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List of works by T.A. Lewis

5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.

scientific article

5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.

scientific article published in May 2004

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint

scientific article

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

scientific article

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

scientific article

Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.

scientific article

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

scientific article

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

scientific article published on 20 March 2012

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia

scientific article

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

scientific article

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction ⬇️

scientific article published on March 14, 2013

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.

scientific article

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

scientific article

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

scientific article published on 2 February 2015

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

scientific article

Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis ⬇️

scientific article published on June 22, 2012

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.

scientific article published on 29 April 2016

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

scientific article published on 30 August 2012

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

scientific article

Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing

scientific article published on 18 October 2019

Organic chemistry of C60 (Buckminsterfullerene): chromatography and osmylation.

scientific article

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL ⬇️

scientific article published on September 13, 2011

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules

scientific article published on 01 March 2007

Roscovitine Inhibits EBNA1 Serine 393 Phosphorylation, Nuclear Localization, Transcription, and Episome Maintenance ⬇️

scientific article published on January 5, 2011

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress ⬇️

scientific article published on May 9, 2011

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

scientific article

Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.

scientific article

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

scientific article published on 14 March 2019

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.

scientific article

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