List of works - Matthew F Krummel

A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease

scientific article

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments

scientific article published on 25 June 2018

A single class II myosin modulates T cell motility and stopping, but not synapse formation

scientific article

A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction

scientific article

Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers

scientific article

Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues

scientific article

An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function

scientific article

Antigen recognition in the islets changes with progression of autoimmune islet infiltration

scientific article

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells

scientific article

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice

scientific article

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells

scientific article

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions.

scientific article

Control of cortical rigidity by the cytoskeleton: emerging roles for septins

scientific article

Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

scientific article

Deletional tolerance mediated by extrathymic Aire-expressing cells

scientific article

Dendritic cells in cancer immunology and immunotherapy

scientific article published on 29 August 2019

Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.

scientific article

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity

scientific article

Duration of antigen receptor signaling determines T-cell tolerance or activation

scientific article

Dynamics of the immunological synapse: finding, establishing and solidifying a connection ⬇️

scientific article published on February 1, 2002

Global Absence and Targeting of Protective Immune States in Severe COVID-19

scientific article published on 28 October 2020

Global Absence and Targeting of Protective Immune States in Severe COVID-19

scientific article published on 29 October 2020

Imaging the function of regulatory T cells in vivo

scientific article published on 12 June 2006

Integration of the movement of signaling microclusters with cellular motility in immunological synapses.

scientific article

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

scientific article

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes

scientific article

Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice

scientific article

Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA.

scientific article

Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Perivascular Mast Cells Dynamically Probe Cutaneous Blood Vessels to Capture Immunoglobulin E ⬇️

scientific article published on January 3, 2013

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

scientific article published in 2022

Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans

scientific article published on 01 June 2019

Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation

scientific article

Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics

scientific article

Regulation of T cell priming by lymphoid stroma.

scientific article

Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm

scientific article

Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

scientific article

Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells

scientific article (publication date: 10 March 2013)

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

scientific article published in 2022

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

scientific article

Stabilized imaging of immune surveillance in the mouse lung

scientific article

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

scientific article

The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies

scientific article published on 20 July 2020

The immunological synapse: a dynamic platform for local signaling

scientific article

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

scientific article

The septin cytoskeleton facilitates membrane retraction during motility and blebbing

scientific journal article

Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung

scientific article

Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine

scientific article

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

scientific article published on 24 August 2021

Understanding the tumor immune microenvironment (TIME) for effective therapy.

scientific article published on 23 April 2018

Visualization of immediate immune responses to pioneer metastatic cells in the lung.

scientific article

Visualizing Cancer

scientific article published on 01 December 2020

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

scientific article

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

scientific article

Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy

scientific article

ZipSeq: barcoding for real-time mapping of single cell transcriptomes

scientific article published on 06 July 2020

iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation

scientific article

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse

scientific article published on 01 January 2020

List of works by Matthew F Krummel

A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments

A single class II myosin modulates T cell motility and stopping, but not synapse formation

A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction

Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers

Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues

An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function

Antigen recognition in the islets changes with progression of autoimmune islet infiltration

Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice

Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions.

Control of cortical rigidity by the cytoskeleton: emerging roles for septins

Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

Deletional tolerance mediated by extrathymic Aire-expressing cells

Dendritic cells in cancer immunology and immunotherapy

Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity

Duration of antigen receptor signaling determines T-cell tolerance or activation

Dynamics of the immunological synapse: finding, establishing and solidifying a connection ⬇️

Global Absence and Targeting of Protective Immune States in Severe COVID-19

Global Absence and Targeting of Protective Immune States in Severe COVID-19

Imaging the function of regulatory T cells in vivo

Integration of the movement of signaling microclusters with cellular motility in immunological synapses.

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

Leukotriene B4 amplifies eosinophil accumulation in response to nematodes

Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice

Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA.

Paracrine costimulation of IFN-γ signaling by integrins modulates CD8 T cell differentiation

Perivascular Mast Cells Dynamically Probe Cutaneous Blood Vessels to Capture Immunoglobulin E ⬇️

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans

Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation

Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics

Regulation of T cell priming by lymphoid stroma.

Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm

Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

Stabilized imaging of immune surveillance in the mouse lung

The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

The NK cell-cancer cycle: advances and new challenges in NK cell-based immunotherapies

The immunological synapse: a dynamic platform for local signaling

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

The septin cytoskeleton facilitates membrane retraction during motility and blebbing

Tracking the Spatial and Functional Gradient of Monocyte-To-Macrophage Differentiation in Inflamed Lung

Tumor-infiltrating lymphocytes are dynamically desensitized to antigen but are maintained by homeostatic cytokine

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

Understanding the tumor immune microenvironment (TIME) for effective therapy.

Visualization of immediate immune responses to pioneer metastatic cells in the lung.

Visualizing Cancer

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy

ZipSeq: barcoding for real-time mapping of single cell transcriptomes

iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse