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List of works by Matthew During

-methyl-d-aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell lines

scientific article published in January 2018

A cautionary note on the potential benefits of striatal dopamine implants

scientific article published in July 1990

A clinical-grade gene therapy vector for pharmacoresistant epilepsy successfully overexpresses NPY in a human neuronal cell line.

scientific article published on 18 December 2017

A novel role of circadian transcription factor DBP in hippocampal plasticity.

scientific article published on 27 October 2005

AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease

scientific article

AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease

scientific article published on May 2004

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats.

scientific article published on February 2005

AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.

scientific article

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

scientific article

ATF3 enhances c-Jun-mediated neurite sprouting

scientific article

Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum.

scientific article published on 3 July 2008

Adeno-associated viral vector-mediated gene transfer results in long-term enzymatic and functional correction in multiple organs of Fabry mice

scholarly article

Adeno-associated virus vectors for gene therapy of neurodegenerative disorders

scientific article

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

scientific article

Adenovirus vector-mediated gene transfer into human epileptogenic brain slices: prospects for gene therapy in epilepsy

scientific article

Adult-onset hippocampal-specific neuropeptide Y overexpression confers mild anxiolytic effect in mice

scientific article published on 24 September 2009

Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy

scientific article published on February 2011

An Immunological Approach to Increase the Brain's Resilience to Insults.

scientific article

An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy

scientific article published on 01 February 2000

Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.

scientific article

Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.

scientific article published in March 2004

Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease

scientific article published in July 2000

Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina

scientific article

Biochemical and behavioral recovery in a rodent model of Parkinson's disease following stereotactic implantation of dopamine-containing liposomes

scientific article published in February 1992

Biodistribution and safety assessment of AAV2-GAD following intrasubthalamic injection in the rat.

scientific article

CREB phosphorylation promotes nerve cell survival

scientific article published on 01 November 1999

Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo

scientific article

Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity

scientific article published on 27 July 2006

Combined injection of rAAV with mannitol enhances gene expression in the rat brain

scientific article

Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice

scientific article published on 19 June 2006

Controlled release of dopamine from a polymeric brain implant: in vitro characterization.

scientific article published in March 1989

Controlled release of dopamine from a polymeric brain implant: in vivo characterization

scientific article published on 01 April 1989

Controlled-release dopamine polymers as a novel approach to the treatment of Parkinson's disease

scientific article published on 01 January 1990

Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis

scientific article

Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice

scientific article

Development and optimization of adeno-associated virus vector transfer into the central nervous system

scientific article

Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice

scientific article published in April 2006

Direct gene transfer into human epileptogenic hippocampal tissue with an adeno-associated virus vector: implications for a gene therapy approach to epilepsy

scientific article published in July 1997

Direct measurement of extracellular lactate in the human hippocampus during spontaneous seizures

scientific article

Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function.

scientific article published in December 2005

Disulfiram facilitates the development and expression of locomotor sensitization to cocaine in rats

scientific article published in November 2003

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

scientific article published on 17 March 2011

Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice

scientific article published in October 2004

Effect of altering titer, serotype, and promoter in recombinant adenoassociate virus gene therapy expression of spinal cord neurons and astrocytes

scientific article published in December 2004

Effect of caffeine on the recognition of and responses to hypoglycemia in humans

scientific article published on 01 October 1993

Effects of dopamine autoreceptor stimulation on the release of colocalized transmitters: in vivo release of dopamine and neurotensin from rat prefrontal cortex.

scientific article

Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates.

scientific article

Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition

scientific article published on July 2010

Environmental enrichment exerts sex-specific effects on emotionality in C57BL/6J mice ⬇️

scientific article published on August 21, 2010

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

scientific article

Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

scientific article

Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival.

scientific article published on 13 January 2014

Extended levodopa release from a subcutaneously implanted polymer matrix in rats

scientific article published on 01 November 1990

FHIT gene therapy prevents tumor development in Fhit-deficient mice.

scholarly article

Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways

scientific article published in February 2007

Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.

scientific article published in June 2001

Functional MRI in NPSLE patients reveals increased parietal and frontal brain activation during a working memory task compared with controls.

scientific article published on 24 November 2007

Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia

scientific article published on January 2015

Gene therapy for Parkinson's disease

scientific article published on 02 March 2004

Gene therapy in epilepsy

scientific article

Gene therapy in epilepsy: the focus on NPY.

scientific article published on 28 December 2006

Gene therapy reduces Parkinson's disease symptoms by reorganizing functional brain connectivity

scientific article published on 01 November 2018

Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease

scientific article

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

scientific article (publication date: September 2003)

Glucose modulates rat substantia nigra GABA release in vivo via ATP-sensitive potassium channels

scientific article

HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity

scientific article published on 8 April 2008

Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP.

scientific article

Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.

scientific article

Homer isoforms differentially regulate cocaine-induced neuroplasticity.

scientific article

Homer proteins regulate sensitivity to cocaine

scientific journal article

Homer2 is necessary for EtOH-induced neuroplasticity.

scientific article published in July 2005

Hypothalamic control of bone formation: distinct actions of leptin and y2 receptor pathways

scientific article

Identification and distribution of aspartoacylase in the postnatal rat brain ⬇️

scientific article published on October 6, 2003

Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain

scientific article

In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector

scientific article published in June 1998

Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis

scientific article published on 21 February 2017

Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation.

scientific article published on 14 May 2015

Interstitial fluid concentrations of glycerol, glucose, and amino acids in human quadricep muscle and adipose tissue. Evidence for significant lipolysis in skeletal muscle

scientific article published on July 1995

Knockdown and overexpression of NR1 modulates NMDA receptor function.

scientific article

Levodopa delivery from controlled-release polymer matrix: delivery of more than 600 days in vitro and 225 days of elevated plasma levels after subcutaneous implantation in rats

scientific article published on 01 November 1990

Local dopamine production in the dorsal striatum restores goal-directed behavior in dopamine-deficient mice

scientific article published in February 2006

Long-term follow-up after gene therapy for canavan disease.

scientific article

Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease

scientific article published on 6 April 2017

Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

scientific article published on October 1994

Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy.

scientific article published on 2 October 2017

Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease

scholarly article

Molecular therapy of obesity and diabetes by a physiological autoregulatory approach

scientific article published on 8 March 2009

Multi-site partitioned delivery of human tyrosine hydroxylase gene with phenotypic recovery in Parkinsonian rats

scientific article published in April 2000

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

scientific article

N-methyl-D-aspartate receptors amplify activation and aggregation of human platelets.

scientific article published on 21 February 2014

NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

scientific article

Network modulation following sham surgery in Parkinson's disease.

scientific article

Neuroactive metabolites of L-tryptophan, serotonin and quinolinic acid, in striatal extracellular fluid. Effect of tryptophan loading

scientific article published in April 1989

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

scientific article

Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight

scientific article

Neuropeptide Y overexpression using recombinant adeno-associated viral vectors.

scientific article published on April 2009

Neuropeptide y attenuates stress-induced bone loss through suppression of noradrenaline circuits

scientific article published in October 2014

Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.

scientific article published on 9 June 2007

Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis

scientific article

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

scientific article published on 17 April 2019

Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

scholarly article

Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid

scientific article

Paradoxical facilitatory effect of low-dose alcohol consumption on memory mediated by NMDA receptors

scientific article published in September 2007

Peroral gene therapy of lactose intolerance using an adeno-associated virus vector

scientific article published in October 1998

Phosphorylation-dependent degradation of transgenic CREB protein initiated by heterodimerization

scientific article published on 13 December 2006

Platelet-Reactive Antibodies in Patients after Ischaemic Stroke-An Epiphenomenon or a Natural Protective Mechanism

scientific article published on 09 November 2020

Potential neurotoxicity of tryptophan

scientific article

Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain

scientific article

Prospects for gene therapy in Parkinson's disease

scientific article published on September 1996

Prospects for gene therapy in pediatric neurosurgery

scientific article

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes.

scientific article published in September 2001

Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development

scientific article published on October 2003

Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion

scientific article published in April 2002

Regression of upper gastric cancer in mice by FHIT gene delivery

scientific article published on 3 July 2003

Regulation of ischemic neuronal death by E2F4-p130 protein complexes

scientific journal article

Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B.

scientific article

Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease.

scientific article

Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.

scientific article

Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo

scientific article published on July 2004

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

scientific article

Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward

scientific article published in February 2006

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

scientific article

Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate.

scientific article published on 14 September 2016

Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats

scholarly article

Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia.

scientific article

Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size

scientific article published on 30 May 2013

Subthalamic GAD gene therapy in a Parkinson's disease rat model

scientific article

Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation.

scientific article

Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism

scientific article published on 12 July 2006

Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain

scientific article published on 21 May 2006

Targets for gene therapy of Parkinson's disease: growth factors, signal transduction, and promoters

scientific article published on March 1997

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

scholarly article

The endocannabinoid system controls key epileptogenic circuits in the hippocampus

scientific article published on August 2006

Transfection of human lactotroph adenoma cells with an adenovirus vector expressing tyrosine hydroxylase decreases prolactin release

scientific article

Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

scientific article published on 4 November 2007

VEGF links hippocampal activity with neurogenesis, learning and memory

scientific journal article

VEGF, a mediator of the effect of experience on hippocampal neurogenesis

scientific article

Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity

scientific article published in October 2007

Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine

scientific article published in August 2003

Viral-based gene transfer to the mammalian CNS for functional genomic studies

scientific article

White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis

scientific article published on September 2011

c-Jun promotes neurite outgrowth and survival in PC12 cells

scientific article published on 01 November 2000

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