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List of works by Grover P. Miller

1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.

scientific article published on 9 January 2017

A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes

scientific article published on 29 July 2019

Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective

scientific article published on 01 August 2008

Assays and applications in warfarin metabolism: what we know, how we know it and what we need to know ⬇️

scientific article published on April 12, 2011

Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans.

scientific article

Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners.

scientific article

Biotransformation and bioactivation reactions - 2017 literature highlights *

scientific article published on 28 June 2018

Biotransformation and bioactivation reactions - 2018 literature highlights

scientific article published on 01 May 2019

CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches

scientific article published on 10 April 2019

CYP2E1 hydroxylation of aniline involves negative cooperativity.

scientific article published on 15 December 2013

CYP2E1 metabolism of styrene involves allostery.

scientific article

CYP2E1 substrate inhibition. MECHANISTIC INTERPRETATION THROUGH AN EFFECTOR SITE FOR MONOCYCLIC COMPOUNDS.

scientific article published in November 2013

CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds

scientific article published on 4 December 2007

Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation

scientific article published on 09 October 2019

Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.

scientific article published on 3 March 2017

Computationally Assessing the Bioactivation of Drugs by N-Dealkylation.

scientific article

Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.

scientific article published on December 2010

Cooperative effects for CYP2E1 differ between styrene and its metabolites.

scientific article published on 18 January 2013

Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures.

scientific article

Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites

scientific article (publication date: 25 November 2013)

Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

scientific article published in September 2002

Global analysis of protein-protein interactions reveals multiple CYP2E1-reductase complexes.

scientific article published on 09 August 2007

Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin

scientific article

Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin

scientific article

Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity

scientific article

Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.

scientific article

Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches

scientific article published on 02 August 2018

Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins

scientific article published on September 2012

Microchannel plate detector detection efficiency to monoenergetic electrons between 3 and 28 keV.

scientific article published on May 2017

Modeling Epoxidation of Drug-like Molecules with a Deep Machine Learning Network.

scientific article published on 9 June 2015

Modeling Reactivity to Biological Macromolecules with a Deep Multitask Network.

scientific article published on 29 July 2016

Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.

scientific article

Novel advances in biotransformation and bioactivation research-2019 year in review

scientific article published on 09 July 2020

Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of 29 patients

scientific article published on 01 November 2018

Novel multi-mode ultra performance liquid chromatography–tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma ⬇️

scientific article published on March 21, 2011

Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps.

scientific article published in July 2002

Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin.

scientific article published on 15 March 2018

Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics

scientific article published on 20 October 2020

Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics

scientific article published on 25 November 2020

Site of reactivity models predict molecular reactivity of diverse chemicals with glutathione.

scientific article

Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases.

scientific article

Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations

scientific article

Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates

scientific article

The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.

scientific article published on 29 November 2007

The role of ERp44 in maturation of serotonin transporter protein.

scientific article

The role of cytochrome P450 3A4-mediated metabolism in sorafenib and lapatinib hepatotoxicity

scientific article published in June 2023

Thermal inactivation of the reductase domain of cytochrome P450 BM3.

scientific article published on July 2005

Toxicological Implications of Mitochondrial Localization of CYP2E1.

scientific article published on 14 March 2017

Warfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism

scientific article published in February 2010

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