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List of works by W. Wurst

"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?

scientific article published in May 2008

A Customizable Protocol for String Assembly gRNA Cloning (STAgR)

scientific article published on 26 December 2018

A Mouse for All Reasons

scientific article

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice

scientific journal article

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

scientific journal article

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

scientific article

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes

scientific article published on 14 February 2020

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

scientific article (publication date: 29 May 2009)

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

scientific article published on 12 October 2017

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome

scientific article published on 6 August 2003

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

article

A new partner for the international knockout mouse consortium

scientific article published on 01 April 2007

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

article

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease

scientific article published on 01 September 2020

A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons

scientific article published on 31 December 2010

A protein quality control pathway regulated by linear ubiquitination

scientific article published on 18 March 2019

A public gene trap resource for mouse functional genomics

scientific article published on June 2004

A robust and reliable non-invasive test for stress responsivity in mice

scientific article

A systems medicine research approach for studying alcohol addiction

scientific article published in November 2013

A truncating Aspm allele leads to a complex cognitive phenotype and region-specific reductions in parvalbuminergic neurons

scientific article published on 13 February 2020

A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation

scientific article published on September 2012

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

scientific article published on 14 November 2016

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

scientific article

Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments

scientific article

Activation of ERK/MAPK in the lateral amygdala of the mouse is required for acquisition of a fear-potentiated startle response

scientific article published on 23 April 2008

Alpha-synuclein fragments trigger distinct aggregation pathways

scientific article published on 03 February 2020

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

scientific article published on 13 June 2017

Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice

scientific article published on 26 October 2005

Amygdala and neocortex: common origins and shared mechanisms

scientific article published on 01 September 2007

An RNAi-based approach to down-regulate a gene family in vivo

scientific article

An integrated genome research network for studying the genetics of alcohol addiction

scientific article published on October 2010

Analysis of locomotor behavior in the German Mouse Clinic

scientific article published on 05 May 2017

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Animal models for arthritis: innovative tools for prevention and treatment

scientific article published on 30 May 2011

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

scientific article published in October 2008

Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif ⬇️

scientific article published on June 1, 1998

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

scientific article

Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation

scientific article

Assessing Cognition in Mice

scientific article published on 2 December 2015

Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice

scientific article

Author Correction: Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception

scientific article published in Nature Communications

Bioinformatics identification of modules of transcription factor binding sites in Alzheimer's disease-related genes by in silico promoter analysis and microarrays

scientific article published on 26 April 2011

Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking

scientific article published on 23 November 2011

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

scientific article

CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues

scientific article

CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.

scientific article published on 18 May 2016

CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells

scientific article

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion

scientific article published on 09 November 2020

Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task

scientific article published in March 2005

Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms

scientific article

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.

scientific article

Cell-based simulation of dynamic expression patterns in the presomitic mesoderm

scientific article

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

scientific article published on 09 September 2019

Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice

scientific article

Centralized mouse repositories

scientific article published on 04 September 2012

Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

scientific article published on 21 May 2018

Comprehensive miRNome-Wide Profiling in a Neuronal Cell Model of Synucleinopathy Implies Involvement of Cell Cycle Genes

scientific article published on 04 March 2021

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.

scientific article

Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge

scientific article

Conditional RNAi in mice.

scientific article published on 10 August 2010

Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors

scientific article

Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference

scientific article published on 22 June 2007

Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS

scientific article published on 19 June 2020

Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.

scientific article published on 26 October 2011

Constitutive and conditional RNAi transgenesis in mice

scientific article published on 22 December 2010

Control of gene editing by manipulation of DNA repair mechanisms

scientific article published on 3 April 2017

Correction: An RNAi-Based Approach to Down-Regulate a Gene Family In Vivo

scientific article published on 19 December 2013

Corrigendum: High-throughput discovery of novel developmental phenotypes.

scientific article published on 8 November 2017

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

scientific article published on 9 September 2015

Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity

scientific article published on 26 January 2007

Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas.

scientific article

Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells

scientific article

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.

scientific article

Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice

Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function

scientific article

Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development

scientific journal article

Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models

scientific article

Delayed dopaminergic neuron differentiation in Lrp6 mutant mice

scientific journal article

Design and Generation of Gene-Targeting Vectors

scientific article published on 01 March 2011

Development of a capillary isoelectric focusing immunoassay to measure DJ-1 isoforms in biological samples

scientific article published on 17 September 2013

Development of an intein-mediated split-Cas9 system for gene therapy

scientific article

Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans

scientific article published on 01 November 2020

Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.

scientific article published in September 2015

Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice

scientific article published on 10 February 2016

Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development

scientific article published on 11 January 2016

Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

scientific article

Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain

scientific article published in January 2007

Direct cloning of isogenic murine DNA in yeast and relevance of isogenicity for targeting in embryonic stem cells

scientific article

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

scientific article published on 20 February 2013

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

scientific article published on 26 June 2017

Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease

scientific article

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

scientific journal article

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines

scientific journal article

Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling

scientific article published on 26 October 2020

Dose-dependent long-term effects of a single radiation event on behaviour and glial cells

scientific article published on 02 December 2020

Dusp8 affects hippocampal size and behavior in mice and humans

scientific article published on 20 December 2019

EUCOMM--the European conditional mouse mutagenesis program.

scientific article

Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1.

scientific article published on 4 June 2012

Ectopic dopaminergic progenitor cells from En1(+/Otx2lacZ) transgenic mice survive and functionally reinnervate the striatum following transplantation in a rat model of Parkinson's disease

scientific article published on 4 May 2010

Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region

scientific journal article

Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps

scientific article

Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector

scientific article

Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads

scientific article

Elevated glutaric acid levels in Dhtkd1-/Gcdh- double knockout mice challenge our current understanding of lysine metabolism

scientific article published on 22 May 2017

Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting

scientific article published in 2024

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors

scientific journal article

Enhanced gene trapping in mouse embryonic stem cells

scientific article

Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

scientific article published in Nature Communications

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts

scientific article published on 07 March 2019

Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

scientific article published in February 2018

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

scientific article

Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis

scientific article

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

scientific article

Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development

scientific article

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.

scientific article published on 9 July 2018

Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice

scientific article

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

scientific article published on 28 April 2015

Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity

scientific article published on 7 February 2007

FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region

scientific article published on 13 May 2006

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum

scientific article

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals

scientific journal article

Fast synchronization of ultradian oscillators controlled by delta-notch signaling with cis-inhibition

scientific article

Fgf15 regulates thalamic development by controlling the expression of proneural genes

scientific article published on 27 August 2015

Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis

scientific article

Fgf9 (Y162C) Mutation Alters Information Processing and Social Memory in Mice

scientific article published on 10 July 2017

Fgfr1-dependent boundary cells between developing mid- and hindbrain

scientific article

Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits

scientific article

Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling

scientific article

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

scientific article published on 06 September 2018

Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect

scientific journal article

Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases.

scientific article published in December 2012

Gene editing in mouse zygotes using the CRISPR/Cas9 system

scientific article published on 2 March 2017

Gene expression profiling following maternal deprivation: involvement of the brain Renin-Angiotensin system

scientific article published on 14 May 2009

Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein

scientific article

Gene knockdown in the mouse through RNAi.

scientific article published on January 2010

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

scientific article

Generating conditional knockout mice

scientific article published on 01 January 2011

Generation and characterization of dickkopf3 mutant mice

scientific article

Generation of shRNA transgenic mice

scientific article published in January 2009

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.

scientific article published on 31 October 2013

Generation of targeted mouse mutants by embryo microinjection of TALENs

scientific article published on 11 January 2014

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders

scientific article published in June 2015

Genetic analysis of susceptibility to diabetes mellitus in F2-hybrids between diabetes-prone BB and various MHC-recombinant congenic rat strains ⬇️

scientific article published on 01 June 1991

Genetic networks controlling the development of midbrain dopaminergic neurons

scientific article published on 6 July 2006

Genetically Controlled Lysosomal Entrapment of Superparamagnetic Ferritin for Multimodal and Multiscale Imaging and Actuation with Low Tissue Attenuation

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice.

scientific article

Genome Editing in Mice Using TALE Nucleases

scientific article published in January 2016

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

scientific article published on 3 May 2005

Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

scientific article published on 03 February 2020

Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

scientific article published in September 2011

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

scientific article

HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region

scientific article published on 18 April 2014

Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis

scientific article

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

scientific journal article

Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality.

scientific article

High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner

scientific article

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.

scientific article published on 28 March 2014

High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains

scientific article published in May 2014

High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.

scientific article

Highly efficient targeted mutagenesis in mice using TALENs

scientific article published on 26 August 2013

Human and mouse essentiality screens as a resource for disease gene discovery

scientific article published on 31 January 2020

Identification of genes required for eye development by high-throughput screening of mouse knockouts

scientific article published on 21 December 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

scientific article published on 18 January 2018

Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3

scientific article published on 24 May 2019

Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models

scientific article published on February 2009

Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice

scientific article published in March 2007

Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1 ⬇️

scientific article published on June 1, 1998

In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system

article

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria

scientific article published on 23 November 2019

Increased dopaminergic innervation in the brain of conditional mutant mice overexpressing Otx2: effects on locomotor behavior and seizure susceptibility

scientific article published on 30 December 2013

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

scientific article

Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus.

scientific article published on December 2010

Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis

scientific article published on July 2006

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.

scientific article

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

scientific article

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

scientific article published in September 2006

LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum

scientific journal article

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

scientific article

LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.

scientific article published on 24 September 2013

Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data

scientific article

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

scientific article

Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk

scientific article

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

scientific article published on 14 September 2003

Local Knockdown of ERK2 in the Adult Mouse Brain Via Adeno-Associated Virus-Mediated RNA Interference.

scientific article published on 20 December 2008

Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.

scientific article published on 04 December 2008

Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.

scientific article published in May 2003

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

scientific article published on 14 September 2020

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

scientific article

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase (TPI) deficiency

scientific article published on 11 June 2019

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults

scientific article

MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation

scientific article published on 4 June 2015

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention

scientific article

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy

scientific article

Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus

scientific journal article

Meis1: effects on motor phenotypes and the sensorimotor system in mice

scientific article published on 23 June 2017

Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice

scientific article published on 28 July 2014

Mga is essential for the survival of pluripotent cells during peri-implantation development

scientific article

MiR-34a deficiency accelerates medulloblastoma formation in vivo

scientific article

MicroRNA-9 controls dendritic development by targeting REST.

scientific article

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

scientific article published on 22 December 2009

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

scientific article

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

scientific article

Modeling disease mutations by gene targeting in one-cell mouse embryos

scientific article

Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.

scholarly article

Molecular characterization, structure and developmental expression of Megane bHLH factor

scientific journal article

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain

scientific article published on 20 August 2014

Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1

scientific article published on 27 December 2019

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

scientific article published on 28 December 2020

Mouse phenotyping

scientific article

Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons

scientific article published on 04 February 2019

Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice

scientific article

Mutations in HID1 Cause Syndromic Infantile Encephalopathy and Hypopituitarism

scientific article published on 05 June 2021

N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant

scientific article

Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss.

scientific article published on 5 May 2013

Nephrin TRAP Mice Lack Slit Diaphragms and Show Fibrotic Glomeruli and Cystic Tubular Lesions

scientific article published on 01 June 2002

NeuBtracker-imaging neurobehavioral dynamics in freely behaving fish.

scientific article

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

scientific article

Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import

article

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. ⬇️

scientific article published in July 2009

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

scientific journal article

Novel allele of crybb2 in the mouse and its expression in the brain.

scientific article published in April 2008

Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.

scientific article published on October 2008

Ontogeny of steroid receptor coactivators in the hippocampus and their role in regulating postnatal HPA axis function

scientific article published on 16 August 2007

Optimized vector for conditional gene targeting in mouse embryonic stem cells

scientific article

Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions

scientific article

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia

scientific article

Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain

scientific journal article

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity

scientific article published on 11 December 2013

Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.

scientific article published on 7 November 2010

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

scientific article

Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability

scientific article published on 29 October 2012

Overview on mouse mutagenesis.

scientific article published on January 2009

Parkin: A stress-protective E3 ubiquitin ligase maintaining mitochondrial integrity

Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons

scientific article published on 04 April 2022

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

scientific article

Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development

scientific article published in October 2009

Permutation-validated principal components analysis of microarray data

scientific article published on 22 March 2002

Phenotypic annotation of the mouse X chromosome

scientific article

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb

scientific article published on 11 January 2012

Pitchfork regulates primary cilia disassembly and left-right asymmetry

scientific article

Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.

scientific article

Pleiotropic effects in Eya3 knockout mice

scientific article

Pleiotropic functions for transcription factor zscan10.

scientific article

Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons

scientific article

Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

scientific article

Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality

scientific journal article

Rapamycin extends murine lifespan but has limited effects on aging

scientific article

Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice.

scientific article published in October 2007

Reduced cerebral injury in CRH-R1 deficient mice after focal ischemia: a potential link to microglia and atrocytes that express CRH-R1.

scientific article

Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice

scientific article published on 01 September 2004

Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1

scientific journal article

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

scientific article

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

scientific article

Resources for proteomics in mouse embryonic stem cells.

scientific article published in February 2011

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

scientific journal article

Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.

scientific article

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

scientific article published on 2 January 2017

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis.

scientific article published in March 2017

Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation

scientific journal article

Sall1, sall2, and sall4 are required for neural tube closure in mice

scientific journal article

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo

scientific article published on September 2008

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

scientific article published on 16 December 2017

Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development

scientific journal article

Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice

scientific article

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms

scientific article published on 2 December 2016

Sharpening of expression domains induced by transcription and microRNA regulation within a spatio-temporal model of mid-hindbrain boundary formation

scientific article

Shh dependent and independent maintenance of basal midbrain

scientific article published on 17 March 2009

Simple derivation of transgene-free iPS cells by a dual recombinase approach

scientific article published on August 2014

Simultaneous Cre-mediated conditional knockdown of two genes in mice

scientific article

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

scientific article published on 27 January 2020

Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis

scientific article published on 06 February 2020

Spatial analysis of expression patterns predicts genetic interactions at the mid-hindbrain boundary

scientific article

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

scientific article

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

scientific article published on 13 April 2017

Splinkerette PCR for more efficient characterization of gene trap events

scientific article published on 01 August 2007

Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes

scientific article published on 20 July 2012

Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1

scientific article published on 01 March 2007

Systematic phenotyping of mouse mutants

Systemic first-line phenotyping

scientific article published on January 2009

TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.

scientific article published on 25 May 2018

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

scientific article published on 8 May 2017

Target validation in mice by constitutive and conditional RNAi.

scientific article

Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function

scientific journal article

Telomere shortening reduces Alzheimer's disease amyloid pathology in mice

scientific article published on 14 June 2011

Tests for Anxiety-Related Behavior in Mice

scientific article published on 2 December 2015

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions

scientific article published on 11 September 2020

The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis

scientific article published on 01 December 2018

The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence

scientific article published on 12 December 2016

The Deep Genome Project

scientific article published on 03 February 2020

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

scientific article

The European dimension for the mouse genome mutagenesis program

scientific article

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

scientific article published on 30 May 2017

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons

scientific article published on 01 March 2020

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

scientific article

The Hsp90 cochaperone p23 is essential for perinatal survival.

scientific article

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse

scientific article

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4

scientific article published on 14 March 2019

The REST remodeling complex protects genomic integrity during embryonic neurogenesis.

scientific article published on 8 January 2016

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

scholarly article by Xianyuan Xiang published in September 2018

The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice

scientific article published on 2 October 2014

The functional annotation of mammalian genomes: the challenge of phenotyping

scientific article published on January 2009

The isthmic neuroepithelium is essential for cerebellar midline fusion ⬇️

scientific article published on September 24, 2003

The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.

scientific article published in June 2003

The knockout mouse project

scientific article

The mammalian gene function resource: the International Knockout Mouse Consortium

scientific article

The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour

scientific journal article

The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse

scientific article published on 30 May 2017

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

scientific article published on 26 March 2020

The specific role of histone deacetylase 2 in adult neurogenesis.

scientific article published on 14 April 2010

Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling

scientific article published on June 2009

Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition

scientific article

Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity

scientific article published on 11 August 2020

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation

scientific article published on 13 November 2014

Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic

scientific article

Urocortin 2 modulates aspects of social behaviour in mice

scientific article published on 26 May 2012

Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.

scientific article published on July 2010

Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation

scientific article

Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele

scientific article published in October 2012

Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation

scientific article published in February 2011

Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests

scientific article

Wnt1-regulated genetic networks in midbrain dopaminergic neuron development

scientific article published on 09 December 2013

Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

scientific journal article

Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception

scientific article published on 23 February 2018

Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine

scientific article published on 31 July 2009

cGMP-dependent protein kinase I, the circadian clock, sleep and learning

scientific article published on July 2009

mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons

scientific journal article

miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1

scientific article published on 22 October 2018

β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons

scientific article published on 15 September 2020

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