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List of works by Silvia A. Mandel

1.011 Early diagnosis for Parkinson's disease according to whole blood gene profile

article

1.100 Early diagnosis for Parkinson's disease according to whole blood gene profile

article

A molecular signature in blood identifies early Parkinson's disease

scientific article

A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A

scientific article published on 11 September 2009

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

scientific article published on 20 October 2006

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis

scientific article

Apomorphine protects against MPTP-induced neurotoxicity in mice

scientific article

Applying transcriptomic and proteomic knowledge to Parkinson's disease drug discovery ⬇️

scientific article published on 01 September 2007

Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures

scientific article published in January 2002

Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer's and Parkinson's diseases

scientific article published on January 2009

Biomarkers for prediction and targeted prevention of Alzheimer's and Parkinson's diseases: evaluation of drug clinical efficacy

scientific article published on 29 June 2010

Brain catalase in the streptozotocin-rat model of sporadic Alzheimer's disease treated with the iron chelator-monoamine oxidase inhibitor, M30.

scientific article published on 25 September 2014

Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases

scientific article published in August 2004

Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG).

scientific article published on October 2008

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.

scientific article published on March 2004

Contribution of Intracellular Non-Haem Iron, NF-kB Activation and Inflammatory Responses to Neurodegeneration in Parkinson’s Disease: Prospects for Neuroprotection

article

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

scientific article published on 6 January 2014

Differential Alterations in Metabolism and Proteolysis-Related Proteins in Human Parkinson's Disease Substantia Nigra

scientific article published on 7 December 2017

Drugs to prevent cell death in Parkinson's disease. Neuroprotection against oxidative stress and inflammatory gene expression

scientific article

Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray

scientific article published in October 2002

Early and late molecular events in neurodegeneration and neuroprotection in Parkinson's disease MPTP model as assessed by cDNA microarray; the role of iron

scientific article published on November 2002

Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss

scientific article

Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss

scholarly article by Edna Grünblatt et al published 28 June 2008 in Journal of Neurochemistry

Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism ⬇️

scientific article published on March 25, 2012

From Anti-Parkinson's Drug Rasagiline to Novel Multitarget Iron Chelators with Acetylcholinesterase and Monoamine Oxidase Inhibitory and Neuroprotective Properties for Alzheimer's Disease ⬇️

scientific article published on January 1, 2012

Gender differences in lay persons' beliefs and knowledge about Alzheimer's disease (AD): a national representative study of Israeli adults

scientific article published on 6 December 2012

Gene Expression Profiling of Sporadic Parkinson's Disease Substantia Nigra Pars Compacta Reveals Impairment of Ubiquitin-Proteasome Subunits, SKP1A, Aldehyde Dehydrogenase, and Chaperone HSC-70

article

Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin

scientific article

Gene and protein signatures in sporadic Parkinson's disease and a novel genetic model of PD.

scientific article published on January 2007

Gene expression analysis in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of Parkinson's disease using cDNA microarray: effect of R-apomorphine

scientific article

Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

article

Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70.

scientific article

Genes and Oxidative Stress in Sporadic and Familial Parkinsonism: cDNA Microarray Studies

article

Genes and oxidative stress in parkinsonism: cDNA microarray studies.

scientific article

Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease ⬇️

scientific article published on January 1, 2012

Genomic aspects of sporadic Parkinson's disease

scientific article published on 27 June 2008

Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders

scientific article

Green tea catechins as brain-permeable, non toxic iron chelators to "iron out iron" from the brain

scientific article published on January 2006

Green tea polyphenol (-) -epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection

scientific article published on 29 November 2006

Green tea polyphenol (-)-epigallocatechin-3-gallate induces neurorescue of long-term serum-deprived PC12 cells and promotes neurite outgrowth

scientific article published in June 2005

Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration

scientific article

Green tea polyphenol (-)-epigallocatechin-3-gallate protects rat PC12 cells from apoptosis induced by serum withdrawal independent of P13-Akt pathway

scientific article

In the Rush for Green Gold: Can Green Tea Delay Age-Progressive Brain Neurodegeneration? ⬇️

scientific article published on December 1, 2012

Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety

scientific article published on January 2006

Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action

scientific article

Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate

scientific article published in January 2004

Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine

scientific article

Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

scientific article published on 19 June 2007

Iron in brain function and neurodegenerative disorders. Editorial

scientific article published in March 2011

Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer’s disease: a tribute to Moussa Youdim ⬇️

scientific article published on March 1, 2011

Low dosage of rasagiline and epigallocatechin gallate synergistically restored the nigrostriatal axis in MPTP-induced parkinsonism

scientific article

MPTP and 6-hydroxydopamine-induced neurodegeneration as models for Parkinson's disease: neuroprotective strategies

scientific article

Manganese corroles prevent intracellular nitration and subsequent death of insulin-producing cells

scientific article

Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives

scientific article published on 01 April 2005

Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration

scientific article

Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A.

scientific article published on December 2009

Molecular mechanisms of the neuroprotective neurorescue action of multi-target green tea polyphenols ⬇️

scientific article published on January 1, 2012

Multi-target iron-chelators improve memory loss in a rat model of sporadic Alzheimer's disease

scientific article published on 6 July 2015

Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway

scientific article

Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs

scientific article

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

scientific article published in September 2004

Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate

scientific article published on 28 March 2003

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

scientific article

Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

scientific article published on 10 September 2009

Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities

scientific article published on September 2010

Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease

scientific article published on January 1, 2011

Neuroprotective strategies in Parkinson's disease : an update on progress

scientific article

Neuroprotective strategies in Parkinson's disease using the models of 6-hydroxydopamine and MPTP.

scientific article

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

scientific article

Neurorescue by a ROS Decomposition Catalyst

scientific article published on 21 July 2016

Novel Therapeutic Approach for Neurodegenerative Pathologies: Multitarget Iron-Chelating Drugs Regulating Hypoxia-Inducible Factor 1 Signal Transduction Pathway ⬇️

scientific article published on 09 December 2011

Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties

scientific article published on December 2007

Oxidative stress indices in Parkinson's disease : biochemical determination

scientific article published on January 2001

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

scientific article

Potent neuroprotective and antioxidant activity of apomorphine in MPTP and 6-hydroxydopamine induced neurotoxicity

scientific article

Proceedings from the "Third International Conference on Mechanism of Action of Nutraceuticals"

scientific article published on 01 September 2005

Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation

scientific article published on January 2010

Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway

scientific article published on 16 August 2007

Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application ⬇️

scientific article published on June 29, 2010

Reduction of iron-regulated amyloid precursor protein and beta-amyloid peptide by (-)-epigallocatechin-3-gallate in cell cultures: implications for iron chelation in Alzheimer's disease

scientific article published on 15 March 2006

Silencing/overexpressing selected genes as a model of sporadic Parkinson's disease

scientific article

Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.

scientific article published on January 2008

Targeting Skp1, an Ubiquitin E3 Ligase Component Found Decreased in Sporadic Parkinson’s Disease ⬇️

scientific article published on December 23, 2011

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators ⬇️

scientific article published on January 30, 2013

Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

scientific article

Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins

scientific article

The Pivotal Role of Iron in NF-kappaB Activation and Nigrostriatal Dopaminergic Neurodegeneration: Prospects for Neuroprotection in Parkinson's Disease with Iron Chelators

scientific article published on 01 January 1999

The copper chelator, D-penicillamine, does not attenuate MPTP induced dopamine depletion in mice

scientific article

The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice

scientific article

The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage

scientific article published on 17 March 2010

The relevance of iron in the pathogenesis of Parkinson's disease

scientific article published on 31 January 2011

Therapeutic potential of a novel multifunctional iron chelator on cognitive decicits and insulin degrading enzyme expression in a rat model of sporadic Alzheimer's disease.

scientific article published on 17 September 2012

Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases ⬇️

scientific article published on January 1, 2011

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

scientific article

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

scientific article published in December 2004

cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells

scientific article published on 5 March 2003

cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson's disease

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