List of works - Sandra L Siedlak

A metabolic basis for Alzheimer disease

scientific article published on October 2003

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

scientific article

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

scientific article

Accumulation of intraneuronal amyloid-β is common in normal brain.

scientific article

Activation of P38 kinase links π phosphorylation, oxidative stress and cell cycle-related events in Alzheimer disease

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

scientific article

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

scientific article

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

scholarly article

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

scientific article

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain

scientific article published on 18 October 2013

Autophagocytosis of mitochondria is prominent in Alzheimer disease

scientific article

Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases.

scientific article

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease ⬇️

scientific article published on February 1, 1992

Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease

scientific article

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

scientific article

Chitin-like polysaccharides in Alzheimer's disease brains

scientific article

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

scientific article published on February 2009

Compensatory responses induced by oxidative stress in Alzheimer disease

scientific article

Dissociated Aβ antibody level in newly diagnosed Alzheimer's disease: A population-based study

article

Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study

scientific article

Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease

scientific article

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

scientific article published on 21 August 2013

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

scientific article published on 23 July 2009

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease

scientific article published on 3 February 2016

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

scientific article published on April 2009

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

scientific article published on 23 April 2008

Frontiers in Alzheimer's disease therapeutics

scientific article

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

scientific article

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

scientific article published on 3 December 2001

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

scientific article published in February 2002

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

scientific article published on 12 November 2011

In Vivo and In Silico Evidence: Hippocampal Cholesterol Metabolism Decreases with Aging and Increases with Alzheimers Disease -- Modeling Brain Aging and Disease

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

scientific article

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

scientific article published on 22 January 2007

Indices of metabolic dysfunction and oxidative stress

scientific article published on 7 March 2007

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

scientific article

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

scientific article

Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model

scientific article

LRRK2 in Parkinson's disease and dementia with Lewy bodies

scientific article

LRRK2 protein is a component of lewy bodies

Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies

scientific article published on 06 March 2008

MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons

scientific article

Mathematical modeling of microtubule dynamics: insights into physiology and disease

scientific article

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

scientific article published in March 2003

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death

scientific article published on 03 January 2020

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation ⬇️

scientific article published on May 1, 2003

Miro1 deficiency in amyotrophic lateral sclerosis

scientific article published on 26 May 2015

Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

scientific article

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

scientific article published on September 2003

Natural Oxidant Balance in Parkinson Disease

scholarly article by George Perry et al published 1 December 2009 in Archives of Neurology

Neurodegenerative processes in Alzheimer’s disease: an overview of pathogenesis with strategic biomarker potential

Neurofilament proteins in neurodegenerative diseases

scientific article

Neuronal leptin resistance in Alzheimer's disease

scholarly article by David Bonda et al published July 2013 in Alzheimer's and Dementia

Neuroprotective properties of Bcl-w in Alzheimer disease

scientific article

Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions

scientific article published in August 2006

Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis ⬇️

scientific article published on October 30, 2010

Oxidative damage to nucleic acids in human prion disease

scientific article published in April 2002

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

scientific article

P1-351: A novel approach to diagnosis: Antigen-antibody disassociation in Alzheimer's disease

scholarly article by Mark A. Smith et al published July 2008 in Alzheimer's and Dementia

P4-162

Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease

scientific article

Posttranslational modifications of α-tubulin in alzheimer disease

scientific article

Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.

scientific article

Prion Protein Protects against Renal Ischemia/Reperfusion Injury

scientific article published on September 2015

Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease

article published in 2005

Redox metals and oxidative abnormalities in human prion diseases

scientific article published on 11 August 2005

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

scientific article

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

scientific article published on January 2008

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

scientific article

Tau modifiers as therapeutic targets for Alzheimer's disease

scientific article

Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?

scientific article

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

scientific article

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

scientific article published on 27 June 2016

The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.

scientific article published in September 2002

Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material

scientific article published in June 2008

Transcriptome-To-Metabolome™ Biosimulation Reveals Human Hippocampal Hypometabolism with Age and Alzheimer’s Disease

Vascular oxidative stress in Alzheimer disease

scientific article

Widespread distribution of reticulon-3 in various neurodegenerative diseases

scientific article

c-Jun phosphorylation in Alzheimer disease

scientific article

List of works by Sandra L Siedlak

A metabolic basis for Alzheimer disease

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

Accumulation of intraneuronal amyloid-β is common in normal brain.

Activation of P38 kinase links π phosphorylation, oxidative stress and cell cycle-related events in Alzheimer disease

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain

Autophagocytosis of mitochondria is prominent in Alzheimer disease

Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases.

Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease ⬇️

Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

Chitin-like polysaccharides in Alzheimer's disease brains

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

Compensatory responses induced by oxidative stress in Alzheimer disease

Dissociated Aβ antibody level in newly diagnosed Alzheimer's disease: A population-based study

Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study

Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

Frontiers in Alzheimer's disease therapeutics

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

In Vivo and In Silico Evidence: Hippocampal Cholesterol Metabolism Decreases with Aging and Increases with Alzheimers Disease -- Modeling Brain Aging and Disease

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

Indices of metabolic dysfunction and oxidative stress

Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

Inhibition of mitochondrial fragmentation protects against Alzheimer's disease in rodent model

LRRK2 in Parkinson's disease and dementia with Lewy bodies

LRRK2 protein is a component of lewy bodies

Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies

MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons

Mathematical modeling of microtubule dynamics: insights into physiology and disease

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation ⬇️

Miro1 deficiency in amyotrophic lateral sclerosis

Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

Natural Oxidant Balance in Parkinson Disease

Neurodegenerative processes in Alzheimer’s disease: an overview of pathogenesis with strategic biomarker potential

Neurofilament proteins in neurodegenerative diseases

Neuronal leptin resistance in Alzheimer's disease

Neuroprotective properties of Bcl-w in Alzheimer disease

Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions

Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis ⬇️

Oxidative damage to nucleic acids in human prion disease

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

P1-351: A novel approach to diagnosis: Antigen-antibody disassociation in Alzheimer's disease

P4-162

Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease

Posttranslational modifications of α-tubulin in alzheimer disease

Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.

Prion Protein Protects against Renal Ischemia/Reperfusion Injury

Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease

Redox metals and oxidative abnormalities in human prion diseases

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

Tau modifiers as therapeutic targets for Alzheimer's disease

Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.

Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material

Transcriptome-To-Metabolome™ Biosimulation Reveals Human Hippocampal Hypometabolism with Age and Alzheimer’s Disease

Vascular oxidative stress in Alzheimer disease

Widespread distribution of reticulon-3 in various neurodegenerative diseases