on 18 May 2019

Sex differences in the injured brain.

scientific article published on October 2011

Sex differences in the manifestation of peripheral diabetic neuropathy in gonadectomized rats: a correlation with the levels of neuroactive steroids in the sciatic nerve.

scientific article published on 15 January 2011

Sex-dimorphic effects of dehydroepiandrosterone in diabetic neuropathy.

scientific article published on 16 September 2011

Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells.

scientific article published in June 2006

Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus.

scientific article published on 23 November 2016

Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1.

scientific article published on December 1994

Steroid effects on the gene expression of peripheral myelin proteins.

scientific article

Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.

scientific article published on September 2003

Steroid metabolism and effects in central and peripheral glial cells.

scientific article

Steroid metabolizing enzymes in pluripotential progenitor central nervous system cells: effect of differentiation and maturation

scientific article published on 01 May 1996

Steroids and glial cell function.

scientific article published on November 2006

Steroids and the reversal of age-associated changes in myelination and remyelination.

scientific article published on September 2003

Steroids, Stress, and the Gut Microbiome-Brain Axis.

scientific article published on 12 October 2017

Sterol regulatory element binding protein-1C knockout mice show altered neuroactive steroid levels in sciatic nerve.

scientific article published on 3 May 2017

Structural and molecular brain sexual differences: A tool to understand sex differences in health and disease

scientific article published on 22 April 2016

Testosterone 5 alpha-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axons

scientific article published on 01 August 1988

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

scientific article published on 01 May 2007

Testosterone metabolism in brain cells and membranes

scientific article published on 01 January 1991

Testosterone metabolism in peripheral nerves: presence of the 5 alpha-reductase-3 alpha-hydroxysteroid-dehydrogenase enzymatic system in the sciatic nerve of adult and aged rats

scientific article published on 01 January 1990

The 5 alpha-reductase activity of the subcortical white matter, the cerebral cortex, and the hypothalamus of the rat and of the mouse: possible sex differences and effect of castration

scientific article published on 01 April 1987

The 5 alpha-reductase in the brain: molecular aspects and relation to brain function

scientific article published on April 1, 1992

The GABAergic extrinsic innervation of the rat fallopian tubes: biochemical evidence and endocrine modulation

scientific article published on 01 January 1986

The action of steroid hormones on peripheral myelin proteins: a possible new tool for the rebuilding of myelin?

scientific article

The brain: a vulnerable target.

scientific article

The endocrine nervous system: source and target for neuroactive steroids.

scientific article published on March 2008

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.

scientific article published on 12 June 2015

The other side of progestins: effects in the brain

scientific article

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity

scientific article published on April 2015

The synthesis of glycoprotein Po and peripheral myelin protein 22 in sciatic nerve of male rats is modulated by testosterone metabolites.

scientific article

Transforming growth factor beta2 is able to modify mRNA levels and release of luteinizing hormone-releasing hormone in a immortalized hypothalamic cell line (GT1-1).

scientific article published on August 1999

Transforming growth factor-beta and astrocytic conditioned medium influence luteinizing hormone-releasing hormone gene expression in the hypothalamic cell line GT1.

scientific article published on December 1996

Type 1 astrocytes influence luteinizing hormone-releasing hormone release from the hypothalamic cell line GT1-1: is transforming growth factor-beta the principle involved?

scientific article published on February 1995

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