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List of works by Don M Gash

A procedure for small-volume brain grafting; vasopressin cells in neonatal and adult Brattleboro rats

scientific article published in May 1984

A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function ⬇️

scientific article published on September 13, 2012

Adrenal chromaffin cells as transplants in animal models of Parkinson's disease

scientific article published on August 1989

Adrenal medullary autografts into the basal ganglia of Cebus monkeys: graft viability and fine structure

scientific article

Adrenal medullary autografts into the basal ganglia of Cebus monkeys: injury-induced regeneration.

scientific article published on October 1988

Adrenal medullary tissue grafting in Parkinson's disease

scientific article published on 01 July 1988

Age-associated changes in rhesus CNS composition identified by MRI.

scientific article

Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey

scientific article published on 01 November 1995

Age-related decline in striatal dopamine release and motoric function in Brown Norway/Fischer 344 hybrid rats ⬇️

scientific article published on April 27, 1998

Amitotic neuroblastoma cells used for neural implants in monkeys

scientific article

Amperometric measures of age-related changes in glutamate regulation in the cortex of rhesus monkeys

scientific article published on 22 August 2007

An automated movement assessment panel for upper limb motor functions in rhesus monkeys and humans

scientific article published in July 1999

An in vivo and in vitro assessment of differentiated neuroblastoma cells as a source of donor tissue for transplantation

scientific article published in January 1987

Animal models of age- and disease-related cognitive decline: perspectives on the models and therapeutic strategies

scientific article published on September 1988

Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease

scientific article

Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques

scientific article published in September 2006

Automated segmentation of multispectral brain MR images

scientific article published in December 2002

Automated video analysis of age-related motor deficits in monkeys using EthoVision

scientific article published on 29 September 2005

Behavioral characteristics of vasopressin-deficient rats (Brattleboro strain).

scientific article published in January 1981

Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats

scientific article published on 28 November 2005

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

scientific article

Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys

scientific article

Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism ⬇️

scientific article published on January 1, 2001

Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys

scientific article published on October 2002

Cografts of adrenal medulla with C6 glioma cells in rats with 6-hydroxydopamine-induced lesions.

scientific article published in January 1990

Comparison of adrenal medullary, carotid body and PC12 cell grafts in 6-OHDA lesioned rats

scientific article

Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: a preclinical safety study

scientific article published on 27 May 2016

Continuous intraputamenal convection-enhanced delivery in adult rhesus macaques

scientific article

Correlation of R2 with total iron concentration in the brains of rhesus monkeys.

scientific article published in February 2005

Critical decline in fine motor hand movements in human aging

scientific article published on 01 October 1999

Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in a nonhuman primate model of aging

scientific article published on 28 January 2015

Developing a stable bilateral model of parkinsonism in rhesus monkeys

scientific article published on 01 January 1993

Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkeys

scientific article published on 3 May 2008

Differentiation characteristics of human neuroblastoma cells in the presence of growth modulators and antimitotic drugs

scientific article

Dopamine neuron stimulating actions of a GDNF propeptide

scientific article (publication date: 18 March 2010)

Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys

scientific article published on 01 August 2000

Dose response to intraventricular glial cell line-derived neurotrophic factor administration in parkinsonian monkeys ⬇️

scientific article published on September 1, 1997

Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro

scientific article published on 07 January 2014

Effect of MPTP on primate chromaffin cells in vitro: relevance for adrenal medullary cell transplantation ⬇️

scientific article published on 01 January 1991

Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys

scientific article published on September 2002

Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence.

scientific article published on 19 April 2011

Fenbendazole treatment may influence lipopolysaccharide effects in rat brain.

scientific article published in October 2007

Fetal hypothalamic transplants promote survival and functional regeneration of axotomized adult supraoptic magnocellular neurons

scientific article published on 01 March 1989

Flow cytometric analyses and sorting of neural cells for transplantation

scientific article

Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys

scientific article published in January 2000

Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys

scientific article published in July 1999

Functional MRI studies in awake rhesus monkeys: methodological and analytical strategies

scientific article published in August 2002

Functional recovery in parkinsonian monkeys treated with GDNF

scientific article

GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop

scientific article published on 03 June 2020

GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys

scientific article published on January 1999

GDNF in treatment of Parkinson's disease: response to editorial

scientific article

GDNF revisited: A novel mammalian cell-derived variant form of GDNF increases dopamine turnover and improves brain biodistribution

scientific article published on 29 May 2018

Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinson's disease

scientific article published on November 1998

Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys.

scientific article published on March 2003

Glial cell line-derived neurotrophic factor-levodopa interactions and reduction of side effects in parkinsonian monkeys

scientific article published on August 1997

Glial cell line-derived neurotrophic factor: a novel therapeutic approach to treat motor dysfunction in Parkinson's disease

scientific article published on March 1997

Globus pallidus plays a critical role in neurotrophic factor induced functional improvements in hemiparkinsonian monkeys

scientific article published on 31 March 2008

Human organ donor adrenals: fine structure, plasticity and viability

scientific article

Immunohistochemical analysis of vasopressin neurons transplanted into the Brattleboro rat.

scientific article

Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor

scientific article (publication date: February 2005)

In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys

scientific article published in February 1996

Increased dopamine clearance in the non-lesioned striatum of rhesus monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) striatal lesions

scientific article published on 01 February 1995

Increased susceptibility to MPTP toxicity in middle-aged rhesus monkeys

scientific article published on 01 November 1995

Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases.

scientific article published on January 2003

Intraocular retinal transplants

scientific article published on 01 August 1985

Intraputamenal infusion of GDNF in aged rhesus monkeys: Distribution and dopaminergic effects ⬇️

scientific article published on June 23, 2003

Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys

scientific article published on January 2008

Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys

scientific article published on 26 January 2006

Lesions of parvocellular subdivisions of the hypothalamic paraventricular nucleus alter open field behavior and acquisition of sensory and spatial discrimination

scientific article published in June 1991

MPTP-Induced pallidal lesions in rhesus monkeys

scientific article

Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI

scientific article published on 01 January 1996

Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease

scientific article published on 18 May 2015

Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques

scientific article published on 31 March 2018

Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys

scientific article

Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging

scientific article published in October 2000

NGF-like trophic support from peripheral nerve for grafted rhesus adrenal chromaffin cells

scientific article published in September 1990

Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients

scientific article

Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): distribution, morphology, and colocalization with cholinergic enzymes

scientific article

Neural transplantation: a review of recent developments and potential applications to the aged brain

scientific article

Neuroblastoma cells in neural transplants: a neuroanatomical and behavioral analysis

scientific article published in August 1987

Neuron-based heredity and human evolution

scientific article

Neuroprotective and neurorestorative properties of GDNF ⬇️

scientific article published on September 1, 1998

Neuroprotective effects of GDNF against 6-OHDA in young and aged rats

scientific article published on March 2001

Neurotoxicity of MPTP and MPP+ in vitro: characterization using specific cell lines.

scientific article published in July 1988

Neurotrophic factors and Parkinson's disease

scientific article published on 01 January 2007

Norepinephrine deficiency and behavioral senescence in aged rats. Transplanted locus ceruleus neurons as an experimental replacement therapy

scientific article published in January 1987

Objectively measuring effects of electro-acupuncture in parkinsonian rhesus monkeys.

scientific article published on 7 October 2017

Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA.

scientific article

Oral levodopa dose-response study in MPTP-induced hemiparkinsonian monkeys: assessment with a new rating scale for monkey parkinsonism

scientific article

Organization, fine structure, and viability of the human adrenal medulla: considerations for neural transplantation

scientific article published on 01 November 1988

Paraneuronal grafts in unilateral 6-hydroxydopamine-lesioned rats: morphological aspects of adrenal chromaffin and carotid body glomus cell implants

scientific article published in January 1988

Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease

scientific article

Pharmacologic MRI (phMRI) as a tool to differentiate Parkinson's disease-related from age-related changes in basal ganglia function

scientific article published on 16 October 2014

Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys

scientific article published on January 2008

Pharmacological activities of glial cell line-derived neurotrophic factor (GDNF): preclinical development and application to the treatment of Parkinson's disease

scientific article published on June 1997

Point source concentration of GDNF may explain failure of phase II clinical trial

scientific article published on 7 September 2006

Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor

scientific article

Reply: GDNF poses troubling questions for doctors, drug maker

scientific article published on 01 June 2006

Research on Parkinson disease

scholarly article by John T Slevin et al published 1 February 2005 in Journal of Neurosurgery

Retinal transplants into adult eyes affected by phototoxic retinopathy

scientific article

Role of social interaction, exercise, diet, and age on developing and untreated diabetes in cynomolgus monkeys

scientific article published on 15 June 2017

Selective cell death of magnocellular vasopressin neurons in neurohypophysectomized rats following chronic administration of vasopressin.

scientific article published in August 1987

Specificity of circadian function in transplants of the fetal suprachiasmatic nucleus

scientific article published on 01 August 1989

Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra

scientific article published on July 2004

Striatal adrenal medulla/sural nerve cografts in hemiparkinsonian monkeys

scientific article published on January 1990

Striatal neuroinflammation promotes Parkinsonism in rats

scientific article

Structural and functional relationships of grafted vasopressin neurons

scientific article published in April 1986

Surgical methodology and protocols for preventing implanted cerebral catheters from becoming obstructed during and after neurosurgery

scientific article published on 04 December 2020

Telencephalic cholinergic system of the New World monkey (Cebus apella): morphological and cytoarchitectonic assessment and analysis of the projection to the amygdala

scientific article published on January 1989

The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys ⬇️

scientific article published on November 1, 1991

Topographical distribution of [125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned rhesus monkey brain following a bolus intraventricular injection

scientific article published on April 1998

Transplantation of norepinephrine neurons into aged rats improves performance of a learned task ⬇️

scientific article published on May 10, 1988

Transplanted vasopressin neurones and central nervous system effects of vasopressin

scientific article published in January 1983

Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats

scientific article published on 17 November 2009

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity

scientific article published in February 2008

Trophic factor distribution predicts functional recovery in parkinsonian monkeys

scientific article

Tyrosine hydroxylase-immunoreactive somata within the primate subfornical organ: species specificity

scientific article published on 01 October 1988

Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal

scientific article published on April 2007

Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal

scholarly article by John T Slevin et al published 15 May 2006 in Neurosurgical Focus

Validation studies of the human movement analysis panel for hand/arm performance

scientific article

Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques

Vasopressin administration prevents functional recovery of the vasopressinergic neurosecretory system following neurohypophysectomy

scientific article published in December 1986

Vasopressin in reaggregated cell cultures of the developing hypothalamus

scientific article published on 01 March 1984

Vasopressin neuron survival in neonatal Brattleboro rats; critical factors in graft development and innervation of the host brain

scientific article published on August 1985

Widespread suppression of huntingtin with convection-enhanced delivery of siRNA ⬇️

scientific article published on November 19, 2011

Xenogeneic adrenal medulla graft rejection rather than survival leads to increased rat striatal tyrosine hydroxylase immunoreactivity

scientific article published in May 1997

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