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List of works by Ole Isacson

6-[18F]fluoro-L-dopa uptake and [76Br]bromolisuride binding in the excitotoxically lesioned caudate-putamen of nonhuman primates studied using positron emission tomography.

scientific article published in February 1992

A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).

scientific article

A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination.

scientific article

A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons

scientific article

A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease.

scientific article published in August 1998

A novel mode of immunoprotection of neural xenotransplants: masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system

scientific article published on 01 April 1995

A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures

scientific article published in January 1992

A special issue based on the third annual conference of the American Society for Neural Transplantation, 1996.

scientific article published in May 1997

A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene.

scientific article published on 31 July 2006

ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.

scientific article published on December 2008

ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress

scientific article

Advances in stem-cell--generated transplantation therapy for Parkinson's disease

scientific article published on April 2014

Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats.

scientific article published in January 1986

An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease

scientific article

Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines.

scientific article published on January 2002

Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat

scientific article published on 01 March 1987

Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods

scientific article published on December 1, 1992

Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics

scientific article

Behavioral effects and gene delivery in a rat model of Parkinson's disease

scientific article published on 01 August 1995

Being too inclusive about synuclein inclusions

scientific article published on 01 September 2010

Benefits and risks of hosting animal cells in the human brain.

scientific article published on September 1997

Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation.

scientific article

CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells

scientific article

Cell therapy ahead for Parkinson's disease.

scientific article published in November 2009

Cell therapy and stem cells in animal models of motor neuron disorders.

scientific article

Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.

scientific article

Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection

scientific article

Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration

scientific article

Cell-mediated delivery of neurotrophic factors and neuroprotection in the neostriatum and substantia nigra

scientific article published on 01 January 1995

Cellular and molecular treatments of neurological diseases.

scientific article

Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?

scientific article published on 01 January 2000

Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system.

scientific article published in February 1998

Clinical translation of stem cells in neurodegenerative disorders.

scientific article

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

scientific article published on October 1999

Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease.

scientific article published in November 1998

Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brain.

scientific article published in October 2002

Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients.

scientific article published on 17 July 2008

Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--I. Subcortical afferents.

scientific article published in November 1988

Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum—III. Efferent projecting graft neurons and their relation to host afferents within the grafts

scientific article published on 01 January 1989

Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.

scientific article published in March 2005

Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage.

scientific article

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research

scientific article

Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats

scientific article published on 01 November 1994

Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment.

scientific article published in September 1999

Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data.

scientific article published on September 1997

Development of Histocompatible Primate‐Induced Pluripotent Stem Cells for Neural Transplantation ⬇️

scientific article published on July 1, 2011

Developmental changes in brain kynurenic acid concentrations.

scientific article published in July 1992

Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons.

scientific article published in May 1997

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.

scientific article

Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism

scientific article published on March 1, 1992

Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease.

scientific article

Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

scientific article published on March 2009

ES cell-derived neuroepithelial cell cultures

scientific article

Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain.

scientific article

Effects of dopamine-rich grafts on conditioned rotation in rats with unilateral 6-hydroxydopamine lesions

scientific article published in July 1986

Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

scientific article published on 01 September 1994

Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease

scientific article published on 03 April 2008

Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

scientific article

Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation

scientific article published on March 1996

Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum.

scientific article published in January 2001

Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates

scientific article published on 20 April 2008

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

scientific article published on 31 December 2013

Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin.

scientific article published on 12 October 2006

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome.

scientific article published on January 2003

Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task.

scientific article published in November 1991

Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex

scientific article published on 01 September 1995

Failure of the ubiquitin-proteasome system in Parkinson's disease

scientific article

Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum

scientific article published on 12 June 2008

Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: anatomical and neurochemical studies of trophic interactions.

scientific article

Fetal homotypic transplant in the excitotoxically neuron-depleted thalamus: light microscopy

scientific article published on 01 August 1988

Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.

scientific article published on 23 September 2015

Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells.

scientific article published on 03 July 2007

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

scientific article

Functional imaging of the dopamine system: in vivo evaluation of dopamine deficiency and restoration.

scientific article

Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson’s disease ⬇️

scientific article published on 05 May 2011

Gene therapy by proteasome activator, PA28γ, improves motor coordination and proteasome function in Huntington's disease YAC128 mice

scientific article

Gene therapy in the CNS.

scientific article

Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors

scientific article published in October 1999

Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease.

scientific article published on 28 March 2016

Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons.

scientific article

Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation

scientific article published in June 2006

Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection

scientific article

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

scientific journal article

Glutamate receptor binding sites in MPTP-treated mice.

scientific article published in June 1993

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain.

scientific article published on 29 March 2018

Herpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use.

scientific article

Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter

scientific article published on 01 October 1993

High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life.

scientific article

Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease

scientific article

Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system.

scientific article

Immune parameters relevant to neural xenograft survival in the primate brain.

scientific article published in January 2003

Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease.

scientific article published in March 2001

Impact of genomics on drug discovery and clinical medicine.

scientific article published in July 2000

Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

scientific article

Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.

scientific article

Improved surgical cell therapy in Parkinson's disease. Physiological basis and new transplantation methodology.

scientific article

In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants.

scientific article

In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis

scientific article published in January 1986

In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells

scientific article

Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression.

scientific article published on 4 November 2017

Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence.

scientific article

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models

scientific article

Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging.

scientific article

Integrated molecular landscape of Parkinson's disease

scientific article

Intra-nigra infusion of AMPA attenuates dopamine-dependent rotation in the rat.

scientific article published in September 1993

Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease.

scientific article published in January 1987

Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application.

scientific article published on January 1983

Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids ⬇️

scientific article published on January 1, 1991

Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells.

scientific article published in January 1986

Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons

scientific article

Isolation and culture of ventral mesencephalic precursor cells and dopaminergic neurons from rodent brains

scientific article published in December 2009

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

scientific article published on 19 October 2013

Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.

scientific article

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

scientific article published in Scientific Reports

Long-term health of dopaminergic neuron transplants in Parkinson's disease patients.

scientific article

Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation.

scientific article published on 07 June 2005

Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons.

scientific article

Lysosomes to combat Parkinson's disease

scientific article published on 01 June 2015

Magnetic resonance imaging to monitor pathology of caudate-putamen after excitotoxin-induced neuronal loss in the nonhuman primate brain.

scientific article published in October 1992

Mapping dopamine function in primates using pharmacologic magnetic resonance imaging

scientific article published on October 2004

Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model.

scientific article published in October 2003

Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations

scientific article

Medial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts

scientific article published in July 1997

Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts

scientific article published on 01 October 2019

Models of repair mechanisms for future treatment modalities of Parkinson's disease.

scientific article

Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy

scientific article published on January 2009

Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival

scientific article published on April 1985

Morphological alteration of thalamic afferents in the excitotoxically lesioned striatum

scientific article published on 01 October 1988

Morris water maze analysis of 192-IgG-saporin-lesioned rats and porcine cholinergic transplants to the hippocampus.

scientific article published on January 1999

Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95

scientific article published on March 2014

NGF reduces striatal excitotoxic neuronal loss without affecting concurrent neuronal stress.

scientific article published in June 1993

Nerve growth factor receptor immunoreactivity in the rat suprachiasmatic nucleus

scientific article published on 01 January 1989

Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting.

scientific article published in December 1985

Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography

scientific article published in August 1987

Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons.

scientific article published on 18 October 2007

Neural transplantation studies reveal the brain's capacity for continuous reconstruction.

scientific article

Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers.

scientific article published in October 1994

Neurite Collapse and Altered ER Ca Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

scientific article published on 27 December 2018

Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse.

scientific article published in October 2006

Neuroimmunophilin ligand enhances neurite outgrowth and effect of fetal dopamine transplants

scientific article published on 01 January 2000

Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

scientific article published on 27 February 2008

Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

scientific article published in March 2002

Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems

scientific article published in August 1992

Neuronal xenotransplantation in Parkinson's disease

scientific article published on 01 May 1997

Neurotrophic factors NGF and FGF-2 alter levels of huntingtin (IT15) in striatal neuronal cell cultures.

scientific article published in September 2000

Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.

scientific article

Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons

scientific article

Ole Isacson: development of new therapies for Parkinson's disease (interview).

scientific article

On neuronal health ⬇️

scientific article published on August 1, 1993

PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex

scientific article published on March 2009

Parkinson's disease: interpretations of transplantation study are erroneous.

scientific article

Parkinsonian Motor Deficits Are Reflected by Proportional A9/A10 Dopamine Neuron Degeneration in the Rat ⬇️

scientific article published on December 1, 2001

Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease

scientific article published on 22 July 2008

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

scientific article

Pig fetal septal neurons implanted into the hippocampus of aged or cholinergic deafferented rats grow axons and form cross-species synapses in appropriate target regions

scientific article published in January 1999

Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results

scientific article published in March 2000

Presence of Schwann cells in neurodegenerative lesions of the central nervous system

scientific article

Problems and solutions for circuits and synapses in Parkinson's disease.

scientific article

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease

scientific article published on 12 April 2014

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

scientific article

Proteasome activator enhances survival of Huntington's disease neuronal model cells

scientific article

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

scientific article published in August 2002

Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage

scientific article published on September 1985

Recent advances in cell-based therapy for Parkinson disease.

scientific article published on January 2008

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease

scientific article published on 08 November 2019

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

scientific article

Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study.

scientific article

Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease.

scientific article

Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex.

scientific article published in January 1993

Remodelling of intrinsic and afferent systems in neocortex with cortical transplants

scientific article published on 01 January 1990

Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations

scientific article published on 18 January 2007

Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease

scientific article

Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease.

scientific article published on February 1995

Sorting the wheat from the chaff in dopamine neuron-based cell therapies.

scientific article

Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat.

scientific article published in December 1996

Specific microRNAs modulate embryonic stem cell-derived neurogenesis.

scientific article published on 15 December 2005

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

scientific article published on 27 June 2020

Stem cells for Parkinson's disease: advancing science but protecting patients

scientific article published on 02 October 2012

Stem cells may reshape the prospect of Parkinson's disease therapy.

scientific article

Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra

scientific article published on March 1988

Striatal grafts in rats with unilateral neostriatal lesions--III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching

scientific article

Striatal grafts in the ibotenic acid-lesioned neostriatum: functional studies.

scientific article published on January 1988

Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells.

scientific article published on 25 August 2005

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease

scientific article published on 26 February 2015

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons ⬇️

scientific article published on January 19, 1990

Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro

scientific article published in October 1985

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

scientific article

Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation

scientific article published on March 2004

The Threshold Theory for Parkinson's Disease.

scientific article published on 25 November 2016

The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.

scientific article

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

scientific article published on 24 August 2018

The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.

scientific article published on February 2005

The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence.

scientific article published in December 1994

The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting

scientific article

The search for genetic mouse models of prodromal Parkinson's disease.

scientific article published on 14 July 2012

The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons.

scientific article

Therapeutic approaches: session XI summary and research needs

scientific article published on 01 December 2001

Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder.

scientific article published on April 1997

Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells.

scientific article

Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft.

scientific article published on October 2006

Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres.

scientific article published on November 1995

Trophic mechanisms are not enough

scientific article published on 01 July 1989

Using stem cells and iPS cells to discover new treatments for Parkinson's disease

scientific article

Viral and Inflammatory Triggers of Neurodegenerative Diseases ⬇️

scientific article published on February 15, 2012

What are the long-term effects of neural grafting in patients with Huntington's disease?

scientific article published on 01 September 2006

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection.

scientific article published on 29 May 2014

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway

scientific journal article

Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology.

scholarly article by W R Galpern et al published 1996 in Experimental Neurology

hVMAT2: A Target of Individualized Medication for Parkinson's Disease.

scientific article published on 02 May 2016

α-Synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

scientific article

α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

scientific article published on 2 February 2016

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