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List of works by Wim Jiskoot

A Comprehensive Evaluation of Nanoparticle Tracking Analysis (NanoSight) for Characterization of Proteinaceous Submicron Particles.

scientific article published on 20 September 2016

A Flow Imaging Microscopy-Based Method Using Mass-to-Volume Ratio to Derive the Porosity of PLGA Microparticles

scientific article published on 26 July 2017

A Liposome-Based Adjuvant Containing Two Delivery Systems with the Ability to Induce Mucosal Immunoglobulin A Following a Parenteral Immunization

scientific article published on 18 January 2019

A Role for Protein Misfolding in Immunogenicity of Biopharmaceuticals

scientific article published in Journal of Biological Chemistry

A combined approach of vesicle formulations and microneedle arrays for transcutaneous immunization against hepatitis B virus ⬇️

scientific article published on February 4, 2012

A new strategy to stabilize oxytocin in aqueous solutions: I. The effects of divalent metal ions and citrate buffer.

scientific article

A new strategy to stabilize oxytocin in aqueous solutions: II. Suppression of cysteine-mediated intermolecular reactions by a combination of divalent metal ions and citrate

scientific article published on 31 January 2012

A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine ⬇️

scientific article published on October 8, 2011

Activation of Human Monocytes by Colloidal Aluminum Salts

scientific article published on 23 August 2019

Addressing the cold reality of mRNA vaccine stability

scientific article published on 12 December 2020

Adjuvant effect of cationic liposomes and CpG depends on administration route.

scientific article published on 21 February 2011

Adjuvant effect of cationic liposomes for subunit influenza vaccine: influence of antigen loading method, cholesterol and immune modulators

scientific article published on 25 July 2013

Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: adjuvant- and site-dependent immunogenicity in mice

scientific article published on 08 October 2011

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

article

Advanced therapy medicinal products: what's in a name?

scientific article published on 29 August 2020

Advances in transcutaneous vaccine delivery: Do all ways lead to Rome? ⬇️

scientific article published on September 24, 2010

Aggregated recombinant human interferon Beta induces antibodies but no memory in immune-tolerant transgenic mice.

scientific article published on 25 May 2010

Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice

scientific article published on 23 October 2018

Antibody Response Against Betaferon® in Immune Tolerant Mice: Involvement of Marginal Zone B-cells and CD4+ T-cells and Apparent Lack of Immunological Memory ⬇️

scientific article published on September 4, 2012

Antibody Response to Aggregated Human Interferon Alpha2b in Wild-type and Transgenic Immune Tolerant Mice Depends on Type and Level of Aggregation

article

Antigen-adjuvant nanoconjugates for nasal vaccination: an improvement over the use of nanoparticles?

scientific article published on 2 November 2010

Asymmetrical Flow Field-Flow Fractionation Method for the Analysis of Submicron Protein Aggregates ⬇️

scientific article published on August 21, 2012

Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses

scientific article published on 05 December 2019

Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

scientific article published on 18 May 2016

Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with milder inflammatory responses compared to a whole-cell vaccine.

scientific article published on December 2016

Buccal and sublingual vaccine delivery

scientific article

CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions

scientific article published on 11 April 2019

CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses

scientific article published on 26 November 2014

CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses

article

Cathodic corrosion of a bulk wire to non-aggregated functional nanocrystals and nanoalloys.

scientific article published on 15 February 2018

Cationic liposomes as adjuvants for influenza hemagglutinin: more than charge alone

scientific article published on 02 April 2012

Cationic liposomes loaded with a synthetic long peptide and poly(I:C): a defined adjuvanted vaccine for induction of antigen-specific T cell cytotoxicity.

scientific article

Characterization of a cyclosporine solid dispersion for inhalation

scientific article published on 15 June 2007

Chemical Modifications of Silicon Surfaces for the Generation of a Tunable Surface Isoelectric Point

scientific article published on 11 February 2014

Chemical and Biophysical Characteristics of Monoclonal Antibody Solutions Containing Aggregates Formed during Metal Catalyzed Oxidation

scientific article

Chemical modifications in aggregates of recombinant human insulin induced by metal-catalyzed oxidation: covalent cross-linking via michael addition to tyrosine oxidation products ⬇️

scientific article

Chitosan-based delivery systems for protein therapeutics and antigens

scientific article

Co-encapsulation of antigen and Toll-like receptor ligand in cationic liposomes affects the quality of the immune response in mice after intradermal vaccination

scientific article published on December 2010

Coated and Hollow Microneedle-Mediated Intradermal Immunization in Mice with Diphtheria Toxoid Loaded Mesoporous Silica Nanoparticles

scientific article published on 13 August 2018

Comparison of analytical methods to detect instability of etanercept during thermal stress testing ⬇️

scientific article published on January 24, 2011

Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques

scientific article published on 24 April 2020

Comprehensive evaluation of microneedle-based intradermal adalimumab delivery versus subcutaneous administration: results of a randomized controlled trial

scientific article published on 05 January 2021

Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles.

scientific article published on September 2010

Conformational analysis of opacity proteins from Neisseria meningitidis

scientific article published in November 2002

Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen

scientific article published on 13 January 2010

Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination

scientific article published on 20 July 2011

Critical Evaluation of Microfluidic Resistive Pulse Sensing for Quantification and Sizing of Nanometer- and Micrometer-Sized Particles in Biopharmaceutical Products

scientific article published on 01 September 2018

Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates

scientific article

Cytosolic delivery of liposomally targeted proteins induced by photochemical internalization

scientific article published on 31 May 2007

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

scientific article published on 01 December 2020

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

scientific article published on 5 August 2013

Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum ⬇️

scientific article published on March 31, 2012

Detergent-aided polymersome preparation

scientific article published on 01 April 2010

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles.

scientific article published on 17 June 2016

Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery

scientific article published on 24 May 2018

Development of a bioassay for quantification of neutralising antibodies against human interferon-beta in mouse sera.

scientific article

Development of a transgenic mouse model immune tolerant for human interferon Beta.

scientific article

Development of a transgenic mouse model to study the immunogenicity of recombinant human insulin

scientific article published on 11 March 2014

Development of methods for extraction and analytical characterization of carbon-based nanomaterials (nanoplastics and carbon nanotubes) in biological and environmental matrices by asymmetrical flow field-flow fractionation

scientific article published on 26 September 2019

Dimeric IgG complexes from IVIg are incapable of inducing in vitro neutrophil degranulation or complement activation.

scientific article

Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice.

scientific article published on 11 July 2017

Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs

scientific article

Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for Pharmacogenetics

scientific article published on 16 December 2020

Distinct conformational stability and functional activity of four highly homologous endonuclease colicins

scientific article published on May 2004

Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying.

scientific article

Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination

scientific article published on 18 June 2010

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity

scientific article published on 8 June 2007

Effect of Treatment Regimen on the Immunogenicity of Human Interferon Beta in Immune Tolerant Mice ⬇️

scientific article published on January 30, 2013

Effect of the spraying conditions and nozzle design on the shape and size distribution of particles obtained with supercritical fluid drying.

scientific article published on 11 April 2008

Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines

scientific article published on 10 May 2011

Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations

scientific article

Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines.

scientific article published on 31 January 2017

Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles ⬇️

scientific article published on April 24, 2013

Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations

scientific article published on 22 November 2009

Elution behavior of insulin on high-performance size exclusion chromatography at neutral pH.

scientific article

Eprex-associated pure red cell aplasia and leachates

scientific article published in June 2006

Erythropoietin-Associated PRCA: Still an Unsolved Mystery

scientific article

Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes.

scientific article published on 18 March 2011

Extrinsic fluorescent dyes as tools for protein characterization

scientific article published on 3 January 2008

Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice

scientific article published in April 2016

Fc gamma receptor binding profile of anti-citrullinated protein antibodies in immune complexes suggests a role for FcγRI in the pathogenesis of synovial inflammation

scientific article published on 15 January 2018

Flow imaging microscopy for protein particle analysis--a comparative evaluation of four different analytical instruments

scientific article

Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations ⬇️

scientific article published on February 5, 2011

Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations

scientific article published on 30 December 2009

Fluorescent nanoparticle adhesion assay: a novel method for surface pKa determination of self-assembled monolayers on silicon surfaces

scientific article published on 7 February 2012

Forced degradation of therapeutic proteins.

scientific article

Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S

scientific article published on 14 July 2020

Formation of amide- and imide-linked degradation products between the peptide drug oxytocin and citrate in citrate-buffered formulations

scientific article published on 25 January 2011

Formulation of cell-based medicinal products: a question of life or death?

scientific article published on 07 July 2020

Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration.

scientific article

Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins

scientific article published on 20 May 2002

Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

scientific article published on 22 August 2019

Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model

scientific article published in December 2008

Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics ⬇️

scientific article published on June 27, 2012

Hollow microneedle-mediated micro-injections of a liposomal HPV E743-63 synthetic long peptide vaccine for efficient induction of cytotoxic and T-helper responses

scientific article

How bio-questionable are the different recombinant human erythropoietin copy products in Thailand?

scientific article published on 21 November 2013

Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment

scientific article published on 16 November 2018

Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta

scientific article published on 24 October 2009

Identification of Formaldehyde-Induced Modifications in Diphtheria Toxin

scientific article published on 31 October 2019

Identification of Oxidation Sites and Covalent Cross-Links in Metal Catalyzed Oxidized Interferon Beta-1a: Potential Implications for Protein Aggregation and Immunogenicity ⬇️

scientific article published on 02 May 2013

Identification of formaldehyde-induced modifications in proteins: reactions with insulin

scientific article published on 01 May 2006

Identification of formaldehyde-induced modifications in proteins: reactions with model peptides

scientific article published on 24 November 2003

IgG-loaded hyaluronan-based dissolving microneedles for intradermal protein delivery

scientific article published on 2 October 2015

Immunogenicity of Therapeutic Proteins: The Use of Animal Models ⬇️

scientific article published on 09 July 2011

Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice ⬇️

scientific article published on September 5, 2012

Immunogenicity of diphtheria toxoid and poly(I:C) loaded cationic liposomes after hollow microneedle-mediated intradermal injection in mice

scientific article published on 02 June 2018

Immunogenicity of meningococcal PorA formulations encapsulated in biodegradable microspheres

scientific article published in February 2004

Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene

scientific article published on 14 September 2011

Immunological evaluation in vitro of nanoparticulate impurities isolated from pharmaceutical-grade sucrose

scientific article published on 18 November 2020

Immunological mechanism underlying the immune response to recombinant human protein therapeutics

scientific article published on 04 December 2009

Immunological risk of injectable drug delivery systems

scientific article published on 27 February 2009

Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity.

scientific article published on 2 June 2015

Impact-insertion applicator improves reliability of skin penetration by solid microneedle arrays.

scientific article

In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice ⬇️

scientific article published on August 15, 2013

In vitro degradation behavior of microspheres based on cross-linked dextran

scientific article

Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans

scientific article published on 31 March 2009

Influenza T-cell epitope-loaded virosomes adjuvanted with CpG as a potential influenza vaccine

scientific article

Innovative therapeutics: from molecules to medicines. 27 June-7 July 2004, Parma, Italy

scientific article published in November 2004

Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition

scientific article published in May 2004

Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles

scientific article published on 21 September 2017

Intranasal immunisation of mice with liposomes containing recombinant meningococcal OpaB and OpaJ proteins.

scientific article

Label-Free, Flow-Imaging Methods for Determination of Cell Concentration and Viability.

scientific article

Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination

scientific article published on 5 July 2015

Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease

scientific article published in April 2004

Light obscuration measurements of highly viscous solutions: sample pressurization overcomes underestimation of subvisible particle counts

scientific article published on 17 June 2014

Liposomal meningococcal B vaccination: role of dendritic cell targeting in the development of a protective immune response.

scientific article published on September 2003

Lysozyme particle formation during supercritical fluid drying: Particle morphology and molecular integrity

Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ.

scientific article published on 10 March 2014

Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography.

scientific article

Measurement of the average mass of proteins adsorbed to a nanoparticle by using a suspended microchannel resonator

scientific article published on 15 October 2014

Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination

scientific article published on 13 May 2009

Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery

scientific article published on 23 May 2017

Mesoporous Silica Nanoparticles with Large Pores for the Encapsulation and Release of Proteins

scientific article published on 17 November 2016

Micelle-associated protein in epoetin formulations: aA risk factor for immunogenicity?

scientific article published on 01 December 2003

Micro-Flow Imaging as a quantitative tool to assess size and agglomeration of PLGA microparticles

scientific article

Microneedle technologies for (trans)dermal drug and vaccine delivery

scientific article published on 04 February 2012

Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations

scientific article

Micro–Flow Imaging and Resonant Mass Measurement (Archimedes) – Complementary Methods to Quantitatively Differentiate Protein Particles and Silicone Oil Droplets ⬇️

scientific article published on April 26, 2013

Misconceptions over Förster resonance energy transfer between proteins and ANS/bis-ANS: Direct excitation dominates dye fluorescence

scientific article published in March 2010

Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations

scientific article published on 23 January 2006

Models for evaluation of relative immunogenic potential of protein particles in biopharmaceutical protein formulations ⬇️

scientific article published on June 26, 2012

Molecular signatures of the evolving immune response in mice following a Bordetella pertussis infection.

scientific article

Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model

scientific article published on 25 April 2019

Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges

scientific article published on April 2016

Multi-antigen immunization using IgG binding domain ZZ as carrier.

scientific article

N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model

scientific article published on 04 August 2006

Nanolayered chemical modification of silicon surfaces with ionizable surface groups for pH-triggered protein adsorption and release: application to microneedles

scientific article published on 29 July 2013

Nanoparticulate Impurities Isolated from Pharmaceutical-Grade Sucrose Are a Potential Threat to Protein Stability.

scientific article published on 24 October 2017

Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations

scientific article published on 30 January 2015

Nanotechnological approaches for the delivery of macromolecules

scientific article

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

scientific article published on 16 July 2010

Near-infrared imaging for studying homogeneity of protein-sugar mixtures

scientific article published on 12 August 2006

Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune response.

scientific article published on 28 October 2014

New method to produce equine antirabies immunoglobulin F(ab′)2 fragments from crude plasma in high quality and yield ⬇️

scientific article published on March 21, 2011

No Touching! Abrasion of Adsorbed Protein Is the Root Cause of Subvisible Particle Formation During Stirring

scientific article published on 12 January 2016

Novel Formaldehyde-Induced Modifications of Lysine Residue Pairs in Peptides and Proteins: Identification and Relevance to Vaccine Development

scientific article published on 05 October 2020

Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats

scientific article published on 28 January 2014

OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis

scientific article

On the Role of Aggregates in the Immunogenicity of Recombinant Human Interferon Beta in Patients with Multiple Sclerosis ⬇️

scientific article published on October 1, 2010

Online fluorescent dye detection method for the characterization of immunoglobulin G aggregation by size exclusion chromatography and asymmetrical flow field flow fractionation

scientific article

Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines.

scientific article published on 21 May 2016

Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice.

scientific article

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality

scientific article published on April 2009

Oxidation of therapeutic proteins and peptides: structural and biological consequences

scientific article

Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice ⬇️

scientific article published on May 5, 2011

PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3(+) T-cells in vitro

scientific article published on 14 March 2013

PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity

scientific article

Parameter optimization toward optimal microneedle-based dermal vaccination.

scientific article published on 20 August 2014

Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods ⬇️

scientific article published on 08 December 2011

Peptide amphiphile nanoparticles enhance the immune response against a CpG-adjuvanted influenza antigen

scientific article published on 27 August 2013

Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo

scientific article published on 08 October 2013

Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines ⬇️

scientific article published on December 12, 2003

Physicochemical and immunological characterization of N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration

scientific article published on 18 February 2009

Physicochemical studies on the stability of influenza haemagglutinin in vaccine bulk material

scientific article

Plain and Mono-pegylated Recombinant Human Insulin Exhibit Similar Stress-Induced Aggregation Profiles ⬇️

scientific article published on February 22, 2011

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

scientific article

Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues

scientific article published on 14 April 2018

Potential Issues With the Handling of Biologicals in a Hospital

scientific article published on 3 March 2017

Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products

scientific article published in May 2010

Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins ⬇️

scientific article published on 07 May 2013

Predicting the influence of liposomal lipid composition on liposome size, zeta potential and liposome-induced dendritic cell maturation using a design of experiments approach

scientific article

Preparation and characterization of diphtheria toxoid-loaded elastic vesicles for transcutaneous immunization

scientific article published on August 2008

Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system

scientific article published on 27 December 2005

Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery

scientific article

Probing bis-ANS binding sites of different affinity on aggregated IgG by steady-state fluorescence, time-resolved fluorescence and isothermal titration calorimetry

scientific article

Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry.

scientific article

Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release ⬇️

scientific article published on December 14, 2011

Protein-polyelectrolyte interactions: Monitoring particle formation and growth by nanoparticle tracking analysis and flow imaging microscopy

scientific article published on May 2015

Quality Comparison of Biosimilar and Copy Filgrastim Products with the Innovator Product

scholarly article by Liem Andhyk Halim et al published 2 October 2018 in Pharmaceutical Research

Quality and Batch-to-Batch Consistency of Original and Biosimilar Epoetin Products

scientific article published on 9 January 2016

Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques

scientific article published on 27 July 2007

Quality of original and biosimilar epoetin products

scientific article

Rational design of nasal vaccines

scientific article published on 01 January 2008

Reaction to the paper: interaction of polysorbate 80 with erythropoietin: a case study in protein-surfactant interactions

scientific article published on 15 March 2006

Recombinant gelatin hydrogels for the sustained release of proteins

scientific article published on 13 March 2007

Reduction of animal use in human vaccine quality control: opportunities and problems

scientific article

Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine

scientific article published on 25 August 2009

Repeated fractional intradermal dosing of an inactivated polio vaccine by a single hollow microneedle leads to superior immune responses.

scientific article

Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes

scientific article published on 01 February 2003

Restricted immune activation and internalisation of anti-idiotype complexes between drug and antidrug antibodies

scientific article published on 26 June 2018

Reversible NaCl-induced aggregation of a monoclonal antibody at low pH: Characterization of aggregates and factors affecting aggregation

scientific article

Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine

scientific article published on 25 January 2010

Selective Production of Polymorphs and Pseudomorphs Using Supercritical Fluid Crystallization from Aqueous Solutions

Self-assembly of recombinant amphiphilic oligopeptides into vesicles.

scientific article published on 14 August 2007

Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red.

scientific article published on 9 February 2007

Shifting Paradigms Revisited: Biotechnology and the Pharmaceutical Sciences

scientific article published on 23 August 2019

Shifting paradigms: biopharmaceuticals versus low molecular weight drugs ⬇️

scientific article published on November 6, 2003

Simplified monopalmitoyl Toll-like receptor 2 ligand mini-UPam for self-adjuvanting neoantigen-based synthetic cancer vaccines

scientific article published on 12 November 2020

Simultaneous automated image analysis and Raman spectroscopy of powders at an individual particle level

scientific article published on 04 November 2020

Sizing the optimal dimensions of a vaccine delivery system: a particulate matter

scientific article published on 17 November 2015

Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics

scientific article published in April 2015

Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation.

scientific article published on 26 March 2011

Stabilised aluminium phosphate nanoparticles used as vaccine adjuvant

scientific article published on 12 June 2019

Stability of Rituximab in Freeze-Dried Formulations Containing Trehalose or Melibiose Under Different Relative Humidity Atmospheres ⬇️

scientific article published on November 28, 2012

Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines

scientific article published in January 2004

Stabilization of IgG by supercritical fluid drying: optimization of formulation and process parameters.

scientific article

Stabilization of proteins in dry powder formulations using supercritical fluid technology

scientific article

Stable sugar-based protein formulations by supercritical fluid drying

scientific article published on 19 June 2007

Strategies for cytosolic delivery of liposomal macromolecules

scientific article

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development ⬇️

scientific article published on October 23, 2010

Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality

scientific article published in April 2022

Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b.

scientific article

Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant ⬇️

scientific article published on September 18, 2012

Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress

scientific article published on 18 June 2009

Structure-immunogenicity relationships of therapeutic proteins

scientific article published on June 2004

Submicron Size Particles of a Murine Monoclonal Antibody Are More Immunogenic Than Soluble Oligomers or Micron Size Particles Upon Subcutaneous Administration in Mice

scientific article published on 10 July 2018

Supercritical fluid drying of carbohydrates: Selection of suitable excipients and process conditions

scientific article published on 06 July 2007

Supramolecular triblock copolymers controlled by the coiled-coil motif: A new tool for drug delivery ⬇️

scientific article published on November 20, 2010

Synthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan

scientific article published on 16 June 2008

Synthetic long peptide-based vaccine formulations for induction of cell mediated immunity: A comparative study of cationic liposomes and PLGA nanoparticles

scientific article

Taylor Dispersion Analysis Compared to Dynamic Light Scattering for the Size Analysis of Therapeutic Peptides and Proteins and Their Aggregates ⬇️

scientific article published on May 11, 2011

Tc17 CD8+ T-cells accumulate in murine atherosclerotic lesions, but do not contribute to early atherosclerosis development

scientific article published on 16 October 2020

The Investigation of Protein Diffusion via H-Cell Microfluidics

scientific article published on 22 January 2019

The chaperone-like protein alpha-crystallin dissociates insulin dimers and hexamers

scientific article published on 01 October 2009

The molecular chaperone alpha-crystallin as an excipient in an insulin formulation

scientific article published on 24 March 2010

The potential of physicochemical and immunochemical assays to replace animal tests in the quality control of toxoid vaccines. The report and recommendations of ECVAM workshop 61

scientific article published on 01 June 2007

Thermal and acid denaturation of bovine lens α‐crystallin ⬇️

scientific article published on March 28, 2011

Towards heat-stable oxytocin formulations: analysis of degradation kinetics and identification of degradation products

scientific article published on 3 April 2009

Towards tailored vaccine delivery: needs, challenges and perspectives.

scientific article published on 05 January 2012

Transcutaneous immunization studies in mice using diphtheria toxoid-loaded vesicle formulations and a microneedle array

scientific article

Transient Molten Globules and Metastable Aggregates Induced by Brief Exposure of a Monoclonal IgG to Low pH ⬇️

scientific article published on April 19, 2012

Trends on Analytical Characterization of Polysorbates and Their Degradation Products in Biopharmaceutical Formulations

scientific article published on 13 March 2017

Triethylenetetramine prevents insulin aggregation and fragmentation during copper catalyzed oxidation ⬇️

scientific article published on February 9, 2013

Virosome and ISCOM vaccines against Newcastle disease: preparation, characterization and immunogenicity

scientific article

Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives

scientific article published on 01 October 2005

What Makes Polysorbate Functional? Impact of Polysorbate 80 Grade and Quality on IgG Stability During Mechanical Stress

scientific article published on 12 October 2019

Whole-Inactivated Influenza Virus Is a Potent Adjuvant for Influenza Peptides Containing CD8+ T Cell Epitopes ⬇️

scientific article published on 14 March 2018

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