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List of works by Jürgen Winkler

A Single Bout of Aerobic Exercise Improves Motor Skill Consolidation in Parkinson's Disease

scientific article published on 22 October 2018

A monocyte gene expression signature in the early clinical course of Parkinson's disease

scientific article published in Scientific Reports

A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice

scientific article published on 29 September 2020

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease

scholarly article by Silke Nuber et al published 10 October 2018 in Neuron

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo ⬇️

scientific article published on 24 March 2014

Acetylcholine-secreting cells improve age-induced memory deficits

scientific article published on July 2003

Acute exercise following skill practice promotes motor memory consolidation in parkinson's disease

scientific article published on 20 December 2020

Adult neural precursor cells unaffected in animal models of DYT1 dystonia

scientific article published in November 2009

Adult neurogenesis in Parkinson's disease

scientific article published on 06 July 2012

Adult neurogenesis in neurodegenerative diseases.

scientific article published on April 2015

Alpha-synuclein activates BV2 microglia dependent on its aggregation state

scientific article published on 22 September 2016

Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress

scientific article published on 22 February 2017

Altered activation patterns within the olfactory network in Parkinson's disease

scientific article

An autosomal recessive limb girdle muscular dystrophy (LGMD2) with mild mental retardation is allelic to Walker-Warburg syndrome (WWS) caused by a mutation in the POMT1 gene

scientific article

Assessment of gait parameters and physical function in patients with advanced cancer participating in a 12-week exercise and nutrition programme: A controlled clinical trial

scientific article published on 12 December 2019

Author Correction: A monocyte gene expression signature in the early clinical course of Parkinson's disease

scientific article published on 07 April 2020

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.

scientific article published on 4 December 2017

Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes

scientific article published on 11 April 2019

Biometric and mobile gait analysis for early diagnosis and therapy monitoring in Parkinson's disease

scientific article published in January 2011

Caspase inhibition decreases cell death in regions of adult neurogenesis.

scientific article published in August 2005

Cellular repair strategies in Parkinson's disease

scientific article published on January 2009

Cerebral ischemia and neurogenesis: a two-time comparison

scientific article published in January 2008

Changes in Gastrointestinal Microbiome Composition in PD: A Pivotal Role of Covariates

scientific article published on 23 September 2020

Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein

scientific article

Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System

scientific article published on 01 March 2020

Clinical Relevance of Standardized Mobile Gait Tests. Reliability Analysis Between Gait Recordings at Hospital and Home in Parkinson's Disease: A Pilot Study

scientific article published on 17 August 2020

Clinical and genetic characteristics of late-onset Huntington's disease

scientific article

Combined analysis of sensor data from hand and gait motor function improves automatic recognition of Parkinson's disease

scientific article

Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease

scientific article published on 10 September 2020

Correction to: Gait variability as digital biomarker of disease severity in Huntington's disease

scientific article published on 27 March 2020

Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy

scientific article published on 16 April 2020

DCX-Related Disorders

scientific article published on 7 February 2019

Decreased neurogenesis after cholinergic forebrain lesion in the adult rat.

scientific article published on July 2004

Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia

scientific article

Different clinical and morphological phenotypes in monozygotic twins with identical DCX mutation

scientific article published in January 2004

Differentiation of atypical Parkinson syndromes.

scientific article published on 27 February 2017

Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor

scientific article published on 01 July 2004

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.

scientific article published on 06 October 2015

Distinct Effects of Chronic Dopaminergic Stimulation on Hippocampal Neurogenesis and Striatal Doublecortin Expression in Adult Mice

Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies.

scientific article published on 19 March 2017

Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model

scientific journal article

Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration.

scientific article published in February 2008

Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein

scientific article published on 9 October 2015

Doublecortin expression levels in adult brain reflect neurogenesis

scientific article

Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter

scientific article published on 15 December 2017

Dynamic footprints of α-synucleinopathic mice recorded by CatWalk gait analysis.

scientific article published on 3 January 2018

Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia

scientific journal article

Early Degeneration of Both Dopaminergic and Serotonergic Axons - A Common Mechanism in Parkinson's Disease.

scientific article published on 22 December 2016

Early detection of Parkinson's disease: unmet needs

scientific article published on 06 March 2008

Enhanced dendritogenesis and axogenesis in hippocampal neuroblasts of LRRK2 knockout mice

scientific article published on 25 December 2012

Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

scientific article

Exploring gait adaptations to perturbed and conventional treadmill training in Parkinson’s disease: Time-course, sustainability, and transfer

scholarly article by Simon Steib et al published April 2019 in Human Movement Science

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose

scientific article published in Scientific Reports

Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis

scientific article published on 07 September 2020

Familial West syndrome and dystonia caused by an Aristaless related homeobox gene mutation

scientific article published on 22 February 2005

Fingolimod effects in neuroinflammation: Regulation of astroglial glutamate transporters?

scientific article

Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model

scientific article published on January 2012

GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model

scientific article published on 11 March 2016

Gait and Cognition in Parkinson's Disease: Cognitive Impairment Is Inadequately Reflected by Gait Performance during Dual Task

scientific article published on 26 October 2017

Gait variability as digital biomarker of disease severity in Huntington's disease

scientific article published on 11 February 2020

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons

scientific article published on 30 December 2013

Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice

scientific article

Granulocyte colony-stimulating factor does not promote neurogenesis after experimental intracerebral haemorrhage.

scientific article published on 19 December 2013

High-resolution diffusion tensor-imaging indicates asymmetric microstructural disorganization within substantia nigra in early Parkinson's disease

scientific article published on 20 January 2018

High-throughput homogeneous mass cleave assay technology for the diagnosis of autosomal recessive Parkinson's disease

scientific article

Hippocampal structure and function are maintained despite severe innate peripheral inflammation

scientific article published on 12 June 2015

Human SPG11 cerebral organoids reveal cortical neurogenesis impairment

scientific article published on 01 March 2019

Human Wild-Type α-Synuclein Impairs Neurogenesis

article

Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease

scientific article published on 12 May 2014

Identification of a heterozygous genomic deletion in the spatacsin gene in SPG11 patients using high-resolution comparative genomic hybridization.

scientific article

Immediate effects of perturbation treadmill training on gait and postural control in patients with Parkinson's disease.

scientific article published on 26 August 2016

Impaired adult neurogenesis in mice lacking the transcription factor E2F1.

scientific article published in October 2002

Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease.

scientific article

Increase of Reproductive Life Span Delays Age of Onset of Parkinson's Disease.

scientific article published on 21 August 2017

Increased generation of granule cells in adult Bcl-2-overexpressing mice: a role for cell death during continued hippocampal neurogenesis.

scientific article published in October 2005

Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy

scientific article published on 30 November 2011

Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson's disease

scientific article published on 01 January 2014

Inertial sensor-based estimation of peak accelerations during heel-strike and loading as markers of impaired gait patterns in PD patients

Instrumented gait analysis: a measure of gait improvement by a wheeled walker in hospitalized geriatric patients.

scientific article published on 27 February 2017

Interindividual Balance Adaptations in Response to Perturbation Treadmill Training in Persons With Parkinson Disease

scientific article published on 01 October 2019

Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells

scientific article published on 11 July 2014

Intracerebroventricular administration of nerve growth factor induces gliogenesis in sensory ganglia, dorsal root, and within the dorsal root entry zone

scientific article published on 16 March 2014

Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration

scientific article published on 01 May 2020

Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T α-synuclein-expressing mice

scientific article published on 01 April 2019

Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells

scientific article (publication date: 2011)

Long-term course of anterior spinal cord herniation presenting with an upper motor neuron syndrome: case report illustrating diagnostic and therapeutic implications

scientific article published on 29 August 2020

Long-term survival and cell death of newly generated neurons in the adult rat olfactory bulb

scientific article published in November 2002

MaD GUI: An Open-Source Python Package for Annotation and Analysis of Time-Series Data

scientific article published in 2022

Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile

scientific article published on 01 May 2018

Mnemonic deficits in animals depend upon the degree of cholinergic deficit and task complexity

scientific article

Mobilisation of hematopoietic CD34+ precursor cells in patients with acute stroke is safe--results of an open-labeled non randomized phase I/II trial

scientific article

Model Testing of PluriTest with Next-Generation Sequencing Data

scientific article

Modulation of sensory inputs and ectopic presence of Schwann cells depend upon the route and duration of nerve growth factor administration

scientific article published on November 2002

Motor output complexity in Parkinson's disease during quiet standing and walking: Analysis of short-term correlations using the entropic half-life

scientific article published on 16 February 2018

Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis

scientific article

Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium

scientific article published in Scientific Reports

Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.

scientific article published in March 2008

Neuronal precursor-specific activity of a human doublecortin regulatory sequence

scientific article published in January 2005

New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications.

scientific article

Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.

scientific article published on 2 March 2018

Novel Biallelic CTSD Gene Variants Cause Late-Onset Ataxia and Retinitis Pigmentosa

scientific article published on 18 May 2020

Novel POMGnT1 mutations define broader phenotypic spectrum of muscle-eye-brain disease

scientific article published on 29 September 2007

Objective sensor-based gait measures reflect motor impairment in multiple sclerosis patients: Reliability and clinical validation of a wearable sensor device

scientific article published on 23 December 2019

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

scientific article published on 13 May 2015

Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy

scientific article published on 31 January 2019

Oxidative stress-induced posttranslational modifications of alpha-synuclein: specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity.

scientific article published on 28 January 2013

Paradoxical kinesia in Parkinson's disease revisited: Anticipation of temporal constraints is critical

scientific article published on 14 April 2016

Parkinson's disease risk score: moving to a premotor diagnosis

scientific article published on May 2011

Paternal inheritance of classic X-linked bilateral periventricular nodular heterotopia

scientific article published on 01 May 2013

Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors

scientific article published on 26 August 2015

Perturbation During Treadmill Training Improves Dynamic Balance and Gait in Parkinson's Disease: A Single-Blind Randomized Controlled Pilot Trial.

scientific article

Perturbation Treadmill Training Improves Clinical Characteristics of Gait and Balance in Parkinson's Disease

scientific article published on 01 January 2019

Physical activity fails to rescue hippocampal neurogenesis deficits in the R6/2 mouse model of Huntington's disease

scientific article published on 21 April 2007

Polyhydroxyphenylvalerate/polycaprolactone nanofibers improve the life-span and mechanoresponse of human IPSC-derived cortical neuronal cells

scientific article published on 12 March 2020

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity

scientific article published on 11 March 2015

Prognostic factors in ALS: a comparison between Germany and China

scientific article published on 28 March 2019

Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate

scientific article published in February 2009

Publisher Correction: Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning.

scientific article

Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy

scientific article published on 14 April 2020

Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts

scientific article

Role of the receptor Mas in macrophage-mediated inflammation in vivo.

scientific article

Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus

scientific article

Sensor-based gait analysis of individualized improvement during apomorphine titration in Parkinson’s disease

scientific article published on 08 September 2018

Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease

scientific article published on 23 July 2015

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease

scientific article

Sevoflurane affects neurogenesis after forebrain ischemia in rats

scientific article published in April 2007

Silhouette-Length-Scaled Gait Parameters for Motor Functional Analysis in Mice and Rats

scientific article published on 01 November 2019

Sporadic Parkinson's disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs.

scientific article published on 10 July 2018

Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease

scientific article published on July 2010

Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb

scientific article published on 24 October 2005

Stride segmentation during free walk movements using multi-dimensional subsequence dynamic time warping on inertial sensor data

scientific article

Subsequence dynamic time warping as a method for robust step segmentation using gyroscope signals of daily life activities.

scientific article published in January 2013

Systematic data analysis and data mining in CatWalk gait analysis by heat mapping exemplified in rodent models for neurodegenerative diseases

scientific article published on 24 July 2019

Temporal and spatial dynamics of brain structure changes during extensive learning.

scientific article

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease

scientific article published on 01 July 2018

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease

scientific article published on 01 June 2019

The Joint-Brain Axis: Insights From Rheumatoid Arthritis on the Crosstalk Between Chronic Peripheral Inflammation and the Brain

scientific article published on 10 December 2020

The Use of Digital Technology and Media in German Parkinson's Disease Patients

scientific article published on 01 January 2020

The innate immune system in Parkinson's disease: a novel target promoting endogenous neuroregeneration.

scientific article published on May 2015

The temporal expression pattern of alpha-synuclein modulates olfactory neurogenesis in transgenic mice

scientific article published on 11 May 2015

Thin corpus callosum and amyotrophy in spastic paraplegia--case report and review of literature

scientific article

Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons

scientific article published on 06 December 2018

Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease

scientific article published on 19 May 2011

Transforming growth factor-beta1 is a negative modulator of adult neurogenesis

scientific article

Transient expression of doublecortin during adult neurogenesis

scientific article (publication date: December 2003)

Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation

scientific article published in 2022

Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy

scientific article published on 30 December 2018

VCP-related multisystem proteinopathy presenting as early-onset Parkinson disease

scientific article

Wearable sensor-based objective assessment of motor symptoms in Parkinson's disease.

scientific article published on 08 August 2015

Wearable sensors objectively measure gait parameters in Parkinson's disease

scientific article published on 11 October 2017

Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification

scientific article published on 19 November 2018

[Genetic testing for Parkinson's disease: indication and practical implementation]

scientific article published on 28 June 2020

alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination

scientific article published on 23 March 2020

α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses.

scientific article published on 26 August 2016

α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy

scientific article

α-Synuclein in Parkinson's disease: causal or bystander?

scientific article published on 25 June 2019

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

article published in the Proceedings of the National Academy of Sciences of the United States of America

α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy

scientific article published on 08 April 2016

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