List of works - Laura Itzhaki

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides

scientific article

A unique binding cavity for divalent cations in the DNA-metal-chromomycin A3 complex

scientific article published on 01 February 1990

A virus that can take the heat.

scientific article published on 4 November 2014

ATPase site architecture and helicase mechanism of an archaeal MCM.

scientific article published in October 2007

Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase.

scientific article published on 11 December 2008

Auxetics at the Molecular Level: A Negative Poisson's Ratio in Molecular Rods

scientific article published on 01 September 2006

Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69

scientific article

Biophysical characterisation of the small ankyrin repeat protein myotrophin.

scientific article

Characterisation of the BRCT Domains of the Breast Cancer Susceptibility Gene Product BRCA1

article

Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.

scientific article published on 27 March 2010

Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis

scientific article

Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2

scientific article published on 01 October 1997

Complex regulation controls Neurogenin3 proteolysis.

scientific article

Conjugation in polyyne rods: to what extent is charge delocalization coupled to geometrical changes?

scientific article published on 01 December 2008

Cooperative organization in a macromolecular complex

scientific article published on 03 August 2003

Crystal structure of the ENT domain of human EMSY.

scientific article

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

scientific article published on 5 December 2016

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

scientific article published on 18 February 2014

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

scientific article published on 5 April 2016

Dissecting and reprogramming the folding and assembly of tandem-repeat proteins

scientific article

Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.

scientific article

Exploring new strategies for grafting binding peptides onto protein loops using a consensus-designed tetratricopeptide repeat scaffold

scientific article published on 01 April 2019

Folding and Association of the Human Cell Cycle Regulatory Proteins ckshs1 and ckshs2†

scientific article published on 01 January 2002

Folding and binding: lingering questions, emerging answers

scientific article published on 20 January 2012

Folding and fibril formation of the cell cycle protein Cks1

scientific article published on 04 May 2006

Folding cooperativity and allosteric function in the tandem-repeat protein class

scientific article published on 01 June 2018

Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module.

scientific article

Following co-operative formation of secondary and tertiary structure in a single protein module

scientific article published on 01 April 1997

From artificial antibodies to nanosprings: the biophysical properties of repeat proteins.

scientific article published on January 2012

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction

scientific article published on 07 January 2020

Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils

scientific article published on 26 February 2007

Hydrogen exchange and protein folding.

scientific article

Hydrogen exchange at equilibrium: a short cut for analysing protein-folding pathways? ⬇️

scientific article published on August 1, 1997

Hydrogen exchange in chymotrypsin inhibitor 2 probed by denaturants and temperature ⬇️

scientific article published on July 4, 1997

Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis

scientific article published on 01 July 1997

Implications of 3D domain swapping for protein folding, misfolding and function.

scientific article published on January 2012

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

scientific article published on 25 March 2013

Intermediates control domain swapping during folding of p13suc1.

scientific article

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

scientific article published on 13 January 2017

Mapping the Topography of a Protein Energy Landscape.

scientific article

Movement of the position of the transition state in protein folding

scientific article published on 01 October 1995

Nanoscale click-reactive scaffolds from peptide self-assembly.

scientific article

Nature and nurture in protein folding and binding

scientific article published on 08 February 2010

Observation of signal transduction in three-dimensional domain swapping

scientific article published on 01 October 2001

Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein.

scholarly article

Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation.

scientific article published on 23 February 2018

Protein folding: When ribosomes pick the structure

scientific article

Protein stability versus function: effects of destabilizing missense mutations onBRCA1DNA repair activity

scientific article published on 01 March 2015

Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2.

scientific article published on November 1995

Single versus parallel pathways of protein folding and fractional formation of structure in the transition state

scientific article published in October 1994

Single-molecule FRET reveals hidden complexity in a protein energy landscape.

scientific article published in January 2015

Stability and folding of the cell cycle regulatory protein, p13 suc1 1 1Edited by F. E. Cohen

scientific article published on 01 November 1998

Stability and folding of the tumour suppressor protein p16

scientific article published on 01 January 1999

Strain in the folding nucleus of chymotrypsin inhibitor 2

scientific article published on 01 January 1997

Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.

scientific article published in October 1994

Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors

scientific article published on 09 May 2022

Subdomain architecture and stability of a giant repeat protein.

scientific article published on 20 September 2013

Synergy between simulation and experiment in describing the energy landscape of protein folding ⬇️

scientific article published on July 21, 1998

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides

scientific article published on 21 June 2019

Tertiary interactions in the folding pathway of hen lysozyme: kinetic studies using fluorescent probes.

scientific article published on May 1994

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

article

The folding pathway of the cell-cycle regulatory protein p13suc1: clues for the mechanism of domain swapping

scientific article published on 01 January 2000

The how's and why's of protein folding intermediates.

scientific article published on 23 October 2012

The quest to understand protein folding

scientific article published on 11 February 2008

The structure of the transition state for folding of domain-swapped dimeric p13suc1.

scientific article

The unfolding story of three-dimensional domain swapping.

scientific article

Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues.

scientific article published in May 2001

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides

scientific article published on 07 February 2019

Toward classification of BRCA1 missense variants using a biophysical approach.

scientific article

Using FlAsH to probe conformational changes in a large HEAT repeat protein.

scientific article published on 26 April 2012

List of works by Laura Itzhaki

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides

A unique binding cavity for divalent cations in the DNA-metal-chromomycin A3 complex

A virus that can take the heat.

ATPase site architecture and helicase mechanism of an archaeal MCM.

Alcohol oxidase (AOX1) from Pichia pastoris is a novel inhibitor of prion propagation and a potential ATPase.

Auxetics at the Molecular Level: A Negative Poisson's Ratio in Molecular Rods

Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69

Biophysical characterisation of the small ankyrin repeat protein myotrophin.

Characterisation of the BRCT Domains of the Breast Cancer Susceptibility Gene Product BRCA1

Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.

Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis

Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2

Complex regulation controls Neurogenin3 proteolysis.

Conjugation in polyyne rods: to what extent is charge delocalization coupled to geometrical changes?

Cooperative organization in a macromolecular complex

Crystal structure of the ENT domain of human EMSY.

Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Dissecting and reprogramming the folding and assembly of tandem-repeat proteins

Domain swapping in p13suc1 results in formation of native-like, cytotoxic aggregates.

Exploring new strategies for grafting binding peptides onto protein loops using a consensus-designed tetratricopeptide repeat scaffold

Folding and Association of the Human Cell Cycle Regulatory Proteins ckshs1 and ckshs2†

Folding and binding: lingering questions, emerging answers

Folding and fibril formation of the cell cycle protein Cks1

Folding cooperativity and allosteric function in the tandem-repeat protein class

Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module.

Following co-operative formation of secondary and tertiary structure in a single protein module

From artificial antibodies to nanosprings: the biophysical properties of repeat proteins.

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction

Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils

Hydrogen exchange and protein folding.

Hydrogen exchange at equilibrium: a short cut for analysing protein-folding pathways? ⬇️

Hydrogen exchange in chymotrypsin inhibitor 2 probed by denaturants and temperature ⬇️

Hydrogen exchange in chymotrypsin inhibitor 2 probed by mutagenesis

Implications of 3D domain swapping for protein folding, misfolding and function.

Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2

Intermediates control domain swapping during folding of p13suc1.

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Mapping the Topography of a Protein Energy Landscape.

Movement of the position of the transition state in protein folding

Nanoscale click-reactive scaffolds from peptide self-assembly.

Nature and nurture in protein folding and binding

Observation of signal transduction in three-dimensional domain swapping

Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein.

Programmed Protein Self-Assembly Driven by Genetically Encoded Intein-Mediated Native Chemical Ligation.

Protein folding: When ribosomes pick the structure

Protein stability versus function: effects of destabilizing missense mutations onBRCA1DNA repair activity

Search for nucleation sites in smaller fragments of chymotrypsin inhibitor 2.

Single versus parallel pathways of protein folding and fractional formation of structure in the transition state

Single-molecule FRET reveals hidden complexity in a protein energy landscape.

Stability and folding of the cell cycle regulatory protein, p13 suc1 1 1Edited by F. E. Cohen

Stability and folding of the tumour suppressor protein p16

Strain in the folding nucleus of chymotrypsin inhibitor 2

Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.

Structure-Based Discovery of Lipoteichoic Acid Synthase Inhibitors

Subdomain architecture and stability of a giant repeat protein.

Synergy between simulation and experiment in describing the energy landscape of protein folding ⬇️

Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides

Tertiary interactions in the folding pathway of hen lysozyme: kinetic studies using fluorescent probes.

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

The folding pathway of the cell-cycle regulatory protein p13suc1: clues for the mechanism of domain swapping

The how's and why's of protein folding intermediates.

The quest to understand protein folding

The structure of the transition state for folding of domain-swapped dimeric p13suc1.

The unfolding story of three-dimensional domain swapping.

Three-dimensional domain swapping in p13suc1 occurs in the unfolded state and is controlled by conserved proline residues.

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides

Toward classification of BRCA1 missense variants using a biophysical approach.

Using FlAsH to probe conformational changes in a large HEAT repeat protein.