List of works - M. Flint Beal

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

scientific article

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

scientific article (publication date: 6 November 2011)

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

scientific journal article

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

scientific article (publication date: 11 July 2006)

Mitochondria take center stage in aging and neurodegeneration

scientific article

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

scholarly article by Patrizia Mecocci et al published November 1994 in Annals of Neurology

Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.

scientific article published on 22 October 2006

Parkinson's disease

scientific article published on 02 October 2007

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

scientific article published on February 1, 1992

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

scientific article published on 01 October 1993

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

scientific article

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

scientific article

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

scientific article published on 22 January 2008

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

scientific article published on November 2002

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

scientific article published in March 1999

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

scholarly article

Oxidatively modified proteins in aging and disease

scientific article

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

scientific article

Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups

scientific article

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

scientific article published in September 2004

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice

scientific article published on 5 June 2002

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

scientific article published in March 2003

Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.

scientific article published on 21 September 2003

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

scholarly article

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

scientific article published on 19 October 2004

Mitochondrial dysfunction in neurodegenerative diseases

scientific article published on 01 August 1998

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

scientific article

Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis

scientific article published on 01 December 1993

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

scientific article published on 6 April 2011

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

scientific article

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

scientific article published on August 15, 1991

Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons

scientific article published in September 1996

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

scientific article

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

scientific article

Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

scientific article published on July 21, 1998

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

scientific article published in February 2008

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

scientific article

Lipid peroxidation in aging brain and Alzheimer's disease

scientific article

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

scientific article published in June 2000

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.

scientific article published on February 1995

Mitochondria, oxidative damage, and inflammation in Parkinson's disease

scientific article

Impaired mitochondrial function in psychiatric disorders

scientific article published on 18 April 2012

Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.

scientific article published in December 1994

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

scientific article published in June 2004

Mitochondrial Dysfunction in Neurodegenerative Diseases

scientific article published on June 13, 2012

Oxidative stress in Huntington's disease

scientific article published in January 1999

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

scientific article

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

scientific article

Oxidative stress in patients with Friedreich ataxia.

scientific article

Urate as a predictor of the rate of clinical decline in Parkinson disease

scientific article

List of works by M. Flint Beal

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

Mitochondria take center stage in aging and neurodegeneration

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.

Parkinson's disease

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

Oxidatively modified proteins in aging and disease

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

Mitochondrial dysfunction in neurodegenerative diseases

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Metabolomic profiling to develop blood biomarkers for Parkinson's disease

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Lipid peroxidation in aging brain and Alzheimer's disease

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.

Mitochondria, oxidative damage, and inflammation in Parkinson's disease

Impaired mitochondrial function in psychiatric disorders

Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

Mitochondrial Dysfunction in Neurodegenerative Diseases

Oxidative stress in Huntington's disease

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

Oxidative stress in patients with Friedreich ataxia.

Urate as a predictor of the rate of clinical decline in Parkinson disease