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List of works by Piu Chan

A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain

scientific article published on 27 April 2016

Acute stepwise challenge test with levodopa in treated patients with parkinsonism

scientific article

Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains

scientific article published on December 2015

Age-associated changes of cerebrospinal fluid amyloid-β and tau in cynomolgus monkeys.

scientific article

Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice

scientific article published on 30 November 2016

Age-related decline in motor behavior and striatal dopamine transporter in cynomolgus monkeys ⬇️

scientific article published on February 11, 2012

Aging influence on functional connectivity of the motor network in the resting state

scientific article

Allele-specific extension allows base-pair neutral homozygotes to be discriminated by high-resolution melting of small amplicons.

scientific article

Alpha-synuclein and dopamine metabolism

scientific article

Alpha-synuclein functions as a negative regulator for expression of tyrosine hydroxylase

scientific article published on June 1, 2011

Alpha-synuclein promotes early neurite outgrowth in cultured primary neurons

scientific article

Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease

scientific article published on 19 December 2017

Altered resting-state brain activity in Parkinson's disease patients with freezing of gait

scientific article published in December 2017

An improved preparation of [18F]FPBM: a potential serotonin transporter (SERT) imaging agent

scientific article

Analysis of glucose metabolism in cynomolgus monkeys during aging ⬇️

scientific article published on November 5, 2011

Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice

scientific article

Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese

scientific article published in November 2005

Association between common genetic risk variants and depression in Parkinson's disease: A dPD study in Chinese

scientific article published on 29 September 2016

Association between genetic variation of CACNA1H and childhood absence epilepsy

scientific article (publication date: August 2003)

Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese.

scientific article

Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population

scientific article published on 04 July 2014

Attention to Automatic Movements in Parkinson's Disease: Modified Automatic Mode in the Striatum

scientific article

Author Correction: Altered resting-state brain activity in Parkinson's disease patients with freezing of gait.

scientific article

Basal ganglia circuits changes in Parkinson's disease patients

scientific article

Brain-derived neurotrophic factor (BDNF) genetic polymorphism greatly increases risk of leucine-rich repeat kinase 2 (LRRK2) for Parkinson's disease ⬇️

scientific article published on September 16, 2011

C-terminal part of alpha-synuclein mediates its activity in promoting proliferation of dopaminergic cells

scientific article

C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells ⬇️

scientific article published on February 18, 2011

Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population

scientific article published on 09 August 2013

Cerebellum and integration of neural networks in dual-task processing ⬇️

scientific article published on October 11, 2012

Changes of functional connectivity of the motor network in the resting state in Parkinson's disease.

scientific article

Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese.

scientific article published on 26 November 2007

Clinical Manifestation of Parkinson's Disease in Association with Rapid Eye Movement Sleep Behavior Disorder Onset

scientific article

Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study

scientific article published on 17 January 2018

Clinical profiles of Parkinson's disease associated with common leucine-rich repeat kinase 2 and glucocerebrosidase genetic variants in Chinese individuals

scientific article published on 3 October 2013

Contemporary epidemiology of gout and hyperuricemia in community elderly in Beijing

scientific article published on 30 September 2013

Correlation between progressive changes in piriform cortex and olfactory performance in early Parkinson's disease

scientific article published on 12 August 2011

DYT1 mutations in early onset primary torsion dystonia and Parkinson disease patients in Chinese populations

scientific article published on 20 November 2008

Depressive symptoms impacting on health-related quality of life in early Parkinson's disease: results from Chinese L-dopa exposed cohort

scientific article

Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes

Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons

scientific article

Discriminative analysis of relapsing neuromyelitis optica and relapsing-remitting multiple sclerosis based on two-dimensional histogram from diffusion tensor imaging

scientific article published on 2 March 2006

Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys

scientific article

Early morning off in patients with Parkinson's disease: a Chinese nationwide study and a 7-question screening scale

scientific article published on 06 July 2020

Effective connectivity of brain networks during self-initiated movement in Parkinson's disease

scientific article published on 29 November 2010

Effective connectivity of neural networks in automatic movements in Parkinson's disease

scientific article

Effects of cysteamine on MPTP-induced dopaminergic neurodegeneration in mice

scientific article published on 7 April 2010

Excessive Iron and α-Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease

scientific article published on 2 March 2016

Exonic sequencing revealed no causative mutation in the BST1 gene in patients with Parkinson's disease

scientific article

Exploring the Effects of Genetic Variants on Clinical Profiles of Parkinson's Disease Assessed by the Unified Parkinson's Disease Rating Scale and the Hoehn-Yahr Stage

scientific article

Frequency-dependent neural activity in Parkinson's disease

scientific article published on 12 July 2014

Functional Connectivity of Vim Nucleus in Tremor- and Akinetic-/Rigid-Dominant Parkinson's Disease

scientific article published on 5 February 2016

Functional connectivity of cortical motor areas in the resting state in Parkinson's disease

scientific article published on 25 August 2010

Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation

scientific article

Health related quality of life in early Parkinson's disease: impact of motor and non-motor symptoms, results from Chinese levodopa exposed cohort

scientific article published on 23 June 2009

Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes

scientific article published in May 2008

Identification of TMEM230 mutations in familial Parkinson's disease

scientific journal article

Imaging of VMAT2 binding sites in the brain by 18F-AV-133: The effect of a pseudo-carrier ⬇️

scientific article published on June 28, 2012

Impaired serial ordering in nondemented patients with mild Parkinson's disease.

scientific article published on 16 May 2018

Impulse control disorders in Parkinson's disease in a Chinese population

scientific article published on 26 June 2009

Increased oligomerization and phosphorylation of α-synuclein are associated with decreased activity of glucocerebrosidase and protein phosphatase 2A in aging monkey brains

scientific article published on 11 June 2015

Inhibition of tyrosine hydroxylase expression in alpha-synuclein-transfected dopaminergic neuronal cells

scientific article published on August 2004

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease

scientific article published on 5 June 2015

Investigation on Abnormal Iron Metabolism and Related Inflammation in Parkinson Disease Patients with Probable RBD.

scientific article published on 2 October 2015

Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance

scientific article published on 2 November 2017

Ischemia, immunosuppression, and SSEA-1-negative cells all contribute to tumors resulting from mouse embryonic stem cell-derived neural progenitor transplantation

scientific article published on 4 October 2013

LRRK2-associated Parkinson's disease patients have better stereopsis than idiopathic Parkinson disease.

scientific article

Lateralization of brain activity pattern during unilateral movement in Parkinson's disease

scientific article published on 19 January 2015

Levodopa Effect on Basal Ganglia Motor Circuit in Parkinson's Disease

scientific article published on 24 September 2016

Linkage analysis and whole-exome sequencing exclude extra mutations responsible for the parkinsonian phenotype of spinocerebellar ataxia-2.

scientific article published on 2 August 2014

Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging

scientific article

MAPT IVS1+124 C>G modifies risk of LRRK2 G2385R for Parkinson's disease in Chinese individuals.

scientific article published on 25 January 2014

MDS clinical diagnostic criteria for Parkinson's disease

scientific article

MDS research criteria for prodromal Parkinson's disease

scientific article

MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes

scientific article published on 3 October 2016

Management Recommendations on Sleep Disturbance of Patients with Parkinson's Disease

scholarly article by Chun-Feng Liu et al published 20 December 2018 in Chinese Medical Journal

Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Combined with Magnetic Beads for Detecting Serum Protein Biomarkers in Parkinson’s Disease ⬇️

scientific article published on January 27, 2011

Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participants

scientific article

Modifications of the interactions in the motor networks when a movement becomes automatic

scientific article

Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.

scientific article published on 29 July 2015

Motor automaticity in Parkinson's disease

scientific article published on 20 June 2015

Myelin oligodendrocyte glycoprotein induces aquaporin-4 autoantibodies in mouse experimental autoimmune encephalomyelitis

scientific article published on 22 May 2013

Neural correlates of bimanual anti-phase and in-phase movements in Parkinson's disease

scientific article

Neural correlates underlying micrographia in Parkinson's disease

scientific article

Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants.

scientific article

Nuclear translocation of alpha-synuclein increases susceptibility of MES23.5 cells to oxidative stress

scientific article published on 18 January 2013

Oscillation development for neurotransmitter-related genes in the mouse striatum

scientific article published in January 2010

Oxidative DNA damage triggers ProNGF-Mediated apoptosis in the striatum of 6-OHDA-treated rats

scientific article

Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells

scientific article published on 7 February 2006

Parkin dosage mutations in patients with early-onset sporadic and familial Parkinson's disease in Chinese: An independent pathogenic role ⬇️

scientific article published on August 26, 2010

Parkinson disease with REM sleep behavior disorder: features, α-synuclein, and inflammation

scientific article published on 6 February 2015

Parkinson disease with constipation: clinical features and relevant factors

scientific article published on 12 January 2018

Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer

scientific article published on 4 February 2016

Parkinson's disease-related spatial covariance pattern identified with resting-state functional MRI.

scientific article

Pathogenesis of normal-appearing white matter damage in neuromyelitis optica: diffusion-tensor MR imaging.

scientific article

Penetrance of LRRK2 G2385R and R1628P is modified by common PD-associated genetic variants

scientific article published on 2 June 2012

Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells

scientific article

Postnatal ontogenesis of molecular clock in mouse striatum

scientific article

Preclinical and clinical neural network changes in SCA2 parkinsonism

scientific article

Prevalence and Incidence of Frailty in Community-Dwelling Older People: Beijing Longitudinal Study of Aging II.

scientific article published on June 2016

Prevalence of Frailty and Associated Factors in the Community-Dwelling Population of China

scientific article published on 23 November 2017

Prevalence of frailty and contributory factors in three Chinese populations with different socioeconomic and healthcare characteristics.

scientific article published on 9 December 2015

Primary familial brain calcifications linked with a novel SLC20A2 gene mutation in a Chinese family

scientific article published on 13 June 2017

Progressive loss of striatal dopamine terminals in MPTP-induced acute parkinsonism in cynomolgus monkeys using vesicular monoamine transporter type 2 PET imaging ([(18)F]AV-133).

scientific article published on 5 September 2013

Pyrosequencing analysis of SNCA methylation levels in leukocytes from Parkinson's disease patients

scientific article published on 8 April 2014

Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson's disease patients

scientific article published on 17 January 2018

Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: application to patients with relapsing neuromyelitis optica

scientific article published on 21 August 2006

Regional homogeneity changes in patients with Parkinson's disease

scientific article published in May 2009

Relapsing neuromyelitis optica and relapsing-remitting multiple sclerosis: differentiation at diffusion-tensor MR imaging of corpus callosum.

scientific article

Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters

scientific article

Role of α-synuclein in neurodegeneration: implications for the pathogenesis of Parkinson's disease

scientific article published in January 2014

Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody

scientific article

Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease

scientific article

Serum uric acid and impaired cognitive function in community-dwelling elderly in Beijing

scientific article

Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells

scientific article published on 21 March 2008

Smoking, genes encoding dopamine pathway and risk for Parkinson's disease

scientific article published on 14 July 2010

Stereopsis impairment is associated with decreased color perception and worse motor performance in Parkinson's disease

scientific article

Suprachiasmatic nucleus slices induce molecular oscillations in fibroblasts

scientific article published on 31 October 2008

The cerebellum in dual-task performance in Parkinson's disease

scientific article published on 30 March 2017

The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study

scientific article

The prevalence and incidence of frailty in Pre-diabetic and diabetic community-dwelling older population: results from Beijing longitudinal study of aging II (BLSA-II)

scientific article

The recommendations of Chinese Parkinson's disease and movement disorder society consensus on therapeutic management of Parkinson's disease

scientific article

Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease

scientific article

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis

scientific article published on 01 April 2019

Validation of the utility of the Brief Smell Identification Test in Chinese patients with Parkinson's disease

article

Voxel-based analysis of diffusion tensor indices in the brain in patients with Parkinson's disease

scientific article

Waist circumference is a better predictor of risk for frailty than BMI in the community-dwelling elderly in Beijing

scientific article published on 27 March 2018

alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

scientific article

α-Synuclein aggregation and neurodegenerative diseases ⬇️

scientific article published on April 1, 2003

α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator ⬇️

scientific article published on February 15, 2011

α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death

scientific article

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