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List of works by Motohiro Nishida

2-Oxo-histidine-containing dipeptides are functional oxidation products

scientific article published on 30 November 2018

A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.

scientific article published on 24 October 2008

A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy.

scientific article published on 14 September 2017

Activation Mechanism of Gi and Go by Reactive Oxygen Species ⬇️

scientific article published on January 7, 2002

Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration.

scientific article

Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.

scientific article published in September 2003

Blocker-resistant presynaptic voltage-dependent Ca2+ channels underlying glutamate release in mice nucleus tractus solitarii.

scientific article published on 11 July 2006

Canonical Transient Receptor Potential Channels and Vascular Smooth Muscle Cell Plasticity ⬇️

scientific article published on 13 January 2020

Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway

Caveolae-independent activation of protein kinase A in rat neonatal myocytes.

scientific article published on 8 June 2005

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.

scientific article

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

scientific article published on 27 October 2017

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

scientific article published on 25 June 2019

Determining the activation of rho as an index of receptor coupling to G₁₂/₁₃ proteins.

scientific article published in January 2011

Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation

scientific article published on 01 March 2003

Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel.

scientific article published on 18 April 2003

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.

scientific article

Dual actions of ANP on endothelial permeability

Dual signaling pathways of arterial constriction by extracellular uridine 5'-triphosphate in the rat

scientific article published on 22 February 2011

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

scientific article

Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide ⬇️

scientific article published on April 28, 2013

G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.

scientific article published in March 2005

GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance ⬇️

scientific article published on January 1, 2013

Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy

scientific journal article

Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts.

scientific article published on 12 April 2005

Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation.

scientific article

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y 2 receptor stimulation through S-nitrosylation of NF-κB ⬇️

scientific article published on April 4, 2011

Heterotrimeric G protein G alpha13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts.

scientific article

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells.

scientific article published in May 2003

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

scientific article

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

scientific article published on 13 November 2018

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

scientific article published on 06 August 2019

Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.

scientific article

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure

scientific article published on 05 August 2014

Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart.

scientific article published on 6 May 2010

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

scientific article published on 16 December 2017

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.

scientific article

Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer

scientific article published on 11 February 2022

Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis ⬇️

scientific article published on July 18, 2012

Mechanism of cardiac hypertrophy via diacylglycerol-sensitive TRPC channels

scientific article published on 01 March 2010

Mechanism of the cardioprotective effects of docetaxel pre-administration against adriamycin-induced cardiotoxicity

scientific article published on 24 February 2011

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells.

scientific article published on 30 June 2016

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts

scientific article published on 10 February 2017

Mitochondrial dynamics in exercise physiology

scientific article published on 01 February 2019

Mutations in EFHC1 cause juvenile myoclonic epilepsy

scientific article

Novel real-time sensors to quantitatively assess in vivo inositol 1,4,5-trisphosphate production in intact cells.

scientific article published on April 2004

Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.

scientific article

Pharmacological properties of novel TRPC channel inhibitors

scientific article published in March 2010

Prolonged stimulation of β-adrenergic receptor with β-agonists impairs insulin actions in H9c2 cells

scientific article published on 26 September 2018

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases.

scientific article

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

scientific article published on 19 January 2016

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension.

scientific article published on 20 March 2017

Purinergic signaling in cardiovascular system.

scientific article published on January 2017

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

scientific article published on 26 February 2018

Reactive Sulfur Species-Mediated Activation of the Keap1-Nrf2 Pathway by 1,2-Naphthoquinone through Sulfenic Acids Formation under Oxidative Stress.

scientific article

Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes

scientific article published on 16 June 2012

Redox Control of Cardiovascular Homeostasis by Angiotensin II ⬇️

scientific article published on January 1, 2013

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.

scientific article published on 18 January 2017

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.

scientific article published on April 2016

Redox signaling regulated by electrophiles and reactive sulfur species

scientific article

Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB ⬇️

scientific article published on November 13, 2010

Regulation of redox signalling by an electrophilic cyclic nucleotide ⬇️

scientific article published on December 17, 2012

Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling.

scientific article published on 14 February 2014

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology.

scientific article

Roles of heterotrimeric GTP-binding proteins in the progression of heart failure.

scientific article published on 06 August 2011

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds

scientific article published on 5 January 2016

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway

scientific article

Sulfide catabolism ameliorates hypoxic brain injury

scientific article published on 25 May 2021

Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner.

scientific article

TRPC channels in exercise-mimetic therapy

article

TRPC3 Channels in Cardiac Fibrosis.

scientific article published on 7 September 2017

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation.

scientific article published on 9 November 2015

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca(2+) concentration in mouse cardiomyocytes

scientific article published on 19 January 2017

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

scientific article

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

scientific article (publication date: 19 December 2016)

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

scientific article published on 05 July 2019

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.

scientific article

TRPC3-mediated Ca2+ influx contributes to Rac1-mediated production of reactive oxygen species in MLP-deficient mouse hearts

scientific article published on 03 May 2011

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.

scientific article

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

scientific article published on 8 August 2017

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

scientific article published on 04 June 2019

Transient receptor potential channels in Alzheimer's disease.

scientific article published on 31 March 2007

Transient receptor potential channels in cardiovascular function and disease.

scientific article published on July 2006

[ Frontiers of Ca(2+) signaling~physiological and pathological roles of voltage-independent Ca(2+) channels]

scientific article published on 01 March 2010

[Bone and Calcium Research Update 2015. Basic mechanisms underlying calcium signaling and their biological potentiality]

scientific article published on 01 January 2015

[Chemical biology of hydrogen sulfide]

scientific article published on 01 June 2013

[Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species].

scientific article

[Function and role of transient receptor potential channels]

scientific article published on 01 April 2013

[Lifestyle Inspires Future Pharmacotherapy and Drug Discovery]

scientific article published on 01 January 2018

[Molecular mechanism underlying the development of heart failure mediated by heterotrimeric G protein signaling]

scientific article published on 01 May 2010

[New Strategies for Exercise-Mimetic Medication]

scientific article published on 01 January 2018

[Novel findings in functions of TRP channel protein and pathophysiology]

[Regulation of cardiovascular functions by the phosphorylation of TRPC channels].

scientific article

[Regulation of redox homeostasis by hydrogen sulfide anion and its clinical application].

scientific article

[Signal transduction in the development of vascular disease and new therapeutic strategy]

scientific article published on 01 November 2010

[TRPC channels and cardiac hypertrophy]

scientific article published on 01 October 2007

[TRPC]

scientific article published on 01 August 2008

β-arrestin2 in Infiltrated Macrophages Inhibits Excessive Inflammation after Myocardial Infarction ⬇️

scientific article published on July 8, 2013

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