List of works - John T Patton

A base-specific recognition signal in the 5' consensus sequence of rotavirus plus-strand RNAs promotes replication of the double-stranded RNA genome segments

scientific article

A four-nucleotide translation enhancer in the 3'-terminal consensus sequence of the nonpolyadenylated mRNAs of rotavirus

scientific article

Absence of genetic differences among G10P[11] rotaviruses associated with asymptomatic and symptomatic neonatal infections in Vellore, India.

scientific article published on 4 June 2014

Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.

scientific article

Analysis of human rotaviruses from a single location over an 18-year time span suggests that protein coadaption influences gene constellations

scientific article

Assortment and packaging of the segmented rotavirus genome.

scientific article

Characterization of rotavirus replication intermediates: a model for the assembly of single-shelled particles.

scientific article published on October 1989

Characterization of subviral particles in cells infected with simian rotavirus SA11.

scientific article published in December 1986

Collection of Recombinant Rotaviruses Expressing Fluorescent Reporter Proteins

scientific article published on 03 July 2019

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

scientific article

Complete genome sequence analysis of candidate human rotavirus vaccine strains RV3 and 116E

scientific article

Coupling of rotavirus genome replication and capsid assembly.

scientific article published on January 2007

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

scientific journal article

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity

scientific article

Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity

scientific article

Culturing, storage, and quantification of rotaviruses.

scientific article

De novo synthesis of minus strand RNA by the rotavirus RNA polymerase in a cell-free system involves a novel mechanism of initiation.

scientific article

Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics

scientific article

Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains

scientific article

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.

scientific article

Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus

scientific article

Effect of intragenic rearrangement and changes in the 3' consensus sequence on NSP1 expression and rotavirus replication

scientific article

Electrophoretic separation of the plus and minus strands of rotavirus SA11 double-stranded RNAs

scientific article published on 01 June 1986

Evidence for equimolar synthesis of double-strand RNA and minus-strand RNA in rotavirus-infected cells

scientific article published on November 1990

Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations

scientific article

Expression of Separate Heterologous Proteins from the Rotavirus NSP3 Genome Segment Using a Translational 2A Stop-Restart Element

scientific article published on 01 July 2020

Features of the 3'-consensus sequence of rotavirus mRNAs critical to minus strand synthesis

scientific article (publication date: 10 April 2001)

Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains

scientific article

Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System

scientific article published on 26 November 2019

Generation of genetically stable recombinant rotaviruses containing novel genome rearrangements and heterologous sequences by reverse genetics.

scientific article published on 27 March 2013

Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in Rotarix and RotaTeq

scientific article published on 21 December 2011

Genome heterogeneity of SA11 rotavirus due to reassortment with "O" agent

scientific article published on 23 October 2006

Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes ⬇️

scientific article published on 23 August 2018

Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions

scientific article published on 10 September 2008

Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities

scientific article published on 29 July 2006

Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity ⬇️

scientific article published on July 22, 2013

Homotypic and heterotypic serum isotype-specific antibody responses to rotavirus nonstructural protein 4 and viral protein (VP) 4, VP6, and VP7 in infants who received selected live oral rotavirus vaccines.

scientific article published on 29 April 2004

Identification and characterization of the helix-destabilizing activity of rotavirus nonstructural protein NSP2.

scientific article

Identification of sequences in rotavirus mRNAs important for minus strand synthesis using antisense oligonucleotides.

scientific article

Inhibition of vesicular stomatitis virus RNA synthesis by 2',3'-dideoxycytidine 5'-triphosphate.

scientific article published in March 1983

Interactions among capsid proteins orchestrate rotavirus particle functions.

scientific article

Intra-genotypic diversity of archival G4P[8] human rotaviruses from Washington, DC

scientific article

Mechanism of intraparticle synthesis of the rotavirus double-stranded RNA genome.

scientific article

Modeling of the rotavirus group C capsid predicts a surface topology distinct from other rotavirus species

scientific article

Molecular characterization of a subgroup specificity associated with the rotavirus inner capsid protein VP2.

scientific article

Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: footprints of a globally transitioning genotype

scientific article published on 15 January 2014

Multiple introductions and antigenic mismatch with vaccines may contribute to increased predominance of G12P[8] rotaviruses in the United States ⬇️

scientific article published on 10 December 2018

Mutational analysis of residues involved in nucleotide and divalent cation stabilization in the rotavirus RNA-dependent RNA polymerase catalytic pocket.

scientific article

Mutations in the rotavirus spike protein VP4 reduce trypsin sensitivity but not viral spread.

scientific article published on 20 February 2013

Non-structural protein NSP2 induces heterotypic antibody responses during primary rotavirus infection and reinfection in children

scientific article published on June 2008

Nonstructural proteins involved in genome packaging and replication of rotaviruses and other members of the Reoviridae

scientific article

Nucleotide and amino acid sequence analysis of the rotavirus nonstructural RNA-binding protein NS35.

scientific article

Open reading frame in rotavirus mRNA specifically promotes synthesis of double-stranded RNA: template size also affects replication efficiency.

scientific article

Predicted structure and domain organization of rotavirus capping enzyme and innate immune antagonist VP3

scientific article

Prevalence of groups A and C rotavirus antibodies in infants with biliary atresia and cholestatic controls.

scientific article published on 23 October 2014

Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate

scientific article

Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.

scientific article

RNA-binding activity of the rotavirus phosphoprotein NSP5 includes affinity for double-stranded RNA.

scientific article

Reassortment in segmented RNA viruses: mechanisms and outcomes

scientific article published on 23 May 2016

Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments

scientific article published on 5 July 2008

Regulation of rotavirus polymerase activity by inner capsid proteins.

scientific article

Replication and Transcription of the Rotavirus Genome

scientific article

Residues of the rotavirus RNA-dependent RNA polymerase template entry tunnel that mediate RNA recognition and genome replication

scientific article

Role of the histidine triad-like motif in nucleotide hydrolysis by the rotavirus RNA-packaging protein NSP2.

scientific article

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

scientific article published on 25 July 2019

Rotavirus Infects Human Biliary Epithelial Cells and Stimulates Secretion of Cytokines IL-6 and IL-8 via MAPK Pathway.

scientific article published on 13 July 2015

Rotavirus NSP1 Requires Casein Kinase II-Mediated Phosphorylation for Hijacking of Cullin-RING Ligases

scientific article

Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7

scientific article

Rotavirus NSP1 mediates degradation of interferon regulatory factors through targeting of the dimerization domain

scientific article published on 03 July 2013

Rotavirus NSP2 interferes with the core lattice protein VP2 in initiation of minus-strand synthesis.

scientific article published in August 2003

Rotavirus RNA polymerases resolve into two phylogenetically distinct classes that differ in their mechanism of template recognition

scientific article

Rotavirus RNA replication and gene expression

scientific article

Rotavirus RNA replication: single-stranded RNA extends from the replicase particle

scientific article published on May 1990

Rotavirus Species B Encodes a Functional Fusion-Associated Small Transmembrane Protein

scientific article published on 30 September 2019

Rotavirus VP2 core shell regions critical for viral polymerase activation.

scientific article

Rotavirus antagonism of the innate immune response

scientific article

Rotavirus diversity and evolution in the post-vaccine world ⬇️

scientific article published on January 1, 2012

Rotavirus glycoprotein NSP4 is a modulator of viral transcription in the infected cell.

scientific article

Rotavirus morphogenesis: domains in the major inner capsid protein essential for binding to single-shelled particles and for trimerization

scientific article

Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3

scientific article

Rotavirus nonstructural protein NSP2 self-assembles into octamers that undergo ligand-induced conformational changes.

scientific article published on 19 December 2000

Rotavirus open cores catalyze 5'-capping and methylation of exogenous RNA: evidence that VP3 is a methyltransferase.

scientific article published in December 1999

Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold

scientific article

Rotavirus replication: plus-sense templates for double-stranded RNA synthesis are made in viroplasms

scientific article

Rotavirus variant replicates efficiently although encoding an aberrant NSP3 that fails to induce nuclear localization of poly(A)-binding protein

scientific article published on 21 March 2012

Shared and group-specific features of the rotavirus RNA polymerase reveal potential determinants of gene reassortment restriction.

scientific article published on 08 April 2009

Silencing the alarms: Innate immune antagonism by rotavirus NSP1 and VP3

scientific article published on 25 February 2015

Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reassortment.

scientific article published on 25 November 2009

Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.

scientific article published on July 2015

Structure and function of the rotavirus RNA-binding proteins.

scientific article

Structure and protein composition of the rotavirus replicase particle

scientific article published on 01 October 1988

Structure-function analysis of rotavirus NSP2 octamer by using a novel complementation system

scientific article

Synthesis of simian rotavirus SA11 double-stranded RNA in a cell-free system.

scientific article published in December 1986

Template recognition and formation of initiation complexes by the replicase of a segmented double-stranded RNA virus.

scientific article published on 3 June 2003

The battle between rotavirus and its host for control of the interferon signaling pathway

scientific article

The rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymerase

scientific article (publication date: August 1994)

The rotavirus nonstructural protein, NS35, possesses RNA-binding activity in vitro and in vivo

scientific article published on 01 December 1992

The switch from transcription to replication of a negative-strand RNA virus

scientific article

Translation enhancer in the 3'-untranslated region of rotavirus gene 6 mRNA promotes expression of the major capsid protein VP6.

scientific article published on 30 October 2003

Type III and Not Type I Interferons Efficiently Prevent the Spread of Rotavirus in Human Intestinal Epithelial Cells

scientific article published in 2022

Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)

scientific article

Vaccine-derived NSP2 segment in rotaviruses from vaccinated children with gastroenteritis in Nicaragua.

scientific article

Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission

article

List of works by John T Patton

A base-specific recognition signal in the 5' consensus sequence of rotavirus plus-strand RNAs promotes replication of the double-stranded RNA genome segments

A four-nucleotide translation enhancer in the 3'-terminal consensus sequence of the nonpolyadenylated mRNAs of rotavirus

Absence of genetic differences among G10P[11] rotaviruses associated with asymptomatic and symptomatic neonatal infections in Vellore, India.

Analysis of a temperature-sensitive mutant rotavirus indicates that NSP2 octamers are the functional form of the protein.

Analysis of human rotaviruses from a single location over an 18-year time span suggests that protein coadaption influences gene constellations

Assortment and packaging of the segmented rotavirus genome.

Characterization of rotavirus replication intermediates: a model for the assembly of single-shelled particles.

Characterization of subviral particles in cells infected with simian rotavirus SA11.

Collection of Recombinant Rotaviruses Expressing Fluorescent Reporter Proteins

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

Complete genome sequence analysis of candidate human rotavirus vaccine strains RV3 and 116E

Coupling of rotavirus genome replication and capsid assembly.

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity

Crystallographic and Biochemical Analysis of Rotavirus NSP2 with Nucleotides Reveals a Nucleoside Diphosphate Kinase-Like Activity

Culturing, storage, and quantification of rotaviruses.

De novo synthesis of minus strand RNA by the rotavirus RNA polymerase in a cell-free system involves a novel mechanism of initiation.

Diversity and relationships of cocirculating modern human rotaviruses revealed using large-scale comparative genomics

Diversity of interferon antagonist activities mediated by NSP1 proteins of different rotavirus strains

Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.

Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus

Effect of intragenic rearrangement and changes in the 3' consensus sequence on NSP1 expression and rotavirus replication

Electrophoretic separation of the plus and minus strands of rotavirus SA11 double-stranded RNAs

Evidence for equimolar synthesis of double-strand RNA and minus-strand RNA in rotavirus-infected cells

Evolutionary dynamics of human rotaviruses: balancing reassortment with preferred genome constellations

Expression of Separate Heterologous Proteins from the Rotavirus NSP3 Genome Segment Using a Translational 2A Stop-Restart Element

Features of the 3'-consensus sequence of rotavirus mRNAs critical to minus strand synthesis

Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains

Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System

Generation of genetically stable recombinant rotaviruses containing novel genome rearrangements and heterologous sequences by reverse genetics.

Genetic analyses reveal differences in the VP7 and VP4 antigenic epitopes between human rotaviruses circulating in Belgium and rotaviruses in Rotarix and RotaTeq

Genome heterogeneity of SA11 rotavirus due to reassortment with "O" agent

Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes ⬇️

Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions

Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities

Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity ⬇️

Homotypic and heterotypic serum isotype-specific antibody responses to rotavirus nonstructural protein 4 and viral protein (VP) 4, VP6, and VP7 in infants who received selected live oral rotavirus vaccines.

Identification and characterization of the helix-destabilizing activity of rotavirus nonstructural protein NSP2.

Identification of sequences in rotavirus mRNAs important for minus strand synthesis using antisense oligonucleotides.

Inhibition of vesicular stomatitis virus RNA synthesis by 2',3'-dideoxycytidine 5'-triphosphate.

Interactions among capsid proteins orchestrate rotavirus particle functions.

Intra-genotypic diversity of archival G4P[8] human rotaviruses from Washington, DC

Mechanism of intraparticle synthesis of the rotavirus double-stranded RNA genome.

Modeling of the rotavirus group C capsid predicts a surface topology distinct from other rotavirus species

Molecular characterization of a subgroup specificity associated with the rotavirus inner capsid protein VP2.

Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: footprints of a globally transitioning genotype

Multiple introductions and antigenic mismatch with vaccines may contribute to increased predominance of G12P[8] rotaviruses in the United States ⬇️

Mutational analysis of residues involved in nucleotide and divalent cation stabilization in the rotavirus RNA-dependent RNA polymerase catalytic pocket.

Mutations in the rotavirus spike protein VP4 reduce trypsin sensitivity but not viral spread.

Non-structural protein NSP2 induces heterotypic antibody responses during primary rotavirus infection and reinfection in children

Nonstructural proteins involved in genome packaging and replication of rotaviruses and other members of the Reoviridae

Nucleotide and amino acid sequence analysis of the rotavirus nonstructural RNA-binding protein NS35.

Open reading frame in rotavirus mRNA specifically promotes synthesis of double-stranded RNA: template size also affects replication efficiency.

Predicted structure and domain organization of rotavirus capping enzyme and innate immune antagonist VP3

Prevalence of groups A and C rotavirus antibodies in infants with biliary atresia and cholestatic controls.

Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate

Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.

RNA-binding activity of the rotavirus phosphoprotein NSP5 includes affinity for double-stranded RNA.

Reassortment in segmented RNA viruses: mechanisms and outcomes

Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments

Regulation of rotavirus polymerase activity by inner capsid proteins.

Replication and Transcription of the Rotavirus Genome

Residues of the rotavirus RNA-dependent RNA polymerase template entry tunnel that mediate RNA recognition and genome replication

Role of the histidine triad-like motif in nucleotide hydrolysis by the rotavirus RNA-packaging protein NSP2.

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

Rotavirus Infects Human Biliary Epithelial Cells and Stimulates Secretion of Cytokines IL-6 and IL-8 via MAPK Pathway.

Rotavirus NSP1 Requires Casein Kinase II-Mediated Phosphorylation for Hijacking of Cullin-RING Ligases

Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7

Rotavirus NSP1 mediates degradation of interferon regulatory factors through targeting of the dimerization domain

Rotavirus NSP2 interferes with the core lattice protein VP2 in initiation of minus-strand synthesis.

Rotavirus RNA polymerases resolve into two phylogenetically distinct classes that differ in their mechanism of template recognition

Rotavirus RNA replication and gene expression

Rotavirus RNA replication: single-stranded RNA extends from the replicase particle

Rotavirus Species B Encodes a Functional Fusion-Associated Small Transmembrane Protein

Rotavirus VP2 core shell regions critical for viral polymerase activation.

Rotavirus antagonism of the innate immune response

Rotavirus diversity and evolution in the post-vaccine world ⬇️

Rotavirus glycoprotein NSP4 is a modulator of viral transcription in the infected cell.

Rotavirus morphogenesis: domains in the major inner capsid protein essential for binding to single-shelled particles and for trimerization