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List of works by Marla Gearing

5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity

scientific article published on 09 April 2016

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

scientific article published on 30 October 2011

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease

scientific article published on 14 December 2016

A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia

scientific article

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

scientific article

A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.

scientific article published on 30 November 2017

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

scientific article

AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells

scientific article

Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration ⬇️

scientific article published on November 29, 2011

Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease

scientific article

Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease.

scientific article published in February 1997

Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes

scientific article

Age group differences in positive and negative affect among oldest-old adults: findings from the Georgia Centenarian Study

scientific article

Aggregates of small nuclear ribonucleic acids (snRNAs) in Alzheimer's disease.

scientific article

Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia

scientific article

Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease

scientific article

Alzheimer's disease with and without coexisting Parkinson's disease changes: apolipoprotein E genotype and neuropathologic correlates

scientific article published in November 1995

Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration

scientific article published on November 2012

Amyloid Precursor Protein (APP) in the Striatum in Alzheimerʼs Disease: An Immunohistochemical Study ⬇️

scientific article published on January 1, 1993

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease.

scientific article published in April 2012

Analysis of graft survival in a trial of stem cell transplant in ALS.

scientific article

Apolipoprotein E and age at onset of Alzheimer’s disease in African American patients ⬇️

scientific article published on November 27, 2001

Apolipoprotein E genotype in diverse neurodegenerative disorders ⬇️

scientific article published on 01 July 1995

Apolipoprotein E genotypes in a neuropathological series from the consortium to establish a registry for Alzheimer's disease ⬇️

scientific article published on September 1, 1997

Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.

scientific article published in June 1994

Applicability of digital analysis and imaging technology in neuropathology assessment

scientific article

Asparaginyl endopeptidase cleaves TDP‐43 in brain ⬇️

scientific article published on August 1, 2012

Association between polychlorinated biphenyls and Parkinson's disease neuropathology

scientific article

Astrocyte-apolipoprotein E associations in senile plaques in Alzheimer disease and vascular lesions: a regional immunohistochemical study

scientific article published in April 1997

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Aβ40 is a major form of β-amyloid in nonhuman primates ⬇️

scientific article published on November 1, 1996

Brain infarction and the clinical expression of Alzheimer disease

scientific article

Brain pathologies in extreme old age.

scientific article

C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy

scientific article published on 20 July 2019

CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease

scientific article published on 17 February 2016

Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion

scholarly article

Cerebral Amyloid Angiopathy: Similarity in African-Americans and Caucasians with Alzheimer's Disease

scientific article

Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease

scientific article published in July 1998

Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression

scientific article

Characterization of osteopontin expression and function after status epilepticus

scientific article

Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease

scientific article published in October 2004

Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype

scientific article published in March 1998

Cognitive performance in centenarians and the oldest old: norms from the Georgia Centenarian Study

scientific article

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

scientific article

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

scientific article

Comparative analysis of C9orf72 and sporadic disease in an ALS clinic population

scientific article published on 3 August 2016

Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain ⬇️

scientific article published on May 23, 2012

Comparison of Lewy body variant of Alzheimer's disease with pure Alzheimer's disease: Consortium to Establish a Registry for Alzheimer's Disease, Part XIX.

scientific article published in June 1999

Complications of Gamma Knife Surgery for Parkinson Disease ⬇️

scientific article published on 01 December 2001

Correlates of functional capacity among centenarians.

scientific article published on 19 September 2011

Corticobasal degeneration: neuropathologic and clinical heterogeneity

scientific article published in April 1997

Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease

scientific article published on 19 August 2009

Dendritic spine remodeling accompanies Alzheimer's disease pathology and genetic susceptibility in cognitively normal aging

scientific article published on 21 September 2018

Dendritic spines provide cognitive resilience against Alzheimer's disease

scientific article

Depression among centenarians and the oldest old: contributions of cognition and personality

scientific article

Diffuse plaques in the striatum in Alzheimer disease (AD): relationship to the striatal mosaic and selected neuropeptide markers

scientific article

Distal and proximal resource influences on economic dependency among the oldest old.

scientific article

Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy

scientific article published on 23 December 2020

Effects of Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease

scientific article published on 18 December 2018

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

scientific article

Elevated serum pesticide levels and risk for Alzheimer disease

scientific article

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

scientific article

Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration ⬇️

scientific article published on April 3, 2013

FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy

scientific article

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage

scientific article

Family history and adaptation among centenarians and octogenarians

scientific article

Fas-associated factor 1 and Parkinson's disease

scientific article

Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R

scientific article published on 19 September 2020

Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders

scientific article published on 01 October 2019

Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain

scientific article published in September 2017

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration

scientific article

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

scientific article published on 09 February 2019

Genome-wide association study and functional validation implicates JADE1 in tauopathy

scientific article published on 01 November 2021

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

scientific article published on 16 June 2015

Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer's disease

scientific article published on 28 September 2020

Global quantitative analysis of the human brain proteome in Alzheimer's and Parkinson's Disease.

scientific article

Glycoproteomics in neurodegenerative diseases

scientific article

Head injury does not alter disease progression or neuropathologic outcomes in ALS

scientific article

Hippocampal sclerosis in advanced age: clinical and pathological features.

scientific article

Identification of proteins in human substantia nigra

scientific article published on May 2008

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease

scientific article published in March 2018

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease

scientific article published on 21 October 2020

Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: a study of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

scientific article published in May 1994

Interleukin 9 alterations linked to alzheimer disease in african americans

scientific article published on 22 July 2019

LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease

scientific article published on September 2006

Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

scientific article published on 03 February 2022

Late-stage CTE pathology in a retired soccer player with dementia

scientific article

Life events and personality predicting loneliness among centenarians: findings from the Georgia Centenarian Study.

scientific article

Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS ⬇️

scientific article published on March 19, 2012

Loss of apolipoprotein E receptor LR11 in Alzheimer disease

scientific article

Loss of dopamine phenotype among midbrain neurons in Lesch-Nyhan disease

scientific article published on 20 June 2014

Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients

scientific article published in July 1993

Mortalin: a protein associated with progression of Parkinson disease?

scientific article

Multidimensional predictors of fatigue among octogenarians and centenarians.

scientific article

Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID).

scientific article published on 7 July 2005

NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease ⬇️

scientific article published on May 10, 2013

Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations

scientific article published on 07 October 2020

Neurofibrillary Pathology in Alzheimer Disease With Lewy Bodies

scientific article (publication date: February 1999)

Neurofibrillary Tangles and Conversion to Mild Cognitive Impairment with Certain Antihypertensives

scientific article published on 01 January 2019

Neurofibrillary pathology in Alzheimer disease with Lewy bodies: two subgroups

scientific article (publication date: February 1999)

Neuron enriched nuclear proteome isolated from human brain.

scientific article published on 17 June 2013

Neuronal LR11/sorLA expression is reduced in mild cognitive impairment

scientific article published on December 2007

Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.

scientific article

Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease

scientific article published on 16 July 2005

Neuropathologic assessment of Alzheimer's disease ⬇️

scientific article published on September 1, 1997

Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis

scientific article

Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease

scientific article (publication date: 27 September 1994)

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

scientific article

Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

scientific article

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

scientific article

PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain

scientific article

Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration ⬇️

scientific article published on October 22, 2010

Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry

scientific article published on 30 May 2008

Plasma testosterone levels in Alzheimer and Parkinson diseases

scientific article published in February 2004

Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease

scientific article

Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease

scientific article

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

scientific article

Predicting happiness among centenarians

scientific article

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study

scientific article published on 05 August 2021

Primary age-related tauopathy (PART): a common pathology associated with human aging

scientific article

Progression of regional neuropathology in Alzheimer disease and normal elderly: findings from the Nun study

scientific article published in October 1999

Progressive supranuclear palsy: neuropathologic and clinical heterogeneity

scientific article

Proteomic analysis of hippocampal dentate granule cells in frontotemporal lobar degeneration: application of laser capture technology.

scientific article

Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection

scientific article published on 25 June 2004

Proteomic identification of novel proteins associated with Lewy bodies

scientific article published on May 2008

Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease

scientific article

Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometer

scientific article

Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease

scientific article published on 01 October 2018

Quantitative Analysis of the Detergent-Insoluble Brain Proteome in Frontotemporal Lobar Degeneration Using SILAC Internal Standards ⬇️

scientific article published on April 4, 2012

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins.

scientific article

RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells

scientific article published on 11 January 2013

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease

scientific article published on 25 May 2018

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

scientific article

Reader response: Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS

scientific article published on 01 September 2018

Regional Variation in the Distribution of Apolipoprotein E and Aβ in Alzheimerʼs Disease ⬇️

scientific article published on 01 November 1995

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

scientific article

Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study

scientific article published on 09 June 2013

Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production ⬇️

scientific article published on December 8, 2010

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration

scientific article published on January 2016

Social resources and longevity: findings from the Georgia centenarian study

scientific article

Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID) ⬇️

scientific article published on July 27, 2011

Successful Recruitment of Centenarians for Post-Mortem Brain Donation: Results from the Georgia Centenarian Study

scientific article published on January 2012

TBK1 interacts with tau and enhances neurodegeneration in tauopathy

scientific article published on 01 January 2021

TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration

scientific article published on 11 September 2019

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD.

scientific article published on 8 January 2018

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

scientific article published on 19 January 2014

Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease

scientific article published on 18 March 2021

Tau deposition in the spinal cord is not specific for CTE-ALS

scientific article published on 02 June 2020

Tau pathology in a family with dementia and a P301L mutation in tau.

scientific article published on April 1999

Tauopathy with paired helical filaments in an aged chimpanzee

scientific article published on July 2008

The CERAD experience, Part VIII: Neuroimaging-neuropathology correlates of temporal lobe changes in Alzheimer's disease

scientific article

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease

scientific article

The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.

scientific article published on 12 July 2018

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

scientific journal article

The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease ⬇️

scientific article published on October 1, 2010

The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series

scientific article published on December 1999

Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities

scientific article

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

scientific article published on 10 September 2013

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.

scientific article

Ubiquitin-positive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies ⬇️

scientific article published on 01 September 1995

Understanding dementia prevalence among centenarians.

scientific article published in March 2012

Validation of machine learning models to detect amyloid pathologies across institutions

scientific article published on 28 April 2020

Viscoelastic Properties of Human Autopsy Brain Tissues as Biomarkers for Alzheimer's Diseases

scientific article published on 29 October 2018

alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases

scientific article

alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease

scientific article

β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans ⬇️

scientific article published on March 1, 1997

β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease ⬇️

scientific article published on May 17, 2011

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