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List of works by Philippe Hantraye

11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation

scientific article published in April 2007

A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina

scientific article

A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor

scientific article published on 2 February 2012

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

scientific article published on 29 May 2013

A standardized method to automatically segment amyloid plaques in Congo Red stained sections from Alzheimer transgenic mice

scientific article published in January 2007

A validation dataset for Macaque brain MRI segmentation

scientific article published on 4 November 2017

Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults.

scientific article

Advanced imaging of transplant survival, fate, differentiation, and integration

scientific article published on 23 March 2017

Age-associated cerebral atrophy in mouse lemur primates

scientific article

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

scientific article

Allele-specific silencing of mutant huntingtin in rodent brain and human stem cells

scientific article

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

scientific article

Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo

scientific article

Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases

scientific article published on 30 November 2019

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

scientific article

Arterial input function measurement without blood sampling using a beta-microprobe in rats

scientific article published in September 2004

Assessment of simplified methods for quantification of [18F]-DPA-714 using 3D whole-brain TSPO immunohistochemistry in a non-human primate

scientific article published on 25 June 2019

Automated Individualization of Size-Varying and Touching Neurons in Macaque Cerebral Microscopic Images

scientific article published on 17 December 2019

Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas ⬇️

scientific article published on January 1, 2010

Automated three-dimensional analysis of histological and autoradiographic rat brain sections: application to an activation study

scientific article published on 21 March 2007

B(0) homogeneity throughout the monkey brain is strongly improved in the sphinx position as compared to the supine position.

scientific article published in March 2006

Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates

scientific article published on 02 December 2019

Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation.

scientific article published on 29 March 2006

Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.

scientific article published in June 2003

Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration.

scientific article published on 16 December 2009

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

scientific article

Clinical relevance of electrophysiological tests in the assessment of patients with Huntington's disease.

scientific article

Clustering of Tau fibrils impairs the synaptic composition of α3-Na/K-ATPase and AMPA receptors

article

Comparative test-retest variability of outcome parameters derived from brain [18F]FDG PET studies in non-human primates

scientific article published on 05 October 2020

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

scientific article published on 18 February 2020

Correction: IRC-082451, a Novel Multitargeting Molecule, Reduces L-DOPA-Induced Dyskinesias in MPTP Parkinsonian Primates

scientific article (publication date: 30 January 2013)

Cortical areas involved in behavioral expression of external pallidum dysfunctions: A PET imaging study in non-human primates

scientific article

Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration

scientific journal article

Current status of neuronal cell xenotransplantation.

scientific article published on 21 September 2015

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Decrease of nicotinic receptors in the nigrostriatal system in Parkinson's disease.

scientific article published on 3 June 2009

Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy.

scientific article published in August 2002

Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1

scientific journal article

Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys

scientific article published on May 2000

Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease.

scientific article published on 4 March 2010

Differential dopamine receptor occupancy underlies L-DOPA-induced dyskinesia in a rat model of Parkinson's disease

scientific article

Diffusion-weighted NMR spectroscopy allows probing of 13C labeling of glutamate inside distinct metabolic compartments in the brain.

scientific article published in August 2008

Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo

scientific article published on 25 February 2019

Dopamine D1 receptor imaging in the rodent and primate brain using the isoquinoline +-[11C]A-69024 and positron emission tomography

scientific article published on 01 July 2008

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

scientific article published on 11 February 2008

Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.

scientific article published in October 2009

Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease

scientific article

Ectosomes: a new mechanism for non-exosomal secretion of tau protein

scientific article

Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study

scientific article

Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate

scientific article

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

scientific article published on July 2004

Engineered lentiviral vector targeting astrocytes in vivo

scientific article

Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

scientific article published on 2 November 2017

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

scientific article

Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier disruption in non-human primates under magnetic resonance guidance.

scientific article published in January 2018

Fetal neural grafts for Huntington's disease: a prospective view

scientific article

Fully automated and adaptive detection of amyloid plaques in stained brain sections of Alzheimer transgenic mice

scientific article published on 01 January 2007

Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation

scientific article published in December 2004

Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice.

scientific article published on 30 April 2011

Gene Therapy for Parkinson's Disease: Preclinical Evaluation of Optimally Configured TH:CH1 Fusion for Maximal Dopamine Synthesis

scientific article published on 16 July 2019

Glycolysis versus TCA cycle in the primate brain as measured by combining 18F-FDG PET and 13C-NMR.

scientific article published in November 2005

High-throughput 3D whole-brain quantitative histopathology in rodents.

scientific article

Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease

scientific article

Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution

scientific article published in April 2009

IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats

scientific article

IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates

scientific article

Imaging in cell-based therapy for neurodegenerative diseases.

scientific article

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions

scientific article

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

scientific article published on 01 March 2020

In Vivo Multidimensional Brain Imaging in Huntington's Disease Animal Models

scientific article published on 01 January 2018

In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

scientific article published on 12 August 2003

In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin

scientific article

In vivo evidence for the selective subcortical degeneration in Huntington's disease.

scientific article

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

scientific article

In vivo imaging of integration and function of striatal grafts in rodent and nonhuman primate animal models

scientific article

In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa).

scientific article published on 9 October 2010

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobe

scientific article

Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease.

scientific article published on 12 November 2011

Insulin growth factor-1 protects against excitotoxicity in the rat striatum

scientific article published in October 2004

Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease

scientific article published on 26 March 2004

Intracellular metabolites in the primate brain are primarily localized in long fibers rather than in cell bodies, as shown by diffusion-weighted magnetic resonance spectroscopy.

scientific article

Intradermal vaccination prevents anti-MOG autoimmune encephalomyelitis in macaques

scientific article published on 03 September 2019

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

scientific article

Isoflurane strongly affects the diffusion of intracellular metabolites, as shown by 1H nuclear magnetic resonance spectroscopy of the monkey brain.

scientific article published on 21 June 2006

Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain

scientific article published on 23 April 2013

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

scientific article published on June 2002

Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease

article

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.

scientific article

Longitudinal characterization of cognitive and motor deficits in an excitotoxic lesion model of striatal dysfunction in non-human primates

scientific article published on 24 May 2019

Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

scientific article

MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates

scientific article published on 25 September 2019

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer's disease

scientific article published on 16 October 2018

Multiinjection approach for D2 receptor binding quantification in living rats using [11C]raclopride and the beta-microprobe: crossvalidation with in vitro binding data.

scientific article

Multimodal neuroimaging provides a highly consistent picture of energy metabolism, validating 31P MRS for measuring brain ATP synthesis

scholarly article

NMR measurement of brain oxidative metabolism in monkeys using 13C-labeled glucose without a 13C radiofrequency channel.

scientific article published in July 2004

Neocortical morphometry in Huntington's disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes

scientific article published on 13 February 2020

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

scientific article published on 30 January 2014

Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain.

scientific article published in October 2005

New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo

scientific article published on 25 May 2016

Normal aging modulates the neurotoxicity of mutant huntingtin

scientific article

Novel therapies in the search for a cure for Huntington's disease

scientific article published in January 2001

Optimized diffusion-weighted spectroscopy for measuring brain glutamate apparent diffusion coefficient on a whole-body MR system

scientific article published in December 2005

Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

scientific article

PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models

scientific article published on 08 April 2020

Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.

scientific article

Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo.

scientific article published in October 2004

Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.

scientific article published on 14 December 2017

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

scientific article

Primatologist: A modular segmentation pipeline for macaque brain morphometry.

scientific article published on 9 September 2017

Quantitative assessment of transcriptome differences between brain territories

scientific article

Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models

scientific article published on 5 February 2008

Quantitative validation of voxel-wise statistical analyses of autoradiographic rat brain volumes: application to unilateral visual stimulation

scientific article published on 15 December 2007

Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.

scientific article published in August 2012

Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain

scientific article published on 03 July 2019

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.

scientific article

Restricted transgene expression in the brain with cell-type specific neuronal promoters

scientific article

Restricted transgene expression in the brain with cell-type specific neuronal promoters

Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration

scientific article published in July 1997

Segmentation of small animal PET/CT mouse brain scans using an MRI-based 3D digital atlas

scientific article published in January 2010

Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

scientific article published on 22 March 2010

Simplified (13)C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo.

scientific article published in December 2009

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo

scientific article

Striatal neural grafting improves cortical metabolism in Huntington's disease patients

scientific article

Subarachnoid Hemorrhage Severely Impairs Brain Parenchymal Cerebrospinal Fluid Circulation in Nonhuman Primate.

scientific article published on 19 May 2017

Sustained effects of nonallele-specific Huntingtin silencing

scientific article published on March 2009

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease.

scientific article published on 25 November 2015

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

scientific article published on 09 October 2019

The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.

scientific article published on February 2015

The neuroprotective agent CNTF decreases neuronal metabolites in the rat striatum: an in vivo multimodal magnetic resonance imaging study

scientific article

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.

scientific article published on 9 March 2018

Three-dimensional SPACE fluid-attenuated inversion recovery at 3 T to improve subthalamic nucleus lead placement for deep brain stimulation in Parkinson's disease: from preclinical to clinical studies

scientific article published on 8 January 2016

Three-dimensional reconstruction of stained histological slices and 3D non-linear registration with in-vivo MRI for whole baboon brain

scientific article

Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation.

scientific article published on August 2005

Translational research for Parkinson׳s disease: The value of pre-clinical primate models.

scientific article published on 02 April 2015

Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue.

scientific article published in August 2003

Transplants of CNTF-producing Cells for the Treatment of Huntington's Disease

article

Up-regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251-infected macaques without major brain involvement.

scientific article published in February 2004

Voxel-Based Statistical Analysis of 3D Immunostained Tissue Imaging

scientific article published on 15 November 2018

[Imaging and translational research: neurodegenerative diseases]

scientific article published on 01 April 2009

mRNA trans-splicing in gene therapy for genetic diseases

scientific article

miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions

scientific article published on 17 September 2020

pH as a biomarker of neurodegeneration in Huntington's disease: a translational rodent-human MRS study.

scientific article

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.

scientific article

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