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List of works by Jason S. McLellan

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

scientific article published on 05 October 2021

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article (publication date: 2015)

A high-throughput inhibition assay to study MERS-CoV antibody interactions using image cytometry

scientific article published on 20 November 2018

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.

scientific article published on May 2017

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

scientific article

A proof of concept for structure-based vaccine design targeting RSV in humans

scientific article published on 01 August 2019

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

scientific article

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity

scientific article published on 19 April 2021

Alternative conformations of a major antigenic site on RSV F

scientific article published on 15 July 2019

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

scientific article published on 17 November 2020

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

scientific article published on 23 September 2020

Broad neutralization of SARS-related viruses by human monoclonal antibodies

scientific article published on 15 June 2020

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

scientific article published on 16 May 2020

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

scientific article published on 10 July 2015

Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus

scientific article published on 08 May 2020

Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses

scientific article published on 7 December 2017

Clinical Potential of Prefusion RSV F-specific Antibodies.

scientific article

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

scientific article

Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures

scientific article published on 08 July 2020

Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures

scientific article published on 29 September 2020

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

scientific article published on 29 November 2017

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

scientific article published on 20 December 2020

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

scientific article published on 16 February 2020

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

scientific article published on 19 February 2020 in Science

Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition

scientific article published on 27 April 2022

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

scientific article published on 11 December 2019

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

scientific article

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

scientific article

Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus

scientific article published on 26 September 2017

Data publication with the structural biology data grid supports live analysis

scientific article

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

scientific article

Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab

scientific article

Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses

scientific article published on 20 November 2019

Early cross-coronavirus reactive signatures of humoral immunity against COVID-19

scientific article published on 15 October 2021

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

scientific article

Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation.

scientific article

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.

scientific article

Five Residues in the Apical Loop of the Respiratory Syncytial Virus Fusion Protein F2 Subunit are Critical for its Fusion Activity.

scientific article

Global site-specific analysis of glycoprotein N-glycan processing.

scientific article published on 3 May 2018

HCMV glycoprotein B nucleoside-modified mRNA vaccine elicits antibody responses with greater durability and breadth than MF59-adjuvanted gB protein immunization

scientific article published on 12 February 2020

Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4.

scientific article

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

scientific article published on 14 August 2017

Immunogenicity of a DNA vaccine candidate for COVID-19

scientific article published on 20 May 2020

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

scientific article published on 7 March 2018

Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.

scientific article published on 24 May 2017

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

scientific article

Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation

scientific article published on 20 January 2018

Infection with MERS-CoV causes lethal pneumonia in the common marmoset

scientific article published in August 2014

Iterative screen optimization maximizes the efficiency of macromolecular crystallization

scientific article published on 24 January 2019

Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway

scientific article

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

scientific article published on 01 October 2020

Local computational methods to improve the interpretability and analysis of cryo-EM maps

scientific article published on 13 May 2020

Molecular Architecture of Early Dissemination and Evolution of the SARS-CoV-2 Virus in Metropolitan Houston, Texas

scientific article published on 02 May 2020

Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

scientific article published on 29 September 2020

Molecular mechanism of respiratory syncytial virus fusion inhibitors ⬇️

scientific article published on 7 December 2015

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

scientific article

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex.

scientific article published on 11 January 2017

Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein.

scientific article published on 26 March 2015

Novel antigens for RSV vaccines

scientific article

Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.

scientific article published on 31 August 2016

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

scientific article published on 13 February 2017

Pre-fusion structure of a human coronavirus spike protein.

scientific article

Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

scientific article

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma

scientific article published on 21 December 2020

Publisher Correction: Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

scientific article published in Scientific Reports

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine.

scientific article published on 20 August 2016

Rapid development of a synthetic DNA vaccine for COVID-19

article

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

scientific article published on 09 December 2016

Receptor binding and proteolysis do not induce large conformational changes in the SARS-CoV spike

scientific article published on 31 March 2018

Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step

scientific article published on 03 August 2020

Respiratory syncytial virus entry and how to block it

scientific article published on 01 April 2019

Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.

scientific article

SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma

scientific article published on 28 December 2020

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

scientific article published on 11 June 2020

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

scientific article published on 05 August 2020

Site-specific analysis of the SARS-CoV-2 glycan shield

scientific article (preprint)

Site-specific glycan analysis of the SARS-CoV-2 spike

scientific article

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

scientific article published on 22 July 2020

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

scientific article published in Scientific Reports

Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle

scientific article

Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate

scientific article

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

scientific article published on 29 April 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

scientific article published on 01 June 2020

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

scientific article (preprint)

Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

scientific article published on 01 September 2019

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

scientific article (publication date: November 2014)

Structural and molecular basis for Ebola virus neutralization by protective human antibodies

scientific article

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

scientific article

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.

scientific article published on 6 March 2018

Structural basis of respiratory syncytial virus neutralization by motavizumab

scientific article

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.

scientific article published on 30 November 2017

Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development

scientific article published on 27 September 2016

Structure and Characterization of Crimean-Congo Hemorrhagic Fever Virus GP38

scientific article published on 31 March 2020

Structure and function of respiratory syncytial virus surface glycoproteins.

scientific article

Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein.

scientific article published on 16 November 2017

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

scientific article

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

scientific article

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

scientific article

Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

scientific article published in December 2010

Structure of a heparin-dependent complex of Hedgehog and Ihog

scholarly article

Structure of the Respiratory Syncytial Virus Polymerase Complex

scientific article published on 05 September 2019

Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development

scientific article published on 11 June 2020

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers

scientific article published on 01 March 2020

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article

Structure-Based Vaccine Antigen Design

scientific article published on 01 January 2019

Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes

scientific article published on 30 May 2020

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

scientific article

Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants

scientific article published on 08 September 2020

Synthesis of 2,6-dideoxysugars via ring-closing olefinic metathesis

scientific article published on 01 October 2002

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.

scientific article published on 30 June 2013

The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation

scientific article published on 13 November 2019

The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes

scientific article published in 2022

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

scientific article

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

scientific article

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

scholarly article by Natalie I Mazur et al published October 2018 in Lancet Infectious Diseases

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

scientific article

Transient opening of trimeric prefusion RSV F proteins

scientific article published on 08 May 2019

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses

scientific article

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

scientific article

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

scientific article (preprint)

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

scientific article published on 27 May 2020

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