List of works - Catherine Llorens-Cortès

125I-[Tyr0,D-Trp8]somatostatin-14 binding sites in the locus coeruleus of the rat are located on both ascending and descending projecting noradrenergic cells

scientific article published on 01 January 1990

6-hydroxydopamine lesions of the locus coeruleus induce a paradoxical increase in growth hormone secretion in male rats

scientific article published on 01 February 1992

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor

scientific article published on 4 April 2017

A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A

scientific article

A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors

scientific article published on August 2014

A tyrosine residue essential for catalytic activity in aminopeptidase A.

scientific article published on November 1997

Adaptive Changes of Neurotransmitter Receptor Mechanisms in the Central Nervous System

scientific article published on January 1, 1983

Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron

scientific article published on 01 September 1999

Aminopeptidase A inhibitors as centrally acting antihypertensive agents.

scientific article published on 03 January 2008

Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure

scientific article (publication date: 2000)

Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats.

scientific article published in June 1997

Angiotensin III: a central regulator of vasopressin release and blood pressure.

scientific article

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System

scientific article

Apelin and vasopressin: two work better than one

scientific article published on 01 July 2012

Apelin counteracts vasopressin-induced water reabsorption via cross talk between apelin and vasopressin receptor signaling pathways in the rat collecting duct

scientific article published on 26 August 2014

Apelin in the control of body fluid homeostasis and cardiovascular functions.

scientific article published on January 2012

Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.

scientific article published in November 2008

Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine

scientific article

Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension

scholarly article

By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.

scientific article published on 30 July 2010

Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release

scientific journal article

Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice

scientific article published on 25 May 2011

Central antihypertensive effects of chronic treatment with RB150: an orally active aminopeptidase A inhibitor in deoxycorticosterone acetate-salt rats.

scientific article published on 28 September 2017

Cloning, pharmacological characterization and brain distribution of the rat apelin receptor

scientific article (publication date: December 2000)

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

scientific article published in February 2007

Comparative expression of vasopressin and angiotensin type-1 receptor mRNA in rat hypothalamic nuclei: a double in situ hybridization study

scientific article published on 01 December 1995

Construction of recombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry.

scientific article published in December 2002

Contribution of apelin to water balance, blood glucose control, and cardiovascular functions

scientific article published on 22 April 2010

Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.

scientific article published on 31 May 2002

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

scientific article published on 18 December 2015

Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons

scientific journal article

Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a.

scientific article published on 23 October 2003

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects.

scientific article published on 4 November 2016

Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols

scientific article published on 01 September 1994

Differential recognition of “enkephalinase” and angiotensin-converting enzyme by new carboxyalkyl inhibitors ⬇️

scientific article published on December 27, 1982

Directed Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities.

scientific article published on 25 November 2015

Distribution of apelin-synthesizing neurons in the adult rat brain.

scientific article published in January 2002

Dopaminergic Regulation of Enkephalin Release ⬇️

scientific article published on April 1, 1991

Effect of apelin on glomerular hemodynamic function in the rat kidney

scientific article published on 28 May 2008

Effects of angiotensin II and antagonists on AT(1) receptor expression in mesangial cells

scientific article published on 01 November 1999

Enkephalin receptors on dopaminergic neurones in rat striatum ⬇️

scientific article published on August 25, 1977

Enkephalinase (EC 3.4.24.11) is highly localized to a striatonigral pathway in rat brain

scientific article published on 01 June 1987

Enkephalinase activity in rat peripheral organs

scientific article published on 01 January 1981

Enkephalinergic Markers in Substantia Nigra and Caudate Nucleus from Parkinsonian Subjects ⬇️

scientific article published on September 1, 1984

Expression of angiotensin II receptor subtypes AT(1A) and AT(1B) in enriched fractions of dispersed rat pituitary cells.

scientific article published in December 1997

Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review.

scientific article

Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons.

scientific article

Histamine and histidine decarboxylase in brain stem nuclei: distribution and decrease after lesions

scientific article published on November 17, 1978

Histidine 450 plays a critical role in catalysis and, with Ca2+, contributes to the substrate specificity of aminopeptidase A

scientific article published on 01 March 2000

Histidine decarboxylase and histamine in discrete nuclei of rat hypothalamus and the evidence for mast-cells in the median eminence

scientific article published on December 24, 1976

Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence ⬇️

scientific article published on August 10, 1978

Identification of endocrine cell populations expressing the AT1B subtype of angiotensin II receptors in the anterior pituitary.

scientific article

Inhibition of enkephalin degradation by phelorphan: effects on striatal [Met5]enkephalin levels and jump latency in mouse hot plate test

scientific article published on 01 September 1988

Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors

scientific article published on 01 April 1994

Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues

scientific article published on 6 September 2017

Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems.

scientific article

Localization of opiate receptors and enkephalins in the rat striatum in relationship with the nigrostriatal dopaminergic system: lesion studies ⬇️

scientific article published on August 4, 1978

Localization of opiate receptors in substantia nigra evidence by lesion studies ⬇️

scientific article published on May 1, 1979

Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.

scientific article

Neuronal and non-neuronal histamine in rat brain: tentative localization of the nerve cell bodies [proceedings]

scientific article published on March 1, 1977

New structural insights into the apelin receptor: identification of key residues for apelin binding

scientific article published on 30 October 2014

Ontogeny of angiotensin II type 1 receptor mRNAs in fetal and neonatal rat brain

scientific article published on 01 November 2001

Ontogeny of angiotensin II type 2 (AT2) receptor mRNA in the rat

scientific article published on 01 April 1995

Opiate receptors on mesolimbic dopaminergic neurons

scientific article published on 01 March 1978

Organisation and functional role of the brain angiotensin system.

scientific article

Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.

scientific article published in May 2001

Plasma Apelin Concentrations in Patients With Polyuria-Polydipsia Syndrome.

scientific article published on 11 March 2016

Potent and selective inhibition of zinc aminopeptidase A (EC 3.4.11.7, APA) by glutamyl aminophosphinic peptides: importance of glutamyl aminophosphinic residue in the P1 position

scientific article published on 01 February 2000

Production and properties of a recombinant soluble form of aminopeptidase A.

scientific article published on June 1998

Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug.

scientific article published in April 2014

Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides

scientific article published on 01 October 1980

Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli

scientific article published on 13 February 2008

Regional distribution of a high-affinity enkephalin-degrading peptidase (‘enkephalinase’) and effects of lesions suggest localization in the vicinity of opiate receptors in brain ⬇️

scientific article published on March 1, 1979

Regulation of angiotensin II receptor subtypes by dexamethasone in rat mesangial cells

scientific article published on 01 April 1996

Regulation of somatostatin synthesis by GABAA receptor stimulation in mouse brain.

scientific article published on May 1992

Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders.

scientific article

Roles of brain angiotensins II and III in thirst and sodium appetite.

scientific article published on 21 September 2005

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists

scientific article published on 27 March 2014

Study of asparagine 353 in aminopeptidase A: characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases.

scientific article published on December 2001

Synthesis and in vitro activities of new non-peptidic APA inhibitors.

scientific article published in February 2005

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

scientific article

The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase.

scientific article published on 19 July 2004

The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions.

scientific article published on 20 April 2011

The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders

scientific article published on 25 June 2019

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

scientific article published in Nature

The role of the brain renin-angiotensin system in hypertension: implications for new treatment.

scientific article published on 07 July 2011

Tissular expression and regulation of type 1 angiotensin II receptor subtypes by quantitative reverse transcriptase-polymerase chain reaction analysis

scientific article published on 01 November 1994

Topographical distribution of histamine and histidine decarboxylase activity in hypothalamus and brain stem. Modifications by lesions [proceedings]

scientific article published on March 1, 1977

Type 1 angiotensin II receptor subtypes in kidney of normal and salt-sensitive hypertensive rats

scientific article published on 01 March 1996

[Apelin, a neuropeptide that counteracts vasopressin secretion]

scientific article published on 01 August 2005

[Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension]

scientific article published on 05 December 2014

List of works by Catherine Llorens-Cortès

125I-[Tyr0,D-Trp8]somatostatin-14 binding sites in the locus coeruleus of the rat are located on both ascending and descending projecting noradrenergic cells

6-hydroxydopamine lesions of the locus coeruleus induce a paradoxical increase in growth hormone secretion in male rats

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor

A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A

A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors

A tyrosine residue essential for catalytic activity in aminopeptidase A.

Adaptive Changes of Neurotransmitter Receptor Mechanisms in the Central Nervous System

Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron

Aminopeptidase A inhibitors as centrally acting antihypertensive agents.

Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure

Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats.

Angiotensin III: a central regulator of vasopressin release and blood pressure.

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System

Apelin and vasopressin: two work better than one

Apelin counteracts vasopressin-induced water reabsorption via cross talk between apelin and vasopressin receptor signaling pathways in the rat collecting duct

Apelin in the control of body fluid homeostasis and cardiovascular functions.

Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.

Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine

Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension

By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.

Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release

Central Apelin Controls Glucose Homeostasis via a Nitric Oxide-Dependent Pathway in Mice

Central antihypertensive effects of chronic treatment with RB150: an orally active aminopeptidase A inhibitor in deoxycorticosterone acetate-salt rats.

Cloning, pharmacological characterization and brain distribution of the rat apelin receptor

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

Comparative expression of vasopressin and angiotensin type-1 receptor mRNA in rat hypothalamic nuclei: a double in situ hybridization study

Construction of recombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry.

Contribution of apelin to water balance, blood glucose control, and cardiovascular functions

Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons

Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a.

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects.

Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols

Differential recognition of “enkephalinase” and angiotensin-converting enzyme by new carboxyalkyl inhibitors ⬇️

Directed Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities.

Distribution of apelin-synthesizing neurons in the adult rat brain.

Dopaminergic Regulation of Enkephalin Release ⬇️

Effect of apelin on glomerular hemodynamic function in the rat kidney

Effects of angiotensin II and antagonists on AT(1) receptor expression in mesangial cells

Enkephalin receptors on dopaminergic neurones in rat striatum ⬇️

Enkephalinase (EC 3.4.24.11) is highly localized to a striatonigral pathway in rat brain

Enkephalinase activity in rat peripheral organs

Enkephalinergic Markers in Substantia Nigra and Caudate Nucleus from Parkinsonian Subjects ⬇️

Expression of angiotensin II receptor subtypes AT(1A) and AT(1B) in enriched fractions of dispersed rat pituitary cells.

Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review.

Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons.

Histamine and histidine decarboxylase in brain stem nuclei: distribution and decrease after lesions

Histidine 450 plays a critical role in catalysis and, with Ca2+, contributes to the substrate specificity of aminopeptidase A

Histidine decarboxylase and histamine in discrete nuclei of rat hypothalamus and the evidence for mast-cells in the median eminence

Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence ⬇️

Identification of endocrine cell populations expressing the AT1B subtype of angiotensin II receptors in the anterior pituitary.

Inhibition of enkephalin degradation by phelorphan: effects on striatal [Met5]enkephalin levels and jump latency in mouse hot plate test

Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors

Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues

Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems.

Localization of opiate receptors and enkephalins in the rat striatum in relationship with the nigrostriatal dopaminergic system: lesion studies ⬇️

Localization of opiate receptors in substantia nigra evidence by lesion studies ⬇️

Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.

Neuronal and non-neuronal histamine in rat brain: tentative localization of the nerve cell bodies [proceedings]

New structural insights into the apelin receptor: identification of key residues for apelin binding

Ontogeny of angiotensin II type 1 receptor mRNAs in fetal and neonatal rat brain

Ontogeny of angiotensin II type 2 (AT2) receptor mRNA in the rat

Opiate receptors on mesolimbic dopaminergic neurons

Organisation and functional role of the brain angiotensin system.

Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.

Plasma Apelin Concentrations in Patients With Polyuria-Polydipsia Syndrome.

Potent and selective inhibition of zinc aminopeptidase A (EC 3.4.11.7, APA) by glutamyl aminophosphinic peptides: importance of glutamyl aminophosphinic residue in the P1 position

Production and properties of a recombinant soluble form of aminopeptidase A.

Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug.

Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides

Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli

Regional distribution of a high-affinity enkephalin-degrading peptidase (‘enkephalinase’) and effects of lesions suggest localization in the vicinity of opiate receptors in brain ⬇️

Regulation of angiotensin II receptor subtypes by dexamethasone in rat mesangial cells

Regulation of somatostatin synthesis by GABAA receptor stimulation in mouse brain.

Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders.

Roles of brain angiotensins II and III in thirst and sodium appetite.

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists

Study of asparagine 353 in aminopeptidase A: characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases.