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List of works by Luiz Gonzaga Tone

8q deletion in MYCN-amplified neuroblastoma of a child born from assisted reproductive technology.

scientific article published in March 2009

A case of near-triploid with t(2;14)(p12;q32) in blast crisis of chronic myeloid leukemia detected by spectral karyotyping (SKY)

scientific article published on 01 April 2007

A new complex rearrangement in infant ALL: t(X;11;17)(p11.2;q23;q12)

scientific article published on 28 October 2018

A novel type of C11orf95-LOC-RELA fusion in a grade II supratentorial ependymoma: report of a case with literature review

scientific article published on 10 January 2019

A point mutation in the RNA-binding domain I results in decrease of PKR activation in acute lymphoblastic leukemia.

scientific article published in January 2005

A simplified approach using Taqman low-density array for medulloblastoma subgrouping

scientific article published on 04 March 2019

A simplified minimal residual disease polymerase chain reaction method at early treatment points can stratify children with acute lymphoblastic leukemia into good and poor outcome groups

scientific article published on June 2009

A study of adrenocortical tumors in children and adolescents by a comparative genomic hybridization technique.

scientific article

Accurate determination of energy needs in children and adolescents with cancer

scientific article published on 01 January 2011

Acute lymphoblastic leukemia with inv(5)(q13q31) in a pediatric patient.

scientific article

Acute monocytic leukemia and multiple abnormalities in a child with duplication of 1q detected by GTG-banding and SKY

scientific article published on 16 June 2005

Altered expression of noncanonical Wnt pathway genes in paediatric and adult adrenocortical tumours

article

Analysis of ETV6/RUNX1 fusions for evaluating the late effects of cancer therapy in ALL (acute lymphoblastic leukemia) cured patients.

scientific article published in January 2004

Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic leukemias.

scientific article

Analysis of the p53 gene by PCR-SSCP in ten cases of Wilms’ tumor

article

Anti-CD20 monoclonal antibody therapy and minimal residual disease status of T-cell/histiocyte-rich large B cell non-Hodgkin lymphoma

scientific article published on 07 April 2011

Anticancer activity of 7-epiclusianone, a benzophenone from Garcinia brasiliensis, in glioblastoma.

scientific article published on 30 October 2015

Antineoplastic effects of NF-κB inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) alone and in co-treatment with radio-and chemotherapy in medulloblastoma cell lines

scientific article published on 13 November 2017

Antiproliferative in vitro effects of BI 2536-mediated PLK1 inhibition on cervical adenocarcinoma cells.

scientific article

Antitumour activity of AMG 900 alone or in combination with histone deacetylase inhibitor SaHa on medulloblastoma cell lines.

scientific article published on 22 May 2015

Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup

scientific article published on 22 April 2020

B lineage acute lymphoblastic leukemia transformation in a child with juvenile myelomonocytic leukemia, type 1 neurofibromatosis and monosomy of chromosome 7. Possible implications in the leukemogenesis

scientific article published on 01 April 2003

BI 2536-mediated PLK1 inhibition suppresses HOS and MG-63 osteosarcoma cell line growth and clonogenicity.

scientific article

BI 6727 and GSK461364 suppress growth and radiosensitize osteosarcoma cells, but show limited cytotoxic effects when combined with conventional treatments.

scientific article

Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: randomized trial from the Brazilian Childhood Cooperative Group--protocol ALL-99.

scientific article published on 8 March 2010

Blastoid mantle cell lymphoma with t(2;8) (p12;q24)

scientific article published on 01 October 2007

Bloom's and myelodysplastic syndromes: Report of a rare pediatric case with gain of an isochromosome 5p

scientific article published on 05 October 2011

Bronchioloalveolar carcinoma arising in a congenital pulmonary airway malformation in a child: case report with an update of this association.

scientific article published on May 2007

CD10 and CD19 fluorescence intensity of B-cell precursors in normal and leukemic bone marrow. Clinical characterization of CD10(+strong) and CD10(+weak) common acute lymphoblastic leukemia

scientific article published on 01 May 1999

CTGF expression is indicative of better survival rates in patients with medulloblastoma

scientific article published on 10 May 2019

CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome

scientific article published on 04 January 2012

Case Report Osteosarcoma arising from osteochondroma of the tibia: case report and cytogenetic findings

scientific article published on 01 March 2012

Childhood B lineage acute lymphoblastic leukemia clonality study by the polymerase chain reaction

scientific article published on 01 November 1997

Childhood radiation-associated atypical meningioma with novel complex rearrangements involving chromosomes 1 and 12.

scientific article published on 3 December 2008

Chromosomal heterogeneity and instability characterize pediatric medulloblastoma cell lines and affect neoplastic phenotype

scientific article published on 17 January 2013

Clinical and cytogenetic analysis of an intracranial inflammatory myofibroblastic tumor induced by a ventriculoperitoneal shunt.

scientific article published in October 2009

Clinico-genetic aspects of a pediatric non-neurofibromatosis type 1 malignant triton tumor with loss of chromosome X.

scientific article published on 18 May 2012

Clonal Evolution as the Limiting Factor in the Detection of Minimal Residual Disease by Polymerase Chain Reaction in Children in Brazil With Acute Lymphoid Leukemia

article

Clonal complex chromosome aberration in non-ossifying fibroma

scientific article published on 01 May 2010

Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression.

scientific article published on January 2010

Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report.

scientific article

Cytogenetic findings in pediatric radiation-induced atypical meningioma after treatment of medulloblastoma: case report and review of the literature.

scientific article published on 18 October 2012

Cytogenetic heterogeneity in biphasic synovial sarcoma associated with telomere instability

scientific article published on 01 February 2010

Cytogenetic instability in childhood acute lymphoblastic leukemia survivors.

scientific article published on 31 August 2010

Cytogenetic study of a case of childhood erythroleukemia

scientific article published on 01 October 1990

Cytostatic in vitro effects of DTCM-glutarimide on bladder carcinoma cells.

scientific article published in January 2012

DKC1 mutation causing different phenotypes in a family with X-linked Hoyeraal-Hreidarsson syndrome.

scientific article published on 8 April 2015

DTCM-glutarimide delays growth and radiosensitizes glioblastoma.

scientific article published on 22 April 2018

Dermatomyositis and acquired ichthyosis as paraneoplastic manifestations of ovarian tumor

scientific article published on 01 August 1997

Detection by a simple and cheaper methodology of Ik6 and Ik10 isoforms of the IKZF1 gene is highly associated with a poor prognosis in B-lineage paediatric acute lymphoblastic leukaemia

scientific article published on 04 September 2019

Development of a Brazilian Portuguese adapted version of the Gap-Kalamazoo communication skills assessment form.

scientific article published on 11 December 2016

Differential expression of E-cadherin gene in human neuroepithelial tumors

scientific article published on 08 April 2008

Distinct response to GDF15 knockdown in pediatric and adult glioblastoma cell lines.

scientific article published on 18 April 2018

Downregulated Adhesion-Associated microRNAs as Prognostic Predictors in Childhood Osteosarcoma.

scientific article

Downregulation of miR-10B* is correlated with altered expression of mitotic kinases in osteosarcoma.

scientific article

Drug-resistance in central nervous system tumors: from the traditional cell-resistance model to the genetically driven approaches on therapy.

scientific article published on April 2007

Electromagnetic fields at extremely low frequencies and the risk for childhood leukemia: do we have enough information to warrant this association?

scientific article published on 5 January 2014

Enhanced TGFalpha-EGFR expression and P53 gene alterations contributes to gastric tumors aggressiveness.

scientific article published in August 2004

Erratum to: The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma

scientific article published on 01 February 2017

Evaluating budesonide efficacy in nasal polyposis and predicting the resistance to treatment.

scientific article

Expression of transcription factors NF-kappaB and AP-1 in nasal polyposis.

scientific article

Expression profile of apoptosis-related genes in childhood adrenocortical tumors: low level of expression of BCL2 and TNF genes suggests a poor prognosis

scientific article published on 22 May 2012

Frequency of polymorphisms and protein expression of cyclin-dependent kinase inhibitor 1A (CDKN1A) in central nervous system tumors.

scientific article

Fungal infection by Paracoccidioides brasiliensis mimicking bone tumor

scientific article published on 01 June 2008

G2/M inhibitors as pharmacotherapeutic opportunities for glioblastoma: the old, the new, and the future

scientific article published on 01 November 2018

Gene expression pattern contributing to prognostic factors in childhood acute lymphoblastic leukemia.

scientific article published on 8 September 2012

Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR

scientific article

Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia.

scientific article published in January 2004

Genomic instability inHoyeraal-Hreidarssonsyndrome

scientific article published on 01 May 2010

Gonadal Function in Adolescent Patients Submitted to Chemotherapy during Childhood or during the Pubertal Period

scientific article published on 01 April 2007

Grade II atypical choroid plexus papilloma with normal karyotype.

scientific article published on 25 June 2009

Growth and sexual maturation of Brazilian patients with sickle cell diseases.

scientific article

HG-17THE HISTONE DEACETYLASE INHIBITOR PCI-24781 SHOWS ANTIPROLIFERATIVE, PRO-APOPTOTIC AND RADIOSENSITIZING EFFECTS ON PEDIATRIC GLIOBLASTOMA CELL-LINES.

scientific article

HIF1A is overexpressed in medulloblastoma and its inhibition reduces proliferation and increases EPAS1 and ATG16L1 methylation.

scientific article published on 15 March 2017

HISTONE DEACETYLASE INHIBITOR PCI-24781 SHOWS ANTIPROLIFERATIVE EFFECTS AGAINST PEDIATRIC GLIOBLASTOMA CELLS.

scientific article published in July 2014

Hereditary hemoglobin disorders in a Brazilian population

scientific article published on 01 January 1983

Hypermethylation of CpG island in the promoter region of CALCA in acute lymphoblastic leukemia with central nervous system (CNS) infiltration correlates with poorer prognosis.

scientific article

Hypoxia-related gene expression profile in childhood acute lymphoblastic leukemia: prognostic implications

scientific article published on 14 February 2014

IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis.

scientific article published on 16 May 2016

IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase

scientific article published on 18 October 2011

Ig and TCR gene rearrangements in childhood ALL is there ethnic and socio-economic diversity of rearrangement patterns?

scientific article published on 28 February 2006

In vitro effect of glucocorticoids on nasal polyps

scientific article published on 01 September 2011

Inactivation of the p15 gene in children with acute lymphoblastic leukemia.

scientific article

Increased risk for acute lymphoblastic leukemia in children with cytochrome P450A1 (CYP1A1)- and NAD(P)H:quinone oxidoreductase 1 (NQO1)-inherited gene variants.

scientific article published on 20 October 2010

Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells.

scientific article

Inhibition of SHH pathway mechanisms by arsenic trioxide in pediatric medulloblastomas: a comprehensive literature review

scientific article published on 16 February 2017

Inhibition of polo-like kinase 1 induces cell cycle arrest and sensitizes glioblastoma cells to ionizing radiation.

scientific article published on 28 May 2013

Insertion (15;14)(q22;q13q32) in a case of Ph+ ALL

scientific article published on 01 August 2008

Intracranial teratoma in children: the role of chromosome 21 trisomy

scientific article published in April 2014

Involvement of the bony orbit in infantile myofibromatosis.

scientific article published on May 2004

Is p190 bcr-abl rearrangement necessary for acute transformation in some p210 CML of childhood?

scientific article published on 20 May 2008

Lack of evidence for mutations or deletions in the CDKN2A/p16 and CDKN2B/p15 genes of Brazilian neuroblastoma patients.

scientific article

Low expression of HLA-DRA, HLA-DPA1, and HLA-DPB1 is associated with poor prognosis in pediatric adrenocortical tumors (ACT)

scientific article published on 23 August 2014

Low-grade astrocytoma in a child with encephalocraniocutaneous lipomatosis.

scientific article published on 4 August 2009

MIR-10b IS inversely correlated with higher tumor grade in osteosarcoma.

scientific article published on 24 November 2017

MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals. ⬇️

scientific article

Megatherapy in the treatment of high-risk relapsed Wilms tumor

scientific article published on 01 August 2004

Methylome analysis and whole-exome sequencing reveal that brain tumors associated with encephalocraniocutaneous lipomatosis are midline pilocytic astrocytomas

scientific article published on 24 August 2018

MiR-708-5p is differentially expressed in childhood acute lymphoblastic leukemia but not strongly associated to clinical features

scientific article published on 11 September 2014

MiR-708-5p is inversely associated with EWS/FLI1 Ewing sarcoma but does not represent a prognostic predictor

scientific article published on 13 November 2018

MicroRNA profile of pediatric pilocytic astrocytomas identifies two tumor-specific signatures when compared to non-neoplastic white matter

scientific article published on 20 December 2018

Minimal residual disease in Brazilian children with acute lymphoid leukemia: comparison of three detection methods by PCR

article

Minimal residual disease in cerebrospinal fluid at diagnosis: a more intensive treatment protocol was able to eliminate the adverse prognosis in children with acute lymphoblastic leukemia

scientific article published on 24 August 2011

Molecular characterization of Wnt pathway and function of β-catenin overexpression in medulloblastoma cell lines

scientific article published on 29 October 2018

Molecular diagnosis of leukemic cerebrospinal fluid cells in children with newly diagnosed acute lymphoblastic leukemia.

scientific article published in August 2004

Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.

scientific article published in April 2007

Mowat-Wilson syndrome: the first report of an association with central nervous system tumors.

scientific article published on 3 October 2013

Moyamoya syndrome associated with neurofibromatosis type I in a pediatric patient.

scientific article published in March 2011

Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: clinical, cytogenetic, and molecular findings.

scientific article published in February 2011

Multiple dicentric chromosomes behind polyploidy in grade II atypical choroid plexus papilloma: a complementary cytogenetic evaluation

scientific article published on 11 December 2008

Neuroimaging findings in Mowat-Wilson syndrome: a study of 54 patients

scientific article

Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression

scientific article published on 16 July 2019

Novel histone deacetylase inhibitors for the treatment of pediatric brain tumors.

scientific article

Numerical chromosome changes in epileptogenic focal cortical dysplasia.

scientific article published in June 2013

Nutritional assessment and serum zinc and copper concentration among children with acute lymphocytic leukemia: a longitudinal study

scientific article published on 01 November 2006

Nutritional assessment and serum zinc and copper concentration in leukemic children

scientific article published on 01 January 1999

PCR detection of clonal IgH and TCR gene rearrangements at the end of induction as a non-remission criterion in children with ALL: comparison with standard morphologic analysis and risk group classification.

scientific article published in July 2003

PLK1 expression and BI 2536 effects in childhood acute lymphoblastic leukemia.

scientific article published on 12 February 2014

PLK1 inhibition radiosensitizes breast cancer cells, but shows low efficacy as monotherapy or in combination with other cytotoxic drugs.

scientific article published on 28 February 2018

PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis.

scientific article published on 10 March 2017

Pediatric glioblastoma cell line shows different patterns of expression of transmembrane ABC transporters after in vitro exposure to vinblastine.

scientific article published on 23 October 2008

Phenotype and genotype of 87 patients with Mowat-Wilson syndrome and recommendations for care

scientific article published on 4 January 2018

Pitfalls in the differential diagnosis of renal tumor in an adolescent.

scientific article published in February 2010

Polo-Like Kinase 1 Pharmacological Inhibition as Monotherapy or in Combination: Comparative Effects of Polo-Like Kinase 1 Inhibition in Medulloblastoma Cells.

scientific article published on 13 February 2017

Polymerase chain reaction on cerebrospinal fluid cells in suspected leptomeningeal involvement in childhood acute lymphoblastic leukemia: comparison to cytomorphological analysis.

scientific article published in September 2003

Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes in a Brazilian population.

scientific article

Polymorphisms in the thymidylate synthase promoter and the DNA repair genes XRCC1 and XPD in a Brazilian population

scientific article published on 01 December 2006

Polymorphisms of DNA repair genes and susceptibility to acute childhood lymphoblastic leukemia

scientific article published on 21 January 2009

Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia.

scientific article published on 21 January 2009

Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa.

scientific article published in July 2008

Primary skeletal leiomyosarcoma arising in the humerus

scientific article published on 01 November 2010

Prognostic value and functional role of ROCK2 in pediatric Ewing sarcoma.

scientific article published on 8 December 2017

Protein expression of matrix metalloproteinase (MMP-1, -2, -3, -9 and -14) in Ewing family tumors and medulloblastomas of pediatric patients

scientific article

Qualitative polymerase chain reaction versus quantitative polymerase chain reaction for the detection of minimal residual disease in children with acute lymphoblastic leukemia

scientific article published on 9 October 2015

Quantitative PCR analysis of the expression profile of genes related to multiple drug resistance in tumors of the central nervous system.

scientific article published on 12 April 2007

ROCK1-PredictedmicroRNAs Dysregulation Contributes to Tumor Progression in Ewing Sarcoma

scientific article published on 21 December 2017

Secondary PSF/TFE3-associated renal cell carcinoma in a child treated for genitourinary rhabdomyosarcoma.

scientific article published in February 2011

Sonic hedgehog signaling is active in human adrenal cortex development and deregulated in adrenocortical tumors

scientific article published on 8 April 2014

Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): Overexpression of Aurora kinases A and B is associated with a poor prognosis.

scientific article published on 20 June 2013

Splenic function in acute leukemia

scientific article published on 01 January 1995

Suppression of Inflammatory Cytokine Secretion by an NF-?B Inhibitor DHMEQ in Nasal Polyps Fibroblasts

scientific article published on 05 June 2012

T cell receptor gamma (TCRG) gene rearrangements in Brazilian children with acute lymphoblastic leukemia: analysis and implications for the study of minimal residual disease.

scientific article

T-cell sinonasal lymphoma presenting as acute orbit with extraocular muscle infiltration.

scientific article published in November 2004

TCRG gene rearrangement patterns in Brazilian children with ALL: an update

scientific article published on 16 July 2009

Tetra-O-methyl nordihydroguaiaretic acid, an inhibitor of Sp1-mediated survivin transcription, induces apoptosis and acts synergistically with chemo-radiotherapy in glioblastoma cells

Tetraploidization in Wilms tumor in an infant.

scientific article published on 10 August 2010

The Antiproliferative and Pro-apoptotic Effects of Methoxyamine on Pediatric Medulloblastoma Cell Lines Exposed to Ionizing Radiation and Chemotherapy.

scientific article published on January 2015

The Brazilian Pediatric Myelodysplastic Cooperative Group strategies: are they relevant to improve educational approach and correct diagnosis?

scientific article published on July 2002

The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma

scientific article

The aurora kinase inhibitor AMG 900 increases apoptosis and induces chemosensitivity to anticancer drugs in the NCI-H295 adrenocortical carcinoma cell line.

scientific article

The co-expression of PML/RAR alpha and AML1/ETO fusion genes is associated with ATRA resistance.

scientific article published in February 2005

The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lines.

scientific article published on 18 April 2016

Translocation (1;5)(q32;q35) in CD30+ anaplastic large cell non-Hodgkin lymphona of childhood. A case report

scientific article published on 01 January 1996

Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia

scientific article published on 14 February 2008

Treatment of sickle cell diseases with aspirin

scientific article published on 01 January 1984

Trissomy of Chromosome 8 and Juvenile Myelomonocytic Leukemia

scientific article published on 01 May 2012

Two Additional Cases of Childhood Embryonal Tumors in Brazilian Children Born From Assisted Reproductive Technologies

scientific article published on 01 October 2009

Unraveling the expression of the oncogene YAP1, a Wnt/beta-catenin target, in adrenocortical tumors and its association with poor outcome in pediatric patients.

scientific article published on October 2016

Use of simplified strategies to evaluate early treatment response in childhood acute lymphoblastic leukemia

scientific article published on 06 January 2006

Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL)

scientific article published on 25 May 2010

Wnt/beta-catenin pathway deregulation in childhood adrenocortical tumors.

scientific article published on 17 August 2011

Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells

scientific article published on January 2014

[Transient pancytopenia induced by parvovirus B19 in a child with hereditary spherocytosis]

scientific article

[Treatment of lymphangioma with alpha-2a-interferon]

scientific article published on 01 March 2001

mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: potential role of TIMP1 as an adverse prognostic factor

scientific article published on 28 October 2009

miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma.

scientific article published on November 2010

microRNA-138-5p as a Worse Prognosis Biomarker in Pediatric, Adolescent, and Young Adult Osteosarcoma

scientific article published on 12 March 2019

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