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List of works by Mark R Cookson

14-3-3 proteins are promising LRRK2 interactors ⬇️

scientific article published on September 15, 2010

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation

scientific article

A soluble α-synuclein construct forms a dynamic tetramer

scientific article published on 17 October 2011

A strategy for designing inhibitors of alpha-synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders

scientific article published on 4 June 2004

ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo

scientific article published on 15 December 2015

AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons.

scientific article published on 11 June 2018

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice

scientific article published on 09 March 2020

Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain

scientific article

Age-associated changes in gene expression in human brain and isolated neurons

scientific article

Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction

scientific article published on September 2013

Age-modulated association between prefrontal NAA and the BDNF gene

scientific article

Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations ⬇️

scientific article published on June 17, 2011

Aging--RNA in development and disease ⬇️

scientific article published on September 6, 2011

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

scientific article published on 15 August 2003

Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells

scientific article

Alpha-synuclein triggers T-cell response. Is Parkinson's disease an autoimmune disorder?

scientific article

Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking

scientific article

An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

scientific article

Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD

scientific article

Animal models for drug discovery in dystonia ⬇️

scientific article published on January 1, 2008

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution

scientific article

Astrocytes in Parkinson's disease and DJ-1

scientific article

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

scientific article

Biochemical characterization of torsinB.

scientific article published on August 2004

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein

scientific article published on August 2016

Cell population-specific expression analysis of human cerebellum ⬇️

scientific article published on November 12, 2012

Cell systems and the toxic mechanism(s) of alpha-synuclein

scientific article

Cellular effects of LRRK2 mutations ⬇️

scientific article published on October 1, 2012

Cellular functions of LRRK2 implicate vesicular trafficking pathways in Parkinson's disease

scientific article published on December 2016

Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines

scientific article

Common genetic variants influence human subcortical brain structures

scientific article

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

scientific article published on 7 March 2018

Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe

scientific article published on 10 June 2016

Converging pathways in neurodegeneration, from genetics to mechanisms

scientific article published on 26 September 2018

Crystallizing ideas about Parkinson's disease

scientific article

Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress

scientific article published on June 2002

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

scholarly article

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

scientific article

DJ-1 regulation of mitochondrial function and autophagy through oxidative stress ⬇️

scientific article published on May 1, 2011

DJ-1, PINK1, and their effects on mitochondrial pathways

scientific article

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA

scientific article

Deep sequencing of coding and non-coding RNA in the CNS

scientific article

Deletion at ITPR1 underlies ataxia in mice and humans (SCA15)

Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans

scientific article published in June 2007

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

scientific article

Development, characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 (PARK7) protein

scientific article published on 25 April 2005

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

scientific article published on 05 October 2018

Differential gene expression in a cell culture model of SOD1-related familial motor neurone disease

scientific article published on August 2002

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

scientific article

Distinct DNA methylation changes highly correlated with chronological age in the human brain

scientific article

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

scientific article published on 22 October 2020

Dominant torsinA mutations in cellular systems

scientific article published on January 1, 2004

Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells

scientific article published on 2 May 2014

Dystonia and the nuclear envelope

scientific article

Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization

scientific article

Emerging pathways in genetic Parkinson's disease: Potential role of ceramide metabolism in Lewy body disease

scientific article published on December 2008

Evidence for natural antisense transcript-mediated inhibition of microRNA function

scientific article

Evolution of Neurodegeneration ⬇️

scientific article published on September 11, 2012

Evolutionary and functional relationships within the DJ1 superfamily

scientific article

Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease

scholarly article by Jeff G. Blackinton et al published December 2007 in Brain Research

FUS mutations in sporadic amyotrophic lateral sclerosis

scientific article

Finding useful biomarkers for Parkinson's disease

article

Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1

scientific article

Gene Linkage and Systems Biology

scientific article published in January 2017

Gene expression in the Parkinson's disease brain ⬇️

scientific article published on December 3, 2011

Genes and parkinsonism

scientific article

Genes associated with Parkinson's disease: regulation of autophagy and beyond

scientific article published on 30 July 2015

Genetic analysis of neurodegenerative diseases in a pathology cohort

Genetic comorbidities in Parkinson's disease

scientific article published on 20 September 2013

Genetic neuropathology of Parkinson's disease.

scientific article

Genetic variability in the regulation of gene expression in ten regions of the human brain

scientific article

Genetics of Parkinson's disease and parkinsonism

scientific article published on October 2006

Genome-wide association study reveals genetic risk underlying Parkinson's disease

scientific article

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma

scientific article

Glial cell inclusions and the pathogenesis of neurodegenerative diseases

scientific article

Glial phagocytic clearance in Parkinson's disease

scholarly article by Marie-Eve Tremblay et al published 5 April 2019 in Molecular Neurodegeneration

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Hero versus antihero: the multiple roles of alpha-synuclein in neurodegeneration

scientific article

Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications

scientific article

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria ⬇️

scientific article published on August 19, 2013

Hexokinases link DJ-1 to the PINK1/parkin pathway

scientific article published on 29 September 2017

High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice

scientific article published on 10 May 2021

How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease

scientific article

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease

scientific article (publication date: June 2003)

Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice

scientific article

Identification of bona-fide LRRK2 kinase substrates

scientific article published on 29 April 2016

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

scientific article

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

scientific article

Identification of the epitope of a monoclonal antibody to DJ-1.

scientific article published on 30 November 2004

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets

scientific article published on 26 February 2020

Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci

scientific article published on 30 January 2013

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

scientific article

Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain

scientific article

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

scientific article published on 24 January 2006

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease? ⬇️

scientific article published on February 23, 2012

Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients

scientific article

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

scientific article (publication date: 19 September 2003)

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

scientific article published on 26 July 2021

LRRK2 Pathways Leading to Neurodegeneration

scientific article published on July 2015

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

scientific article

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

scientific article

LRRK2 links genetic and sporadic Parkinson's disease

scientific article published on 05 March 2019

LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies

scientific article published on 01 October 2020

LRRK2 mediates tubulation and vesicle sorting from lysosomes

scientific article published on 11 November 2020

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

scientific article

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

scientific article published on 21 November 2017

LRRK2: dropping (kinase) inhibitions and seeking an (immune) response

scientific article published on 24 March 2014

Lardy brains make Parkinson's disease mice worse

scientific article published on 20 August 2014

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

scientific article

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

scientific article published on 14 April 2009

Lysosomal impairment in Parkinson's disease

scientific article published on 11 April 2013

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

scientific article

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

scientific article

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

scientific article published on January 2017

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

scientific article

Mechanisms of Mutant LRRK2 Neurodegeneration

scientific article published in January 2017

Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

scholarly article

Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein

scientific article published on 23 July 2009

Microarray analysis reveals induction of heat shock proteins mRNAs by the torsion dystonia protein, TorsinA.

scientific article published in May 2003

Mitochondria and dopamine: new insights into recessive parkinsonism

scientific article published in August 2004

Mitochondrial Quality Control and Dynamics in Parkinson's Disease ⬇️

scientific article published on July 7, 2011

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

scientific article

Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis

scientific article published on July 2002

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

scientific article

Molecules that cause or prevent Parkinson's disease

scientific article

Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies

scientific article

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

scientific article

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

scientific article

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

scientific article (publication date: May 2014)

Neurodegeneration: how does parkin prevent Parkinson's disease?

scientific article

Neurons inflict self-harm

scientific article published in November 2005

Normal localization of deltaF323-Y328 mutant torsinA in transfected human cells

scientific article published on July 2002

Novel genetic loci associated with hippocampal volume

scientific article published on 18 January 2017

Novel genetic loci underlying human intracranial volume identified through genome-wide association

scientific article (publication date: 3 October 2016)

Oxidative Stress and Motor Neurone Disease

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

scientific article published on 14 December 2017

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

scientific article

Parkin and alpha-synuclein: opponent actions in the pathogenesis of Parkinson's disease

scientific article

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

scientific article

Parkin's substrates and the pathways leading to neuronal damage

scientific article

Parkinson disease, cancer, and LRRK2: causation or association?

scientific article published on 8 February 2012

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

scientific article

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

scientific article

Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics

scientific article published on 22 February 2019

Parkinson's disease: insights from pathways

scientific article

Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways ⬇️

scientific article published on September 1, 2012

Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue

scientific article

Pathways to Parkinsonism

scientific article (publication date: 9 January 2003)

Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease

scientific article

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

scientific article

Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

scientific article published on March 2009

Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease

scientific article published on 06 January 2009

Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain

scientific article

Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

scientific article published on 19 March 2021

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

Proteomics: techniques and applications in neuroscience

scientific article published on 17 October 2019

Proteomics; applications in familial Parkinson's disease

scientific article published on 09 July 2019

RING finger 1 mutations in Parkin produce altered localization of the protein

scientific article published on 30 September 2003

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

scientific article

RNA-binding proteins implicated in neurodegenerative diseases

scientific article published on 23 September 2016

Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment

scientific article

Resolving the polymorphism-in-probe problem is critical for correct interpretation of expression QTL studies

scientific article published on 21 February 2013

Role of LRRK2 kinase dysfunction in Parkinson disease

scientific article

Roles of the proteasome in neurodegenerative disease: refining the hypothesis

scientific article published in September 2004

Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis

scientific article published on September 2002

Sequence conservation between mouse and human synphilin-1

scientific article (publication date: 29 March 2002)

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

scientific article

Structure, function, and leucine-rich repeat kinase 2: On the importance of reproducibility in understanding Parkinson's disease

scientific article published on 15 July 2016

The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity

scientific article published on 11 March 2016

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

scientific article published on 20 March 2017

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

scientific article

The LRRK2 signalling system

scientific article published on 8 January 2018

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

scientific article

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

scientific article

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

scientific article

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

scholarly article

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice

scientific article

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

scientific article

The biochemistry of Parkinson's disease

scientific article

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

scientific article

The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease

scholarly article by Sara Bandres-Ciga et al published April 2019 in Movement Disorders

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

scientific article

The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research

scientific article published on February 2016

The future of neurodegenerative diseases: emerging targets, treatments and technologies

scientific article published in September 2012

The impact of fraudulent and irreproducible data to the translational research crisis - solutions and implementation

scientific article

The persistence of memory

scientific article published in December 2006

The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics

scientific article published on 05 March 2009

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

scientific article

Transcriptomic changes in brain development

scientific article

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging

scientific article published on 4 December 2017

Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease

scientific article

Unaltered alpha-synuclein blood levels in juvenile Parkinsonism with a parkin exon 4 deletion

scientific article published on 19 November 2004

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

scientific article

Unravelling the role of defective genes

scientific article

Use of cysteine-reactive cross-linkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers

scientific article

Variation in tau isoform expression in different brain regions and disease states

scientific article published on 19 February 2013

alpha-Synuclein and neuronal cell death

scientific article

mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex

scientific article published on 17 February 2013

mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition

scientific article published on 21 March 2018

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

scientific article (publication date: 12 October 2016)

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