List of works - Titus J Boggon

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

scientific article

A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils

scientific article published on October 2013

AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis

scientific article

ARGuing for a new kinase class

scientific article published on 01 May 2019

Activating alleles of JAK3 in acute megakaryoblastic leukemia

scientific article published on July 2006

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

scientific article (publication date: April 2005)

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

scientific article

Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2.

scientific article published on 02 September 2009

Apocrustacyanin C(1) crystals grown in space and on earth using vapour-diffusion geometry: protein structure refinements and electron-density map comparisons

scientific article

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

scientific article

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

scientific article (publication date: October 2007)

C-cadherin ectodomain structure and implications for cell adhesion mechanisms

scientific article

CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation

scientific article

CDC42 binds PAK4 via an extended GTPase-effector interface

scientific article published on 2 January 2018

Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating

scientific article

Cerebral cavernous malformation proteins at a glance.

scientific article published on 30 January 2014

Clamping Together Hemidesmosomes and Latching Them in Place

scientific article published on 01 June 2019

Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide

scientific article

Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output

scientific article published on 21 March 2019

Correction: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide

scientific article published on 20 February 2020

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

scientific article

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

scientific article published on 14 April 2005

Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide

scientific article published on 31 December 2019

Crystallographic Studies of the Cerebral Cavernous Malformations Proteins

scientific article published on 01 January 2020

Data publication with the structural biology data grid supports live analysis

scientific article

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation

scientific article

Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis

scientific article

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

scientific article

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

scientific article

EGFR-mutated lung cancer: a paradigm of molecular oncology

scientific article

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

scientific article

Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation

scientific article published on 17 February 2009

Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer

scientific article published on 28 September 2009

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).

scientific article

Genomic landscape of cutaneous T cell lymphoma

scientific article published on 20 July 2015

Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays

scientific article

Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth

scientific article

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors

scientific article

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

scientific article

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

scientific article published in December 2007

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.

scientific article

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

scientific article published on 27 June 2006

JAK3: a two-faced player in hematological disorders

scientific article published on 09 September 2009

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

scientific article published on 28 January 2013

Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.

scientific article

Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin–Arg–lysozyme complex

scientific article

MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

scientific article published on 19 July 2018

MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.

scientific article published on 21 May 2013

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

scientific article

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

scientific article

Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia

scientific article

Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)

scientific article

Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer

scientific article published on 12 March 2019

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

scientific article

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition

scientific article published on 10 October 2016

Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy

scientific article published on 15 February 2019

Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis

scientific article published on 10 July 2019

PAK4 crystal structures suggest unusual kinase conformational movements

scientific article

PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape

scientific article

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

scientific article

PseudoGTPase domains in p190RhoGAP proteins: a mini-review

scientific article published on 04 December 2018

Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex

scientific article

RAC1P29S is a spontaneously activating cancer-associated GTPase

scientific article

Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration

scientific article

Recognition of physiological phosphorylation sites by p21-activated kinase 4

scientific article published on 22 June 2020

Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension

scientific article published on 13 February 2016

Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies

scientific article published on November 2007

SH2 Domain Binding: Diverse FLVRs of Partnership

scientific article published on 18 September 2020

SHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound states

scientific article

Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.

scientific article

Signaling, Regulation, and Specificity of the Type II p21-activated Kinases

scientific article

Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development

scientific article

Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases

scientific article published on May 2016

Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

scientific article

Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

scientific article

Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface

scientific article

Structural and numerical variation of FLT3/ITD in pediatric AML.

scientific article published on 27 February 2008

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region

scientific article

Structural basis for paxillin binding and focal adhesion targeting of β-parvin

scientific article

Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations

scientific article

Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase

scientific article

Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus

scientific article

Structure and clinical relevance of the epidermal growth factor receptor in human cancer

scientific article published on April 2008

Structure and regulation of Src family kinases

scientific article

Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.

scientific article published on 3 August 2015

Structure of the ABL2/ARG kinase in complex with dasatinib

scientific article

Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity

scientific article

Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition

scientific article

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

scientific article

Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6

scientific article

Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth

scientific article published on 9 November 2016

The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain

scientific article published on 15 June 2020

The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase

scientific article published on 30 August 2018

The cerebral cavernous malformations proteins.

scientific article published on 31 August 2015

The crystal structure of pseudokinase PEAK1 (Sugen Kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization

scientific article published on 6 December 2017

The pseudoGTPase group of pseudoenzymes

scientific article published on 07 September 2020

The repeat region of cortactin is intrinsically disordered in solution

scientific article published in December 2017

The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer

scientific article published on 24 December 2014

The structural basis of integrin-linked kinase-PINCH interactions

scientific article

The use of structural biology in Janus kinase targeted drug discovery

scientific article published on April 2011

Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry

scientific article published on 08 February 2022

Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin

scientific article

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

scientific article

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

scientific article published on 30 January 2014

Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.

scientific article

Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth

scientific article

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

scientific article

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

scientific article

Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells

scientific article published on 3 October 2011

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

scientific article

Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy

scientific article published on 17 October 2019

p190RhoGAP proteins contain pseudoGTPase domains

scientific article

p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms

scientific article published on 22 April 2013

γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A

scientific article published on 02 October 2019

List of works by Titus J Boggon

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils

AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis

ARGuing for a new kinase class

Activating alleles of JAK3 in acute megakaryoblastic leukemia

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2.

Apocrustacyanin C(1) crystals grown in space and on earth using vapour-diffusion geometry: protein structure refinements and electron-density map comparisons

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

C-cadherin ectodomain structure and implications for cell adhesion mechanisms

CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation

CDC42 binds PAK4 via an extended GTPase-effector interface

Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating

Cerebral cavernous malformation proteins at a glance.

Clamping Together Hemidesmosomes and Latching Them in Place

Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide

Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output

Correction: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide

Crystallographic Studies of the Cerebral Cavernous Malformations Proteins

Data publication with the structural biology data grid supports live analysis

Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation

Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

EGFR-mutated lung cancer: a paradigm of molecular oncology

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation

Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).

Genomic landscape of cutaneous T cell lymphoma

Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays

Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.

JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

JAK3: a two-faced player in hematological disorders

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.

Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin–Arg–lysozyme complex

MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL.

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia

Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)

Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition

Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy

Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis

PAK4 crystal structures suggest unusual kinase conformational movements

PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

PseudoGTPase domains in p190RhoGAP proteins: a mini-review

Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex

RAC1P29S is a spontaneously activating cancer-associated GTPase

Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration

Recognition of physiological phosphorylation sites by p21-activated kinase 4

Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension

Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies

SH2 Domain Binding: Diverse FLVRs of Partnership

SHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound states

Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.

Signaling, Regulation, and Specificity of the Type II p21-activated Kinases

Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development

Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases

Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface

Structural and numerical variation of FLT3/ITD in pediatric AML.

Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region

Structural basis for paxillin binding and focal adhesion targeting of β-parvin