List of works - Hermann M. Schätzl

A genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasis

scientific article

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus

scientific article published on 01 December 2008

A recombinant Toscana virus nucleoprotein in a diagnostic immunoblot test system.

scientific article published in November 1998

A seroepidemiological survey of antibodies to HTLV-I/HTLV-II in selected population groups in Paraguay

scientific article published on January 1, 1992

An astrocyte cell line that differentially propagates murine prions

scientific article published on 19 June 2020

Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein

scientific journal article

Antibodies to a nonconjugated prion protein peptide 95-123 interfere with PrP( Sc ) propagation in prion-infected cells

scientific article published on 05 January 2007

Aptamers against prion proteins and prions.

scientific article

Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line

scientific article

Autophagy induction by trehalose counteracts cellular prion infection

scientific article

Autophagy pathways in the treatment of prion diseases

scientific article published on 01 February 2019

Autophagy regulates exosomal release of prions in neuronal cells.

scientific article published on 26 April 2018

Autophagy, prion infection and their mutual interactions

scientific article published on 18 September 2009

Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells

scientific article

Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection

scientific article published on 4 December 2007

Cell-to-cell propagation of infectious cytosolic protein aggregates

scientific article published on 18 March 2013

Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression

scientific article published on 16 October 2019

Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis

scientific article

Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replication

scientific article published on 11 October 2005

Chronic wasting disease

scientific article published on 01 January 2011

Chronic wasting disease: Emerging prions and their potential risk.

scientific article

Combining autophagy stimulators and cellulose ethers for therapy against prion disease

scientific article from 2019

Concomitant administration of a virosome-adjuvanted hepatitis a vaccine with routine childhood vaccines at age twelve to fifteen months: a randomized controlled trial

scientific article published on 01 September 2007

Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.

scientific article published on 14 December 2010

Correction: Disulfide-crosslink scanning reveals prion-induced conformational changes and prion strain-specific structures of the pathological prion protein PrP

scientific article published in Journal of Biological Chemistry

CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells

scientific article

Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein

scientific article (publication date: 2013)

Detection of PrP(Sc) in peripheral tissues of clinically affected cattle after oral challenge with bovine spongiform encephalopathy.

scientific article

Dimerization of the cellular prion protein inhibits propagation of scrapie prions

scientific article published on 10 April 2018

Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.

scientific article

Disulfide-crosslink scanning reveals prion-induced conformational changes and prion strain-specific structures of the pathological prion protein PrPSc.

scientific article published on 22 June 2018

Drug targets in prion diseases

scientific article published in February 2009

Dynamic interactions of Sup35p and PrP prion protein domains modulate aggregate nucleation and seeding

scientific article

Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay.

scientific article published on May 2013

Early detection of prion protein aggregation with a fluorescent pentameric oligothiophene probe using spectral confocal microscopy

scientific article published on 16 August 2020

Elevated Epstein-Barr virus loads and lower antibody titers in competitive athletes.

scientific article

Endemic chronic wasting disease causes mule deer population decline in Wyoming

scientific article published on 19 October 2017

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

scientific article published on 12 November 2002

Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART.

scientific article

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms

scientific article published in December 2017

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.

scientific article published on 6 September 2012

Fatal Epstein-Barr virus-associated lymphoproliferative disorder following treatment with a novel mTOR inhibitor for relapsed chronic lymphocytic leukemia leukemia cells

scientific article

From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins

scientific article published on 10 September 2020

From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease

scientific article

GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.

scientific article published on 14 February 2010

Gene-edited murine cell lines for propagation of chronic wasting disease prions

scientific article published on 01 August 2019

Genomic characterization of a novel HIV type 1 B/G intersubtype recombinant strain from an injecting drug user in Germany.

scientific article

Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to bovine spongiform encephalopathy and scrapie infections.

scientific article published on 23 September 2004

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

scholarly article

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition.

scientific article

Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro.

scientific article

In vitro and in vivo neurotoxicity of prion protein oligomers.

scientific article

Individuals with antibodies against hepatitis B core antigen as the only serological marker for hepatitis B infection: high percentage of carriers of hepatitis B and C virus.

scientific article published in July 1995

Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation

scientific article published on 13 October 2009

Inhibition of prion amplification by expression of dominant inhibitory mutants--a systematic insertion mutagenesis study

scientific article

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

scientific article

Introducing a rigid loop structure from deer into mouse prion protein increases its propensity for misfolding in vitro

scientific article (publication date: 2013)

Is codon 129 of prion protein polymorphic in human beings but not in animals?

scientific article published on 01 May 1997

Isolated norovirus GII.7 strain within an extended GII.4 outbreak.

scientific article published in May 2010

LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer's Disease.

scientific article published on 17 October 2015

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

scientific article

Metformin reduces prion infection in neuronal cells by enhancing autophagy

scientific article published on 23 December 2019

Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake.

scientific article

Modulation of Host Cell Death by SARS Coronavirus Proteins

scholarly article by Claudia Diemer published in October 2009

Molecular basis of cerebral neurodegeneration in prion diseases.

scientific article published on February 2007

Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrPc

scientific article

Neurotrophic factors: ready to go?

scientific article published on November 1995

Overexpression of quality control proteins reduces prion conversion in prion-infected cells

scientific article published in Journal of Biological Chemistry

Parvovirus B19 and necrotizing enterocolitis in neonates

scientific article published on 07 February 2012

Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.

scientific article

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo

scientific article

Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells.

scientific article published on 11 March 2003

Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses.

scientific article published in September 2007

Preparation and Characterization of Cellulose Ether Liposomes for the Inhibition of Prion Formation in Prion-Infected Cells

scientific article published on 23 March 2019

Prevalence of human T-cell lymphotropic virus infections in Germany.

scientific article

Prion diseases: from molecular biology to intervention strategies

scientific article published on December 2003

Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells

scientific article published on 11 February 2016

Prion infection influences murine endogenous retrovirus expression in neuronal cells

scientific article published on 15 March 2006

Prion protein/protein interactions: fusion with yeast Sup35p-NM modulates cytosolic PrP aggregation in mammalian cells.

scientific article

Prion strains depend on different endocytic routes for productive infection.

scientific article

Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells

scientific article published on 11 September 2009

Prion-like propagation of cytosolic protein aggregates: insights from cell culture models

scientific article published on 04 October 2009

Prion-protein-specific aptamer reduces PrPSc formation

scientific article

Prion: gene, structure, and species barrier

scientific article published on 01 January 2005

Promising developments bringing prion diseases closer to therapy and prophylaxis

scientific article

Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein

scientific article

Recognition of lumenal prion protein aggregates by post-ER quality control mechanisms is mediated by the preoctarepeat region of PrP.

scientific article published in April 2004

Recombinant prion protein vaccination of transgenic elk PrP mice and reindeer overcomes self-tolerance and protects mice against chronic wasting disease

scientific article published in Journal of Biological Chemistry

Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins

scientific article published on 27 April 2007

Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model

scientific article published on 24 January 2020

Severe acute respiratory syndrome coronavirus replication is severely impaired by MG132 due to proteasome-independent inhibition of M-calpain

scientific article

Small-scale Subcellular Fractionation with Sucrose Step Gradient

scientific article published in June 2014

Small-scale Triton X-114 Extraction of Hydrophobic Proteins

scientific article published in June 2014

Stability and conformational properties of doppel, a prion-like protein, and its single-disulphide mutant.

scientific article published on July 2003

Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation.

scientific article

Targeting prion proteins in neurodegenerative disease

scientific article published in July 2008

The anticancer drug imatinib induces cellular autophagy.

scientific article published on March 2007

The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions.

scientific article published on 14 December 2017

The first B/G intersubtype recombinant form of human immunodeficiency virus type 1 (HIV-1) identified in Germany was undetected or underquantitated by some commercial viral load assays.

scientific article

The immune response to different doses of inactivated hepatitis A vaccine

scientific article published on 01 January 1993

The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding

scientific article

The octarepeat region of prion protein, but not the TM1 domain, is important for the antioxidant effect of prion protein.

scientific article published on 9 September 2008

The prion protein requires cholesterol for cell surface localization.

scientific article published on 8 November 2005

The tyrosine kinase inhibitor STI571 induces cellular clearance of PrPSc in prion-infected cells.

scientific article published on 9 July 2004

The tyrosine kinase inhibitor imatinib mesylate delays prion neuroinvasion by inhibiting prion propagation in the periphery.

scientific article published on August 2007

The yeast Sup35NM domain propagates as a prion in mammalian cells

scholarly article

Therapeutic vaccination reduces HIV sequence variability

article

Therapy in prion diseases: from molecular and cellular biology to therapeutic targets

scientific article published in February 2009

Toxic effects of intracerebral PrP antibody administration during the course of BSE infection in mice

scientific article published on 15 July 2007

Ultra-sensitive detection of prion protein fibrils by flow cytometry in blood from cattle affected with bovine spongiform encephalopathy

scientific article

Vaccination against hepatitis A: comparison of different short-term immunization schedules

scientific article published on 01 January 1992

Vaccination with prion peptide-displaying papillomavirus-like particles induces autoantibodies to normal prion protein that interfere with pathologic prion protein production in infected cells.

scientific article published on 20 February 2007

Variability of the Hepatitis B Surface Protein in HBV-Infected Liver Transplant Recipients

scientific article published on 01 July 1997

Viruses with Single-Stranded, Positive-Sense RNA Genomes

[Reuse of "single use" medical devices after quality assured reprocessing: hygienic, legal and economic aspects. Potential for cost savings in interventional cardiology]

scientific article published on 01 November 2002

List of works by Hermann M. Schätzl

A genome-wide survey for prion-regulated miRNAs associated with cholesterol homeostasis

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus

A recombinant Toscana virus nucleoprotein in a diagnostic immunoblot test system.

A seroepidemiological survey of antibodies to HTLV-I/HTLV-II in selected population groups in Paraguay

An astrocyte cell line that differentially propagates murine prions

Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein

Antibodies to a nonconjugated prion protein peptide 95-123 interfere with PrP( Sc ) propagation in prion-infected cells

Aptamers against prion proteins and prions.

Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line

Autophagy induction by trehalose counteracts cellular prion infection

Autophagy pathways in the treatment of prion diseases

Autophagy regulates exosomal release of prions in neuronal cells.

Autophagy, prion infection and their mutual interactions

Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells

Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection

Cell-to-cell propagation of infectious cytosolic protein aggregates

Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression

Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis

Charged bipolar suramin derivatives induce aggregation of the prion protein at the cell surface and inhibit PrPSc replication

Chronic wasting disease

Chronic wasting disease: Emerging prions and their potential risk.

Combining autophagy stimulators and cellulose ethers for therapy against prion disease

Concomitant administration of a virosome-adjuvanted hepatitis a vaccine with routine childhood vaccines at age twelve to fifteen months: a randomized controlled trial

Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.

Correction: Disulfide-crosslink scanning reveals prion-induced conformational changes and prion strain-specific structures of the pathological prion protein PrP

CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells

Critical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion protein

Detection of PrP(Sc) in peripheral tissues of clinically affected cattle after oral challenge with bovine spongiform encephalopathy.

Dimerization of the cellular prion protein inhibits propagation of scrapie prions

Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.

Disulfide-crosslink scanning reveals prion-induced conformational changes and prion strain-specific structures of the pathological prion protein PrPSc.

Drug targets in prion diseases

Dynamic interactions of Sup35p and PrP prion protein domains modulate aggregate nucleation and seeding

Early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay.

Early detection of prion protein aggregation with a fluorescent pentameric oligothiophene probe using spectral confocal microscopy

Elevated Epstein-Barr virus loads and lower antibody titers in competitive athletes.

Endemic chronic wasting disease causes mule deer population decline in Wyoming

Essential role of the prion protein N terminus in subcellular trafficking and half-life of cellular prion protein.

Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART.

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms

Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms.

Fatal Epstein-Barr virus-associated lymphoproliferative disorder following treatment with a novel mTOR inhibitor for relapsed chronic lymphocytic leukemia leukemia cells

From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins

From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease

GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.

Gene-edited murine cell lines for propagation of chronic wasting disease prions

Genomic characterization of a novel HIV type 1 B/G intersubtype recombinant strain from an injecting drug user in Germany.

Glycosylation deficiency at either one of the two glycan attachment sites of cellular prion protein preserves susceptibility to bovine spongiform encephalopathy and scrapie infections.

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition.

Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro.

In vitro and in vivo neurotoxicity of prion protein oligomers.

Individuals with antibodies against hepatitis B core antigen as the only serological marker for hepatitis B infection: high percentage of carriers of hepatitis B and C virus.

Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation

Inhibition of prion amplification by expression of dominant inhibitory mutants--a systematic insertion mutagenesis study

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Introducing a rigid loop structure from deer into mouse prion protein increases its propensity for misfolding in vitro

Is codon 129 of prion protein polymorphic in human beings but not in animals?

Isolated norovirus GII.7 strain within an extended GII.4 outbreak.

LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer's Disease.

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

Metformin reduces prion infection in neuronal cells by enhancing autophagy

Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake.

Modulation of Host Cell Death by SARS Coronavirus Proteins

Molecular basis of cerebral neurodegeneration in prion diseases.

Neuroendocrine cultured cells counteract persistent prion infection by down-regulation of PrPc

Neurotrophic factors: ready to go?

Overexpression of quality control proteins reduces prion conversion in prion-infected cells

Parvovirus B19 and necrotizing enterocolitis in neonates

Peptide aptamers expressed in the secretory pathway interfere with cellular PrPSc formation.

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo

Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells.

Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses.

Preparation and Characterization of Cellulose Ether Liposomes for the Inhibition of Prion Formation in Prion-Infected Cells

Prevalence of human T-cell lymphotropic virus infections in Germany.

Prion diseases: from molecular biology to intervention strategies

Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells