Search filters

List of works by Serge Przedborski

A computational model of motor neuron degeneration

scientific article published on 31 July 2014

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

scientific article published on 07 May 2015

A novel mitochondrial 12SrRNA point mutation in parkinsonism, deafness, and neuropathy

scientific article published in November 2000

A sequel to the tale of p25/Cdk5 in neurodegeneration

scientific article published on December 2008

A tale on animal models of Parkinson's disease

scientific article published on May 2011

Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice

scientific article

Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats

scientific article published in June 1993

Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease

scientific article

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

scientific article published on February 2000

Alpha-tocopherol levels in parkinsonian brains

scientific article

Apoptosis-inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins

scientific article published on August 2010

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

scientific article

Autoradiography of dopamine receptors and dopamine uptake sites in the spontaneously hypertensive rat.

scientific article published in November 1990

Axonal Degeneration: RIPK1 Multitasking in ALS.

scientific article published in October 2016

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

scientific journal article

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

scientific journal article

Bilateral modulation of [3H]neurotensin binding by unilateral intrastriatal 6-hydroxydopamine injections: evidence from a receptor autoradiographic study

scientific article published in November 1991

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

scientific article published in March 2002

Brain glucose metabolism and dopamine D2 receptor analysis in a patient with hemiparkinsonism-hemiatrophy syndrome

scientific article

Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis

scientific article published in February 1996

Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death ⬇️

scientific article published on November 1, 2001

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

scientific journal article

COX-2 and neurodegeneration in Parkinson's disease.

scientific article

Cholecystokinin distribution in the human striatum and related subcortical structures

scientific article published on January 1989

Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. III. Inactivation of CCK-8 by a phosphoramidon-sensitive endopeptidase ⬇️

scientific article published on May 1, 1984

Classic and New Animal Models of Parkinson's Disease ⬇️

scientific article published on March 28, 2012

Clinical Presentation and Pharmacological Therapy in Corticobasal Degeneration ⬇️

scientific article published on July 1, 1998

Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression

scientific article published in November 1999

Control of mitochondrial integrity in Parkinson's disease

scientific article published in January 2010

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease ⬇️

scientific article published on October 31, 2003

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS.

scientific article

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

scholarly article

Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

scientific article

D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease

scientific article published in September 2003

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease ⬇️

scientific article published on September 12, 2011

D2-Like Dopamine Autoreceptor Activation Reduces Quantal Size in PC12 Cells ⬇️

scientific article published on August 1, 1998

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

scientific journal article

Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis ⬇️

scientific article published on May 1, 2013

Deletion of Prevents Motor Neuron Death but not

article published in eNeuro

Developmental cell death in dopaminergic neurons of the substantia nigra of mice

scientific article published in August 2000

Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 mice

scientific article

Does increased superoxide dismutase activity really cause muscular dystrophy?

scientific article published in July 1999

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

scientific article

Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease

scientific article (publication date: February 1991)

Early differential diagnosis of Parkinson's disease with 18F-fluorodeoxyglucose and positron emission tomography

scientific article

Effect of HECNU in malignant supratentorial gliomas--a phase II study

scientific article published in November 1988

Effect of Unilateral Perinatal Hypoxic-Ischemic Brain Injury in the Rat on Dopamine D1and D2Receptors and Uptake Sites: A Quantitative Autoradiographic Study ⬇️

scientific article published on December 1, 1991

Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on striatal muscarinic cholinergic receptors and high-affinity choline uptake sites: a quantitative autoradiographic study

scientific article

Effect of unilateral perinatal hypoxic-ischemic brain injury on striatal dopamine uptake sites and D1 and D2 receptors in adult rats ⬇️

scientific article published on August 19, 1991

Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture

scientific article published on July 1997

Engineered modeling and the secrets of Parkinson's disease

scientific article

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

scientific article

Experimental developments in movement disorders: update on proposed free radical mechanisms ⬇️

scientific article published on August 1, 1998

Fentanyl-induced dyskinesias

scientific article published in September 1995

Free radical and nitric oxide toxicity in Parkinson's disease.

scientific article published in January 2003

Freezing of gait in PD: prospective assessment in the DATATOP cohort

scientific article

Gene dosage and pathogenesis of Parkinson's disease

scientific article

Genetic clues to the pathogenesis of Parkinson's disease

scientific article published in July 2004

Glutamate pathway implication in amyotrophic lateral sclerosis: what is the signal in the noise?

scientific article published in December 2010

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Hemiparkinsonism-hemiatrophy syndrome: clinical and neuroradiologic features

scientific article

Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes

scientific article

Identification of neurodegenerative factors using translatome-regulatory network analysis

scientific article published on 27 July 2015

Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors

scientific article published in 2024

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) ⬇️

scientific article published on June 23, 1998

Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis

scientific article published in February 2001

Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

scientific article published in April 2002

Increased superoxide dismutase activity improves survival of cultured postnatal midbrain neurons.

scientific article published in October 1996

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

article

Induction of mania by apomorphine in a depressed parkinsonian patient

scientific article (publication date: 1992)

Inflammation and Parkinson's disease pathogenesis

scientific article published in January 2010

Inflammation in ALS and SMA: sorting out the good from the evil

scientific article

Inflammatory demyelinating polyradiculoneuropathy associated with human immunodeficiency virus infection

scientific article published in July 1988

Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.

scientific article published in May 2003

Intrabody and Parkinson's disease

scientific article

Is Amyotrophic Lateral Sclerosis a Mitochondrial Channelopathy? ⬇️

scientific article published on August 26, 2010

Is there a pathogenic role for mitochondria in Parkinson's disease?

scientific article published in December 2009

Isolated palsy of the superior branch of the oculomotor nerve due to chronic erosive sphenoid sinusitis.

scientific article published in December 1993

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

scholarly article

L-3-hydroxyacyl-CoA dehydrogenase II protects in a model of Parkinson's disease

scientific article published in July 2004

Lack of changes in ventricular cerebrospinal fluid concentrations of homovanillic acid following acute challenge with levodopa

scientific article published in January 1992

Lack of efficacy of phenytoin in the syndrome of inappropriate anti-diuretic hormone secretion of neurological origin

scientific article published on July 1989

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

scientific article published in June 2001

Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease

scientific article published on 5 August 2011

Long-term behavioral and biochemical effects of 6-hydroxydopamine injections in rat caudate-putamen

scientific article

MPTP as a mitochondrial neurotoxic model of Parkinson's disease

scientific article published in August 2004

Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease

scientific article

Mechanisms of MPTP toxicity

scientific article published on January 1, 1998

Metabolic correlates of levodopa response in Parkinson's disease

scientific article published in December 2001

Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine

scientific article published in November 2001

Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis

scientific article

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

scientific article published in May 2002

Mitochondria: The Next (Neurode)Generation ⬇️

scientific article published on June 23, 2011

Mitochondrial Dynamics and Bioenergetic Dysfunction Is Associated with Synaptic Alterations in Mutant SOD1 Motor Neurons ⬇️

scientific article published on January 4, 2012

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition ⬇️

scientific article published on November 11, 2011

Mitophagy and Parkinson's disease: Be eaten to stay healthy ⬇️

scientific article published on 02 August 2012

Mitophagy in cells with mtDNA mutations: being sick is not enough

scientific article

Mitophagy: the latest problem for Parkinson's disease ⬇️

scientific article published on 09 December 2010

Molecular targets for neuroprotection

scientific article

Motor blocks in Parkinson's disease ⬇️

scientific article published on February 1, 1992

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

scientific article

Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear Cajal bodies

scientific article

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease ⬇️

scientific article published on April 29, 2003

Nervous system manifestations and neuroradiologic findings in acquired immunodeficiency syndrome (AIDS).

scientific article published in January 1989

Neurodegeneration and Inflammation in Parkinson's disease ⬇️

scientific article published on January 1, 2012

Neurodegeneration: what is it and where are we?

scientific article

Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

scientific article

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease

scientific article published on 17 July 2009

Neuropeptide Y, somatostatin, and cholecystokinin neurone preservation in anaplastic astrocytomas.

scientific article published in January 1988

Neuroprotection and neuroregeneration triggered through the FUS-induced opening of the blood-brain barrier in a Parkinson’s mouse model.

scientific article published on 30 June 2015

Neurotensin high affinity binding sites and endopeptidase 24.11 are present respectively in the meningothelial and in the fibroblastic components of human meningiomas

scientific article

Neurotensin receptors in human meningiomas

scientific article

Nigrostriatal dopaminergic function in familial amyotrophic lateral sclerosis patients with and without copper/zinc superoxide dismutase mutations

scientific article published in December 1996

Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons

scientific article

Nitration and inactivation of tyrosine hydroxylase by peroxynitrite

scientific article

Nitric oxide and reactive oxygen species in Parkinson's disease

scientific article

Novel subcellular localization for α-synuclein: possible functional consequences

scientific article

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

scientific article

Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance

scientific article published on December 2008

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation

scientific article published on 12 July 2019

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

scientific article

Parkinson's disease: animal models and dopaminergic cell vulnerability

scientific article

Parkinson's disease: mechanisms and models

scientific article (publication date: 11 September 2003)

Pathogenesis of nigral cell death in Parkinson's disease

scientific article

Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

scientific article

Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode ⬇️

scientific article published on April 30, 2012

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

scientific article

Positron emission tomography in hemiparkinsonism-hemiatrophy syndrome.

scientific article published in January 1993

Positron emission tomography-guided stereotactic brain biopsy

scientific article published in October 1992

Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia

scientific article published in December 2005

Programmed cell death in amyotrophic lateral sclerosis

scientific article

Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance

scientific article published on January 2004

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

scientific article published on 14 March 2016

Proteasome inhibition and Parkinson's disease modeling

scientific article published on August 2006

Protocol for the MPTP mouse model of Parkinson's disease

scientific article

Quantitative autoradiographic changes in 5-[3H]HT-labeled 5-HT1 serotonin receptors in discrete regions of brain in the rat model of persistent dyskinesias induced by iminodipropionitrile (IDPN).

scientific article published in August 1990

Quantitative autoradiographic distribution of [3H]-MPTP binding in the brains of superoxide dismutase transgenic mice

scientific article published in June 1991

Quantitative autoradiographic distribution of [3H]mazindol-labeled dopamine uptake sites in the brains of superoxide dismutase transgenic mice

scientific article published in July 1990

Randomized control trials in ALS: lessons learned

scientific article

Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

scientific article

Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease

scientific article

Recent advances in amyotrophic lateral sclerosis research

scientific article

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

scientific article

Retrograde degeneration of nigrostriatal neurons induced by intrastriatal 6-hydroxydopamine injection in rats ⬇️

scientific article published on February 1, 1991

Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons

scientific article published on 16 January 2018

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

scientific article published on May 1996

Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta

scientific article

Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease ⬇️

scientific article published on December 1, 2003

Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence

scientific article published in June 1991

Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans

scientific article

Sleep EEG in depressed and nondepressed patients with Parkinson's disease ⬇️

scientific article published on January 1, 1991

Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit

scientific article

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

scholarly article

Superoxide dismutase, catalase, and glutathione peroxidase activities in copper/zinc-superoxide dismutase transgenic mice

scientific article published on May 1992

Targeting programmed cell death in neurodegenerative diseases ⬇️

scientific article published on May 1, 2003

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

scientific article published on 03 June 2015

The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease

scientific article

The Postnatal Development of AMPA Receptor Subunits in the Basal Ganglia of the Rat ⬇️

scientific article published on January 1, 1998

The Role of Nitric Oxide in Parkinson's Disease ⬇️

scientific article published on January 1, 2001

The Role of the Innate Immune System in ALS ⬇️

scientific article published on August 14, 2012

The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form

scientific article

The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

scientific article

The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice

scholarly article

The kinase domain of mitochondrial PINK1 faces the cytoplasm

scientific article

The last decade in Parkinson's disease research. Basic sciences

scientific article

The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway

scholarly article

The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety

scientific article

The parkinsonian toxin MPTP: action and mechanism.

scientific article published in January 2000

The role of glial cells in Parkinson's disease

scientific article

The rotenone model of Parkinson's disease

scientific article published in July 2003

The two-century journey of Parkinson disease research

scientific article published on March 2017

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

scholarly article

Toxicity of the specific antimuscarinic agent methoctramine and other non-specific anticholinergic drugs in human neuroblastoma cell lines in vitro ⬇️

scientific article published on September 1, 1993

Toxin-induced models of Parkinson's disease

scientific article

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity ⬇️

scientific article published on May 1, 1992

Trichothiodystrophy, mental retardation, short stature, ataxia, and gonadal dysfunction in three Moroccan siblings

scientific article published in April 1990

Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

scholarly article

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity ⬇️

scientific article published on September 2, 1997

Variations of homovanillic acid levels in ventricular cerebrospinal fluid ⬇️

scientific article published on May 1, 1992

What can pluripotent stem cells teach us about neurodegenerative diseases?

scientific article

When Schwann Cells Conspire with Mitochondria, Neighboring Axons Are under Attack by Glia-Derived Neurotoxic Lipids ⬇️

scientific article published on March 6, 2013

α-Synuclein is localized to mitochondria-associated ER membranes

scientific article published on January 2014

α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.

scientific article

Paulina is supported by:

About Paulina

Help