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List of works by Meindert Danhof

3-Hydroxymethyl antipyrine excretion in urine after an oral dose of antipyrine. A reconsideration of previously published data and synthesis of a pure reference substance

scientific article published on January 1982

8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo

article by E A Van Schaick et al published November 1997 in Journal of Pharmacology and Experimental Therapeutics

8-substituted adenosine and theophylline-7-riboside analogues as potential partial agonists for the adenosine A1 receptor

scientific article published on 01 August 1995

A Competitive Interaction Model Predicts the Effect of WAY-100,635 on the Time Course of R -(+)-8-Hydroxy-2-(di-n-propylamino)tetralin-Induced Hypothermia ⬇️

scientific article published on January 1, 2002

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

scientific article published on 18 November 2016

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children

scientific article published on 27 June 2019

A Semiphysiological Population Model for Prediction of the Pharmacokinetics of Drugs under Liver and Renal Disease Conditions ⬇️

scientific article published on April 12, 2011

A bodyweight-dependent allometric exponent for scaling clearance across the human life-span.

scientific article

A comparison of two semi-mechanistic models for prolactin release and prediction of receptor occupancy following administration of dopamine D2 receptor antagonists in rats

scientific article published on 6 July 2016

A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus

scientific article published on 22 March 2006

A model-based approach for the evaluation of once daily dosing of lamivudine in HIV-infected children

scientific article published on May 2014

A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar

scientific article published on 20 November 2013

A model-based approach to treatment comparison in acute migraine

scientific article published on November 2006

A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates

scientific article published on 25 September 2013

A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs.

scientific article published on 19 May 2009

A new sublingual formulation of apomorphine in the treatment of patients with Parkinson's disease

scholarly article by Teus van Laar et al published November 1996 in Movement Disorders

A novel maturation function for clearance of the cytochrome P450 3A substrate midazolam from preterm neonates to adults

scientific article

A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the rat.

scientific article published in October 1991

A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia ⬇️

scientific article published on December 1, 2001

A system approach to pharmacodynamics. III: An algorithm and computer program, COLAPS, for pharmacodynamic modeling

scientific article published in May 1991

Adaptive trials in paediatric development: dealing with heterogeneity and uncertainty in pharmacokinetic differences in children ⬇️

scientific article published on August 1, 2012

Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin

scientific article published in March 2003

Advances in paediatric pharmacokinetics

scientific article

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?

scientific article published on 10 August 2016

Allometric relationships between the pharmacokinetics of propofol in rats, children and adults

scientific article published on June 2005

Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man

scientific article published on 31 May 2007

Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats

scientific article published in July 1988

Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes

scientific article published on 3 December 2007

Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling

scientific article published on October 1, 1997

Analysis of responses in migraine modelling using hidden Markov models

scientific article

Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine

scientific article published in January 2007

Antipyrine metabolite formation in children in the acute phase of malnutrition and after recovery

scientific article published on October 1980

Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat.

scientific article published in June 1999

Application of a mechanism-based disease systems model for osteoporosis to clinical data ⬇️

scientific article published on January 12, 2013

Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation.

scientific article

Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain

scientific article published on November 1995

Application of serial sampling of cerebrospinal fluid in pharmacodynamic studies with a drug active in the CNS: heptabarbital concentrations at onset and offset of loss of righting reflex in rats

scientific article published on 01 May 1988

Application of the convection-dispersion equation to modelling oral drug absorption

scientific article published on 6 October 2006

Assay of R-apomorphine, S-apomorphine, apocodeine, isoapocodeine and their glucuronide and sulfate conjugates in plasma and urine of patients with Parkinson's disease ⬇️

scientific article published on November 21, 1997

Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans

scientific article

Assessment of the enantiomeric purity of R- and S-N6-phenylisopropyladenosine (PIA): implications for adenosine receptor subclassification

scientific article

Authors' Reply to Standing et al.: "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials"

scientific article published on 01 November 2018

Biomarker exposure-response relationships as the basis for rational dose selection: Lessons from a simulation exercise using a selective COX-2 inhibitor

scientific article published on 31 August 2015

Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships

scientific article published in November 2003

Body weight-dependent pharmacokinetics of busulfan in paediatric haematopoietic stem cell transplantation patients: towards individualized dosing

scientific article published in May 2012

Bone physiology, disease and treatment: towards disease system analysis in osteoporosis

scientific article published on January 2010

Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents

scientific article published in January 2005

Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography

scientific article published on 25 August 2008

Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

scientific article published in December 2016

Characterization and modulation of the transferrin receptor on brain capillary endothelial cells

scientific article

Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs

scientific article published in December 1988

Characterization of the pharmacodynamics of several antiepileptic drugs in a direct cortical stimulation model of anticonvulsant effect in the rat.

scientific article published in May 1994

Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats

scientific article published in October 2003

Characterizing QT interval prolongation in early clinical development: a case study with methadone

scientific article published on 24 January 2017

Chronobiology and Pharmacologic Modulation of the Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned?

scientific article published on 02 October 2015

Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology.

scientific article published on 9 August 2013

Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients.

scientific article published in February 2004

Compartmental modeling of transdermal iontophoretic transport II: in vivo model derivation and application

scientific article

Compartmental modeling of transdermal iontophoretic transport: I. In vitro model derivation and application

scientific article published in November 2004

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

scientific article

Coping with time scales in disease systems analysis: application to bone remodeling ⬇️

scientific article published on October 26, 2011

Correction to: Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials

scientific article published on 01 August 2018

Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

scientific article published on 01 October 2018

Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers

scientific article published on 8 May 2006

Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers

scientific article published on February 2002

Coupling of metal containing homing devices to liposomes via a maleimide linker: use of TCEP to stabilize thiol-groups without scavenging metals

scientific article published in September 2004

Covariate effects and population pharmacokinetics of lamivudine in HIV-infected children

scientific article published on May 2014

Critical Illness Is a Major Determinant of Midazolam Clearance in Children Aged 1 Month to 17 Years ⬇️

scientific article published on August 1, 2012

Current issues relating to drug safety especially with regard to the use of biomarkers: a meeting report and progress update

scientific article published on 17 November 2006

Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree

scientific article

Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy

scientific article published on 18 April 2007

Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo

scientific article

Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay

scientific article published in July 1997

Determination of the threshold for convulsions by direct cortical stimulation

scientific article published on 01 March 1989

Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations ⬇️

scientific article published on May 1, 2013

Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model.

scientific article published in July 2013

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants.

scientific article

Developmental pharmacokinetics of propylene glycol in preterm and term neonates

scientific article published on January 2013

Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors

scientific article

Differential effects of enzyme induction on antipyrine metabolite formation

scientific article published on March 1982

Disease Progression Analysis: Towards Mechanism-Based Models

Disease severity is a major determinant for the pharmacodynamics of propofol in critically ill patients

scientific article

Disease system analysis: basic disease progression models in degenerative disease

scientific article published on 22 July 2005

Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia

scientific article

Dopamine D2 receptor occupancy as a predictor of catalepsy in rats: a pharmacokinetic-pharmacodynamic modeling approach.

scientific article published on 3 May 2014

Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo

scientific article published in March 2003

Drug disposition in obesity: toward evidence-based dosing

scientific article

Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system

scientific article

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments

scientific article published on 5 February 2018

Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Dose Optimisation in Epilepsy Patients.

scientific article

Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels.

scientific article published in July 2000

Effects of repeated seizure induction on seizure activity, post-ictal and interictal behavior

scientific article published in December 1998

Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release

scientific article published in November 2002

Enantioselective high-performance liquid chromatographic analysis of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin. Application to a pharmacokinetic-pharmacodynamic study in rats

scientific article published on 28 January 2000

Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations

scientific article published on 01 July 2017

Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D₂ Receptor Occupancy

scientific article published on 10 March 2016

Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease

scientific article published on 8 February 2012

Evaluation of the impact of UGT polymorphism on the pharmacokinetics and pharmacodynamics of the novel PPAR agonist sipoglitazar

scientific article published on 24 January 2013

Evaluation of the long-term durability and glycemic control of fasting plasma glucose and glycosylated hemoglobin for pioglitazone in Japanese patients with type 2 diabetes.

scientific article

Evaluation of treatment response in depression studies using a Bayesian parametric cure rate model

scientific article

Evidence-based morphine dosing for postoperative neonates and infants

scientific article published in June 2014

Explaining variability in ciclosporin exposure in adult kidney transplant recipients

scientific article

Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

scientific article published in April 2009

Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients

scientific article published on 10 May 2016

Extending a Systems Model of the APP Pathway: Separation of β- and γ-Secretase Sequential Cleavage Steps of APP.

scientific article published on 21 March 2018

Extensions to the visual predictive check to facilitate model performance evaluation

scientific article published on 16 January 2008

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development ⬇️

scientific article published on February 5, 2012

Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives

scientific article published in May 2003

Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats

scientific article

High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: application to pharmacokinetic/pharmacodynamic studies in rats

scientific article published in August 2005

High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats

scientific article published on 01 October 1993

High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats

scientific article published in August 2000

Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation

scientific article

Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children.

scientific article

Impact of chronic inflammation on the pharmacokinetic-pharmacodynamic relationship of naproxen

scientific article published on 12 August 2009

Impact of disease, drug and patient adherence on the effectiveness of antiviral therapy in pediatric HIV.

scientific article published on 3 January 2017

Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain

scientific article published on 6 October 2008

In vitro and in silico analysis of the effects of D receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

scientific article published on 21 September 2018

In vitro iontophoresis of R-apomorphine across human stratum corneum. Structure-transport relationship of penetration enhancement

scientific article published in November 2002

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant

scientific article

Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling

scientific article published on January 2009

Increased sensitivity to the anticonvulsant effect of valproate in aging BN/BiRij rats

scientific article published on 01 July 1993

Individualized Dosing Algorithms and Therapeutic Monitoring for Antiepileptic Drugs.

scientific article published on 27 June 2017

Individualized dosing regimens in children based on population PKPD modelling: Are we ready for it? ⬇️

scientific article published on March 3, 2011

Influence of covariate distribution on the predictive performance of pharmacokinetic models in paediatric research

scientific article published on July 2014

Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol

scientific article published on March 1, 1998

Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs.

scientific article published on 21 March 2014

Integration of PKPD relationships into benefit-risk analysis

scientific article

Iontophoretic R-apomorphine delivery in combination with surfactant pretreatment: in vitro validation studies ⬇️

scientific article published on November 6, 2003

Iontophoretic delivery of apomorphine. I: In vitro optimization and validation

scientific article published on December 1, 1997

Iontophoretic delivery of apomorphine. II: An in vivo study in patients with Parkinson's disease.

scientific article

Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models

scientific article

Liquid chromatographic determination of the adenosine receptor agonist CGS 21680 in blood using on-line solid-phase extraction on a phenylboronic acid support and fluorescence detection

scientific article published on 01 August 1994

Long-term sedation with propofol 60 mg ml(-1) vs. propofol 10 mg(-1) ml in critically ill, mechanically ventilated patients

scientific article published in March 2004

Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates

scientific article published on 01 June 2014

Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action

scientific article published in May 2003

Markers of disease severity in chronic obstructive pulmonary disease.

scientific article

Markers of exacerbation severity in chronic obstructive pulmonary disease

scientific article

Maturation of the glomerular filtration rate in neonates, as reflected by amikacin clearance.

scientific article published in February 2012

Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of the Dopamine D2 Receptor Occupancy of Olanzapine in Rats ⬇️

scientific article published on June 7, 2011

Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans.

scientific article published on 12 July 2012

Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.

scientific article published in November 1999

Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam.

scientific article published in March 2000

Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats

scientific article published on 15 September 2003

Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model

scientific article published on 27 December 2007

Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol

scientific article

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

scientific article published on 18 March 2008

Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats

scientific article

Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo.

scientific article published in August 1999

Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats

scientific article

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers

scientific article published on 01 June 2006

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors.

scientific article published in November 1997

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats

scientific article published on 19 July 2006

Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers

scientific article published on 24 August 2005

Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis

scientific article published on January 2007

Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers

scientific article published in January 2007

Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations

scientific article

Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex

scientific article

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients

scientific article

Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro.

scientific article published in January 2010

Metabolic and cardiovascular effects of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine in diabetic Zucker rats: influence of the disease on the selectivity of action

scientific article published on 01 October 1998

Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations.

scientific article published on 9 March 2017

Model-Based Optimisation of Deferoxamine Chelation Therapy

scientific article

Model-based analysis of thromboxane B₂ and prostaglandin E₂ as biomarkers in the safety evaluation of naproxen

scientific article published on 22 March 2014

Model-based evaluation of drug-induced QTc prolongation for compounds in early development

scientific article

Model-based prediction of the acute and long-term safety profile of naproxen in rats

scientific article

Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop

scientific article published on 7 October 2014

Modeling of prolactin response following dopamine D2 receptor antagonists in rats: can it be translated to clinical dosing?

scientific article published in December 2017

Modelling and simulation of the Positive and Negative Syndrome Scale (PANSS) time course and dropout hazard in placebo arms of schizophrenia clinical trials.

scientific article published in April 2012

Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate

scientific article published on December 1998

Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline

scientific article

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

scientific article published on 18 May 2018

Morphine glucuronidation in preterm neonates, infants and children younger than 3 years

scientific article

Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat

scientific article published on 01 March 1999

Naloxone reversal of buprenorphine-induced respiratory depression

scientific article published on 01 July 2006

Negligible sublingual absorption of nifedipine

scientific article published on 01 December 1987

Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo

scientific article

Nifedipine: influence of renal function on pharmacokinetic/hemodynamic relationship

scientific article published on 01 May 1985

Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration

scientific article

Not-in-trial simulation I: Bridging cardiovascular risk from clinical trials to real-life conditions

scientific article published on December 2013

Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples.

scientific article published on 26 February 2010

Ontogeny of hepatic glucuronidation; methods and results

scientific article published on July 2012

Optimised protocol design for the screening of analgesic compounds in neuropathic pain ⬇️

scientific article published on November 30, 2012

Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?

scientific article

Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo

scientific article published on 01 December 1996

Partial agonism of theophylline-7-riboside on adenosine receptors

scientific article published on 01 December 1994

Phamacokinetic-pharmacodynamic modelling of behavioural responses

scientific article published in January 1998

Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat.

scientific article published in May 2004

Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction

scientific article

Pharmacodynamic interaction between midazolam and a low dose of ethanol in vivo ⬇️

scientific article published on January 1, 1995

Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern

scientific article published on November 1998

Pharmacodynamics of tolerance development to the anesthetic and anticonvulsant effects of phenobarbital in rats

scientific article

Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children.

scientific article

Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat

scientific article published on 21 August 2007

Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats

scientific article published on 01 May 1989

Pharmacokinetic modelling of the haemodynamic effects of the A2a adenosine receptor agonist CGS 21680C in conscious normotensive rats

scientific article published on February 1995

Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo

scientific article published in May 1996

Pharmacokinetic-pharmacodynamic Modelling of the Analgesic Effect of Alfentanil in the Rat Using Tooth Pulp Evoked Potentials ⬇️

scientific article published on February 1, 1998

Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo

scientific article published in June 2000

Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain

scientific article published on 5 May 2010

Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat ⬇️

scientific article published on December 1, 1997

Pharmacokinetic-pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model

scientific article published on 01 June 2000

Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex.

scientific article

Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview

scientific article published on January 1988

Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility.

scientific article published on 6 March 2013

Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats

scientific article

Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system

scientific article published in July 1988

Pharmacokinetic-pharmacodynamic modeling of the D₂ and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats.

scientific article published on 22 March 2012

Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats ⬇️

scientific article published on February 1, 1998

Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics

scientific article published on 8 February 2005

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers

scientific article published in June 1992

Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior

scientific article published on 28 July 2007

Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats

scientific article published on 4 October 2007

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor ⬇️

scientific article published on March 1, 1998

Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity

scientific article published in April 1991

Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats

scientific article

Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: part II: the use of subscales of the PANSS score

scientific article published on 06 March 2013

Pharmacokinetic-pharmacodynamic modelling of drug-induced QTc interval prolongation in man: prediction from in vitro human ether-à-go-go-related gene binding and functional inhibition assays and conscious dog studies

scientific article published on 18 July 2016

Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats ⬇️

scientific article published on October 1, 1997

Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats

scientific article

Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats

scientific article published in January 1990

Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats

scientific article published on 01 April 1995

Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan

scientific article

Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat

Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs

scientific article published on 2 December 2014

Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics.

scientific article

Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain

scientific article published in May 2005

Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect

scientific article

Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery

scientific article published on October 2002

Pharmacokinetics and hemodynamic effects of long-term nisoldipine treatment in hypertensive patients

scientific article published on 01 April 1989

Pharmacokinetics and hemodynamic effects of nisoldipine and its interaction with cimetidine

scientific article published on 01 March 1988

Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: in vitro-in vivo correlation

scientific article published on 01 July 2006

Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery.

scientific article published in December 2006

Pharmacokinetics and pharmacodynamics of propofol 6% SAZN versus propofol 1% SAZN and Diprivan-10 for short-term sedation following coronary artery bypass surgery

scientific article published in April 2000

Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera

scientific article published on 21 January 2009

Pharmacokinetics of clindamycin in pregnant women in the peripartum period.

scientific article

Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks.

scientific article

Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans

scientific article published on 12 March 2016

Pharmacometrics as a discipline is entering the "industrialization" phase: standards, automation, knowledge sharing, and training are critical for future success.

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Pharmacotherapy in pediatric epilepsy: from trial and error to rational drug and dose selection - a long way to go.

scientific article

Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists

scientific article published in December 1997

Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.

scientific article published on 17 May 2012

Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN.

scientific article published in October 1999

Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients

scientific article published on 13 November 2007

Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

scientific article published on 06 February 2016

Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients

scientific article published on November 1, 2011

Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients

scientific article published on 20 January 2006

Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography

scientific article published in November 2005

Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: a comparison between propofol 6% and propofol 1%.

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Population pharmacokinetic model of fluvoxamine in rats: utility for application in animal behavioral studies

scientific article published on 12 October 2006

Population pharmacokinetic model of the pregabalin-sildenafil interaction in rats: application of simulation to preclinical PK-PD study design

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Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists

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Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats

scientific article published on 14 January 2008

Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats

scientific article published on 14 April 2008

Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints

scientific article published on 22 January 2019

Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale

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Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat.

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Population pharmacokinetics of abacavir in infants, toddlers and children ⬇️

scientific article published on June 1, 2013

Population pharmacokinetics of deferiprone in healthy subjects

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Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration

scientific article

Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults

scientific article published on 23 January 2014

Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting.

scientific article published on 04 May 2011

Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model

scientific article published on 11 September 2017

Predicting the "First dose in children" of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages

scientific article published on 28 March 2014

Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations

scientific article published on October 2009

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

scientific article

Prediction of methotrexate CNS distribution in different species - influence of disease conditions.

scientific article published on 22 January 2014

Prediction of morphine clearance in the paediatric population : how accurate are the available pharmacokinetic models?

scientific article published on 1 November 2012

Prediction of propofol clearance in children from an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model

scientific article published in April 2010

Predictive Performance of a Recently Developed Population Pharmacokinetic Model for Morphine and its Metabolites in New Datasets of (Preterm) Neonates, Infants and Children

scientific article published in January 2011

Predictive performance of a busulfan pharmacokinetic model in children and young adults.

scientific article published in October 2012

Pretreatment with a water-based surfactant formulation affects transdermal iontophoretic delivery of R-apomorphine in vitro

scientific article published on April 1, 2003

Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery

scientific article

Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery.

scientific article published in March 2006

Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine.

scientific article

Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats.

scientific article published in May 1999

Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans

scientific article

Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats

scientific article published on 01 July 1989

Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach

scientific article

Relevance of absorption rate and lag time to the onset of action in migraine

scientific article

Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm

scientific article published on April 1997

Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats

scientific article published on 15 February 2007

Response to letter to the editor from Dr. Mahmood: Original publication: "Predicting the 'first dose in children' of CYP3A-metabolized drugs: evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages"

scientific article published on 01 June 2015

Ribose-Modified Adenosine Analogs as Potential Partial Agonists for the Adenosine Receptor

scientific article published on 01 September 1995

Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation

scientific article published on 30 November 2018

Sampling Optimization in Pharmacokinetic Bridging Studies: Example of the Use of Deferiprone in Children With β-Thalassemia

scientific article published on 01 April 2016

Scaling of pharmacokinetics across paediatric populations: the lack of interpolative power of allometric models ⬇️

scientific article published on September 1, 2012

Seizure patterns in kindling and cortical stimulation models of experimental epilepsy ⬇️

scientific article published on October 3, 1997

Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats

scientific article published in June 1998

Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain

scientific article published on 05 October 2013

Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia

scientific article published on 20 February 2013

Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing

scientific article published on 31 December 2014

Sensitivity of the Montgomery Asberg Depression Rating Scale to response and its consequences for the assessment of efficacy

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Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy

scientific article

Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration

scientific article published on 2 May 2014

Stability and pharmacokinetics of flumazenil in the rat

scientific article published on 01 January 1991

Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat.

scientific article published on December 1999

Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology

scientific article

Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders.

scientific article published on July 2011

Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid.

scientific article published on December 2015

Studies on the different metabolic pathways of antipyrine as a tool in the assessment of the activity of different drug metabolizing enzyme systems in man [proceedings]

scientific article published on January 1980

Summary data of potency and parameter information from semi-mechanistic PKPD modeling of prolactin release following administration of the dopamine D2 receptor antagonists risperidone, paliperidone and remoxipride in rats

scientific article

Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?

scientific article published on March 2007

Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models

scientific article

Systemic and direct nose-to-brain transport pharmacokinetic model for remoxipride after intravenous and intranasal administration.

scientific article published on 8 September 2011

Systems Pharmacology Analysis of the Amyloid Cascade after β-Secretase Inhibition Enables the Identification of an Aβ42 Oligomer Pool

scientific article published on 29 January 2016

Systems pharmacology - Towards the modeling of network interactions

scientific article published on 27 April 2016

Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling

scientific article

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

scientific article published on 4 December 2017

Targeting liposomes with protein drugs to the blood-brain barrier in vitro

scientific article published on 18 April 2005

The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults

scientific article published on January 2014

The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model

scientific article published in February 1999

The contribution of nisoldipine-induced changes in liver blood flow to its pharmacokinetics after oral administration

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The disposition of antipyrine and its metabolites in young and elderly healthy volunteers

scientific article

The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments.

scientific article published on 13 November 2007

The future of drug development: the paradigm shift towards systems therapeutics

article

The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.

scientific article published on 29 March 2013

The impact of arteriovenous concentration differences on pharmacodynamic parameter estimates

scientific article published on February 1, 1997

The impact of composite AUC estimates on the prediction of systemic exposure in toxicology experiments

scientific article published on 14 April 2015

The implications of target saturation for the use of drug-target residence time

scientific article published on 01 December 2018

The influence of infusion rate on the pharmacokinetics and haemodynamic effects of nisoldipine in man.

scientific article

The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women

scientific article published on December 2008

The missing link between clinical endpoints and drug targets in depression

scientific article published in February 2010

The pharmacokinetics and pharmacological effect of (S)-5-OH-DPAT following controlled delivery with transdermal iontophoresis

scientific article

The role of population PK-PD modelling in paediatric clinical research.

scientific article published on 26 March 2010

The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system

scientific article published on 01 August 1989

The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model

scientific article published on 28 September 2016

Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication

scientific article published on 21 August 2002

Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects

scientific article published on 01 December 1997

Towards a European strategy for medicines research (2014-2020): The EUFEPS position paper on Horizon 2020.

scientific article published on 6 October 2012

Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo

scientific article

Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCl concentration

scientific article

Transdermal iontophoresis of rotigotine: influence of concentration, temperature and current density in human skin in vitro

scientific article published in April 2004

Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro

scientific article

Transdermal iontophoretic delivery of a novel series of dopamine agonists in vitro: physicochemical considerations

scientific article published on June 2010

Translating QT interval prolongation from conscious dogs to humans

scientific article published on 10 September 2016

Translation of drug effects from experimental models of neuropathic pain and analgesia to humans ⬇️

scientific article published on 03 March 2012

Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy

scientific article published on 30 December 2015

Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

scientific article published on 25 June 2014

Transport of desglycinamide-arginine vasopressin across the blood-brain barrier in rats as evaluated by the unit impulse response methodology

scientific article

Transport of vasopressin fragments across the blood-brain barrier: in vitro studies using monolayer cultures of bovine brain endothelial cells

scientific article published on 01 June 1989

Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro

scientific article

Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man

scientific article published on 01 November 1984

Variability in the pharmacokinetics of nisoldipine as caused by differences in liver blood flow response

scientific article published on 01 August 1989

What is the right dose for children? ⬇️

scientific article published on October 1, 2010

[Individualized dosing guidelines for children]

scientific article published in January 2013

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