List of works by William Jacobs

2165. Helicobacter pylori Infections in the Bronx, New York: Whole-Genome Sequencing for Rapid Genotypic Susceptibility Testing

A Mycobacterium tuberculosis cytochrome bd oxidase mutant is hypersensitive to bedaquiline.

scientific article

A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis

article

A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population.

scientific article published on 29 April 2015

A neonatal oral Mycobacterium tuberculosis-SIV prime / intramuscular MVA-SIV boost combination vaccine induces both SIV and Mtb-specific immune responses in infant macaques

scientific article

A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis

scientific journal article

A novel transposon trap for mycobacteria: isolation and characterization of IS1096 ⬇️

scientific article published on December 1, 1991

A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.

scientific article published on 9 September 2002

A recombinant attenuated Mycobacterium tuberculosis vaccine strain is safe in immunosuppressed simian immunodeficiency virus-infected infant macaques

scientific article

Acetic Acid, the active component of vinegar, is an effective tuberculocidal disinfectant

scientific article (publication date: 25 February 2014)

Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp.

scientific article

Addressing the Metabolic Stability of Antituberculars through Machine Learning.

scientific article published on 14 September 2017

Adoptive Transfer of Phosphoantigen-Specific γδ T Cell Subset Attenuates Mycobacterium tuberculosis Infection in Nonhuman Primates.

scientific article published on 19 May 2017

Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.

scientific article published on February 2005

An HSV-2 single-cycle candidate vaccine deleted in glycoprotein D, ΔgD-2, protects male mice from lethal skin challenge with clinical isolates of HSV-1 and HSV-2.

scientific article published on 5 December 2017

An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning

scientific article published on 5 December 2017

An obligately aerobic soil bacterium activates fermentative hydrogen production to survive reductive stress during hypoxia

scientific article

An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restriction-fragment-length polymorphisms.

scientific article published in January 1992

Analogs of the antituberculous agent pyrazinamide are competitive inhibitors of NADPH binding to M. tuberculosis fatty acid synthase I.

scientific article

Analyses of Mycobacterium tuberculosis proteins.

scientific article

Analysis of the exochelin locus in Mycobacterium smegmatis: biosynthesis genes have homology with genes of the peptide synthetase family

scientific article

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

scientific article published on 16 June 2013

Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis

scientific journal article

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

scientific article (publication date: 23 March 2015)

Auxotrophic vaccines for tuberculosis

scientific article published on 01 March 1996

Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine.

scientific article published on 21 September 2016

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis

scientific article

Biosynthesis of diaminopimelate, the precursor of lysine and a component of peptidoglycan, is an essential function of Mycobacterium smegmatis.

scientific article published on November 1996

Bxz1, a new generalized transducing phage for mycobacteria.

scientific article

CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.

scientific article published on 06 September 2016

Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis

scientific article published on 8 February 2016

Characterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene.

scientific article

Characterization of large deletion mutants of Mycobacterium tuberculosis selected for isoniazid resistance

scientific article published on 06 July 2020

Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.

scientific article

Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine

scientific article published on 31 October 2006

Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations

scientific article

Cluster K mycobacteriophages: insights into the evolutionary origins of mycobacteriophage TM4

scientific article

Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange.

scientific article

Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

scientific journal article

Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

scientific article published on November 2005

Conjugal rites of mycobacteria.

scientific article

Construction of D29 shuttle phasmids and luciferase reporter phages for detection of mycobacteria

scientific article published on 01 December 1996

Construction of an unmarked recombinant BCG expressing a pertussis antigen by auxotrophic complementation: protection against Bordetella pertussis challenge in neonates.

scientific article published on 25 September 2009

Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing

scientific article

Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response

scientific article

Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase

scientific article (publication date: 4 March 2003)

Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis

scientific article (publication date: 16 May 2003)

Cytosolic free calcium regulation in renal tubules from spontaneously hypertensive rats.

scientific article published in January 1990

Defects in glycopeptidolipid biosynthesis confer phage I3 resistance in Mycobacterium smegmatis.

scientific article published on 10 September 2009

Defining a temporal order of genetic requirements for development of mycobacterial biofilms

scientific article published on 19 June 2017

Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent

scientific article published on 06 July 2016

Deletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosis

scientific journal article

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

scientific article published on 16 September 2019

Development of BCG as a recombinant vaccine vehicle.

scientific article published on January 1990

Development of a murine mycobacterial growth inhibition assay for evaluating vaccines against Mycobacterium tuberculosis

scientific article published on 20 May 2009

Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

scientific article published on 27 October 2020

Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids

scientific article published on 01 March 2006

Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

scientific article

ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans

scientific article

Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing

scientific article published on 27 March 2019

Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves

scientific article published on 09 January 2009

Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase

scientific article

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

scientific article

Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.

scientific article published on 10 April 2017

Enhanced specialized transduction using recombineering in Mycobacterium tuberculosis

scientific article

Erratum for O'Donnell et al., "Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing"

scientific article published on 24 May 2019

Erratum to: Genetic Dissection of Mycobacterial Biofilms

scientific article published on 01 January 2015

Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia

scientific article published on 12 August 2014

Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations

scientific article

Evaluation of a High-Intensity Green Fluorescent Protein Fluorophage Method for Drug- Resistance Diagnosis in Tuberculosis for Isoniazid, Rifampin, and Streptomycin.

scientific article published on 17 June 2016

Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovisDeltaRD1.

scientific article published on 11 March 2009

Evolution of a thienopyrimidine antitubercular relying on medicinal chemistry and metabolomics insights.

scientific article published in June 2015

Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine

scientific article published on 01 May 2019

Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses

scientific article published on 08 June 2020

Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform

scientific article

Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: comparisons to responses elicited by M. bovis bacille Calmette Guerin.

scientific article published on 4 September 2007

Flow Cytometry Sorting of Recombinant Mycobacterial Species Yields Bacterial Clones with Enhanced Insert Expression ⬇️

scientific article published on November 10, 2010

Fluorescent Reporter DS6A Mycobacteriophages Reveal Unique Variations in Infectibility and Phage Production in Mycobacteria.

scientific article published on 26 September 2016

Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis

scientific article

Formulation of a mmaA4 gene deletion mutant of Mycobacterium bovis BCG in cationic liposomes significantly enhances protection against tuberculosis.

scientific article published on 19 March 2012

Gene Transfer in Mycobacterium tuberculosis: Shuttle Phasmids to Enlightenment.

scientific article

Gene essentiality testing in mycobacterium smegmatis using specialized transduction.

scientific article published in January 2009

Generation of IL-3-Secreting CD4+ T Cells by Microbial Challenge at Skin and Mucosal Barriers

scientific article published on 16 May 2019

Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis

scientific article

Genetic Manipulation of Mycobacterium tuberculosis

scientific article published on 01 August 2007

Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria

scientific article published on 01 April 1997

Genetic dissection of mycobacterial biofilms.

scientific article published on January 2015

Genetic methods for deciphering virulence determinants of Mycobacterium tuberculosis

scientific article published on 01 January 2002

Genome organization and characterization of mycobacteriophage Bxb1

scientific article published on 01 December 2000

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

scientific article published on 05 September 2019

Genomics and proteomics of mycobacteriophage patience, an accidental tourist in the Mycobacterium neighborhood

scientific article

GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria.

scientific article published in December 2005

Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.

scientific article published on 05 May 2008

HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression.

scientific article

HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates

scientific article

HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses

scientific article published on 01 August 2020

Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent.

scientific article published on 13 June 2008

Helicobacter pylori Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing

scientific article published on 24 February 2020

Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease.

scientific article

Herpes simplex virus type 2 glycoprotein H interacts with integrin αvβ3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells.

scientific article

High throughput crystallography of TB drug targets.

scientific article published on June 2007

High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model

scientific article published on 07 January 2020

Identification of Mycobacterium tuberculosis Counterimmune (cim) Mutants in Immunodeficient Mice by Differential Screening

scientific article published in February 2009

Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening

scientific journal article

Identification of a genomic fragment of Mycobacterium tuberculosis responsible for in vivo growth advantage.

scientific article published on August 1993

Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant.

scientific article published on 28 April 2008

Identification of a regulated alkaline phosphatase, a cell surface-associated lipoprotein, in Mycobacterium smegmatis.

scientific article published on August 2003

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

scientific article

Identification of genes involved in the sequestration of iron in mycobacteria: the ferric exochelin biosynthetic and uptake pathways.

scientific article published on November 1994

Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates

article

In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis.

scientific article

Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination

scientific article published on 17 October 2016

Induction of high levels of protective immunity in mice after vaccination using dendritic cells infected with auxotrophic mutants of Mycobacterium tuberculosis.

scientific article published on 2 November 2005

Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1

scientific article published on 01 May 2019

Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.

scientific article published on 7 May 2007

Interleukin-17A as a Biomarker for Bovine Tuberculosis

scientific article published on 16 December 2015

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach

scientific article

Isolation and analysis of Mycobacterium tuberculosis mycolic acids

scientific article published on 01 June 2007

Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria

scientific journal article

Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis.

scientific article published on 7 May 2013

Leprosy vaccine

scientific article published on 01 April 1994

Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages.

scientific article

Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis.

scientific article

Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.

scientific article

Loss of phenotypic inheritance associated with ydcI mutation leads to increased frequency of small, slow persisters in Escherichia coli

scientific article published on 06 February 2020

LspA-independent action of globomycin on Mycobacterium tuberculosis

article

Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice

scientific article (publication date: 2011)

Maternal Immunization with a Single-Cycle Herpes Simplex Virus (HSV) Candidate Vaccine, ΔgD-2, Protects Neonatal Mice from Lethal Viral Challenge.

scientific article published on 4 October 2017

Measurements of the in vitro anti-mycobacterial activity of ivermectin are method-dependent--authors' response.

scientific article published on 9 April 2014

Measurements of the in vitro anti-mycobacterial activity of ivermectin are method-dependent.

scientific article published on 25 February 2014

Mechanism of thioamide drug action against tuberculosis and leprosy

scientific article

Mechanisms for isoniazid action and resistance.

scientific article

Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.

scientific article

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

scientific article

Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70.

scientific article published on May 1996

Molecular determinants of drug resistance in tuberculosis.

scientific article

Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge.

scientific article published in August 2004

Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex

scientific journal article

Mutually Exclusive Genotypes for Pyrazinamide and 5-Chloropyrazinamide Resistance Reveal a Potential Resistance-Proofing Strategy.

scientific article published in April 2011

Mycobacteria lacking the RD1 region do not induce necrosis in the lungs of mice lacking interferon-gamma.

scientific article published in October 2006

Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids

scientific article

Mycobacteriophage vector systems.

scientific article

Mycobacterium smegmatis biofilm formation and sliding motility are affected by the serine/threonine protein kinase PknF.

scientific article published on 19 November 2007

Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation

scientific article published on 5 December 2016

Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence

scientific journal article

Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.

scientific article

Mycobacterium tuberculosis exploits human interferon γ to stimulate macrophage extracellular trap formation and necrosis.

scientific article published on 8 March 2013

Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages.

scientific article published on April 2004

Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD

scientific article published on 10 July 2006

Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.

scientific article

NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis

scientific article

New strategies for leprosy and tuberculosis and for development of bacillus Calmette-Guérin into a multivaccine vehicle.

scientific article

Non-acid-fastness in Mycobacterium tuberculosis ΔkasB mutant correlates with the cell envelope electron density.

scientific article published on 18 April 2012

Noncanonical SMC protein in Mycobacterium smegmatis restricts maintenance of Mycobacterium fortuitum plasmids.

scientific article

Novel diaryl ureas with efficacy in a mouse model of malaria.

scientific article published on 20 December 2012

Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

scientific article

Old microbes with new faces: molecular biology and the design of new vaccines

scientific article published on August 1, 1992

Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target

scientific article published on 3 September 2009

Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application

scientific article published on 14 March 2017

Origins of highly mosaic mycobacteriophage genomes

scientific article (publication date: 18 April 2003)

Overproduction of mycobacterial ribosomal protein S13 induces catalase/peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis.

scientific article published on April 1996

Phosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates

scientific article (publication date: August 2013)

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis

scientific article

Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis

scientific article (publication date: May 2014)

Photographic and luminometric detection of luciferase reporter phages for drug susceptibility testing of clinical Mycobacterium tuberculosis isolates.

scientific article published on October 2003

Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis.

scientific article published on 26 August 2016

Postprimary Tuberculosis and Macrophage Necrosis: Is There a Big ConNECtion?

scientific article

Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2.

scientific article published on March 2006

Potential role for ESAT6 in dissemination of M. tuberculosis via human lung epithelial cells.

scientific article

Prime-boost with Mycobacterium smegmatis recombinant vaccine improves protection in mice infected with Mycobacterium tuberculosis

scientific article

Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.

scientific article published on May 2004

Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model

scientific journal article

Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection

scientific journal article

Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis

scientific article published on 01 February 1991

Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis

scientific article (publication date: September 2000)

Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I

scientific article

Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli

scientific article published on 13 November 2006

Rapid Mycobacterium species assignment and unambiguous identification of mutations associated with antimicrobial resistance in Mycobacterium tuberculosis by automated DNA sequencing.

scientific article published in February 1995

Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages

scientific article published on 01 May 1993

Rapid film-based determination of antibiotic susceptibilities of Mycobacterium tuberculosis strains by using a luciferase reporter phage and the Bronx Box.

scientific article

Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis.

scientific article published on 18 October 2006

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.

scientific article published on 29 May 2018

Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques

scientific article published on 30 July 2014

Recombinant attenuated M.tuberculosis-SIVgag(rAMtb-gag) vaccination primes for SIV-specific CD8 T cell response that are boosted by Ad5-SIVgag in mice.

scientific article published on 13 September 2012

Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model

scientific article (publication date: 2014)

Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages.

scientific article

Reply to Wallis.

scientific article published on 16 October 2013

Reply to Yew et al., "Vitamin C and Mycobacterium tuberculosis Persisters"

article

Reporter phage and breath tests: emerging phenotypic assays for diagnosing active tuberculosis, antibiotic resistance, and treatment efficacy.

scientific article published on November 2011

Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.

scientific article published on August 2014

Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.

scientific article

Robust immunity to an auxotrophic Mycobacterium bovis BCG-VLP prime-boost HIV vaccine candidate in a nonhuman primate model.

scientific article published on 28 February 2013

Safety and immunogenicity of the Mycobacterium tuberculosis DeltalysA DeltapanCD vaccine in domestic cats infected with feline immunodeficiency virus

scientific article published on 14 January 2009

Screening of a cosmid library of Mycobacterium bovis BCG in Mycobacterium smegmatis for novel T-cell stimulatory antigens.

scientific article published on June 1993

Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence.

scientific article

Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria.

scientific article

Simultaneous Force Regression and Movement Classification of Fingers via Surface EMG within a Unified Bayesian Framework.

scientific article published on 26 February 2018

Small molecules targeting Mycobacterium tuberculosis type II NADH dehydrogenase with antimycobacterial activity.

scientific article published on 31 January 2018

Specialized transduction designed for precise high-throughput unmarked deletions in Mycobacterium tuberculosis.

scientific article

Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis

scientific article (publication date: October 2002)

Specific identification of Mycobacterium tuberculosis with the luciferase reporter mycobacteriophage: use of p-nitro-alpha-acetylamino-beta-hydroxy propiophenone.

scientific article published on December 1997

Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves "chlamydial anomaly".

scientific article

Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

scientific article published on 12 April 2002

Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis

scientific article

Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis

scientific article

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis

scientific article published on 20 March 2009

Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis

scientific article (publication date: November 2014)

Sulfite reduction in mycobacteria

scientific article

Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes

scientific article published on 19 November 2018

Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis.

scientific article published on October 2003

Synthesis and biological activity of alkynoic acids derivatives against mycobacteria

scientific article

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

scientific article published on 8 February 2006

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

scientific article published on 29 September 2005

Systematic Review of Patient-Specific Surgical Simulation: Toward Advancing Medical Education(☆).

scientific article published on 06 June 2017

T-h-2 immunity and CD3+CD45RBlow-activated T cells in mice immunized with recombinant bacillus Calmette-Guérin expressing HIV-1 principal neutralizing determinant epitope.

scientific article published in June 2006

Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

scientific article (publication date: 6 June 2003)

The Complete Genome Sequence of the Emerging Pathogen Mycobacterium haemophilum Explains Its Unique Culture Requirements

scientific article

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

scientific article published on 11 December 2008

The Isoniazid Paradigm of Killing, Resistance, and Persistence in Mycobacterium tuberculosis

scientific article published on 21 February 2019

The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development

scientific article

The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis

scientific article published on 18 July 2019

The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase

scientific journal article

The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol

scientific journal article

The TB structural genomics consortium: providing a structural foundation for drug discovery.

scientific article

The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis

scientific journal article

The effects of reactive nitrogen intermediates on gene expression in Mycobacterium tuberculosis

scientific article published on 01 September 2003

The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol.

scientific article published in May 1997

The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates

scientific journal article

The p60 and NamA autolysins from Listeria monocytogenes contribute to host colonization and induction of protective memory

scientific article published on 31 October 2014

The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue

scientific article

The serine/threonine protein kinase PknI controls the growth of Mycobacterium tuberculosis upon infection

scientific journal article

The significance of GlgE as a new target for tuberculosis.

scientific article

The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.

scientific article

The use of luciferase-reporter phage for antibiotic-susceptibility testing of mycobacteria

scientific article published on 01 January 1998

Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis

scientific article

Transcriptome Analysis of Mycobacteria-Specific CD4+ T Cells Identified by Activation-Induced Expression of CD154.

scientific article

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

scientific article published on 13 August 2006

Transposon mutagenesis in mycobacteria using conditionally replicating mycobacteriophages.

scientific article

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

scientific article

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria.

scientific article published on 26 April 2010

Triclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-ResistantMycobacterium tuberculosis

scientific article

Tuberculosis symposium: emerging problems and promise.

scientific article

Two nonredundant SecA homologues function in mycobacteria.

scientific article

Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis

scientific journal article

US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation.

scientific article published on 10 November 2017

Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence.

scientific article published on April 1994

Use of recombinant BCG as a vaccine delivery vehicle

scientific article published on January 1, 1992

Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques

scientific article

Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice.

scientific article published on 3 January 2018

Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

scientific article published on 28 April 2015

φ(2)GFP10, a high-intensity fluorophage, enables detection and rapid drug susceptibility testing of Mycobacterium tuberculosis directly from sputum samples.

scientific article published on 25 January 2012

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