List of works by Romano Danesi

5-Fluorouracil catabolism to 5-fluoro-5,6-dihydrouracil is reduced by acute liver impairment in mice.

scientific article published in March 2005

5-fluorouracil administered as a 48-hour chronomodulated infusion in combination with leucovorin and cisplatin: a randomized phase II study in metastatic colorectal cancer.

scientific article published in January 2001

5-fluorouracil pharmacokinetics predicts disease-free survival in patients administered adjuvant chemotherapy for colorectal cancer.

scientific article published in May 2008

A benefit-risk assessment of basiliximab in renal transplantation.

scientific article published on January 2004

A clinical pharmacogenetic characterization of DPD polymorphisms for pre-treatment screening of patients candidates to fluoropyrimidine therapy.

scientific article published on 11 February 2014

A new validated HPLC-UV method for therapeutic monitoring of daptomycin in comparison with reference mass spectrometry

scientific article published on 25 January 2020

A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients.

scientific article published on 25 March 2008

A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay.

scientific article

A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity

scientific article published on 01 October 2006

A phase I and pharmacokinetic study of irinotecan given as a 7-day continuous infusion in metastatic colorectal cancer patients pretreated with 5-fluorouracil or raltitrexed.

scientific article published in March 2004

A phase I study of continuous hepatic arterial infusion of Irinotecan in patients with locally advanced hepatocellular carcinoma

scientific article published on 13 September 2011

A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer.

scientific article published on 04 June 2008

A rapid high-performance liquid chromatography method to measure linezolid and daptomycin concentrations in human plasma

scientific article published in April 2010

A single nucleotide polymorphism in EZH2 predicts overall survival rate in patients with cholangiocarcinoma

scientific article

ABCB1 polymorphisms are associated with clozapine plasma levels in psychotic patients

scientific article published in August 2009

ALK-1-negative anaplastic large cell lymphoma associated with breast implants: a new clinical entity.

scientific article published on 11 May 2011

AR-V7 and AR-FL expression is associated with clinical outcome: a translational study in patients with castrate resistant prostate cancer

scientific article published on 04 May 2019

ATP-binding cassette transmembrane transporters and their epigenetic control in cancer: an overview.

scientific article

Acetylcholinesterase blockade does not account for the adverse cardiovascular effects of the antitumor drug irinotecan: a preclinical study.

scientific article published in December 2001

Administration interval and daptomycin toxicity: a case report of rhabdomyolysis.

scientific article published on December 2010

Akt1 rs2498801 is related to survival in head and neck squamous cell cancer treated with radiotherapy

scientific article published on January 2015

An aromatase polymorphism (g.132810C>T) predicts risk of bisphosphonate-related osteonecrosis of the jaw.

scientific article published in April 2012

An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients.

scientific article published in November 2004

An improved HPLC method for therapeutic drug monitoring of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites in human plasma

scientific article published on 01 June 1999

Angiogenic inhibitors in gastric cancers and gastroesophageal junction carcinomas: A critical insight

scientific article published on 05 March 2015

Anthracycline cardiotoxicity: in vivo and in vitro effects on biochemical parameters and heart ultrastructure of the rat

scientific article published on 01 January 1991

Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine.

scientific article

Antineoplastic activity of the multitarget tyrosine kinase inhibitors CLM3 and CLM94 in medullary thyroid cancer in vitro.

scientific article published on 21 August 2014

Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells

scientific article published on April 2011

Antiproliferative and proapoptotic activity of sunitinib on endothelial and anaplastic thyroid cancer cells via inhibition of Akt and ERK1/2 phosphorylation and by down-regulation of cyclin-D1.

scientific article published on 22 August 2013

Application of a pharmacokinetic/pharmacogenetic approach to assess the nicotine metabolic profile of smokers in the real-life setting.

scientific article published on 31 August 2016

Appropriateness of repetitive therapeutic drug monitoring and laboratory turnaround time

scientific article published on 01 November 2019

Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.

scientific article published on 16 February 2010

Association of the hOCT1/ABCB1 genotype with efficacy and tolerability of imatinib in patients affected by chronic myeloid leukemia.

scientific article

Augmentation of clozapine with aripiprazole in severe psychotic bipolar and schizoaffective disorders: a pilot study.

scientific article

Author's reply: To PMID 22443211.

scientific article

BMI1 silencing enhances docetaxel activity and impairs antioxidant response in prostate cancer

scientific article published on April 2011

Biologic basis of ovarian metastasis of colorectal cancer.

scientific article published on February 2004

Biweekly chemotherapy with oxaliplatin, irinotecan, infusional Fluorouracil, and leucovorin: a pilot study in patients with metastatic colorectal cancer

scientific article published in October 2002

Blood-based PD-L1 analysis in tumor-derived extracellular vesicles: Applications for optimal use of anti-PD-1/PD-L1 axis inhibitors

scientific article published on 30 October 2020

Breast lymphomas around breast implants

scientific article published on 01 January 2014

CLM29, a multi-target pyrazolopyrimidine derivative, has anti-neoplastic activity in medullary thyroid cancer in vitro and in vivo.

scientific article published on 12 June 2014

CLM3, a multitarget tyrosine kinase inhibitor with antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo.

scientific article published on January 2014

CLM94, a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo.

scientific article published on 25 January 2012

CYP17A1 polymorphism c.-362T>C predicts clinical outcome in metastatic castration-resistance prostate cancer patients treated with abiraterone

scientific article published on 18 September 2020

CYP2D6 polymorphisms and the impact on tamoxifen therapy

scientific article

Cancer stem cell epigenetics and chemoresistance.

scientific article published on October 2009

Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: a new modality treatment.

scientific article published in February 1997

Cardiac toxicity of antineoplastic anthracyclines.

scientific article

Cardiotoxicity and cytotoxicity of the anthracycline analog 4'-deoxy-4'-iodo-doxorubicin.

scientific article published in January 1991

Cardiovascular implantable electronic device endocarditis treated with daptomycin with or without transvenous removal.

scientific article published on 20 March 2012

Case report of a successful treatment of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and MRSA/vancomycin-resistant Enterococcus faecium cholecystitis by daptomycin.

scientific article published on 22 February 2011

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

scientific article

Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells

scientific article

Ceramide Analogues in Apoptosis: A New Strategy for Anticancer Drug Development

article

Ceramide analogues in apoptosis: a new strategy for anticancer drug development.

scientific article

Changes of specific atrial granules induced by doxorubicin in dog's heart.

scientific article

Characterization of the toxicity of distamycin derivatives on cancer cell lines and rat heart

scientific article published on 01 November 1992

Chemoembolization is effective as second-line therapy in patients with colorectal carcinoma metastatic to the liver

scientific article published on 01 November 2002

Cholinergic toxic syndrome by the anticancer drug irinotecan: acetylcholinesterase does not play a major role.

scientific article

Chronic administration of suramin induces neurotoxicity in rats.

scientific article published in November 1997

Circulating DNA in diagnosis and monitoring EGFR gene mutations in advanced non-small cell lung cancer

scientific article

Circulating biomarkers of response to immunotherapy in cancer treatment

scientific article published on 06 November 2019

Circulating tumor DNA and the future of EGFR-mutant lung cancer treatment

scientific article published on 01 December 2019

Clinical and experimental pharmacokinetic interaction between 6-mercaptopurine and methotrexate

scientific article published on 01 January 1996

Clinical and pharmacodynamic evaluation of metronomic cyclophosphamide, celecoxib, and dexamethasone in advanced hormone-refractory prostate cancer.

scientific article published on 21 July 2009

Clinical pharmacokinetics of antibacterials in cerebrospinal fluid.

scientific article published on July 2013

Clinical pharmacokinetics of irinotecan-based chemotherapy in colorectal cancer patients

scientific article published on September 2006

Clinical pharmacology of intravitreal anti-VEGF drugs.

scientific article

Clinical pharmacology of monoclonal antibodies targeting PD-1 axis in urothelial cancers

scientific article published on 24 April 2020

Clinical pharmacology of monoclonal antibodies targeting anti-PD-1 axis in urothelial cancers

scientific article published on 26 September 2019

Clinical, pharmacodynamic and pharmacokinetic results of a prospective phase II study on oral metronomic vinorelbine and dexamethasone in castration-resistant prostate cancer patients.

scientific article published on 24 August 2016

Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers

scientific article published on 2 March 2012

Comment on "High expression of CD39/ENTPD1 in malignant epithelial cells of human rectal adenocarcinoma".

scientific article published on 17 September 2015

Comparative distribution of azithromycin in lung tissue of patients given oral daily doses of 500 and 1000 mg.

scientific article published on 25 February 2003

Comparative evaluation of molecular methods for the quantitative measure of torquetenovirus viremia, the new surrogate marker of immune competence

scientific article published on 19 April 2019

Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and reduced test dose in cancer patients

scientific article published on 01 August 2000

Concise Review: Chronic Myeloid Leukemia: Stem Cell Niche and Response to Pharmacologic Treatment

scientific article published on 8 February 2018

Concise Review: Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer: The Role of Cancer Stem Cells.

scientific article published on 20 January 2018

Conformationally Restrained Ceramide Analogues: Effects of Lipophilic Modifications on the Antiproliferative Activity

article published in 2003

Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.

scientific article published in January 2003

Contribution of KRAS mutations and c.2369C > T (p.T790M) EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC: a study on circulating tumor DNA.

scientific article published on 20 January 2016

Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients.

scientific article

Corrigendum to "Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors" [Cancer Treatm. Rev. 74 (2019) 21-28]

scientific article published on 06 November 2019

Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients.

scientific article

Cytofluorescence localization and disposition of doxorubicin and doxorubicinol in rat cardiac tissue

scientific article published on 01 July 1988

Cytotoxic activity of gemcitabine and correlation with expression profile of drug-related genes in human lymphoid cells

article

DPYD IVS14+1G>A and 2846A>T genotyping for the prediction of severe fluoropyrimidine-related toxicity: a meta-analysis

scientific article published on August 2013

DPYD and UGT1A1 genotyping to predict adverse events during first-line FOLFIRI or FOLFOXIRI plus bevacizumab in metastatic colorectal cancer.

scientific article published on 21 December 2017

DPYD*6 plays an important role in fluoropyrimidine toxicity in addition to DPYD*2A and c.2846A>T: a comprehensive analysis in 1254 patients

scientific article published on 06 February 2019

Dabrafenib treatment in a patient with BRAF V600E ganglioglioma: circulating exosome-derived cancer RNA supports treatment choice and clinical monitoring

scientific article published on 01 December 2019

Depression of the immune responsiveness in mice treated with thioacetamide after antigen exposure

scientific article published on 01 September 1989

Detection of ALK and KRAS Mutations in Circulating Tumor DNA of Patients With Advanced ALK-Positive NSCLC With Disease Progression During Crizotinib Treatment.

scientific article

Detection of KRAS mutant alleles in circulating cell-free tumor DNA in colorectal cancer patients resistant to cetuximab

scientific article published on 11 February 2014

Determinants of bone specific metastasis in prostate cancer.

scientific article published on 16 February 2017

Different Underlying Mechanism Might Explain the Absence of a Significant Difference in Area Under the Concentration-Time Curve of Linezolid for Different ABCB1 Genotypes

Different recommendations for daptomycin dosing over time in patients with severe infections

scientific article published on 11 April 2014

Differential affinities of AF-DX 116, atropine and pirenzepine for muscarinic receptors of guinea pig gastric fundus, atria and urinary bladder: might atropine distinguish among muscarinic receptor subtypes?

scientific article published on 01 January 1990

Dihydropyrimidine dehydrogenase polymorphisms and fluoropyrimidine toxicity: ready for routine clinical application within personalized medicine?

scientific article

Discordant somatic and germlineVEGF-Agenotype in a cancer patient resistant to paclitaxel/bevacizumab with chemosensitive hepatic metastasis

scientific article published on 01 August 2009

Discovery of novel mutations in the dihydropyrimidine dehydrogenase gene associated with toxicity of fluoropyrimidines and viewpoint on preemptive pharmacogenetic screening in patients

scientific article published on 2 September 2015

Docetaxel plus oral metronomic cyclophosphamide: a phase II study with pharmacodynamic and pharmacogenetic analyses in castration-resistant prostate cancer patients.

scientific article

Dose-finding study and pharmacokinetics of epirubicin and paclitaxel over 3 hours: a regimen with high activity and low cardiotoxicity in advanced breast cancer

scientific article published on 01 July 1997

Drug-drug interactions in breast cancer patients treated with CDK4/6 inhibitors

scientific article published on 19 January 2019

Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015.

scientific article published on 14 January 2016

EGFR ligands as pharmacodynamic biomarkers in metastatic colorectal cancer patients treated with cetuximab and irinotecan.

scientific article published on 3 July 2013

EGFR-TKIs in non-small-cell lung cancer: focus on clinical pharmacology and mechanisms of resistance

scientific article published on 22 May 2018

EPMA position paper in cancer: current overview and future perspectives

scientific article published on 15 April 2015

EPMA-World Congress 2015

scientific article

EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis

scientific article published on December 2012

EZH2 polymorphism and benefit from bevacizumab in colorectal cancer: another piece to the puzzle

scientific article published on 01 March 2012

Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer.

scientific article

Effect of Suramin on Human Prostate Cancer Cells in Vitro ⬇️

scientific article published on February 1, 1991

Effects of 4'-O-tetrahydropyranyl-doxorubicin on isolated perfused rat heart and cardiac mitochondrial cytochrome C oxidase activity

scientific article published on 01 July 1987

Effects of amiodarone, thyroid hormones and CYP2C9 and VKORC1 polymorphisms on warfarin metabolism: a review of the literature.

scientific article

Efficacy and safety of basiliximab in kidney transplantation.

scientific article

Embryonic stem cell pathways and chemotherapy response: an unexplored route

scientific article published on 11 December 2012

Endothelial nitric oxide synthase c.-813C>T predicts for proteinuria in metastatic breast cancer patients treated with bevacizumab-based chemotherapy

scientific article published on 16 September 2019

Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.

scientific article

Epigenetics and chemoresistance in colorectal cancer: an opportunity for treatment tailoring and novel therapeutic strategies

scientific article published on 28 September 2011

Epileptogenesis and oncogenesis: An antineoplastic role for antiepileptic drugs in brain tumours?

scientific article published on 07 April 2020

Exogenous doxorubicinol induces cardiotoxic effects in rats

scientific article published on 01 July 1987

Expression of gemcitabine- and cisplatin-related genes in non-small-cell lung cancer.

scientific article

Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer.

scientific article

Faithful markers of circulating cancer stem cells: is CD133 sufficient for validation in clinics?

scientific article published on 25 July 2011

First-line metronomic chemotherapy in a metastatic model of spontaneous canine tumours: a pilot study.

scientific article published on 21 April 2011

Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells.

scientific article

Forum: journal club

scientific article published on 01 August 2000

From the beginning to resistance: Study of plasma monitoring and resistance mechanisms in a cohort of patients treated with osimertinib for advanced T790M-positive NSCLC

scientific article published on 19 March 2019

General and cardiac toxicity of adriamycinol in rats

scientific article published on 01 September 1986

Genetic determinants in the study of colorectal cancer

scientific article published on 01 November 2004

Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients.

scientific article published on 21 August 2015

Genetic variation: effect on prostate cancer.

scientific article

Genotype A1/A2 associated with neuroleptic malignant syndrome.

scientific article published in August 2005

Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.

scientific article published in June 1998

Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins

scientific article published on 01 March 1996

Hematologic toxicity of immunosuppressive treatment.

scientific article

High-dose thiotepa and melphalan with hemopoietic progenitor support following induction therapy with epirubicin-paclitaxel-containing regimens in metastatic breast cancer (MBC).

scientific article published in January 2001

Histone lysine demethylases in breast cancer

scientific article

Human skin disposition of cefpodoxime after oral administration of its proxetil ester

scientific article published on 01 November 1992

Hypertension and hand-foot skin reactions related to VEGFR2 genotype and improved clinical outcome following bevacizumab and sorafenib

scientific article

IL-8 and eNOS polymorphisms predict bevacizumab-based first line treatment outcomes in RAS mutant metastatic colorectal cancer patients

scientific article published on 25 January 2017

Idarubicin and idarubicinol effects on breast cancer multicellular spheroids.

scientific article published on December 2005

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

scientific article published on 14 April 2021

Imatinib administration in two patients with liver metastases from GIST and severe jaundice

scientific article published on October 2003

Impact of cytidine deaminase polymorphisms on toxicity after gemcitabine: the question is still ongoing.

scientific article published on 29 March 2010

Impact of locoregional approaches to liver metastases in patients with colorectal cancer

scientific article published on 01 May 2003

Impact ofABCG2polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

article

Implications of KRAS mutations in acquired resistance to treatment in NSCLC.

scientific article published on 21 December 2017

Importance of preclinical investigations of the integration of capecitabine into polychemotherapy regimens.

scientific article published on January 2005

Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling

scientific article published in June 2005

In vitro and in vivo antitumour effects of novel, orally active bile acid-conjugated platinum complexes on rat hepatoma

scientific article published on 16 August 2006

In vitro antiangiogenic activity of selective somatostatin subtype-1 receptor agonists

scientific article published on 01 September 2007

In vitro studies on gemcitabine combinations with other antiblastics.

scientific article published on May 2006

In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients.

scientific article published on 25 July 2006

In-vitro evidence of autocrine secretion of vascular endothelial growth factor by endothelial cells from human placental blood vessels

scientific article published on 01 August 2001

Incidence and relative risk of adverse events of special interest in patients with castration resistant prostate cancer treated with CYP-17 inhibitors: A meta-analysis of published trials

scientific article published on 27 February 2016

Incidence of T790M in Patients With NSCLC Progressed to Gefitinib, Erlotinib, and Afatinib: A Study on Circulating Cell-free DNA

scientific article published on 13 October 2019

Infusions of fluorouracil and leucovorin: effects of the timing and semi-intermittency of drug delivery

scientific article published on 01 October 1999

Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients.

scientific article

Inhibition of experimental angiogenesis by the somatostatin analogue octreotide acetate (SMS 201-995).

scientific article published in February 1997

Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells.

scientific article published on June 2001

Inhibitory effect of suramin in rat models of angiogenesis in vitro and in vivo

scientific article published on 01 January 1999

Inhibitory effect of the somatostatin analogue SMS 201-995 and cytokines on the proliferation of human colon adenocarcinoma cell lines.

scientific article

Interaction between gemcitabine and topotecan in human non-small-cell lung cancer cells: effects on cell survival, cell cycle and pharmacogenetic profile.

scientific article published on February 2005

Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer

scientific article

Involvement of basic fibroblast growth factor in suramin-induced inhibition of V79/AP4 fibroblast cell proliferation ⬇️

scientific article published on June 1, 1993

Irinotecan in 5-fluorouracil-refractory colorectal cancer.

scientific article published in August 2002

Irinotecan in combination with thalidomide in patients with advanced solid tumors: a clinical study with pharmacodynamic and pharmacokinetic evaluation.

scientific article published on 6 May 2006

Irinotecan synergistically enhances the antiproliferative and proapoptotic effects of axitinib in vitro and improves its anticancer activity in vivo

scientific article published on March 2011

KRAS inhibition in non-small cell lung cancer: Past failures, new findings and upcoming challenges

scientific article published on 31 July 2020

Key concepts and critical issues on epoetin and filgrastim biosimilars. A position paper from the Italian Society of Hematology, Italian Society of Experimental Hematology, and Italian Group for Bone Marrow Transplantation.

scientific article published on July 2011

Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients

scientific article published on 14 May 2022

Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma.

scientific article

Lessons from the first ecancer symposium on angiogenesis in gastric cancer.

scientific article published on 21 July 2015

Limited sampling model for the analysis of 5-fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer

scientific article

Linezolid in the central nervous system: comparison between cerebrospinal fluid and plasma pharmacokinetics

scientific article published on 17 May 2011

Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role

scientific article published on 01 January 1993

Management of adverse events associated with idelalisib treatment in chronic lymphocytic leukemia and follicular lymphoma: A multidisciplinary position paper

scientific article published on 05 September 2018

Management of adverse events associated with tyrosine kinase inhibitors: Improving outcomes for patients with hepatocellular carcinoma

scientific article published on 15 May 2019

Management of metabolic adverse events of targeted therapies and immune checkpoint inhibitors in cancer patients: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)/Società Italiana Farmacologia (SIF) multidiscipl

scientific article published on 15 August 2020

Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells.

scientific article

Mathematical modeling of drug resistance due to KRAS mutation in colorectal cancer

scientific article published on 6 November 2015

Maximum tolerable doses of intravenous zidovudine in combination with 5-fluorouracil and leucovorin in metastatic colorectal cancer patients. Clinical evidence of significant antitumor activity and enhancement of zidovudine-induced DNA single strand

scientific article published on 01 June 1997

Melanocortin Receptor-4 Gene Polymorphisms in Glioblastoma Patients Treated with Concomitant Radio-Chemotherapy

scientific article published on February 2017

Metabolism of 6-mercaptopurine in the erythrocytes, liver, and kidney of rats during multiple-dose regimens.

scientific article published in January 1999

Methods: for studying pharmacogenetic profiles of combination chemotherapeutic drugs

scientific article published on 03 June 2015

Metronomic 5-fluorouracil, oxaliplatin and irinotecan in colorectal cancer.

scientific article

Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1.

scientific article

Metronomic chemotherapy for metastatic prostate cancer: a 'young' concept for old patients?

scientific article published on September 2010

Metronomic cyclophosphamide in elderly patients with advanced, castration-resistant prostate cancer.

scientific article published on May 2010

MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.

scientific article

Modulation of Epidermal Growth Factor Receptor Status by Chemotherapy in Patients With Locally Advanced Non–Small-Cell Lung Cancer Is Rare

scientific article published on 01 December 2004

Molecular analysis of cell-free circulating DNA for the diagnosis of somatic mutations associated with resistance to tyrosine kinase inhibitors in non-small-cell lung cancer

scientific article published on 11 April 2014

Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer

scientific article published on 9 November 2015

Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells

scientific article

Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice.

scientific article published on 05 May 2011

Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.

scientific article published on 10 January 2008

Morphohistochemical characterization of suramin--induced chronic toxicity in rat kidney

scientific article published on 01 November 1992

Novel Pyrazolopyrimidine Derivatives as Tyrosine Kinase Inhibitors with Antitumoral Activity in Vitro and in Vivo in Papillary Dedifferentiated Thyroid Cancer.

scientific article published in January 2011

Novel Pyrazolopyrimidine Derivatives as Tyrosine Kinase Inhibitors with Antitumoral Activityin Vitroandin Vivoin Papillary Dedifferentiated Thyroid Cancer

article published in 2011

Novel pyrazolopyrimidine derivatives as tyrosine kinase inhibitors with antitumoral activity in vitro and in vivo in papillary dedifferentiated thyroid cancer.

scientific article published on 8 December 2010

Optimal use of recombinant granulocyte colony-stimulating factor with chemotherapy for solid tumors

scientific article published on August 2011

Optimized granulocyte colony-stimulating factor prophylaxis in adult cancer patients: from biological principles to clinical guidelines.

scientific article published on 23 March 2012

Optimizing pemetrexed-gemcitabine combination in patients with advanced non-small cell lung cancer: a pharmacogenetic approach.

scientific article published in April 2011

Optimizing treatment of renal cell carcinoma with VEGFR-TKIs: a comparison of clinical pharmacology and drug-drug interactions of anti-angiogenic drugs

scientific article published on 17 January 2020

Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: pharmacokinetic considerations and clinical implications.

scientific article published on 30 January 2013

Overexpression and functional relevance of somatostatin receptor-1, -2, and -5 in endometrium and endometriotic lesions.

scientific article published on 25 August 2010

Overexpression of TK1 and CDK9 in plasma-derived exosomes is associated with clinical resistance to CDK4/6 inhibitors in metastatic breast cancer patients

scientific article published on 26 July 2019

PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC

scientific article published on 06 March 2018

PI3K mutations detected in liquid biopsy are associated to reduced sensitivity to CDK4/6 inhibitors in metastatic breast cancer patients

scientific article published on 10 October 2020

Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells ⬇️

scientific article published on June 1, 1995

Pathophysiology and pharmacological targets of VEGF in diabetic macular edema.

scientific article

Patients with NSCLC may display a low ratio of p.T790M vs. activating EGFR mutations in plasma at disease progression: implications for personalised treatment.

scientific article published on 15 September 2017

Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines

scientific article published on January 1, 1992

Pegfilgrastim for the prevention of chemotherapy-induced febrile neutropenia in patients with solid tumors.

scientific article

Penetration of clofoctol into human lung.

scientific article

Periodontal tissue disposition of azithromycin

scientific article published on 01 December 1997

Periorbital necrotising fasciitis

scientific article

Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer

scientific article

Pharmacodynamics of current and emerging PD-1 and PD-L1 inhibitors for the treatment of non-small cell lung cancer

scientific article published on 30 January 2020

Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins

scientific article

Pharmacogenetic determinants of anti-cancer drug activity and toxicity.

scientific article

Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab.

scientific article published in December 2014

Pharmacogenetics and Metabolism from Science to Implementation in Clinical Practice: The Example of Dihydropyrimidine Dehydrogenase.

scientific article published on 25 January 2017

Pharmacogenetics and proteomics of anticancer drugs in non-Hodgkin's lymphoma.

scientific article published on January 2003

Pharmacogenetics of BCR/ABL Inhibitors in Chronic Myeloid Leukemia

scientific article

Pharmacogenetics of androgen signaling in prostate cancer: Focus on castration resistance and predictive biomarkers of response to treatment.

scientific article published on 6 March 2018

Pharmacogenetics of anti-estrogen treatment of breast cancer

scientific article published on 13 September 2011

Pharmacogenetics of antiangiogenic and antineovascular therapies of age-related macular degeneration.

scientific article published on July 2012

Pharmacogenetics of anticancer drug sensitivity in non-small cell lung cancer

scientific article

Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer

scientific article published on June 2006

Pharmacogenetics of neoplastic diseases: new trends

scientific article published on April 2004

Pharmacogenomics and cancer stem cells: a changing landscape?

scientific article

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.

scientific article

Pharmacogenomics of gemcitabine in non-small-cell lung cancer and other solid tumors

scientific article published on January 2009

Pharmacokinetic Markers of 5-Fluorouracil Toxicity in Clinical Trials and Real World

article

Pharmacokinetic and pharmacogenetic predictive markers of irinotecan activity and toxicity.

scientific article published on December 2011

Pharmacokinetic optimisation of the treatment of cancer with high dose zidovudine.

scientific article published on February 1998

Pharmacokinetic optimisation of treatment schedules for anthracyclines and paclitaxel in patients with cancer.

scientific article

Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs.

scientific article

Pharmacokinetics and pharmacodynamics of combination chemotherapy with paclitaxel and epirubicin in breast cancer patients

scientific article published on May 2002

Pharmacokinetics and tolerance of nicotinamide combined with radiation therapy in patients with glioblastoma multiforme.

scientific article published in January 1994

Pharmacokinetics, a main actor in a many-sided approach to severe 5-FU toxicity prediction

scientific article published on 5 November 2008

Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer

scientific article

Pharmacologic rationale for early G-CSF prophylaxis in cancer patients and role of pharmacogenetics in treatment optimization.

scientific article published on 25 December 2008

Pharmacological issues of linezolid: an updated critical review

scientific article published on July 2010

Phase ib of sorafenib in combination with everolimus in patients with advanced solid tumors, selected on the basis of molecular targets.

scientific article published on 27 March 2014

Phenylacetate inhibits protein isoprenylation and growth of the androgen-independent LNCaP prostate cancer cells transfected with the T24 Ha-ras oncogene.

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Phosphorylation of AKT and ERK1/2 and mutations of PIK3CA and PTEN are predictive of breast cancer cell sensitivity to everolimus in vitro

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Plasma and tissue disposition of paclitaxel (taxol) after intraperitoneal administration in mice

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Plasma pharmacokinetics of cinmetacin following oral administration in healthy volunteers.

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Polycomb genes and cancer: time for clinical application?

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Polycomb genes are associated with response to imatinib in chronic myeloid leukemia.

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Population pharmacokinetic analysis of 5-FU and 5-FDHU in colorectal cancer patients: search for biomarkers associated with gastro-intestinal toxicity

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Population pharmacokinetics and probability of target attainment of meropenem in critically ill patients

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Population pharmacokinetics of daptomycin in patients affected by severe Gram-positive infections.

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Precision Medicine in Lymphoma by Innovative Instrumental Platforms

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Predicting fluoropyrimidine-related toxicity: turning wish to will, the PAMM-EORTC position

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Predicting survival with artificial neural networks.

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Prognostic value of CD133 caused by mutant K-Ras and B-Raf--letter

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Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma.

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Promoting predictive, preventive and personalised medicine: European event of global importance

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Protein kinase inhibitors for the treatment of advanced and progressive radiorefractory thyroid tumors: From the clinical trials to the real life

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Radiomics and liquid biopsy in oncology: the holons of systems medicine

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Real-Time PCR and Droplet Digital PCR: two techniques for detection of the JAK2(V617F) mutation in Philadelphia-negative chronic myeloproliferative neoplasms.

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Recent advances in epigenomics in NSCLC: real-time detection and therapeutic implications.

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Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan: A Phase 2 Single-Arm Clinical Trial

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Reduced cardiotoxicity and increased cytotoxicity in a novel anthracycline analogue, 4'-amino-3'-hydroxy-doxorubicin

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Refining sorafenib therapy: lessons from clinical practice.

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Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusions in cancer patients.

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Reply to Ugo De Giorgi, Vincenza Conteduca, and Emanuela Scarpi's Letter to the Editor re: Marzia Del Re, Elisa Biasco, Stefania Crucitta, et al. The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Re

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Role of Low-Molecular-Weight Heparin in Hospitalized Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia: A Prospective Observational Study

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Selective anti-endothelial effects of protracted low-dose BAL-9504, a novel geranylgeranyl-transferase inhibitor

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Severe 5-fluorouracil toxicity associated with a marked alteration of pharmacokinetics of 5-fluorouracil and its catabolite 5-fluoro-5,6-dihydrouracil: a case report.

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Should CYP2D6 be genotyped when treating with tamoxifen?

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ShouldCYP2D6be genotyped when treating with tamoxifen?

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Simultaneous, But Not Consecutive, Combination With Folinate Salts Potentiates 5-Fluorouracil Antitumor Activity In Vitro and In Vivo

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Single nucleotide polymorphisms and clinical outcome in patients with biliary tract carcinoma treated with epirubicin, cisplatin and capecitabine.

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Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

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Steroids in prostate cancer: the jury is still out... and even more confused

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Study of apoptosis induction and deoxycytidine kinase/cytidine deaminase modulation in the synergistic interaction of a novel ceramide analog and gemcitabine in pancreatic cancer cells.

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Sunitinib in Metastatic Renal Cell Carcinoma: The Pharmacological Basis of the Alternative 2/1 Schedule

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Superoxide anion production by adriamycinol from cardiac sarcosomes and by mitochondrial NADH dehydrogenase

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Superoxide anion production by doxorubicin analogs in heart sarcosomes and by mitochondrial NADH dehydrogenase

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Suppression of Fas expression and down-regulation of Fas ligand in highly aggressive human thyroid carcinoma

Suramin as an anticomplementary agent in xenotransplantation

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Suramin in adrenal cancer: modulation of steroid hormone production, cytotoxicity in vitro, and clinical antitumor effect.

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Suramin in patients with metastatic colorectal cancer pretreated with fluoropyrimidine-based chemotherapy. A phase II study

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Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane.

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Suramin therapy for malignant thymoma: a case report

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Suramin, a novel antitumor compound.

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Synergistic antiproliferative activity of suramin and alpha 2A-interferon against human colorectal adenocarcinoma cell lines: in vitro studies.

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Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.

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Synergistic cytotoxicity and molecular interaction on drug targets of sorafenib and gemcitabine in human pancreas cancer cells

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Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines.

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Synergistic cytotoxicity, inhibition of signal transduction pathways and pharmacogenetics of sorafenib and gemcitabine in human NSCLC cell lines

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Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer

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Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

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Targeting vascular endothelial growth factor pathway in first-line treatment of metastatic colorectal cancer: state-of-the-art and future perspectives in clinical and molecular selection of patients

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The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients.

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The Role of Adjuvant Therapy After Liver Resection for Colorectal Metastases

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The amount of activating EGFR mutations in circulating cell-free DNA is a marker to monitor osimertinib response

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The antiproliferative effect of suramin on the cancer cell line SW-13 is mediated by the inhibition of transforming growth factor beta 1 (TGF-beta 1).

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The c.480C>G polymorphism of hOCT1 influences imatinib clearance in patients affected by chronic myeloid leukemia

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The effect of osteogenic growth peptide (OGP) on proliferation and adhesion of HEMC-1 human endothelial cells.

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The effect of rhGM-CSF on the proliferation of osteogenic sarcoma cells

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The effects of the somatostatin analog octreotide on angiogenesis in vitro.

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The emerging role of histone lysine demethylases in prostate cancer

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The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer

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The gemcitabine/epirubicin/paclitaxel combination in advanced breast cancer

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The hOCT1 and ABCB1 polymorphisms do not influence the pharmacodynamics of nilotinib in chronic myeloid leukemia.

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The heparan sulfate suleparoide inhibits rat corneal angiogenesis and in vitro neovascularization

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The increase in activating EGFR mutation in plasma is an early biomarker to monitor response to osimertinib: a case report

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The influence of amrinone on cardiac toxicity induced by adriamycin in rats.

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The penetration of roxithromycin into human skin

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The pharmacokinetic profile of clofoctol in rat plasma and tissues after oral and rectal administration

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The pharmacological bases of the antiangiogenic activity of paclitaxel

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The role of drug-drug interactions in prostate cancer treatment: Focus on abiraterone acetate/prednisone and enzalutamide

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The role of pharmacogenetics in adjuvant treatment of non-small cell lung cancer.

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The rs2071559 AA VEGFR-2 genotype frequency is significantly lower in neovascular age-related macular degeneration patients.

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Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients

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Time-Dependent Pharmacokinetics of 5-Fluorouracil and Association With Treatment Tolerability in the Adjuvant Setting of Colorectal Cancer

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Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients.

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Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.

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Trapidil inhibits endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane and in the rat cornea

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Ultrastructural and biochemical evidence of apoptosis induced by a novel inhibitor of protein geranylgeranylation in human MIA PaCa-2 pancreatic cancer cells

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Uncommon dihydropyrimidine dehydrogenase mutations and toxicity by fluoropyrimidines: a lethal case with a new variant.

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Understanding EGFR heterogeneity in lung cancer

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Understanding the Mechanisms of Resistance in EGFR-Positive NSCLC: From Tissue to Liquid Biopsy to Guide Treatment Strategy

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Unusual gastrointestinal and cutaneous toxicities by bleomycin, etoposide, and cisplatin: a case report with pharmacogenetic analysis to personalize treatment.

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VEGF-A polymorphisms predict progression-free survival among advanced castration-resistant prostate cancer patients treated with metronomic cyclophosphamide.

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VEGF-A polymorphisms predict short-term functional response to intravitreal ranibizumab in exudative age-related macular degeneration

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Variable correlation between 6-mercaptopurine metabolites in erythrocytes and hematologic toxicity: implications for drug monitoring in children with acute lymphoblastic leukemia

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Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.

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Vascular endothelial growth factor pharmacogenetics: a new perspective for anti-angiogenic therapy

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[A selective antimuscarinic agent: pirenzepine. Review of its pharmacologic and clinical properties]

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[Clinical efficacy of clofoctol in treating odontogenic infections]

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[Effect of amrinone on the cardiotoxicity induced by adriamycin in the rat]

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[Recent pharmacotoxicologic and clinical findings on adriamycin]

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[The antianginal effects of a new delayed-release formulation of diltiazem in patients with stable angina pectoris: its evaluation by the ergometry test and dynamic electrocardiogram]

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[The physiopathological aspects of the atrial natriuretic factor]

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erbB in NSCLC as a molecular target: current evidences and future directions

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