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List of works by Birger Brodin

5-Hydroxy-L-tryptophan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination

scientific article

A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics.

scientific article

A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)

scientific article

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers.

scientific article published on 27 October 2017

Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs

scientific article published on 13 December 2010

An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.

scientific article published on 17 June 2014

An increase in [Ca2+]i activates basolateral chloride channels and inhibits apical sodium channels in frog skin epithelium.

scientific article published on November 1996

Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

scientific article published on 28 March 2013

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells.

scientific article

Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances

scientific article published on 30 December 2010

Carbonic anhydrase inhibitors: transepithelial transport of thioureido sulfonamide inhibitors of the cancer-associated isozyme IX is dependent on efflux transporters

scientific article published in April 2006

Carrier-mediated γ-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers

scientific article published on 20 March 2012

Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media

scientific article published in March 2005

Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates.

scientific article published on 13 November 2017

Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.

scientific article published in January 2017

Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

scientific article

Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1

scientific article

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

scientific article

Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

scientific article published on 12 January 2018

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

scientific article published on 7 November 2017

Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates.

scientific article

Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1).

scientific article

Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions.

scientific article

Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line.

scientific article

Discovery of ligands for the human intestinal Di-/Tripeptide transporter (hPEPT1) using a QSAR-assisted virtual screening strategy

scientific article published in September 2009

Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

scientific article published on 19 August 2019

Electrophysiological evidence for an ATP-gated ion channel in the principal cells of the frog skin epithelium.

scientific article

Epidermal growth factor and insulin short-term increase hPepT1-mediated glycylsarcosine uptake in Caco-2 cells.

scientific article published on June 2003

Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2.

scientific article published on 14 October 2003

Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line.

scientific article published in July 2001

Evaluating the involvement of cerebral microvascular endothelial Na(+)/K(+)-ATPase and Na(+)-K(+)-2Cl(-) co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration.

scientific article

Evidence for P2Y-type ATP receptors on the serosal membrane of frog skin epithelium

scientific article

Evidence for a Na+/Ca2+ exchange mechanism in frog skin epithelium

scientific article

Function and expression of the proton-coupled amino acid transporter PAT1 along the rat gastrointestinal tract: implications for intestinal absorption of gaboxadol

scientific article published on October 2012

Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes

scientific article published on 01 January 2014

Genetic variants of the human dipeptide transporter PEPT1.

scientific article published on 28 October 2005

Glutamate Transporters in the Blood-Brain Barrier

scientific article published in January 2017

Glutamate efflux at the blood-brain barrier: cellular mechanisms and potential clinical relevance.

scientific article

Human peptide transporters: therapeutic applications

IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies.

scientific article published on 14 December 2015

Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

scientific article published on December 2010

Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1.

scientific article

In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches.

scientific article

In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues

scientific article published on April 2014

In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs.

scientific article published on 24 March 2016

In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

scientific article published on 28 March 2006

In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

scientific article published on 5 March 2012

In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model.

scientific article published in January 2004

In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids.

scientific article published on 4 June 2012

Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo.

scientific article

Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan

scientific article published on 7 July 2009

Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption

scientific article published on January 2004

Intracellular calcium modulates basolateral K(+)-permeability in frog skin epithelium

scientific article published on January 1994

In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use.

scientific article published on 11 February 2016

Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media.

scientific article

PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats

scientific article published on 12 November 2013

Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth

scientific article

Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model.

scientific article published in July 2005

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism.

scientific article published in January 2003

Prostaglandin E2 release from dermis regulates sodium permeability of frog skin epithelium

scientific article published on 01 March 1995

Pyrimidine and nucleoside gamma-esters of L-Glu-Sar: synthesis, stability and interaction with hPEPT1.

scientific article published in May 2005

Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides as Delivery Vectors.

scientific article

Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

scholarly article by G.I. Stafford et al published September 2013 in South African Journal of Botany

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

scientific article published on November 2013

Small transepithelial osmotic gradients affect apical sodium permeability in frog skin

scientific article published on 01 June 1993

Sorption and mobility of ivermectin in different soils.

scientific article published on 23 October 2008

Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

article published in the Proceedings of the National Academy of Sciences of the United States of America

Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier

scientific article published on February 2016

The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

scientific article published on 2 September 2013

The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain

scientific article published on 27 March 2018

The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics

scientific article

Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.

scientific article

Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line

scientific article published on September 2002

Transport of peptidomimetic drugs by the intestinal Di/tri-peptide transporter, PepT1.

scientific article

Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro

article

hPEPT1 affinity and translocation of selected Gln-Sar and Glu-Sar dipeptide derivatives.

scientific article published in May 2005

hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3.

scientific article

miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells

scientific article published on 02 January 2019

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