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List of works by Karin M. Danzer

ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues

scientific article published on 3 November 2016

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

scientific article published on 26 April 2011

Age Increases Monocyte Adhesion on Collagen.

scientific article published on 17 May 2017

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

scientific article published on 17 November 2015

Aggregated α-Synuclein Increases SOD1 Oligomerization in a Mouse Model of Amyotrophic Lateral Sclerosis.

scientific article published on 17 June 2016

Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry

scientific article

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity

scientific article

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency

scientific article published on 5 January 2018

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss

scientific article (publication date: 2014)

Commentary: alpha-synuclein interacts with SOD1 and promotes its oligomerization

scientific article published on 01 January 2016

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

scientific article published in August 2007

Drug targets from genetics: α-synuclein

scientific article published on September 2011

Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS

scientific article published on 20 July 2018

Enhanced hyaluronan signaling and autophagy dysfunction by VPS35 D620N

scientific article published on 12 June 2020

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

scientific article

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

scientific article

Functional protein kinase arrays reveal inhibition of p-21-activated kinase 4 by alpha-synuclein oligomers

scientific article published on 18 September 2007

Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro ⬇️

scientific article published on July 21, 2011

Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice

scientific article published on 21 August 2020

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

scientific article

Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity ⬇️

scientific article published on September 27, 2010

Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice

scientific article published on 07 October 2020

Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

scientific article published on 11 January 2019

Hot-spot KIF5A mutations cause familial ALS

Impaired activation of ALS monocytes by exosomes

scientific article published on 12 September 2016

Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease

scientific article published on 15 August 2019

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies

scientific article published on 8 December 2015

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients

scientific article

Intracellular Alpha-Synuclein and Immune Cell Function

scientific article published on 15 October 2020

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species

scientific article published on 01 November 2019

LRRK2 contributes to monocyte dysregulation in Parkinson's disease

scientific article published on 24 November 2016

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 G298S ALS mouse model

scientific article published on 30 August 2019

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

scientific article

NEK1 mutations in familial amyotrophic lateral sclerosis

scientific article published on 5 March 2016

PGC-1 is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis ⬇️

scientific article published on May 12, 2013

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

scientific article published on 24 February 2016

Proteasome impairment by α-synuclein.

scientific article published on 25 September 2017

Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins

scientific article published on 29 February 2008

Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition

scientific article published in February 2007

Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA

scientific article published on 03 September 2020

Release and uptake of pathologic alpha-synuclein

scientific article published on 6 February 2018

Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations

scientific article published in December 2019

SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden

scientific article published on 02 November 2019

Screening for CHCHD10 mutations in a large cohort of sporadic ALS patients: no evidence for pathogenicity of the p.P34S variant

scientific article published on 11 September 2015

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

scientific article published on 4 August 2009

Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers

scientific article published on 5 September 2014

Serum microRNAs in sporadic amyotrophic lateral sclerosis.

scientific article

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

scientific article published on 7 February 2008

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

scientific article

TDP-43 is intercellularly transmitted across axon terminals

scientific article

Telomere shortening leads to earlier age of onset in ALS mice

scientific article published on February 2016

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

scientific article published on 8 June 2015

The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion

scientific article published on 15 July 2017

The Role of Lipids in the Initiation of α-Synuclein Misfolding

scientific article published on 15 September 2020

Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease

scientific article published on 11 August 2014

α-Synuclein in Parkinson's disease: pathogenic function and translation into animal models

scientific article published on 24 September 2013

α-synuclein interacts with SOD1 and promotes its oligomerization

scientific article

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