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List of works by P. Weydt

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset

scientific article

A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort.

scientific article

ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues

scientific article published on 3 November 2016

Can lesions to the motor cortex induce amyotrophic lateral sclerosis?

scientific article published on 20 November 2013

Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival.

scientific article published in September 2005

Cannabis: old medicine with new promise for neurological disorders

scientific article

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression

scientific article published on 15 November 2017

Clinical Trials in Spinal and Bulbar Muscular Atrophy-Past, Present, and Future

scientific article

Comparative biochemical characterization of the monoacylglycerol lipase inhibitor KML29 in brain, spinal cord, liver, spleen, fat and muscle tissue

scientific article published on 12 December 2014

Comparison of Sirtuin 3 Levels in ALS and Huntington's Disease-Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models

scientific article

Contrasting effects of selective MAGL and FAAH inhibition on dopamine depletion and GDNF expression in a chronic MPTP mouse model of Parkinson's disease

scientific article

Current pharmacological management of amyotrophic [corrected] lateral sclerosis and a role for rational polypharmacy

scientific article published on April 2004

Deficits in verbal fluency in presymptomatic C9orf72 mutation gene carriers-a developmental disorder

scientific article published on 27 August 2020

Development, implementation, and evaluation of a movie-based curriculum to teach psychopathology

scientific article

Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 hexanucleotide repeat expansion

scientific article published on 04 March 2020

Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase

scientific article published on 17 September 2018

Drug therapy for amyotrophic lateral sclerosis: Where are we now?

scientific article

Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age ⬇️

scientific article published on 04 June 2013

Electrodiagnostic evaluation of hereditary motor and sensory neuropathies

scientific article

Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice.

scientific article

Evaluation of monoacylglycerol lipase as a therapeutic target in a transgenic mouse model of ALS.

scientific article published on 31 March 2017

Full-length PGC-1α salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation ⬇️

scientific article published on July 29, 2013

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

scientific article

High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington's disease expansion mutation carriers shows normal mitochondrial respiratory function.

scientific article

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis.

scientific article published on 8 June 2017

Incidence and geographical variation of amyotrophic lateral sclerosis (ALS) in Southern Germany--completeness of the ALS registry Swabia

scientific article

July 2017 ENCALS statement on edaravone

scientific article

Medicinal cannabis: rational guidelines for dosing

scientific article published on May 2004

Modafinil to treat fatigue in amyotrophic lateral sclerosis: an open label pilot study

scientific article published in January 2005

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis

scientific article published on 6 December 2017

Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

scientific article

NEK1 mutations in familial amyotrophic lateral sclerosis

scientific article published on 5 March 2016

Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis.

scientific article

Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis

scientific article published on 17 December 2015

Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients

scientific article published on 21 August 2015

Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis

scientific article

Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases.

scientific article

Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway.

scientific article

PGC-1 is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis ⬇️

scientific article published on May 12, 2013

Peripheral monocytes are functionally altered and invade the CNS in ALS patients

scientific article published on 24 February 2016

Poly-GP in cerebrospinal fluid links C9orf72-associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD.

scientific article

Prodromal Huntington disease as a model for functional compensation of early neurodegeneration

scientific article

Provision of assistive technology devices among people with ALS in Germany: a platform-case management approach

scientific article published on 30 January 2018

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease

scientific article published on 17 August 2017

Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers

scientific article published on 5 September 2014

Serum microRNAs in sporadic amyotrophic lateral sclerosis.

scientific article

Skeletal muscle in amyotrophic lateral sclerosis: emerging concepts and therapeutic implications

scientific article

Survey of cannabis use in patients with amyotrophic lateral sclerosis

scientific article

Targeting protein aggregation in neurodegeneration--lessons from polyglutamine disorders

scientific article

Targeting toxic proteins for turnover

scientific article

The concept and diagnostic criteria of primary lateral sclerosis

scientific article published on 15 November 2016

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

scientific article published on 08 January 2009

The metabolic and endocrine characteristics in spinal and bulbar muscular atrophy

scientific article published on 20 February 2018

The role of PGC-1α in the pathogenesis of neurodegenerative disorders

scientific article published on October 2010

The role of microglial cells in amyotrophic lateral sclerosis

scientific article

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

scientific article

Towards a European Registry and Biorepository for Patients with Spinal and Bulbar Muscular Atrophy.

scientific article published on 7 January 2016

Two-point magnitude MRI for rapid mapping of brown adipose tissue and its application to the R6/2 mouse model of Huntington disease

scientific article

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