List of works by Eric O Freed

"Expand and Click": A New Method for Labeling HIV-1 Envelope Glycoproteins.

scientific article published on May 2017

A Consensus View of ESCRT-Mediated Human Immunodeficiency Virus Type 1 Abscission.

scientific article

A Triazinone Derivative Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity

scientific article published on 16 September 2016

A cell-penetrating helical peptide as a potential HIV-1 inhibitor

scientific article

A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41.

scientific article

A second-site suppressor significantly improves the defective phenotype imposed by mutation of an aromatic residue in the N-terminal domain of the HIV-1 capsid protein

scientific article published on 19 October 2006

A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat

scientific article

A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.

scientific article published on 09 October 2013

ARRDC1 as a mediator of microvesicle budding

scientific article published on 29 February 2012

Activation of different split functionalities on re-association of RNA-DNA hybrids

scientific article published on 31 March 2013

Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide.

scientific article published on 04 October 2013

Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors

scientific article

An Alix fragment potently inhibits HIV-1 budding: characterization of binding to retroviral YPXL late domains.

scientific article published on 8 December 2006

Analysis of HIV-1 Matrix-Envelope Cytoplasmic Tail Interactions

scientific article published on 15 October 2019

Announcing the 2015 viruses Young Investigator Prize and Graduate Student/Postdoctoral Fellow Travel awards

scientific article published on 12 February 2015

Anti-HIV-1 therapeutics: from FDA-approved drugs to hypothetical future targets

scientific article

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain ⬇️

scientific article

Antiviral innate immunity: editorial overview.

scientific article published on 22 January 2014

Application of ring-closing metathesis macrocyclization to the development of Tsg101-binding antagonists

scientific article

Association of human immunodeficiency virus type 1 gag with membrane does not require highly basic sequences in the nucleocapsid: use of a novel Gag multimerization assay

scientific article

Authentication Analysis of MT-4 Cells Distributed by the National Institutes of Health AIDS Reagent Program

scientific article published on 26 November 2019

Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1.

scientific article published on December 2007

Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation

scientific article

Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body

scientific article published on February 2004

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication

scientific article published on 01 December 2019

Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease

scientific article

CryoET structures of immature HIV Gag reveal six-helix bundle

scientific article

Crystallographic and Functional Analysis of the ESCRT-I /HIV-1 Gag PTAP Interaction

scientific article

Defects in cellular sorting and retroviral assembly induced by GGA overexpression

scientific article

Defects in human immunodeficiency virus budding and endosomal sorting induced by TSG101 overexpression.

scientific article

Depletion of cellular cholesterol inhibits membrane binding and higher-order multimerization of human immunodeficiency virus type 1 Gag.

scientific article

Determinants of activity of the HIV-1 maturation inhibitor PA-457.

scientific article published on 22 August 2006

Distribution of ESCRT machinery at HIV assembly sites reveals virus scaffolding of ESCRT subunits

scientific article published on 16 January 2014

Dual-acting stapled peptides target both HIV-1 entry and assembly

scientific article

Effect of mutations in the human immunodeficiency virus type 1 protease on cleavage of the gp41 cytoplasmic tail

scientific article

Effects of Gag mutation and processing on retroviral dimeric RNA maturation

scientific article

Elucidating the basis for permissivity of the MT-4 T-cell line to replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail

scientific article published on 16 September 2020

Elucidating the mechanism by which compensatory mutations rescue an HIV-1 matrix mutant defective for gag membrane targeting and envelope glycoprotein incorporation

scientific article published on 7 February 2015

Elucidation of New Binding Interactions with the Human Tsg101 Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands

scientific article

Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain

scientific article

Evidence of a role for soluble -ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release

scientific article published in 2014

Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release

scientific article

Evidence that productive human immunodeficiency virus type 1 assembly can occur in an intracellular compartment

scientific article published on 18 March 2009

FIV Gag: virus assembly and host-cell interactions

scientific article

Functional replacement of a retroviral late domain by ubiquitin fusion

scientific article published on 09 August 2008

Functional role of Alix in HIV-1 replication

scientific article published on September 2009

GGA and Arf proteins modulate retrovirus assembly and release

scientific article published on April 2008

Generation and validation of a highly sensitive bioluminescent HIV-1 reporter vector that simplifies measurement of virus release

scientific article published on 19 May 2020

Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions

scientific article published on 13 September 2019

Getting IN on Viral RNA Condensation and Virion Maturation.

scientific article published on August 2016

Global rescue of defects in HIV-1 envelope glycoprotein incorporation: implications for matrix structure

scientific article

HIV type 1 Gag as a target for antiviral therapy

scientific article

HIV-1 Gag: flipped out for PI(4,5)P(2).

scholarly article

HIV-1 Matrix Trimerization-Impaired Mutants Are Rescued by Matrix Substitutions That Enhance Envelope Glycoprotein Incorporation

scientific article published on 12 December 2019

HIV-1 Maturation: Lessons Learned from Inhibitors

scientific article published on 26 August 2020

HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor

scientific article

HIV-1 and the host cell: an intimate association

scientific article published on April 2004

HIV-1 assembly, release and maturation.

scientific article published on 29 June 2015

HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation

scientific article

HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease

scholarly article

HIV-1 gag: an emerging target for antiretroviral therapy.

scientific article

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

scientific article

HIV-1 packs in PACSIN2 for cell-to-cell spread

article published in the Proceedings of the National Academy of Sciences of the United States of America

Heavy metal protease takes a tiki torch to HIV assembly

scientific article published on 01 June 2019

High-Mannose But Not Complex-Type Glycosylation of Tetherin Is Required for Restriction of HIV-1 Release

scientific article published on 5 January 2018

How to package the RNA of HIV-1

scientific article published on 17 November 2020

Human Immunodeficiency Virus Type 1 N-Terminal Capsid Mutants Containing Cores with Abnormally High Levels of Capsid Protein and Virtually No Reverse Transcriptase ⬇️

scientific article published on December 1, 2003

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

scientific article

Human immunodeficiency virus type 1 assembly, release, and maturation.

scientific article published on January 2007

Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: application to the preparation of Tsg101-directed HIV-1 budding antagonists

scientific article

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.

scientific article

Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation ⬇️

article

Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice. ⬇️

scientific article published on 4 November 2015

Identification of potent maturation inhibitors against HIV-1 clade C

scientific article

Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)

scientific article published on 11 March 2009

In COS cells Vpu can both stabilize tetherin expression and counteract its antiviral activity

scientific article published on 31 October 2014

In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).

scientific article

Influenza virus not cRAFTy enough to dodge viperin

scientific article published in August 2007

Inhibition of HIV-1 Replication by Amphotericin B Methyl Ester

scientific article published in Journal of Biological Chemistry

Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence

scientific article published on 23 July 2008

Intracellular Reassociation of RNA-DNA Hybrids that Activates RNAi in HIV-Infected Cells.

scientific article

Ion-abrasion scanning electron microscopy reveals surface-connected tubular conduits in HIV-infected macrophages

scientific article (publication date: September 2009)

Late domain-dependent inhibition of equine infectious anemia virus budding

scientific article published on January 2004

Lipids and membrane microdomains in HIV-1 replication

scientific article

Macrophages and Cell-Cell Spread of HIV-1.

scientific article

Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins

scientific article

Mechanisms of HIV type 1-induced cognitive impairment: evidence for hippocampal cholinergic involvement with overstimulation of the VIPergic system by the viral coat protein core

scientific article published in November 2002

Mechanisms of enveloped virus release

scientific article published in December 2004

Meeting Review: 2018 International Workshop on Structure and Function of the Lentiviral gp41 Cytoplasmic Tail

scientific article published on 07 November 2018

Methods for the study of HIV-1 assembly.

scientific article

MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production

scientific article

Molecular characterization of feline immunodeficiency virus budding

scientific article

Multifunctional RNA nanoparticles

scientific article

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

article

Mutation of dileucine-like motifs in the human immunodeficiency virus type 1 capsid disrupts virus assembly, gag-gag interactions, gag-membrane binding, and virion maturation

scientific article

Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle

scientific article published on 11 April 2019

Mutations in the feline immunodeficiency virus envelope glycoprotein confer resistance to a dominant-negative fragment of Tsg101 by enhancing infectivity and cell-to-cell virus transmission

scientific article published on 10 September 2013

Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes

scientific article published on 15 November 2018

Myristate Exposure in the Human Immunodeficiency Virus Type 1 Matrix Protein Is Modulated by pH ⬇️

scientific article published on November 9, 2010

NMR structure of the myristylated feline immunodeficiency virus matrix protein

scientific article published on 30 April 2015

New insights into HIV assembly and trafficking

scientific article

Novel approaches to inhibiting HIV-1 replication.

scientific article

Novel targets for HIV therapy

scientific article

Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function

scientific article

PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity

scientific article published on 30 December 2020

PSGL-1 blocks SARS-CoV-2 S protein-mediated virus attachment and infection of target cells

scientific article published on 03 May 2020

PSGL-1 restricts HIV-1 infectivity by blocking virus particle attachment to target cells

scientific article published on 09 April 2020

Peptide inhibitors of HIV-1 egress

scientific article published in December 2008

Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane

scientific article

Photoinduced reactivity of the HIV-1 envelope glycoprotein with a membrane-embedded probe reveals insertion of portions of the HIV-1 Gp41 cytoplasmic tail into the viral membrane

scientific article

Point Mutations in the HIV-1 Matrix Protein Turn Off the Myristyl Switch

scientific article

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat

scientific article

Pravastatin does not have a consistent antiviral effect in chronically HIV-infected individuals on antiretroviral therapy

scientific article published in July 2005

Preface

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Quenching protein dynamics interferes with HIV capsid maturation.

scientific article published on 24 November 2017

Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate

scientific article

Real-time visualization of HIV-1 GAG trafficking in infected macrophages

scientific article (publication date: March 2008)

Recent progress in antiretrovirals--lessons from resistance

scientific article published on 18 April 2008

Reevaluation of the requirement for TIP47 in human immunodeficiency virus type 1 envelope glycoprotein incorporation

scientific article published on 16 January 2013

Regulation of human immunodeficiency virus type 1 Env-mediated membrane fusion by viral protease activity

scientific article published on January 2004

Resistance to Second-Generation HIV-1 Maturation Inhibitors

scientific article published on 05 March 2019

Retrovirus budding.

scientific article

Retroviruses 2004: review of the 2004 Cold Spring Harbor Retroviruses Conference

scientific article published in 2004

Role of lipid rafts in virus replication

scientific article

S-acylation of SARS-CoV-2 Spike Protein: Mechanistic Dissection, In Vitro Reconstitution and Role in Viral Infectivity

scientific article

SAR by oxime-containing peptide libraries: application to Tsg101 ligand optimization

scientific article

Single molecule fate of HIV-1 envelope reveals late-stage viral lattice incorporation.

scientific article

Site-specific Mutations in HIV-1 gp41 Reveal a Correlation between HIV-1-mediated Bystander Apoptosis and Fusion/Hemifusion

scientific article published in Journal of Biological Chemistry

Structural and Mechanistic Studies of the Rare Myristoylation Signal of the Feline Immunodeficiency Virus

scientific article published on 19 May 2020

Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein

scientific article published on 15 March 2016

Structural and functional insights into the HIV-1 maturation inhibitor binding pocket

scientific article

Structural basis for viral late-domain binding to Alix

scientific article

Structure of the Myristylated Human Immunodeficiency Virus Type 2 Matrix Protein and the Role of Phosphatidylinositol-(4,5)-Bisphosphate in Membrane Targeting

scientific article

Structure-based in silico identification of ubiquitin-binding domains provides insights into the ALIX-V:ubiquitin complex and retrovirus budding

scientific article published on 29 January 2013

TIM-family proteins inhibit HIV-1 release.

scientific article

TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins

scientific article published on 06 March 2019

Targeting the HIV entry, assembly and release pathways for anti-HIV gene therapy

scientific article

The HIV-TSG101 interface: recent advances in a budding field

scientific article published on 01 February 2003

The Role of Lipids in Retrovirus Replication

scientific article

The Use of Minimal RNA Toeholds to Trigger the Activation of Multiple Functionalities.

scientific article published on 29 February 2016

The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species

scientific article published on 22 April 2016

The autophagy protein ATG9A promotes HIV-1 infectivity

scientific article published on 03 July 2019

The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation

scientific article

The cell biology of HIV-1 and other retroviruses

scientific article

The cytoplasmic tail of retroviral envelope glycoproteins.

scientific article

The ins and outs of viral infection: keystone meeting review

scientific article published on 25 September 2014

The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability

scientific article published on 26 October 2011

The late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent manner

scientific article

The role of matrix in HIV-1 envelope glycoprotein incorporation

scientific article

The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release

scientific article published on 14 April 2020

Trimer Enhancement Mutation Effects on HIV-1 Matrix Protein Binding Activities

scientific article published on 30 March 2016

Viral late domains ⬇️

scientific article

Viral latency and potential eradication of HIV-1.

scientific article published on August 2012

Virology. Rafting with Ebola

scientific article

Virus Assembly

Virus maturation as a new HIV-1 therapeutic target

scientific article

Welcome to viruses: a new open-access, multidisciplinary forum for virology

scientific article

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