List of works - Lino Tessarollo

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

scientific article published on 22 February 2009

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

scientific article

A new gain-of-function mouse line to study the role of Wnt3a in development and disease.

scientific article published on 13 July 2016

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

scientific article

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

scientific article

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

scientific article published on 18 October 2018

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

scientific article published on 01 April 2020

Ablation of TrkA function in the immune system causes B cell abnormalities

scientific journal article

An inducible and reversible mouse genetic rescue system

scientific article

Assaying Homodimers of NF-κB in Live Single Cells

scientific article published on 07 November 2019

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation

scientific article

BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

scientific article

BRCA2 deficiency in mice leads to meiotic impairment and infertility

scientific journal article

BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation

scientific article published on 26 February 2016

Bcl11a is essential for normal lymphoid development ⬇️

scientific article published on April 28, 2003

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

scientific article

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

scientific article published in September 2017

Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

scientific journal article

Cdk2 catalytic activity is essential for meiotic cell division in vivo

scientific article published on July 2016

Cdk2 knockout mice are viable

scientific article (publication date: 14 October 2003)

Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.

scientific article

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1

scientific article published on 06 January 2012

Chronic centrosome amplification without tumorigenesis

scientific article

Control of hyperphagia prevents obesity in BDNF heterozygous mice

scientific article published in December 2004

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages ⬇️

scientific article published on April 8, 2013

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.

scientific article published on 21 February 2012

Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous

scientific article published on 23 December 2020

Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis

scientific article

Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice

scientific article published on 24 March 2018

Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.

scientific article

Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication

scientific article published on 5 June 2017

Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

scientific article published on 24 December 2019

Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes

scientific article

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

scientific article

Emi2 Is Essential for Mouse Spermatogenesis.

scientific article published in July 2017

Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo

scientific article published on January 2009

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

scientific article

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116 ⬇️

scientific article published on May 16, 2013

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells

scientific article

Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas

scientific article

Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).

scientific article published on 4 June 2015

Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo

scientific article published on August 2004

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.

scientific article published on 13 January 2016

Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development.

scientific article published on 14 December 2015

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

scientific article

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.

scientific article

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier ⬇️

scientific article published on March 18, 2011

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

scientific article published on 19 April 2016

Gene targeting in mouse embryonic stem cells

scientific article published in January 2009

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice

scientific article

Generation of Functional Mouse Hippocampal Neurons

scientific article published on 01 August 2020

Genetic deletion of trkB.T1 increases neuromuscular function

scientific article published on 5 October 2011

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

scientific article published on 11 September 2008

Genomic instability in mice lacking histone H2AX

scientific journal article

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

scientific article

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene ⬇️

scientific article published on 01 September 2003

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

scientific article

Host-derived tumor endothelial marker 8 promotes the growth of melanoma

scientific article published on 21 July 2009

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

scientific article

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

scientific article published on 28 June 2018

Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability.

scientific article

Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice

scientific article

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

scientific article (publication date: August 2016)

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

scientific journal article

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

scientific article published on 13 November 2019

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways

scientific article published on 21 January 2014

Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.

scholarly article

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis

scientific article

Manipulating mouse embryonic stem cells

scientific article published on 01 January 2009

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

scientific journal article

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

scientific article

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

scientific article

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

scientific journal article

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

scientific article

Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells

scientific article published on 26 November 2012

Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice

scientific journal article

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

scientific article published on 28 July 2017

NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea

scientific journal article

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli

scientific article published on 08 September 2016

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

scientific journal article

Normal viability of Kai1/Cd82 deficient mice ⬇️

scientific article published on February 8, 2013

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

scientific article published on 23 April 2020

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

article

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression

scientific article published on 01 June 2018

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

scientific article

Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence

scientific article published on 02 December 2020

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

scientific journal article

RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells.

scientific article

RanBPM is essential for mouse spermatogenesis and oogenesis

scientific article

RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.

scientific article

Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

scientific article published on 20 August 2019

Regulation of Kit Expression in Early Mouse Embryos and ES Cells

scientific article published on 28 January 2019

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons

scientific article published on 18 March 2015

SSSPTA is essential for serine palmitoyltransferase function during development and hematopoiesis

scientific article published on 01 January 2021

Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium

scientific article

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals

scientific article published on 16 May 2016

Sexually Dimorphic BDNF Signaling Directs Sensory Innervation of the Mammary Gland ⬇️

scientific article published on December 7, 2012

Spatial Shaping of Cochlear Innervation by Temporally Regulated Neurotrophin Expression

scientific article published in 2001

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

scientific article published on 28 December 2016

Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice

scientific article

Sptlc1 is essential for myeloid differentiation and hematopoietic homeostasis

scientific article published on 01 November 2019

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease

scientific article (publication date: November 2002)

Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity

scientific article published on February 2012

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development

scientific article

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway

scientific article published on August 2004

The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok

scientific article published on 09 January 2019

The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development

scientific journal article

The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development

scientific article (publication date: 2012)

The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo

scientific article

The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells

scientific article

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

scientific article published in January 2012

TrkA in vivo function is negatively regulated by ubiquitination

scientific article published on March 2014

TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior

scientific article published in 2022

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells

scientific article

List of works by Lino Tessarollo

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

A new gain-of-function mouse line to study the role of Wnt3a in development and disease.

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

Ablation of TrkA function in the immune system causes B cell abnormalities

An inducible and reversible mouse genetic rescue system

Assaying Homodimers of NF-κB in Live Single Cells

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation

BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability.

BRCA2 deficiency in mice leads to meiotic impairment and infertility

BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation

Bcl11a is essential for normal lymphoid development ⬇️

Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation

Cdk2 catalytic activity is essential for meiotic cell division in vivo

Cdk2 knockout mice are viable

Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1

Chronic centrosome amplification without tumorigenesis

Control of hyperphagia prevents obesity in BDNF heterozygous mice

Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages ⬇️

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.

Delayed onset of inherited ALS by deletion of the BDNF receptor TrkB.T1 is non-cell autonomous

Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis

Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice

Detection of differential fetal and adult expression of chloride intracellular channel 4 (CLIC4) protein by analysis of a green fluorescent protein knock-in mouse line.

Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication

Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells

Dystrophin is required for the normal function of the cardio-protective K(ATP) channel in cardiomyocytes

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery

Emi2 Is Essential for Mouse Spermatogenesis.

Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116 ⬇️

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells

Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas

Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).

Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivo

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.

Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development.

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier ⬇️

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Gene targeting in mouse embryonic stem cells

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice

Generation of Functional Mouse Hippocampal Neurons

Genetic deletion of trkB.T1 increases neuromuscular function

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

Genomic instability in mice lacking histone H2AX

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene ⬇️

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

Host-derived tumor endothelial marker 8 promotes the growth of melanoma

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability.

Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways

Lack of adrenomedullin in the mouse brain results in behavioral changes, anxiety, and lower survival under stress conditions.

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis

Manipulating mouse embryonic stem cells

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.

Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells

Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

NT-3 replacement with brain-derived neurotrophic factor redirects vestibular nerve fibers to the cochlea

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli