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List of works by Malcolm Macleod

A (mini) pill for stroke?

A European initiative to unclog pipeline for new medicines

scientific article published on 01 April 2019

A call for transparent reporting to optimize the predictive value of preclinical research

scientific article

A concerted appeal for international cooperation in preclinical stroke research

scientific article (publication date: June 2013)

A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals ⬇️

scientific article

A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)

A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus).

scientific article published on 12 June 2019

A systematic review and meta-analysis of erythropoietin in experimental stroke

scientific article

A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

scientific article published on December 2014

A systematic review and meta-analysis of the efficacy of piracetam and piracetam-like compounds in experimental stroke

scientific article

A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

scientific article published on 29 January 2018

Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression

Alpha Calcitonin Gene-Related Peptide Increases Cerebral Vessel Diameter in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis.

scientific article published on 25 July 2017

Animal models of bone cancer pain: systematic review and meta-analyses ⬇️

scientific article published on 07 March 2013

Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis

scientific article published on 20 May 2019

Animal models of neurological disease: are there any babies in the bathwater?

scientific article published on 01 December 2010

Aortic arch atheroma

scientific article published on May 2006

Atheroma of the aortic arch: an important and poorly recognised factor in the aetiology of stroke

scientific article published on July 2004

Atheroma of the aortic arch: the missing link in the secondary prevention of stroke?

scientific article (publication date: November 2003)

Bacterial meningitis associated with a complex ischiorectal abscess

Biomedical research: increasing value, reducing waste

scientific article

Bringing rigour to translational medicine

scientific article

Can animal models of disease reliably inform human studies?

scientific article

Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes

scientific article published in December 2020

Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies.

scientific article published on 17 February 2016

Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis

scientific article published in October 2000

Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques.

scientific article published on 03 April 2014

Comment on "Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome"

scientific article published in Science

Comparison of treatment effects between animal experiments and clinical trials: systematic review

scientific article published on 15 December 2006

Conjugal amyotrophic lateral sclerosis: a case report from Scotland

scientific article

Correction: Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

scientific article published on 10 November 2015

Corrigendum to 'Meta-analysis of data from animal studies: A practical guide': [Journal of Neuroscience Methods 221 (2014) 92-102].

scientific article published on 12 December 2015

Current issues in the treatment of acute posterior circulation stroke

scientific article published on January 2006

D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

scientific article published on 30 August 2017

Design animal studies better

scientific article published in Nature

Development of a psychological intervention for fatigue after stroke.

scientific article published on 17 August 2017

Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia

scientific article

Dopamine agonists in animal models of Parkinson's disease: a systematic review and meta-analysis

scientific article published on 04 March 2011

Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis ⬇️

scientific article

EBRNetwork – a call to action for evidence-based research.

scientific article

Edaravone improves functional and structural outcomes in animal models of focal cerebral ischemia: a systematic review

scientific article published on 22 October 2013

Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis

scientific article published on January 2014

Effect of deprivation and gender on the incidence and management of acute brain disorders.

scientific article

Effect of deprivation on time to hospital in acute stroke

scientific article published in April 2003

Effect of endothelin receptor antagonists on clinically relevant outcomes after experimental subarachnoid hemorrhage: a systematic review and meta-analysis

scientific article

Effect of hyperthermia and anoxia on glucocorticoid and mineralocorticoid receptor expression in neonatal rat hippocampus

scientific article published on 18 November 2008

Effect size and statistical power in the rodent fear conditioning literature - A systematic review.

scientific article

Effect size and statistical power in the rodent fear conditioning literature - a systematic review

article

Efficacy and safety of mesenchymal stromal cells in preclinical models of acute lung injury: a systematic review protocol.

scientific article

Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis

scientific article published on 02 September 2014

Embrace heterogeneity to improve reproducibility: A perspective from meta-analysis of variation in preclinical research

scientific article published on 27 October 2020

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach

scientific article published on 31 January 2008

End-of-life decisions in patients with severe acute brain injury

scientific article published on 25 March 2014

EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke

scientific article published on 15 May 2014

Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

scientific article

Evaluation of combination therapy in animal models of cerebral ischemia

scientific article

Evaluation of excess significance bias in animal studies of neurological diseases

scientific article

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

scientific article

Evidence synthesis in trial design: an example from the neurosciences.

scientific article published on 29 November 2013

Evidence-based Translational Medicine ⬇️

scientific article published on April 4, 2013

Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials

scientific article

Exercise reduces infarct volume and facilitates neurobehavioral recovery: results from a systematic review and meta-analysis of exercise in experimental models of focal ischemia.

scientific article published on 18 February 2014

Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium

scientific article published on 01 April 2015

Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies.

scientific article published on 11 January 2018

Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

scientific article

Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

scientific article published on 17 June 2016

Findings of a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia

scientific article

Framework for advancing rigorous research

scientific article published on 04 March 2020

Frequency and Phenotype Associations of Rare Variants in 5 Monogenic Cerebral Small Vessel Disease Genes in 200,000 UK Biobank Participants

scientific article published in 2022

Gender and deprivation and rates of referral and thereby admission to a national neurorehabilitation service

scientific article

Good laboratory practice: preventing introduction of bias at the bench

scientific article published on 14 August 2008

Greater Incidence of Both Fatal and Nonfatal Strokes in Disadvantaged Areas

article

Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction

scientific article

How can we improve the pre-clinical development of drugs for stroke?

scientific article published on 31 August 2007

Hypertension and experimental stroke therapies

scientific article published on 05 June 2013

Hypothermia for Stroke: Call to Action 2010 ⬇️

scientific article published on December 1, 2010

Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis

scientific article published on 3 May 2007

Hypothermia protects human neurons.

scientific article

Hypothermia revisited: Impact of ischaemic duration and between experiment variability.

scientific article published in January 2017

Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE.

scientific article published in November 2017

Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis

scientific article published on 03 January 2019

Improving the efficiency of the development of drugs for stroke

scientific article published on July 2012

Improving the translational hit of experimental treatments in multiple sclerosis

scientific article published on 04 August 2010

Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis

scientific article

Increasing value and reducing waste in animal models of rheumatological disease

scientific article published in June 2015

Increasing value and reducing waste in biomedical research regulation and management

scientific article (publication date: 11 January 2014)

Increasing value and reducing waste in research design, conduct, and analysis

scientific article

Informatics: Make sense of health data

scientific article

Injury-induced mineralocorticoid receptor expression involves differential promoter usage: a novel role for the rat MRbeta variant

scientific article

Interventions for post-stroke fatigue

scientific article

Introducing our series: research synthesis and meta-research in biology

scientific article published on 05 March 2020

Introduction to the EQIPD quality system

scientific article published on 24 May 2021

Ischaemic heart disease and cholesterol. "Cholesterol papers" add to the confusion...

scientific article published on April 1994

Learning lessons from MVA85A, a failed booster vaccine for BCG.

scientific article published on 10 January 2018

Machine learning algorithms for systematic review: reducing workload in a preclinical review of animal studies and reducing human screening error

article

Magnetic resonance imaging in experimental stroke and comparison with histology: systematic review and meta-analysis

scientific article

Making the most of animal data – improving the prospect of success in pragmatic trials in the neurosciences.

scientific article

Meta-analysis of data from animal studies: a practical guide

scientific article

Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure

scientific article

Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research

scientific article published in May 2021

Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research

scientific article published in 2022

MicroRNA – Taking Regulation of Protein Synthesis to Another Level

Mineralocorticoid receptor expression and increased survival following neuronal injury

scientific article published in April 2003

Mineralocorticoid receptor mRNA expression is increased in human hippocampus following brief cerebral ischaemia

scientific article published in April 2009

Model of understanding fatigue after stroke

scientific article published on 03 February 2015

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

scientific article published in 2022

Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke

scientific article

NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons.

scientific article published on 16 April 2018

Nitric-oxide-synthase-mediated cyclic guanosine monophosphate production in neonatal rat cerebellar prisms is resistant to calcineurin inhibition

scientific article published in March 2002

No publication without confirmation.

scientific article

Not Tonight, Darling, I Might Get a Headache

scholarly article by Malcolm Macleod & Phil M. White published July 2011 in Stroke Journal

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis.

scientific article published on 31 May 2016

On the neuroprotective actions of FK506

doctoral thesis

Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis

scientific article published on 07 June 2019

Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells

scientific article published on 8 January 2005

P60WHY ANIMAL MODELS OF GENE THERAPY HAVE LET GLIOMA PATIENTS DOWN.

scientific article

PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment

scientific article published on 30 April 2018

Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis ⬇️

scientific article published on April 25, 2012

Pooling of animal experimental data reveals influence of study design and publication bias

scientific article

Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis

scientific article published in the British Medical Journal

Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing

scientific article

Preclinical studies of human disease: time to take methodological quality seriously

scientific article published on 29 April 2011

Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis

scientific article

Prof Benchie and Dr Athena-A modern tragedy….

scientific article published on 27 June 2015

Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution

scientific article published on 11 May 2016

Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals

Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest

scientific article published on 03 May 2016

Psychological associations of poststroke fatigue: a systematic review and meta-analysis

scientific article published on 29 April 2014

PubMed: http://www.pubmed.org

scientific article

Publication bias in reports of animal stroke studies leads to major overstatement of efficacy

scientific article

Reader response: Evaluating depression and suicidality in tetrabenazine users with Huntington disease

Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan

scientific article published in 2020

Reduced NMDA-induced apoptosis in neurons lacking ataxia telangiectasia mutated protein

scientific article published in February 2003

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

scientific article published on 14 July 2020

Reprint: Good laboratory practice: preventing introduction of bias at the bench

scientific article published on 17 September 2008

Reprint: Good laboratory practice: preventing introduction of bias at the bench

scientific article

Research: increasing value, reducing waste - Authors' reply

scientific article

Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke

scientific article

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

scientific article published on 13 October 2015

Risk of bias reporting in the recent animal focal cerebral ischaemia literature

scientific article

SWIFT-Review: a text-mining workbench for systematic review

scientific article published on 23 May 2016

Scope of preclinical testing versus quality control within experiments.

scientific article published on 4 June 2009

Serum withdrawal causes apoptosis in SHSY 5Y cells.

scientific article

Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: systematic review and meta-analysis of large animal studies

scientific article published on 03 September 2014

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. ⬇️

scientific article

Sodium and chloride channelopathies with myositis: coincidence or connection?

scientific article

Some salt with your statin, professor?

scientific article

Standardized mean differences cause funnel plot distortion in publication bias assessments

scientific article published on 8 September 2017

Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke.

scientific article published on 29 November 2017

Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies

scientific article

Stem cell-based therapy for experimental stroke: a systematic review and meta-analysis.

scientific article published on 12 June 2012

Stroke

scientific article 2008

Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice

scientific article published on 23 June 2009

Study protocol - A systematic review and meta-analysis of hypothermia in experimental traumatic brain injury: Why have promising animal studies not been replicated in pragmatic clinical trials?

scientific article

Surveying the literature from animal experiments: systematic review and meta-analysis are important contributions

scientific article published in July 2005

Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update

scientific article published on 15 August 2016

Systematic review and meta-analysis of interventions tested in animal models of lacunar stroke.

scientific article published on 02 January 2014

Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted?

scientific article published on January 2013

Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke

scientific article

Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke

scientific article

Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury

scientific article

Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke

scientific article

Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

scientific article published on 20 May 2013

Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke

scientific article published on July 2009

Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically

scientific article

Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism ⬇️

scientific article

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

scientific article published on 14 July 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

scientific article published on 15 July 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

scientific article published in August 2020

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

scientific article published on 14 July 2020

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

scientific article published on 20 July 2020

The Devil Is in the Details: Incomplete Reporting in Preclinical Animal Research.

scientific article

The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis

scientific article

The Experimental Design Assistant

scientific article published on 28 September 2017

The Experimental Design Assistant

scientific article published on 29 September 2017

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).

scientific article published on January 2017

The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine

scientific article

The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

article

The development and evaluation of an online application to assist in the extraction of data from graphs for use in systematic reviews

scholarly article by Fala Cramond et al published 25 January 2019 in Wellcome Open Research

The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease.

scientific article published on 11 August 2015

The effect of tumour associated epilepsy on performance/handicap scales used in cerebral glioma

scientific article published on 01 January 1995

The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke

scientific article (publication date: February 2009)

The reproducibility opportunity

scientific article published on 01 September 2018

The use of text-mining and machine learning algorithms in systematic reviews: reducing workload in preclinical biomedical sciences and reducing human screening error

scholarly article published 31 January 2018

Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis

scientific article

Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial

scientific article published on 20 April 2019

Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials?

scientific article

Towards minimum reporting standards for life scientists

Translational Research

scientific article published on 01 July 2012

Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models

scientific article

Transparency in the reporting of in vivo pre-clinical pain research: The relevance and implications of the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines

scientific article published on 01 April 2013

Treatment of intracerebral hemorrhage in animal models: meta-analysis

scientific article published in February 2011

Understanding in vivo modelling of depression in non-human animals: a systematic review protocol

article

Understanding the provenance and quality of methods is essential for responsible reuse of FAIR data

scientific article published on 21 March 2024

Using animal models to understand cancer pain in humans

scientific article published on June 2014

Vanishing diplopia: a problem case

scientific article published on 01 August 2007

Voltage-gated potassium channel antibody-related encephalopathy: a case which may extend the documented phenotype of this condition

scientific article published on 12 June 2012

What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma.

scientific article published on 24 September 2008

What's a good doctor and how do you make one? How not to do it

Why animal research needs to improve ⬇️

scientific article published on September 28, 2011

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