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List of works by Valerie M Weaver

6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF- B-dependent resistance to apoptosis in 3D mammary acini

scientific article published on 02 October 2007

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype

scientific article

A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.

scientific article published on 21 December 2017

A human breast cell model of preinvasive to invasive transition.

scientific article published on March 2008

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

A tense situation: forcing tumour progression

scientific article published on February 2009

A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma

scientific article published on 10 September 2018

ATPS-63OSMOTIC SWELLING REGULATES TUMOR GROWTH AND DRUG UPTAKE IN HUMAN GLIOBLASTOMA.

scientific article

Activation of protein kinase C modulates dihydroxycholecalciferol synthesis in rat renal tubules

scientific article published on 01 May 1992

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

scientific article

Adaptation to low dietary calcium in magnesium-deficient rats

scientific article published on 01 June 1988

Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin

scientific article published on 15 July 2003

Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard

scientific article published in November 2005

Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma.

scientific article published on 5 February 2018

Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors

scientific article

Balancing forces: architectural control of mechanotransduction

scientific article published on May 2011

Biophysics. Enforcing order on signaling

scientific article published in March 2010

Cell and tissue mechanics: the new cell biology frontier.

scientific article published on July 2017

Cell biology. Strength under tension.

scientific article published in August 2013

Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease

scientific article published on 15 September 2016

Collagen architecture in pregnancy-induced protection from breast cancer

scientific article published on 10 July 2013

Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy

scientific article

CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis

scientific article published on 03 March 2009

Death in the third dimension: apoptosis regulation and tissue architecture

scientific article published on February 2004

Deconstructing signaling in three dimensions

scientific article published on 28 March 2014

Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis

scientific article published on January 2007

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

scientific article

Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells

scientific article published on 3 August 2017

Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers

scientific article published on 26 February 2018

Dynamic interplay between the collagen scaffold and tumor evolution

scientific article published on 06 September 2010

Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis

scientific article

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

scientific article

Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis.

scientific article published in July 1994

Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties

scientific article

Excess area dependent scaling behavior of nano-sized membrane tethers

scientific article published on 8 November 2017

Exploring the Link Between Human Embryonic Stem Cell Organization and Fate Using Tension-Calibrated Extracellular Matrix Functionalized Polyacrylamide Gels ⬇️

scientific article published on January 1, 2012

Extracellular matrix assembly: a multiscale deconstruction

scientific article

Extracellular matrix degradation and remodeling in development and disease

scientific article

Extracellular matrix: the central regulator of cell and tissue homeostasis

scientific article published on 01 January 1997

Feeling Stress: The Mechanics of Cancer Progression and Aggression

scientific article published on 28 February 2018

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells

scientific article published on 06 July 2018

Fighting the force: Potential of homeobox genes for tumor microenvironment regulation

scientific article (publication date: April 2015)

Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension

scientific article published on 20 May 2009

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

scientific article published on 4 April 2016

Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate

scientific article

Force-dependent breaching of the basement membrane

scientific article published on 23 December 2016

Forcing form and function: biomechanical regulation of tumor evolution

scientific article published on October 2010

Forcing the third dimension

scientific article

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

scientific article

Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells

scientific article

G'rab'bing the microenvironment for invasion

scientific article

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

scientific article

HIGH INTERSTITIAL FLUID PRESSURE REGULATES TUMOR GROWTH AND DRUG UPTAKE IN HUMAN GLIOBLASTOMA.

scientific article published in July 2014

HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.

scientific article

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.

scientific article

Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression

scientific article

In situ force mapping of mammary gland transformation

scientific article published on 15 August 2011

Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate

scientific article

Integrin-mediated signalling through the MAP-kinase pathway.

scientific article published on January 2008

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

scientific article published on 5 April 2017

Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness

scientific article published on March 2016

Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer

scientific article published on 18 July 2017

MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.

scientific article published on 16 May 2013

Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis

scientific article published on 19 July 2007

Matrix crosslinking forces tumor progression by enhancing integrin signaling

scientific article

Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer.

scientific article published on 8 June 2016

Mechanics, malignancy, and metastasis: the force journey of a tumor cell

scientific article

Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?

scientific article

Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.

scientific article

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

scientific article

Modeling Tissue Polarity in Context

scientific article published on 25 July 2018

Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures

scientific article published on January 2008

Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer

scientific article published on 4 December 2012

Monitoring developmental force distributions in reconstituted embryonic epithelia

scientific article published on 02 September 2015

Morphogenesis: Laying down the tracks

scientific article published on 22 May 2012

Multicellular architecture of malignant breast epithelia influences mechanics

scientific article

Multiscale modeling of form and function

scientific article published in April 2009

NT-11TARGETING INTERSTITIAL FLUID PRESSURE TO REDUCE TUMOR GROWTH AND INCREASE DRUG UPTAKE IN BRAIN TUMORS.

scientific article published in November 2014

New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.

scientific article published on 15 March 2018

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.

scientific article published on 17 June 2013

Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis

scientific article

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha

scientific article published on 11 January 2016

Protein synthesis, DNA degradation, and morphological changes during programmed cell death in labial glands of Manduca sexta

scientific article published on January 1997

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

scientific article (publication date: July 2005)

Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion

scientific article published on January 2008

Rapid disorganization of mechanically interacting systems of mammary acini

scientific article

Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology

scientific article published on December 1998

Regulation of renal 25(OH)D3 1α-hydroxylase: signal transduction pathways ⬇️

scientific article published on December 1, 1991

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

scientific article (publication date: 7 April 1997)

STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.

scientific article

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells

scientific article published in June 2010

Scanning angle interference microscopy reveals cell dynamics at the nanoscale

scientific article

Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes

scientific article

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

scientific article published on 09 October 2018

Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas

scientific article

Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype

scientific article

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

scientific article published on 01 August 2020

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

scientific article published on 14 October 2016

Tensional homeostasis and the malignant phenotype

scientific article (publication date: September 2005)

The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate

scientific article published on 21 March 2018

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

scientific article

The development of a functionally relevant cell culture model of progressive human breast cancer.

scientific article published on June 1995

The extracellular matrix at a glance

scientific article

The extracellular matrix modulates the hallmarks of cancer

scientific article

The extracellular matrix: a dynamic niche in cancer progression

scientific article (publication date: 20 February 2012)

The microenvironment matters.

scientific article

The organizing principle: microenvironmental influences in the normal and malignant breast

scientific article

The tension mounts: mechanics meets morphogenesis and malignancy

scientific article

The tissue diagnostic instrument.

scientific article

The tissue microenvironment as an epigenetic tumor modifier

scientific article

The ultrastructure of MCF-10A acini

scientific article published on July 2006

Three-dimensional context regulation of metastasis

scientific article published on 24 September 2008

Tissue Force Programs Cell Fate and Tumor Aggression

scientific article published on 16 October 2017

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

scientific article published on 19 July 2016

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.

scientific article published on 16 March 2014

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression

scientific article published on 7 November 2016

Tissue mechanics regulate brain development, homeostasis and disease

scientific article published on January 2017

Tumor mechanics and metabolic dysfunction

scientific article

Tumor microenvironment and progression

scientific article published on May 2011

Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells

scientific article

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

scientific article published on 30 November 2020

Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.

scientific article

Understanding tissue context influences on intratumour heterogeneity

scientific article

Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick

scientific article published on May 2011

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

scientific article

Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions.

scientific article published on 23 June 2016

Vitamin D receptors and compensatory tissue growth in spontaneously diabetic BB rats

scientific article published in January 1991

Watch thy neighbor: cancer is a communal affair

scientific article published in March 2004

YAP forces fibroblasts to feel the tension

scientific article published in June 2013

Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon

scientific article published on 29 October 2020

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

scientific article published on September 2002

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site

scientific article published on 6 September 2017

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