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List of works by Aaron Isaacs

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Combined Linkage and Exome Sequencing Analysis for Electrocardiogram Parameters in the Erasmus Rucphen Family Study

scientific article published on 8 November 2016

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

scientific article published on 5 March 2018

A double-blind cross-over trial of Prenazone (DA 2370) and phenylbutazone in rheumatoid arthritis ⬇️

scientific article published on May 1, 1975

A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project

scientific article

A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.

scientific article

A genome-wide association study of optic disc parameters

scientific article

A genome-wide linkage study of individuals with high scores on NEO personality traits

scientific article published on 09 August 2011

A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol

scientific article

A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level

scientific article

A metabolomic profile is associated with the risk of incident coronary heart disease

scientific article published on 4 April 2014

A non-gas-producing strain of B. proteus

scientific article published on 01 January 1947

A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals

article

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

scientific article published on 23 November 2016

A serological trail of Asian-influenza vaccine after the autumn epidemic

scientific article published in April 1958

A study of some recent methods for the determination of total sulphur in rubber

scientific article published in 1915

A study of the SORL1 gene in Alzheimer's disease and cognitive function

scientific article published in January 2009

A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk

scientific article (publication date: 24 January 2017)

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

scientific journal article

Absence of interferon in lungs fom fatal cases of influenza

scientific article published on 01 January 1962

Administration of live influenza virus to volunteers

scientific article published in October 1956

Alpha-adducin polymorphism, atherosclerosis, and cardiovascular and cerebrovascular risk

scientific article published on 2 November 2006

An approach to the patient with suspected pericardial disease

scientific article published on February 2016

An inhibitor of the production of interferon (“blocker”) ⬇️

scientific article published on 01 June 1966

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.

scientific article published on 13 June 2019

Anti-haemolytic action of viridans (alpha) variants of haemolytic streptococci

scientific article published on 01 April 1948

Antiviral Action of Interferon ⬇️

scientific article published on August 27, 2010

Antiviral action of interferon in embryonic cells

scientific article published in October 1960

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks

scientific article

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

scientific article

Association of the IGF1 gene with fasting insulin levels

scientific article published on 10 February 2016

Atrial fibrillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fibrosis, inflammation, and endothelial dysfunction

scientific article published in 2022

Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

scientific article published on 01 December 2018

BHPR research: qualitative * 1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

scientific article published on 3 April 2012

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

CLEC4MandSTXBP5gene variations contribute to von Willebrand factor level variation in von Willebrand disease

scientific article published on 9 May 2015

Catalase production by gram-positive cocci; a simple test for differentiating enterococci from a micrococci

scientific article published on 01 January 1948

Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis.

scientific article published on 18 November 2009

Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium

scientific article published on 8 November 2011

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Common variants in Mendelian kidney disease genes and their association with renal function

scientific article published on 12 September 2013

Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis

scientific article published on 24 October 2008

Comprehensive evaluation of smoking exposures and their interactions on DNA methylation

scientific article published in 2024

Continental Divide: Heidegger, Cassirer, Davos

Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

scientific article published on 30 March 2015

Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study.

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Depression & your patient ⬇️

scientific article published on 01 July 1998

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Discovery and refinement of loci associated with lipid levels

scientific article

Discovery of novel heart rate-associated loci using the Exome Chip

scientific article

Discriminative Ability of Plasma Branched-Chain Amino Acid Levels for Glucose Intolerance in Families At Risk for Type 2 Diabetes

scientific article

Disease variants alter transcription factor levels and methylation of their binding sites

scientific article published on 5 December 2016

Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

scientific article published on 05 March 2013

Effect of inhibitors on interference between influenza and vaccinia viruses

scientific article

Effect of interferon on the growth of viruses on the chick chorion.

scientific article

Effects of streptozotocin-induced diabetes in apolipoprotein AI deficient mice

scientific article

Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide

scientific article published on 25 April 2008

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016

Epistatic Effect of Cholesteryl Ester Transfer Protein and Hepatic Lipase on Serum High-Density Lipoprotein Cholesterol Levels

scientific article published on 17 April 2007

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

FOREIGN NUCLEIC ACIDS

scientific article published on 01 October 1963

FTO genotype is associated with phenotypic variability of body mass index

scientific article published on 16 September 2012

Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes

scientific article

Familial aggregation of preeclampsia and intrauterine growth restriction in a genetically isolated population in The Netherlands

scientific article published on 9 July 2008

Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population

scientific article

Feprazone compared with indomethacin in the management of rheumatoid arthritis

scientific article published on 01 July 1975

Fifteen Genetic Loci Associated With the Electrocardiographic P Wave

scientific article

Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

scientific article

Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

scientific article

Foreign nucleic acids as the stimulus to make interferon

scientific article published on 01 July 1963

Further studies on interferon

scientific article

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

scientific article published in Nature Communications

GenABEL: an R library for genome-wide association analysis

scientific article (publication date: 15 May 2007)

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect

scientific article published on 22 December 2010

Genetic Determinants of Electrocardiographic P-wave Duration and Relation to Atrial Fibrillation

scientific article published on 21 August 2020

Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study

scientific article published on 15 January 2008

Genetic architecture of circulating lipid levels

scientific article

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic determinants of circulating sphingolipid concentrations in European populations

scientific article published on 02 October 2009

Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease

scientific article published on 10 June 2010

Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification

scientific article published on 16 December 2012

Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population

scientific article published on 28 July 2010

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants in RBFOX3 are associated with sleep latency

scientific article

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study

scientific article published in July 2009

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals

scientific article published on 01 July 2019

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association analysis identifies multiple loci related to resting heart rate

scientific article

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

scientific article

Genome-wide association and functional follow-up reveals new loci for kidney function

scientific article

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

scientific article published on 24 January 2019

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

scientific article

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

scientific article

Genome-wide linkage analysis of serum creatinine in three isolated European populations.

scientific article published on 22 April 2009

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

scientific article published on 21 June 2016

Growth of influenza virus in the chick chorion

scientific article published in January 1953

Haplotype analyses of the APOA5 gene in patients with familial combined hyperlipidemia

article

Haplotype of the angiotensinogen gene is associated with coronary heart disease in familial hypercholesterolemia.

scientific article

Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study

scientific article

Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

scientific article

Heritability in a SCN5A-mutation founder population with increased female susceptibility to non-nocturnal ventricular tachyarrhythmia and sudden cardiac death

scientific article published on 3 August 2017

Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes

scientific article published on March 2007

INTERFERON.

scientific article published on January 1963

Identification of context-dependent expression quantitative trait loci in whole blood

scientific article published on 5 December 2016

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Infection of volunteers with Asian influenza virus

scientific article published in November 1957

Influence of increased oxygenation on influenza virus infection in mice

scientific article published in September 1961

Influenza in an isolated community; an epidemic on Ocean Island

scientific article published on 01 January 1950

Inhibition by interferon of the growth of vaccinia virus in the rabbit skin

scientific article published in September 1959

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

scientific article published on 8 September 2012

Interference between inactive and active influenza viruses in the chick embryo

scientific article published on 01 November 1950

Interference between inactive and active influenza viruses in the chick embryo. I. Quantitative aspects of interference

scientific article published on 01 March 1950

Interference between inactive and active influenza viruses in the chick embryo. II. The site of interference

scientific article published on 01 March 1950

Interference between influenza and vaccinia viruses

scientific article

Interference in the chick chorion

scientific article published on 01 August 1953

Interferon

scientific article published on 01 May 1961

Interferon as a factor in recovery from virus infection.

scientific article published in September 1962

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in the general population: the Rotterdam Study

scientific article published on 9 October 2014

Interferon production by different viruses

scientific article published on 01 January 1963

JavaCyte, a novel open-source tool for automated quantification of key hallmarks of cardiac structural remodeling

scientific article published on 18 November 2020

Laboratory methods used in investigating influenza

scientific article published on 01 October 1948

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2

scientific article published on 08 August 2012

Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene

scientific article published on 22 October 2009

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

scientific article

Low Density Lipoprotein Exposure of Plasmacytoid Dendritic Cells Blunts Toll-like Receptor 7/9 Signaling via NUR77

scientific article published on 17 May 2022

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

scientific article

Mechanism of Recovery from Viral Infection in the Chick Embryo

scientific article published in Nature

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

scientific article

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

scientific article published on 11 September 2011

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

scientific article published on 16 January 2013

Metabolic effects of interferon on chick fibroblasts

scientific article published on 01 January 1960

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

Mode of Action of Interferon

scientific article published in Nature

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

scientific article published on 21 May 2020

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.

scientific article published on 21 November 2016

Neurophysiological correlates of senile dementia: II. The somatosensory evoked response ⬇️

scientific article published on February 1, 1971

Neutralising action of human nasal secretions on neurotropic influenza virus

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

New loci associated with kidney function and chronic kidney disease

scientific article

Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality

scientific article published on 11 November 2019

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Nucleotide excision DNA repair is associated with age-related vascular dysfunction

scientific article

Optimal temperature for growth and sensitivity to interferon among different viruses

scientific article published on 01 January 1963

P-Q variation in influenza viruses

scientific article published on 01 April 1953

P1-309

PNPLA3, TM6SF2, and MBOAT7 Genotypes and Coronary Artery Disease

scientific article published on 01 February 2017

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

Particle counts and infectivity titrations for animal viruses

scientific article published on 01 January 1957

Pathways of influenza spread

scientific article published on 01 September 1954

Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology

scientific article

Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267.

scientific article published on September 2015

Pillars Article: Virus Interference. II. Some Properties of Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 268-273.

scientific article published on September 2015

Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study

scientific article published on 30 November 2012

Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia.

scientific article published on 18 January 2013

Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study

scientific article published on 16 August 2008

Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology

scientific article

Production and action of interferon

scientific article published on 01 January 1962

Protection of mice against the lethal action of an encephalitis virus

scientific article published on 01 October 1960

Pulmonary neuroendocrine cells in the airways of lung allografts

scientific article published on 01 April 1995

Reactivation of Neutral Mixtures of Influenza Virus and Serum by Virus Inactivated by Heat

Recent evolution and spread of strains of influenza-A virus

scientific article published in November 1956

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

scientific article

Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions

scientific article published on 05 December 2012

Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease

article

Relationship of the Ubiquilin 1 gene with Alzheimer's and Parkinson's disease and cognitive function.

scientific article published in August 2007

Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

scientific article

Rhinitis due to actinobacillosis in a UK suckler cow herd

scientific article published on 01 May 2012

Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease

scientific article published on 13 June 2013

Role of interferon in recovery from virus infections

scientific article published in July 1960

STUDIES ON INTERFERON

scientific article published on 01 July 1965

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms

scientific article

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies

scientific article

Some factors affecting the production of interferon.

scientific article

Studies on the mechanism of action of interferon

scientific article published on 01 February 1961

Studies on the production, mode of action and properties of interferon.

scientific article

The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis

scientific article published in August 2004

The action of trypsin on normal serum inhibitors of influenza virus agglutination.

scientific article

The apolipoprotein E gene and its age-specific effects on cognitive function

scientific article

The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels

scientific article

The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease

scientific article

The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study

scientific article published on 01 June 2007

The effects of the acetic acid analogs of thyroxine and triiodothyronine on glycolysis in ascites tumor cells in vitro

scientific article published on 01 December 1955

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia

scientific article published on 25 October 2006

The molecular genetic architecture of self-employment

scientific article

The nucleic acid content of influenza virus

scientific article published in December 1957

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

The role of interferon

scientific article published on 01 May 1963

The use of V. cholerae filtrates in the destruction of non-specific inhibitor in ferret sera

scientific article

The viruses of epidemic influenza

scientific article published on 01 January 1953

The viruses of epidemic influenza

The viruses of the 1952-3 influenza epidemic ⬇️

scientific article published on January 1954

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Tuberculosis presenting as inflammatory bowel disease. Report of two cases

scientific article published on 01 February 1984

Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram

scientific article published on 08 March 2016

VEGF polymorphisms are associated with endocardial cushion defects: a family-based case-control study

scientific article published on 01 January 2010

Validation.

scientific article published in December 2001

Variants in STAT5B Associate with Serum TC and LDL-C Levels

article published in 2011

Variation in laboratory stocks of influenza viruses: biological characters of variants

scientific article

Variation in laboratory stocks of influenza viruses: genetic aspects of the variations.

scientific article

Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease

scientific article published on 12 October 2010

Viral interference and interferon

scientific article published on 01 September 1959

Virus interference. I. The interferon

scientific article (publication date: 12 September 1957)

Virus interference. I. The interferon. By A. Isaacs and J. Lindenmann, 1957.

scientific article published in October 1987

Virus interference. II. Some properties of interferon

scientific article (publication date: 12 September 1957)

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

scientific article

[Research on viral interference]

scientific article published on 01 January 1957

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