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List of works by Guy A Caldwell

A Predictable Worm: Application of Caenorhabditis elegans for Mechanistic Investigation of Movement Disorders ⬇️

scientific article published on April 1, 2012

Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease

scientific article

An animal model to discern torsin function: suppression of protein aggregation in C. elegans

scientific article published on 01 January 2004

Animal models for drug discovery in dystonia ⬇️

scientific article published on January 1, 2008

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic

scientific article published on 15 February 2019

Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.

scientific article published on 18 July 2008

C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.

scientific article published on May 2010

C. elegans as a model system to accelerate discovery for Parkinson disease

scientific article published on 24 February 2017

Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease

scientific article published on 31 December 2010

Chemical enhancement of torsinA function in cell and animal models of torsion dystonia

scientific article

Correction to: The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity

article

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

scientific article published on June 2006

Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration

scientific article published on 01 December 2018

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

scientific article

Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.

scientific article published on 13 October 2017

Enhanced pentylenetetrazole sensitivity in a C. elegans mutant associated with DNM1 encephalopathy

scientific article published on 20 August 2020

Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans

scientific article published on 14 July 2004

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s Disease

scientific article

From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models

scientific article published in 2022

Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

scientific article published on February 2012

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

scientific article

Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson's models.

scientific article

Generation of stable transgenic C. elegans using microinjection

scientific article

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration

scientific article published on 29 June 2019

Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans.

scientific article published on 12 October 2017

Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans

scientific article published on 22 September 2006

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

scientific article

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

scholarly article

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity ⬇️

scientific article published on May 29, 2012

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models ⬇️

scientific article published on July 18, 2011

Invertebrate Models of Dystonia ⬇️

scientific article published on January 1, 2013

Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration

scientific article

Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy

scientific article published on 09 June 2022

Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction.

scientific article

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

scientific article

Lysosomal impairment in Parkinson's disease

scientific article published on 11 April 2013

Modeling dopamine neuron degeneration in Caenorhabditis elegans

article published in 2011

Modeling neurodegeneration in Caenorhabditis elegans

scientific article published on 26 October 2020

NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease

scientific article published in October 2017

No Country for Old Worms: A Systematic Review of the Application of to Investigate a Bacterial Source of Environmental Neurotoxicity in Parkinson's Disease

scientific article published on 29 October 2018

Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants.

scientific article

Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.

scientific article published on 21 September 2009

Phenazine derivatives cause proteotoxicity and stress in C. elegans

scientific article published on 7 October 2014

Phenotypic modulation of pentylenetetrazole-induced convulsive behaviors in C. elegans carrying a mutation associated with Alzheimer's disease

scientific article published on 20 August 2020

Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

scientific article

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

scientific article published on January 2014

Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases

scientific article published on 3 July 2013

RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway

scientific article

Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins

scientific article published in February 2003

The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity

scientific article published on 10 February 2018

The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro

scientific article

The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response

scientific article

The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

scientific article published on 22 January 2014

The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.

scientific article

The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro

scientific article published on 15 July 2008

Therapeutic genetic variation revealed in diverse Hsp104 homologs

scientific article published on 15 December 2020

Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

scientific article published in April 2005

TorsinA participates in endoplasmic reticulum-associated degradation

scientific article

TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.

scientific article published on 05 December 2013

Traversing a wormhole to combat Parkinson's disease

scientific article published on July 2008

Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation

scientific article

Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids

scientific article published on 10 February 2004

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

scientific article published on 20 October 2009

Vacuolar protein sorting protein 41 (VPS41) at an intersection of endosomal traffic in neurodegenerative disease

scientific article published on 01 July 2019

Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling ⬇️

scientific article published on February 26, 2013

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

scientific article

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