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List of works by Annette H. van der Helm-van Mil

A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis

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A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

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A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis

scientific article published on 26 October 2007

A prediction rule for disease outcome in patients with Recent-onset undifferentiated arthritis: How to guide individual treatment decisions

scientific article published on 01 February 2007

ACPA-negative RA consists of subgroups: patients with high likelihood of achieving sustained DMARD-free remission can be identified by serological markers at disease presentation

scientific article published on 14 May 2019

Achieving evidence for the management of arthralgia at risk for RA. Response to: 'The cost of arthralgia 'pretreatment' to prevent rheumatoid arthritis' by Rothschild

scientific article published on 24 January 2020

Aiming for a shorter rheumatoid arthritis MRI protocol: can contrast-enhanced MRI replace T2 for the detection of bone marrow oedema?

scientific article published on 28 June 2014

An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility

scientific article published on 01 September 2005

An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting.

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Anti-Carbamylated Protein Antibodies and Higher Baseline Disease Activity in Rheumatoid Arthritis-A Replication Study in Three Cohorts: Comment on the Article by Truchetet et al

scientific article published on 27 October 2018

Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis

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Anticitrullinated protein antibodies and rheumatoid factor are associated with increased mortality but with different causes of death in patients with rheumatoid arthritis: a longitudinal study in three European cohorts

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Appropriate use of the EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis

scientific article published on 15 December 2016

Are MRI-detected erosions specific for RA? A large explorative cross-sectional study

scientific article published on 28 February 2018

Are rheumatoid arthritis patients discernible from other early arthritis patients using 1.5T extremity magnetic resonance imaging? a large cross-sectional study

scientific article published on 15 July 2014

Association of Variants inIL2RAWith Progression of Joint Destruction in Rheumatoid Arthritis

scientific article published on 01 July 2013

Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles.

scientific article published on September 2007

Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.

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Association of tumor necrosis factor α polymorphism and radiographic progression in rheumatoid arthritis: Comment on the article by Khanna et al

scientific article published on 01 March 2007

Association of valine and leucine at HLA-DRB1 position 11 with radiographic progression in rheumatoid arthritis, independent of the shared epitope alleles but not independent of anti-citrullinated protein antibodies.

scientific article published on April 2015

Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage.

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Autoantibodies to two novel peptides in seronegative and early rheumatoid arthritis.

scientific article published on 19 April 2016

Automatic quantification of tenosynovitis on MRI of the wrist in patients with early arthritis: a feasibility study

scientific article published on 12 November 2018

Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis

scientific article published on 01 September 2011

Biomarkers in the prediction of radiographic progression in early rheumatoid arthritis: comment on the article by Young-Min et al

scientific article published on 01 May 2008

Bone mineral density loss in clinically suspect arthralgia is associated with subclinical inflammation and progression to clinical arthritis.

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Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies.

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Can anti-cyclic citrullinated peptide antibody-negative RA be subdivided into clinical subphenotypes?

scientific article published on 27 October 2011

Changes in the clinical presentation of patients with rheumatoid arthritis from the early 1990s to the years 2010: earlier identification but more severe patient reported outcomes.

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Characterising arthralgia in the preclinical phase of rheumatoid arthritis using MRI

scientific article published on 09 April 2014

Classification of rheumatoid arthritis: comparison of the 1987 American College of Rheumatology criteria and the 2010 American College of Rheumatology/European League Against Rheumatism criteria

scientific article published on 01 January 2011

Clinical expertise and its accuracy in differentiating arthralgia patients at risk for rheumatoid arthritis from other patients presenting with joint symptoms

scientific article published on 07 January 2016

Clinical guidelines: Classifying RA the 2010 way--what does it mean for the clinic?

scientific article published on 01 January 2011

Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis.

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DMARD-free remission as novel treatment target in rheumatoid arthritis: A systematic literature review of achievability and sustainability

scientific article published on 01 May 2020

Depression and anxiety associate with less remission after 1 year in rheumatoid arthritis.

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Development and validation of a clinical rule for recognition of early inflammatory arthritis

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Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis.

scientific article published on 17 May 2009

Diagnostic value of performing chest x-rays in patients presenting with recent-onset arthritis

scientific article published on 21 November 2011

Differences in the symptomatic phase preceding ACPA-positive and ACPA-negative RA: a longitudinal study in arthralgia during progression to clinical arthritis

scientific article published on 12 June 2017

Differential methylation within the major histocompatibility complex region in rheumatoid arthritis: a replication study

scientific article published on 30 September 2014

Difficulties making a fist in clinically suspect arthralgia: an easy applicable phenomenon predictive for RA that is related to flexor tenosynovitis

scientific article published on 02 May 2019

Disease-modifying antirheumatic drug-free sustained remission in rheumatoid arthritis: an increasingly achievable outcome with subsidence of disease symptoms.

scientific article published on 13 May 2015

Disease-modifying treatment in rheumatoid arthritis: treat early and do not forget to try to taper and stop

scientific article published on 23 December 2016

Do autoantibody-responses mature between presentation with arthralgia suspicious for progression to rheumatoid arthritis and development of clinically apparent inflammatory arthritis? A longitudinal serological study

scientific article published on 03 November 2020

Does a genetic variant in FOXO3A predict a milder course of rheumatoid arthritis?

scientific article published in June 2014

Does adding the presence of MRI detected bone marrow oedema improve the accuracy of the 2010 EULAR/ACR criteria for rheumatoid arthritis?

scientific article published on 19 November 2014

Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis?

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Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study.

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Does the season at symptom onset influence the long-term severity of radiographic joint destruction in rheumatoid arthritis?

scientific article published on 04 July 2012

Does treatment strategy influence the ability to achieve and sustain DMARD-free remission in patients with RA? Results of an observational study comparing an intensified DAS-steered treatment strategy with treat to target in routine care

scientific article published on 07 May 2019

EULAR/eumusc.net standards of care for rheumatoid arthritis: cross-sectional analyses of importance, level of implementation and care gaps experienced by patients and rheumatologists across 35 European countries

scientific article published on 01 September 2020

Early identification of rheumatoid arthritis: the risk of overtreatment in perspective

scientific article published on 10 August 2018

Effects of wearing high heels on the forefoot: an MRI evaluation.

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Erratum to: Aiming for a shorter rheumatoid arthritis MRI protocol: can contrast-enhanced MRI replace T2 for the detection of bone marrow oedema?

scientific article published on 01 March 2017

Erratum to: Automatic quantification of bone marrow edema on MRI of the wrist in patients with early arthritis: A feasibility study (Magn Reson Med. 2018; 79:1127-1134)

scientific article published on 08 February 2019

Evaluation of the association between anticarbamylated protein antibodies and the longitudinal course of functional ability in rheumatoid arthritis

scientific article published on 23 December 2015

Evaluation of the contribution of cumulative levels of inflammation to the variance in joint destruction in rheumatoid arthritis.

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Evaluation of the joint distribution at disease presentation of patients with rheumatoid arthritis: a large study across continents.

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Evaluation of the predictive accuracy of MRI-detected erosions in hand and foot joints in patients with undifferentiated arthritis

scientific article published on 31 July 2018

Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.

scientific article published on December 2007

Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis

scientific article published on 2 April 2007

Genetic Factors for the Severity of ACPA-negative Rheumatoid Arthritis in 2 Cohorts of Early Disease: A Genome-wide Study.

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Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study.

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Genetic variants in the prediction of rheumatoid arthritis

scientific article published on 03 May 2010

Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis

scientific article published on 01 February 2011

Genetic variation of the Fc gamma receptor 3B gene and association with rheumatoid arthritis.

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How to define baseline erosiveness to predict radiologic progression in rheumatoid arthritis

scientific article published on 01 September 2013

Hypernatremia from a hunger strike as a cause of osmotic myelinolysis.

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Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint

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Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis.

scientific article published on 16 August 2013

Identifying MRI-detected inflammatory features specific for rheumatoid arthritis: two-fold feature reduction maintains predictive accuracy in clinically suspect arthralgia patients

scientific article published on 01 May 2018

Imaging: Use of MRI as an outcome measure in clinical trials in RA

scientific article published on 16 October 2012

Improved treatment strategies reduce the increased mortality risk in early RA patients

scientific article published on 09 August 2010

Increasing incidence of autoantibody-negative RA is replicated and is partly explained by an aging population

scientific article published on 29 May 2020

Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia.

scientific article published on 3 May 2018

Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients.

scientific article published on 10 August 2017

Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritis

scientific article published on 01 July 2005

Is HLA-B27 increased in patients diagnosed with undifferentiated arthritis? Results from the Leiden early arthritis cohort.

scientific article published on 15 August 2014

Is early remission associated with improved survival or is arthritis persistency associated with increased mortality in early arthritis? Comparisons with the general population

scientific article published on 12 July 2013

Is the modified disease activity score superior to the disease activity score in early arthritis and rheumatoid arthritis? Comment on the article by Baker et al

scientific article published on 01 November 2014

Large joint involvement at first presentation with RA, an unfavourable feature: results of a large longitudinal study with functioning and DMARD-free sustained remission as outcomes.

scientific article published on 10 August 2017

Long-term impact of delay in assessment of patients with early arthritis

scientific article published on 01 December 2010

Longitudinal IP-10 Serum Levels Are Associated with the Course of Disease Activity and Remission in Patients with Rheumatoid Arthritis

scientific article published on 07 June 2017

MRI-detected subclinical joint inflammation is associated with radiographic progression

scientific article published on 29 July 2014

Magnetic Resonance Imaging-Detected Features of Inflammation and Erosions in Symptom-Free Persons From the General Population

scientific article published on 29 September 2016

Moderate use of alcohol is associated with lower levels of C reactive protein but not with less severe joint inflammation: a cross-sectional study in early RA and healthy volunteers.

scientific article published on 7 January 2018

No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes

scientific article published on 13 July 2004

No impact of serum uric acid on the outcome of recent-onset arthritis

scientific article published on 22 March 2012

Not only synovitis but also tenosynovitis needs to be considered: why it is time to update textbook images of rheumatoid arthritis

scientific article published on 19 December 2019

Osteoprotegerin as biomarker for persistence of rheumatoid arthritis

scientific article published on 08 December 2015

PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts.

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Patients with early arthritis consume less alcohol than controls, regardless of the type of arthritis.

scientific article published on 20 June 2013

Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis.

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Predicting arthritis outcomes--what can be learned from the Leiden Early Arthritis Clinic?

scientific article published on 16 July 2010

Predicting the severity of joint damage in rheumatoid arthritis; the contribution of genetic factors

scientific article published on 15 January 2014

Pretreatment serum levels of anti-cyclic citrullinated peptide antibodies are associated with the response to methotrexate in recent-onset arthritis

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Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: Results from two large early arthritis cohorts

scientific article published on 01 August 2009

Preventing progression from arthralgia to arthritis: targeting the right patients.

scientific article published on 9 November 2017

Protection against rheumatoid arthritis by HLA: nature and nurture.

scientific article published on December 2008

Protective effect of HLA-DRB1*13 alleles during specific phases in the development of ACPA-positive RA.

scientific article published on 29 December 2015

Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.

scientific article published on April 2009

Realising early recognition of arthritis in times of increased telemedicine: the value of patient-reported swollen joints

scientific article published on 07 January 2021

Reliability of Magnetic Resonance Imaging (MRI) Scoring of the Metatarsophalangeal Joints of the Foot according to the Rheumatoid Arthritis MRI Score

scientific article published on 15 September 2019

Repair of joint erosions in rheumatoid arthritis: prevalence and patient characteristics in a large inception cohort.

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Reply

Response to: 'The significance of the squeeze test to identify arthritis was underestimated or not?' by Luo et al

scientific article published on 07 August 2015

Rheumatoid arthritis phenotype at presentation differs depending on the number of autoantibodies present.

scientific article published in April 2016

Rheumatoid factor and anti-citrullinated protein antibody positivity, but not level, are associated with increased mortality in patients with rheumatoid arthritis: results from two large independent cohorts.

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Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients

scientific article published on 06 March 2007

Screening for two or three autoantibodies in persons at risk for RA: implications of current data for clinical practice

scientific article published on 01 May 2019

Sequence of joint tissue inflammation during rheumatoid arthritis development

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Serum pyridinoline levels and prediction of severity of joint destruction in rheumatoid arthritis

scientific article published on 01 June 2013

Smoking as a risk factor for the radiological severity of rheumatoid arthritis: a study on six cohorts

scientific article published on 03 January 2014

Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se: a multicenter cohort study.

scientific article published on December 2016

Studying associations between variants inTRAF1-C5andTNFAIP3-OLIG3and the progression of joint destruction in rheumatoid arthritis in multiple cohorts

scientific article published on 14 May 2012

Sustained drug-free remission in rheumatoid arthritis after DAS-driven or non-DAS-driven therapy: a comparison of two cohort studies

scientific article published on 15 February 2012

Symptoms associated with inflammatory arthritis are common in the primary care population: results from the joint symptoms survey

scientific article published on 01 November 2019

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

scientific article published on 16 March 2019

Tapering towards DMARD-free remission in established rheumatoid arthritis: 2-year results of the TARA trial

scientific article published on 01 June 2020

The HLA–DRB1 shared epitope alleles are primarily a risk factor for anti–cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis

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The HLA–DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide

scientific article published on 01 February 2007

The RAGE G82S polymorphism is not associated with rheumatoid arthritis independently of HLA-DRB1*0401

scientific article published on 17 January 2006

The additive value of magnetic resonance imaging for bone edema in predicting rheumatoid arthritis development in early undifferentiated arthritis: Comment on the article by Duer‐Jensen et al

scientific article published on 01 January 2012

The anti-carbamylated protein antibody response is of overall low avidity despite extensive isotype switching

scientific article published on 01 September 2018

The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor

scientific article published on 26 April 2016

The diagnostic accuracy of the squeeze test to identify arthritis: a cross-sectional cohort study

scientific article published on 24 April 2015

The earlier, the better or the worse? Towards accurate management of patients with arthralgia at risk for RA

scientific article published on 08 January 2020

The effects of rheumatoid factor and anticitrullinated peptide antibodies on bone erosions in rheumatoid arthritis.

scientific article published on 6 October 2014

The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis

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The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

scientific article published on 15 August 2017

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical.

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The risk of individual autoantibodies, autoantibody combinations and levels for arthritis development in clinically suspect arthralgia.

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The specificity of anti-carbamylated protein antibodies for rheumatoid arthritis in a setting of early arthritis.

scientific article published on 24 November 2015

The squeeze test of MCP joints: a scarcity of scientific data, especially from primary care.

scientific article published on 28 February 2017

The target of ACPA

scientific article published on 30 June 2016

The use of MRI-detected synovitis to determine the number of involved joints for the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis - is it of additional benefit?

scientific article published on 20 April 2018

The value of inquiring about functional impairments for early identification of inflammatory arthritis: a large cross-sectional derivation and validation study from the Netherlands

scientific article published on 13 December 2020

The window of opportunity in ACPA-positive rheumatoid arthritis is not explained by ACPA characteristics

scientific article published on 10 April 2011

Tic-tac-toe does not provide lessons for appreciating the HLA-rheumatoid arthritis relationship: Comment on the editorial by Bridges et al

scientific article published on 01 November 2008

Toward a data-driven evaluation of the 2010 American College of Rheumatology/European League Against Rheumatism criteria for rheumatoid arthritis: is it sensible to look at levels of rheumatoid factor?

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Triple Positivity for Anti-Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti-Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis

scientific article published on 16 September 2018

Two-year cost effectiveness between two gradual tapering strategies in rheumatoid arthritis: cost-utility analysis of the TARA trial

scientific article published on 09 September 2020

Undifferentiated arthritis characteristics and outcomes when applying the 2010 and 1987 criteria for rheumatoid arthritis

scientific article published on 27 September 2011

Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis

scientific article published on 01 April 2018

Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity

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Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: Moving toward individualized treatment decision-making

scientific article published on 01 August 2008

Validity of the rheumatoid arthritis MRI score applied to the forefeet using the OMERACT filter: a systematic literature review

scientific article published on 05 December 2018

Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis a

scientific article published on 01 August 2009

Variation in radiologic joint destruction in rheumatoid arthritis differs between monozygotic and dizygotic twins and pairs of unrelated patients

scientific article published on 01 June 2006

What is the additional value of MRI of the foot to the hand in undifferentiated arthritis to predict rheumatoid arthritis development?

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What is the prevalence of MRI-detected inflammation and erosions in small joints in the general population? A collation and analysis of published data.

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What is the value of musculoskeletal ultrasound in patients presenting with arthralgia to predict inflammatory arthritis development? A systematic literature review

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Which patients presenting with arthralgia eventually develop rheumatoid arthritis? The current state of the art.

scientific article published on 14 November 2017

Window of opportunity in rheumatoid arthritis - definitions and supporting evidence: from old to new perspectives.

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