Search filters

List of works by Shigeyoshi Itohara

A convenient imino aldol reaction in ethyl alcohol catalyzed by a cation-exchange resin.

scientific article published in November 2001

A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia

scientific article

A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus

scientific article

A report on 2 cases of myositis ossificans in childhood

scientific article published on 01 December 1998

A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane.

scientific article published in January 2004

Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage.

scientific article published on 6 August 2007

Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1

scientific article published on 28 March 2009

Amygdala kindling induces nestin expression in the leptomeninges of the neocortex ⬇️

scientific article published on January 7, 2013

An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents

scientific article published on 02 August 2018

Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder.

scientific article published on 11 June 2018

Antagonistic negative and positive neurons of the basolateral amygdala

scientific article

Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses.

scientific article

Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients.

scientific article

Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage

scientific article published on 04 August 2018

Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments.

scholarly article

BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.

scientific article

Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.

scientific article

CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain

scientific article published on October 2013

CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus

scientific article published on 22 August 2016

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

scientific article

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

scientific article published on 2 February 2005

Causal relationship between the loss of RUNX3 expression and gastric cancer

scientific journal article

Cdk5/p35 functions as a crucial regulator of spatial learning and memory

scientific article published on 18 November 2014

Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice

scientific article published on 22 October 2015

Cellular prion protein prevents brain damage after encephalomyocarditis virus infection in mice.

scientific article published on 12 April 2008

Cellular prion protein regulates intracellular hydrogen peroxide level and prevents copper-induced apoptosis.

scientific article

Cognitive deficits in single App knock-in mouse models

scientific article published on July 2016

Connexin43 and bergmann glial gap junctions in cerebellar function.

scientific article published on 15 December 2008

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.

scientific article published in July 2006

Cortical glutamatergic neurons mediate the motor sedative action of diazepam.

scientific article published on 26 October 2007

Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa.

scientific article published in March 2005

Cutting-edge approaches to unwrapping the mysteries of sleep.

scientific article

DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death

scientific article published in March 2009

Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells

scientific journal article

Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.

scientific article published on 18 October 2013

Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia

scientific article published on 25 August 2003

Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice.

scientific article published in March 1996

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma

scientific article

Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo

scientific article published on 26 March 2019

Detection of species specific epitopes of mouse and hamster prion proteins (PrPs) by anti-peptide antibodies

scientific article published on 01 January 1996

Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.

scientific article published on May 2014

Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood

scientific article

Different antigenicities of the N-terminal region of cellular and scrapie prion proteins.

scientific article published in November 2013

Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection.

scientific article published in March 2005

Diminished corneal angiogenesis in gelatinase A‐deficient mice ⬇️

scientific article published on November 16, 2001

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

scientific article published on 7 February 2005

Distribution of cellular isoform of prion protein in T lymphocytes and bone marrow, analyzed by wild-type and prion protein gene-deficient mice.

scientific article

Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development

scientific article published on 01 January 1990

Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins.

scientific article

Diversity, Development, Ligands, and Probable Functions of γδ T Cells ⬇️

scientific article published on January 1, 1991

Diversity, development, ligands, and probable functions of gamma delta T cells.

scientific article

Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.

scientific article published in December 1999

Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice.

scientific article published in March 2004

Dual involvement of G-substrate in motor learning revealed by gene deletion.

scientific article

Dynamic characteristics and adaptability of mouse vestibulo-ocular and optokinetic response eye movements and the role of the flocculo-olivary system revealed by chemical lesions.

scientific article published on June 1998

Editorial

scientific article published on 02 September 2016

Effect of MMP-2 deficiency on atherosclerotic lesion formation in apoE-deficient mice

scientific article published on 23 March 2006

Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility.

scientific article

Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis

scientific article

Enhanced enteric invasion of scrapie agents into the villous columnar epithelium via maternal immunoglobulin

scientific article published on 01 December 2010

Entry of CD4-CD8- immature thymocytes into the CD4/CD8 developmental pathway is controlled by tyrosine kinase signals that can be provided through TCR components.

scientific article published in October 1994

Enzyme-linked immunosorbent assay to detect subgroup-specific antibodies to avian leukosis viruses.

scientific article

Establishment of bovine leukemia virus-producing and -nonproducing B-lymphoid cell lines and their proviral genomes.

scientific article published on January 1987

Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion

scientific article published on 30 April 2008

Expression of normal cellular prion protein (PrP(c)) on T lymphocytes and the effect of copper ion: Analysis by wild-type and prion protein gene-deficient mice.

scientific article published in August 2003

Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory

scientific article published in October 2007

Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice.

scientific article published on May 2005

GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67.

scientific article published on 31 March 2008

GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states

scientific article published on April 2007

Gamma delta T cells--gene to biology

scientific article published on 01 October 1995

Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood.

scientific article published on 24 October 2009

Genetic dissection of medial habenula–interpeduncular nucleus pathway function in mice ⬇️

scientific article published on March 12, 2013

Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation.

scientific article published on 12 February 2007

Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.

scientific article

Granuphilin molecularly docks insulin granules to the fusion machinery.

scientific article

High-efficiency CAG-FLPe deleter mice in C57BL/6J background.

scientific article published in April 2006

Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells ⬇️

scientific article published on July 1, 1991

Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells ⬇️

scientific article published on June 20, 1995

Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia

scientific article published in Nature

Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells.

scientific article published on 13 April 2011

Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice.

scientific article

Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE.

scientific article published in May 2000

Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.

scientific article

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production ⬇️

scientific article published on May 20, 2013

Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release.

scientific article published in March 2007

Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory

scientific article published in June 2008

Inhibition of nitric oxide synthesis and gene knockout of neuronal nitric oxide synthase impaired adaptation of mouse optokinetic response eye movements.

scientific article

Inhibition of obliterative airway disease development in murine tracheal allografts by matrix metalloproteinase-9 deficiency

scientific article published on 01 April 2005

Insufficient resistance of trehalose-6,6-dimycolate-treated T-cell receptor delta gene mutant (TCR delta-/-) mice against influenza virus infection.

scientific article published in January 1999

Intracerebral pathogenicity of influenza A viruses for chickens.

scientific article published in January 1980

Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility

scientific article published on 24 June 2015

Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice.

scientific article

Isolation of a sarcoma virus from a spontaneous chicken tumor

scientific article published on December 1, 1978

JDP2 suppresses adipocyte differentiation by regulating histone acetylation

scientific article

Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel.

scientific article

Learning induces a CDC2-related protein kinase, KKIAMRE.

scientific article

Lesion-induced thalamocortical axonal plasticity in the S1 cortex is independent of NMDA receptor function in excitatory cortical neurons.

scientific article published on November 2002

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.

scientific article

MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway

scientific article published on 10 April 2007

Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments

scientific article

Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia.

scientific article

Matrix metalloproteinase-2 plays a critical role in the pathogenesis of white matter lesions after chronic cerebral hypoperfusion in rodents.

scientific article published on 28 September 2006

Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus

scientific article published in September 2011

Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation.

scientific article published on 3 February 2006

Mice deficient in gamma delta T cells are resistant to lethal infection with Salmonella choleraesuis.

scientific article

Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions

scientific article published on 01 January 1995

Molecular cloning of infectious proviral genomes of bovine leukemia virus.

scientific article published in July 1987

Monoclonal antibodies discriminating netrin-G1 and netrin-G2 neuronal pathways

scientific article published on 22 October 2007

Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives

scientific journal article

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

article

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

scientific article published on November 19, 1992

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

scientific article published on 01 July 2003

NMDAR-regulated dynamics of layer 4 neuronal dendrites during thalamocortical reorganization in neonates

scientific article published on 27 March 2014

Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.

scientific article published on 06 August 2013

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation

scientific journal article

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice

scientific article published on 19 July 2018

Netrin-G/NGL complexes encode functional synaptic diversification.

scientific article published in November 2014

Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits.

scientific article

Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins

scientific journal article

Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.

scientific article

Normal delay eyeblink conditioning in mice devoid of astrocytic S100B ⬇️

scientific article published on December 10, 2010

Octapeptide repeat region and N-terminal half of hydrophobic region of prion protein (PrP) mediate PrP-dependent activation of superoxide dismutase

scientific article published on 01 January 2005

Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion. ⬇️

scientific article published on 24 June 2013

Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation

scientific journal article

Pael receptor is involved in dopamine metabolism in the nigrostriatal system

scientific article published on 15 August 2007

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

scientific article published in May 2005

Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer

scientific article published on 26 December 2013

Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus.

scientific article

Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency

scientific article published on 11 October 2017

PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line.

scientific article published on March 2005

Prion protein suppresses perturbation of cellular copper homeostasis under oxidative conditions.

scientific article published on January 2004

Prions prevent brain damage after experimental brain injury: a preliminary report

scientific article published on 01 January 2003

Prions prevent neuronal cell-line death.

scientific article

Protective Roles of γδ T Cells and Interleukin-15 inEscherichia coliInfection in Mice ⬇️

scientific article published on July 1, 1998

Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice

scientific journal article

Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling

scientific journal article

RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood.

scientific article published on 21 August 2014

Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus.

scientific article published on 22 August 2016

Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors.

scientific article

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice

scientific article published on 01 March 1998

Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.

scientific article

Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice.

scientific article

Reduced formation of granulomata in gamma(delta) T cell knockout BALB/c mice inoculated with Mycobacterium avium subsp. paratuberculosis

scientific article published on 01 September 2000

Reduced response of splenocytes after mitogen-stimulation in the prion protein (PrP) gene-deficient mouse: PrPLP/Doppel production and cerebral degeneration.

scientific article

Regulatory role of peritoneal NK1.1+ alpha beta T cells in IL-12 production during Salmonella infection.

scientific article published in August 1999

Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer

scientific article

Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress.

scientific article published on July 2014

Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.

scientific article published on 5 February 2007

Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.

scientific article

Role of adenylate cyclase 1 in retinofugal map development

scientific article published on May 2012

Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine release.

scientific article published on May 2007

Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice

scientific article

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.

scientific article published on 31 August 2008

Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neurons ⬇️

scientific article published on 01 March 2003

S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation

scientific article published on 23 July 2015

Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults

scientific article published on 28 February 2017

Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus.

scientific article

Self-tolerance to transgenic γδ T cells by intrathymic inactivation

scientific article published in Nature

Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel.

scientific article published on January 2007

Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.

scientific article

Single App knock-in mouse models of Alzheimer's disease.

scientific article published on 13 April 2014

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

scientific article published in September 2003

Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity.

scientific article published on 8 January 2014

Spinal RacGAP α-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance

scientific article published on 26 July 2017

Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits

scientific article published on 01 March 2014

Stimulus-induced behavior in F1 hybrids of seizure-sensitive and seizure-resistant gerbils.

scientific article

Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.

scientific article published on May 2007

Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo.

scientific article published on 24 October 2016

Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.

scientific article

Syncytia infectivity of assay of bovine leukemia virus.

scientific article published in January 1982

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

article

T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells.

scientific article published on April 1990

Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors

scientific article

Thalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex.

scientific article published on 30 January 2015

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.

scientific article

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

scientific journal article

The role of gamma delta T cells in priming macrophages to produce tumor necrosis factor-alpha

scientific article published on 01 May 1995

The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis

scientific article published on 01 September 2002

The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.

scientific article

Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.

scientific article published on 28 August 2013

Transfection of prion protein gene suppresses coxsackievirus B3 replication in prion protein gene-deficient cells.

scientific article published on December 2003

Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity.

scientific article

Tumor necrosis factor attenuates prion protein-deficient neuronal cell death by increases in anti-apoptotic Bcl-2 family proteins.

scientific article published on October 2003

Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice.

scientific article published in September 1997

Ventral CA1 neurons store social memory

scientific article

X11-like protein deficiency is associated with impaired conflict resolution in mice.

scientific article published in May 2009

gammadelta T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-gamma and IL-13 in mice.

scientific article published in May 2000

Paulina is supported by:

About Paulina

Help