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List of works by Orly Weinreb

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice

scientific article published on 8 November 2016

A model of MPTP-induced Parkinson's disease in the goldfish

scientific article published in January 2007

A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing

scientific article published on 25 August 2006

A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor

scientific article published on January 2011

A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate

scientific article

A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist

scientific article published on 17 July 2018

Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis

scientific article

Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in scopolamine mouse model and inflammatory cells

scientific article published on 28 October 2016

Beneficial Effects of Multitarget Iron Chelator on Central Nervous System and Gastrocnemius Muscle in SOD1(G93A) Transgenic ALS Mice

scientific article

Beneficial behavioral, neurochemical and molecular effects of 1-(R)-aminoindan in aged mice

scientific article published on 15 June 2015

Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG).

scientific article published on October 2008

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases.

scientific article published on March 2004

Chronic treatment with serotonin reuptake inhibitor antidepressant (SSRI) combined with an antipsychotic regulates GABA-A receptor in rat prefrontal cortex

scientific article published on 12 October 2011

DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline

scientific article published on 6 January 2014

Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease

scientific article published on 15 June 2016

Does 1-(R)-aminoindan Possess Neuroprotective Properties Against Experimental Parkinson's Disease? ⬇️

scientific article published on December 28, 2010

Effect of long-term treatment with rasagiline on cognitive deficits and related molecular cascades in aged mice

scientific article

Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism ⬇️

scientific article published on March 25, 2012

Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin

scientific article

Gene expression changes in peripheral mononuclear cells from schizophrenic patients treated with a combination of antipsychotic with fluvoxamine

scientific article published on 29 April 2007

Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain.

scientific article published on 25 April 2009

Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders

scientific article

Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil

scientific article published on December 2006

Improvement in verbal memory following SSRI augmentation of antipsychotic treatment is associated with changes in the expression of mRNA encoding for the GABA-A receptor and BDNF in PMC of schizophrenic patients

scientific article published in May 2015

Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy

scientific article

Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa

scientific article published in October 2017

Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer’s disease: a tribute to Moussa Youdim ⬇️

scientific article published on March 1, 2011

Ladostigil: A Novel Multimodal Neuroprotective Drug with Cholinesterase and Brain-Selective Monoamine Oxidase Inhibitory Activities for Alzheimers Disease Treatment ⬇️

scientific article published on April 1, 2012

Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives

scientific article published on 01 April 2005

Molecular mechanisms of the neuroprotective neurorescue action of multi-target green tea polyphenols ⬇️

scientific article published on January 1, 2012

Molecular mechanisms underlying synergistic effects of SSRI-antipsychotic augmentation in treatment of negative symptoms in schizophrenia

scientific article published on 04 July 2009

Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus

scientific article

Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice ⬇️

scientific article published on July 31, 2012

Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway

scientific article

Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs

scientific article

Multifunctional pharmacotherapy: what can we learn from study of selective serotonin reuptake inhibitor augmentation of antipsychotics in negative-symptom schizophrenia?

scientific article published on January 2009

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

scientific article published in September 2004

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice ⬇️

scientific article published on March 10, 2012

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

scientific article published on 9 July 2004

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

scientific article

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

scientific article published on 22 October 2014

Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets

scientific article published on 10 April 2015

Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease

scientific article published on 29 August 2015

Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

scientific article published on 10 September 2009

Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities

scientific article published on September 2010

Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease

scientific article published on January 1, 2011

Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

scientific article

Novel Therapeutic Approach for Neurodegenerative Pathologies: Multitarget Iron-Chelating Drugs Regulating Hypoxia-Inducible Factor 1 Signal Transduction Pathway ⬇️

scientific article published on 09 December 2011

Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties

scientific article published on December 2007

Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway

scientific article

Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators

scientific article

Proceedings from the "Third International Conference on Mechanism of Action of Nutraceuticals"

scientific article published on 01 September 2005

Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease

scientific article published on January 2014

Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation

scientific article published on January 2010

Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity

scientific article published on 19 June 2010

Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition

scientific article

Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application ⬇️

scientific article published on June 29, 2010

Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine

scientific article published on 7 September 2005

SSRI augmentation of antipsychotic alters expression of GABAA receptor and related genes in PMC of schizophrenia patients ⬇️

scientific article published on December 16, 2010

Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases.

scientific article published on January 2008

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators ⬇️

scientific article published on January 30, 2013

The Multi-Target Drug M30 Shows Pro-Cognitive and Anti-Inflammatory Effects in a Rat Model of Alzheimer's Disease

scientific article published on July 2015

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease ⬇️

scientific article published on April 17, 2012

The Role of GABA-A Receptor in the Synergism Between SSRI and Antipsychotic in Schizophrenia; Implications for Antipsychotic Modes of Actions ⬇️

scientific article published on January 1, 2013

The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection

scientific article published on February 2007

The application of proteomics for studying the neurorescue activity of the polyphenol (-)-epigallocatechin-3-gallate

scientific article published on 13 January 2008

The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex

scientific article published on 21 June 2005

The involvement of BDNF-CREB signaling pathways in the pharmacological mechanism of combined SSRI- antipsychotic treatment in schizophrenia

scientific article published on 11 April 2017

The involvement of GABA(A) receptor in the molecular mechanisms of combined selective serotonin reuptake inhibitor-antipsychotic treatment

scientific article

The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity

scientific journal article

The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline

scientific article published on 10 December 2009

The neuroprotective mechanism of action of the multimodal drug ladostigil

scientific article published on May 2008

The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats

scientific article

The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice

scientific article

The novel multitarget iron chelating and propargylamine drug M30 affects APP regulation and processing activities in Alzheimer's disease models

scientific article published on 29 May 2017

Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases ⬇️

scientific article published on January 1, 2011

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

scientific article

Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs

scientific article published in December 2004

cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells

scientific article published on 5 March 2003

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