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List of works by David B. Weiner

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates

scientific article

A DNA-launched nanoparticle vaccine elicits CD8+ T-cell immunity to promote in vivo tumor control

scientific article published on 10 September 2020

A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy

scientific article published on 27 September 2018

A Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in rhesus Macaques

scientific article published on 01 January 2003

A Novel DNA Vaccine Platform Enhances Neo-antigen-like T Cell Responses against WT1 to Break Tolerance and Induce Anti-tumor Immunity.

scientific article published on 22 February 2017

A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection

scientific article published on 14 November 2014

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge

scientific article published on 24 January 2019

A Synthetic Micro-Consensus DNA Vaccine Generates Comprehensive Influenza A H3N2 Immunity and Protects Mice Against Lethal Challenge by Multiple H3N2 Viruses

scholarly article by Sarah T C Elliott published in September 2018

A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge.

scientific article

A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis.

scientific article published on 20 June 2016

A novel prototype device for electroporation-enhanced DNA vaccine delivery simultaneously to both skin and muscle.

scientific article published in January 2011

A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus

scientific article published on 29 October 2020

A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

scientific article

Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques.

scientific article

Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques

scientific article

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation

Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity

scientific article published on 16 June 2020

Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines

scientific article (publication date: 11 July 2002)

Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity

scientific article

Alarmin IL-33 elicits potent TB-specific cell-mediated responses.

scientific article

Alteration of the tumor stroma using a consensus DNA vaccine targeting Fibroblast Activation Protein (FAP) synergizes with anti-tumor vaccine therapy in mice

scientific article published on 21 December 2017

An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates.

scientific article

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

scientific article published on 21 September 2017

An optimized SIV DNA vaccine can serve as a boost for Ad5 and provide partial protection from a high-dose SIVmac251 challenge ⬇️

scientific article published on March 8, 2012

An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo

scientific article

Analysis of the potential for HIV-1 Vpr as an anti-cancer agent.

scientific article published on March 2009

Analytical and biological characterization of supercoiled plasmids purified by various chromatographic techniques

scientific article published in December 2005

Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice

scientific article published on 01 March 2019

Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma

scientific article published on 3 October 2005

Anti-cancer activity of the HIV accessory molecule viral protein R (Vpr): Delivery as a DNA expression plasmid or biologically active peptides.

scientific article published in February 2010

Anti-tumor activity mediated by protein and peptide transduction of HIV viral protein R (Vpr).

scientific article

Approaches for the design and evaluation of HIV-1 DNA vaccines

scientific article published in August 2004

Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule

scientific article published on 22 February 2008

Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100

scientific article published on 30 November 2016

Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine

scientific article published on 31 October 2017

CD8+ T Cells Impact Rising PSA in Biochemically Relapsed Cancer Patients Using Immunotherapy Targeting Tumor-Associated Antigens

scientific article published on 03 March 2020

CD8+ cell depletion of SHIV89.6P-infected macaques induces CD4+ T cell proliferation that contributes to increased viral loads

scientific article published on 28 September 2009

CLTA-4 blockade in vivo promotes the generation of short-lived effector CD8 T cells and a more persistent central memory CD4 T cell response

scientific article

CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control

scientific article (publication date: 2012)

Cancer vaccines: is the future now?

scientific article

Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling

scientific article (publication date: 6 December 2002)

Cellular immune response in the presence of protective antibody levels correlates with protection against 1918 influenza in ferrets ⬇️

scientific article published on 04 January 2011

Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques

scientific article published on 14 April 2008

Chikungunya: a potentially emerging epidemic?

scientific article

Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy.

scientific article

Clinical applications of DNA vaccines: current progress

scientific article

Co-Administration of Molecular Adjuvants Expressing NF-Kappa B Subunit p65/RelA or Type-1 Transactivator T-bet Enhance Antigen Specific DNA Vaccine-Induced Immunity

scientific article published on 25 March 2014

Co-delivery of PSA and PSMA DNA vaccines with electroporation induces potent immune responses.

scientific article

Co-immunization with an optimized plasmid-encoded immune stimulatory interleukin, high-mobility group box 1 protein, results in enhanced interferon-gamma secretion by antigen-specific CD8 T cells

article

Co-immunization with plasmid IL-12 generates a strong T-cell memory response in mice

scientific article

Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help

scientific article published in July 2005

Coimmunization with an optimized IL15 plasmid adjuvant enhances humoral immunity via stimulating B cells induced by genetically engineered DNA vaccines expressing consensus JEV and WNV E DIII.

scientific article published on 6 March 2009

Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques

scientific article published on 11 March 2008

Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity

scientific article

Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques

scientific article published on 14 February 2007

Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines

scientific article

Comparative analysis of immune responses induced by vaccination with SIV antigens by recombinant Ad5 vector or plasmid DNA in rhesus macaques.

scientific article

Complete Regression of Established Subcutaneous B16 Murine Melanoma Tumors after Delivery of an HIV-1 Vpr-Expressing Plasmid by in Vivo Electroporation

article

Correction to: In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies

scientific article published on 02 April 2020

Correction: Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization

scientific article (publication date: 22 January 2013)

Current strategies and limitations of HIV vaccines.

scientific article published on February 2010

Cytokines as adjuvants for improving anti-HIV responses

scientific article published on January 2008

DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections.

scientific article published on 6 July 2017

DNA Vaccines: A Strategy for Developing Novel Multivalent TB Vaccines

scientific article

DNA vaccination in immunotherapy of cancer.

scientific article

DNA vaccination protects mice against Zika virus-induced damage to the testes

scientific article

DNA vaccine VGX-3100 with electroporation induces regression of cervical intraepithelial neoplasia 2/3 and clears HPV infection with robust T cell responses: results of a randomized, double-blind, placebo-controlled Phase II trial

article

DNA vaccines 2010: A gumbo of accomplishment and excitement in New Orleans

scientific article published on 16 July 2011

DNA vaccines 2014 meeting: Highlights and overview

scientific article published on 9 July 2015

DNA vaccines for targeting bacterial infections.

scientific article published on July 2010

DNA vaccines targeting heavy chain C-terminal fragments of Clostridium botulinum neurotoxin serotypes A, B, and E induce potent humoral and cellular immunity and provide protection from lethal toxin challenge

scientific article

DNA vaccines: prime time is now

scientific article published on 04 April 2020

DNA-Encoded Glutamine Synthetase Enzyme as Ammonia-Lowering Therapeutic for Hyperammonemia

scientific article published on 09 September 2020

DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells

scientific article published on 30 October 2012

DNA-encoded bispecific T cell engagers and antibodies present long-term antitumor activity.

scientific article

DR5 Activation of Caspase-8 Induces DC Maturation and Immune Enhancement In Vivo

scientific article published on 18 December 2007

Design and characterization of a plasmid vector system capable of rapid generation of antibodies of multiple isotypes and specificities

scientific article published on 6 September 2008

Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model

scientific article published on 22 May 2019

Designing consensus immunogens to break tolerance to self-antigens for cancer therapy

scientific article published on 30 October 2018

Developing DNA vaccines that call to dendritic cells

scientific article

Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics

scientific article published on 15 November 2018

Development of a novel DNA SynCon tetravalent dengue vaccine that elicits immune responses against four serotypes.

scientific article

Development of an intradermal DNA vaccine delivery strategy to achieve single-dose immunity against respiratory syncytial virus

scientific article published on 13 April 2017

Durability of response to VGX-3100 treatment of HPV16/18 positive cervical HSIL

scientific article published on 11 November 2020

Efficient systemic expression of bioactive IL-15 in mice upon delivery of optimized DNA expression plasmids

scientific article published on 01 December 2007

Electroporation delivery of DNA vaccines: prospects for success ⬇️

scientific article published on April 27, 2011

Electroporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus

scientific article published on 11 February 2009

Engineered DNA Vaccination against Follicle-Stimulating Hormone Receptor Delays Ovarian Cancer Progression in Animal Models

scientific article published on 13 December 2018

Engineering cross-presentation in vivo

scientific article

Enhanced cellular immune responses elicited by an engineered HIV-1 subtype B consensus-based envelope DNA vaccine

scientific article published on 01 February 2007

Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms

scientific article published on 26 June 2020

Expression and evolutionary analysis of West Nile virus (Merion strain).

scientific article published on December 2005

Generation of antigen-specific immunity following systemic immunization with DNA vaccine encoding CCL25 chemokine immunoadjuvant

scientific article published on November 2012

HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo

scientific article

HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation

scientific article

HIV-1 Viral Protein-R (VPR) Protects against Lethal Superantigen Challenge While Maintaining Homeostatic T Cell Levels in Vivo

article

HIV-1 Vpr and anti-inflammatory activity

scientific article

HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells

scientific article (publication date: 4 October 2002)

HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro

article

HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis

scientific article

HIV-1 Vpr: regulator of viral survival

scientific article published on March 2009

HIV-1 p24(gag) derived conserved element DNA vaccine increases the breadth of immune response in mice

scientific article

HIV-1 viral genes and mitochondrial apoptosis.

scientific article published on 12 July 2008

HIV-1 viral protein R compromises cellular immune function in vivo ⬇️

scientific article published on January 1, 2002

HIV-mediated phosphatidylinositol 3-kinase/serine-threonine kinase activation in APCs leads to programmed death-1 ligand upregulation and suppression of HIV-specific CD8 T cells

scientific article

Hepatitis C virus NS3/NS4A DNA vaccine induces multiepitope T cell responses in rhesus macaques mimicking human immune responses [corrected]

scientific article published on 27 September 2011

Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens

scientific article

High antibody and cellular responses induced to HIV-1 clade C envelope following DNA vaccines delivered by electroporation.

scientific article

High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity model

scientific article

Highly optimized DNA vaccine targeting human telomerase reverse transcriptase stimulates potent antitumor immunity.

scientific article

Host cell killing by the West Nile Virus NS2B-NS3 proteolytic complex: NS3 alone is sufficient to recruit caspase-8-based apoptotic pathway

scientific article published on 21 October 2005

Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism

scientific article published on 17 September 2008

Human immunodeficiency virus type 1 vaccine development: recent advances in the cytotoxic T-lymphocyte platform "spotty business".

scientific article

IFNL3-adjuvanted HCV DNA vaccine reduces regulatory T cell frequency and increases virus-specific T cell responses

scientific article published on 21 February 2020

IL-15 as memory T-cell adjuvant for topical HIV-1 DermaVir vaccine

scientific article published on 14 April 2008

IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques

scientific article

IL-33 isoforms: their future as vaccine adjuvants?

scientific article published on 6 February 2015

Immune Modulation through 4-1BB Enhances SIV Vaccine Protection in Non-Human Primates against SIVmac251 Challenge ⬇️

scientific article published on September 15, 2011

Immune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis

scientific article published on 29 January 2020

Immunogenicity of a DNA vaccine candidate for COVID-19

scientific article published on 20 May 2020

Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine

scientific article

Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus

scientific article

Immunogenicity of novel consensus-based DNA vaccines against avian influenza.

scientific article

Immunogenicity testing of a novel engineered HIV-1 envelope gp140 DNA vaccine construct

scientific article published on July 2006

Immunotherapy Against HPV16/18 Generates Potent T H 1 and Cytotoxic Cellular Immune Responses ⬇️

scientific article published on October 10, 2012

Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer

scientific article published on 21 September 2018

Immunotherapy with VGX-3100 (HPV16 and HPV18 plasmids) + INO-9012 (DNA encoding IL-12) in human papillomavirus (HPV) associated head and neck squamous cell carcinoma (HNSCCa): interim safety and immunogenicity results.

scientific article published on 4 November 2015

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure-Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity

scientific article published on 27 February 2020

In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies

scientific article published on 10 March 2020

In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus

scientific article published on 05 April 2019

In vivo delivery of synthetic DNA-encoded antibodies induces broad HIV-1-neutralizing activity

scientific article published on 01 February 2020

In vivo electroporation of constitutively expressed HIF-1α plasmid DNA improves neovascularization in a mouse model of limb ischemia.

scientific article

In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

scientific article

Inclusion of a CRF01_AE HIV envelope protein boost with a DNA/MVA prime-boost vaccine: Impact on humoral and cellular immunogenicity and viral load reduction after SHIV-E challenge

scientific article published on 9 January 2012

Incorporation of a Novel CD4+ Helper Epitope Identified from Aquifex aeolicus Enhances Humoral Responses Induced by DNA and Protein Vaccinations

scientific article published on 04 August 2020

Increased PD-1 expression in cynomolgus and rhesus macaques during lentiviral infection.

scientific article published on 21 December 2006

Increased immunogenicity of HIV vaccination with constant-current electroporation and molecular adjuvants in mice and rhesus macaques.

scientific article published on 21 December 2006

Independence of granzyme B secretion and interferon- gamma production during acute simian immunodeficiency virus infection

scientific article published on 14 April 2006

Induction of HIV-specific memory T-cell responses by topical DermaVir vaccine

scientific article published on 22 January 2007

Induction of Intrahepatic HCV NS4B, NS5A and NS5B-Specific Cellular Immune Responses following Peripheral Immunization ⬇️

scientific article published on December 21, 2012

Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen

scientific article published on 18 November 2008

Induction of broad cytotoxic T cells by protective DNA vaccination against Marburg and Ebola

scientific article published on 14 May 2013

Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway

scientific article

Induction of robust cellular immunity against HPV6 and HPV11 in mice by DNA vaccine encoding for E6/E7 antigen.

scientific article

Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response

scientific article published on 01 August 2006

Integration of needle-free jet injection with advanced electroporation delivery enhances the magnitude, kinetics, and persistence of engineered DNA vaccine induced immune responses

scientific article published on 04 June 2019

Interferons as potential adjuvants in prophylactic vaccines

scientific article published on October 2010

Interleukin 33: a switch-hitting cytokine

scientific article

Interleukin-21 inhibits humoral response to an HIV DNA vaccine by enhancing Bcl-6 and Pax-5 expression

scientific article published on 01 April 2012

Intradermal DNA vaccination enhanced by low-current electroporation improves antigen expression and induces robust cellular and humoral immune responses.

scientific article

Intradermal SynCon® Ebola GP DNA Vaccine is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers

scientific article published on 01 July 2019

Intradermal Synthetic DNA Vaccination Generates Leishmania-Specific T Cells in the Skin and Protection against Leishmania major

scientific article published on 23 July 2019

Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques

scientific article published on 08 November 2007

Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP<sup>®</sup> DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults

scientific article published on 07 December 2020

Introduction to DNA vaccines – Las Vegas

scientific article published on 01 February 2010

Ki-67 staining for determination of rhesus macaque T cell proliferative responses ex vivo

scientific article

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

scientific article

Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization

scientific article published on 29 November 2006

Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine

scientific article (publication date: 2011)

Mapping of immune responses following wild-type and mutant ABeta42 plasmid or peptide vaccination in different mouse haplotypes and HLA Class II transgenic mice

scientific article

Mechanism of HIV-1 viral protein R-induced apoptosis ⬇️

scientific article published on May 9, 2003

Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses

scientific article published on 24 April 2008

Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model

scientific article

Molecular genetic relationship of the 3' untranslated region among Thai dengue-3 virus, Bangkok isolates, during 1973-2000.

scientific article

Monkeying around with HIV vaccines: using rhesus macaques to define 'gatekeepers' for clinical trials

scientific article

Multivalent Smallpox DNA Vaccine Delivered by Intradermal Electroporation Drives Protective Immunity in Nonhuman Primates Against Lethal Monkeypox Challenge ⬇️

scientific article published on January 1, 2011

Multivalent TB vaccines targeting the esx gene family generate potent and broad cell-mediated immune responses superior to BCG.

scientific article published on January 2014

Neutralization of hepatitis B virus by a novel DNA-encoded monoclonal antibody

scientific article published on 28 May 2020

Next generation DNA vaccines for HIV-1.

scientific article

Nonstructural protein 2 (nsP2) of Chikungunya virus (CHIKV) enhances protective immunity mediated by a CHIKV envelope protein expressing DNA Vaccine

scientific article published on February 2013

Novel SIVmac DNA vaccines encoding Env, Pol and Gag consensus proteins elicit strong cellular immune responses in cynomolgus macaques

scientific article published on 5 February 2009

Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein-Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth

scientific article published on 24 May 2019

Novel engineered HIV-1 East African Clade-A gp160 plasmid construct induces strong humoral and cell-mediated immune responses in vivo

scientific article

Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody.

scientific article published on 17 August 2017

Novel synthetic plasmid and Doggybone DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice

scientific article

Nucleic Acid Approaches to Antibody-based Therapeutics for COVID-19: A Perspective

scientific article published on 02 July 2020

Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab.

scientific article published on 17 September 2013

Parameters for DNA vaccination using adaptive constant-current electroporation in mouse and pig models

scientific article published on 15 April 2008

Peripheral immunization induces functional intrahepatic Hepatitis C specific immunity following selective retention of vaccine-specific CD8 T cells by the liver ⬇️

scientific article published on December 1, 2011

Phage-displayed mimotopes recognizing a biologically active anti-HIV-1 gp120 murine monoclonal antibody

scientific article

Phase I/II trial of the anti-HIV activity of mifepristone in HIV-infected subjects ACTG 5200

scientific article

Plasmid immunization primes unique DTH responses to HIV-1MN envelope epitopes as compared to recombinant protein vaccination

scientific article

Plasmid vaccination of stable HIV-positive subjects on antiviral treatment results in enhanced CD8 T-cell immunity and increased control of viral "blips".

scientific article

Plasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo

scientific article

Preclinical evaluation of multi antigenic HCV DNA vaccine for the prevention of Hepatitis C virus infection.

scientific article published on 07 March 2017

Present status of human HIV vaccine development

scientific article published on January 2003

Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus

scientific article

Protection against Borreliella burgdorferi infection mediated by a synthetically engineered DNA vaccine

scientific article published on 12 August 2020

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

scientific article published on 29 July 2015

Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid

scholarly article

Protective Efficacy and Long-Term Immunogenicity in Cynomolgus Macaques by Ebola Virus Glycoprotein Synthetic DNA Vaccines

scientific article published on 01 January 2019

Protective immunity by an engineered DNA vaccine for Mayaro virus

scientific article published in February 2019

Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine.

scientific article

Protocols for Developing Novel Chikungunya Virus DNA Vaccines.

scientific article published on January 2016

REDD1 Is Essential for Optimal T Cell Proliferation and Survival

scientific article published on 24 August 2015

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus.

scientific article

Rapid development of a synthetic DNA vaccine for COVID-19

article

Rapid response to an emerging infectious disease - Lessons learned from development of a synthetic DNA vaccine targeting Zika virus

scientific article published on 16 March 2018

Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice

scientific article published on 19 August 2005

Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques

scientific article published on 21 August 2019

Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model

scientific article published in April 2004

Robust antibody and cellular responses induced by DNA-only vaccination for HIV

scientific article published on 21 May 2020

SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients

scientific article published on 27 August 2020

SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques

article

Safety and Immunogenicity of PENNVAX®-G DNA Prime Administered by Biojector® 2000 or CELLECTRA® Electroporation Device with Modified Vaccinia Ankara-CMDR Boost

scientific article published on 2 September 2017

Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine - Preliminary Report.

scientific article published on 4 October 2017

Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults ⬇️

scientific article published on January 5, 2012

Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for delivery

scientific article published on 08 July 2013

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

scientific article published on 24 December 2020

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial

scientific article published on 24 July 2019

Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects

scientific article

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b tri

scientific article published on 16 September 2015

Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo ⬇️

scientific article published on 07 September 2011

Sequential priming with simian immunodeficiency virus (SIV) DNA vaccines, with or without encoded cytokines, and a replicating adenovirus-SIV recombinant followed by protein boosting does not control a pathogenic SIVmac251 mucosal challenge

scientific article published on 27 August 2008

Simplifying checkpoint inhibitor delivery through generation of synthetic DNA-encoded monoclonal antibodies (DMAbs)

Strong HCV NS3- and NS4A-specific cellular immune responses induced in mice and Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine

scientific article published on 8 August 2008

Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.

scientific article

Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor

scientific article published on March 2004

Sustained suppression of SHIV89.6P replication in macaques by vaccine-induced CD8+ memory T cells

scientific article published in September 2008

Synergy of Immune Checkpoint Blockade with a Novel Synthetic Consensus DNA Vaccine Targeting TERT.

scientific article published on 21 November 2017

Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

scientific article published on 01 June 2020

Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model

scientific article published on 10 January 2020

Synthetic DNA approach to cytomegalovirus vaccine/immune therapy

scientific article

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig

article

Synthetic DNA vaccine strategies against persistent viral infections ⬇️

scientific article published on May 1, 2013

Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants.

scientific article published on 4 November 2013

Synthetic DNA-encoded monoclonal antibody delivery of anti-CTLA-4 antibodies induces tumor shrinkage in vivo

scientific article published on 04 October 2018

Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals

scientific article

Systemic immunization with CCL27/CTACK modulates immune responses at mucosal sites in mice and macaques

scientific article

T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev

scientific article published on 01 November 2002

The HIV-1 Accessory Gene vpr Can Inhibit Antigen-Specific Immune Function

article

The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-induced cell cycle arrest.

scientific article

The HIV-1 Vpr and glucocorticoid receptor complex is a gain of function interaction that prevents the nuclear localization of PARP-1.

scientific article published on 21 December 2006

The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1

scientific article

Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA + IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques

scientific article published in June 2008

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity

scientific article published on 30 June 2015

Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques ⬇️

scientific article published on August 4, 2010

Use of interleukin 15 to enhance interferon-gamma production by antigen-specific stimulated lymphocytes from rhesus macaques

scientific article published in August 2003

VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus

article

Vaccination with synthetic constructs expressing cytomegalovirus immunogens is highly T cell immunogenic in mice.

scientific article published on November 2012

ZIKA-001: Safety and Immunogenicity of an Engineered DNA Vaccine Against ZIKA virus infection

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