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List of works by Maria Manuel Dias da Mota

2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes

scientific article

A mediator for malaria stickiness in A versus O blood

scientific article published in April 2015

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax

scientific article published on July 2013

A novel carbon monoxide-releasing molecule fully protects mice from severe malaria

scientific article published on 12 December 2011

A novel flow cytometric hemozoin detection assay for real-time sensitivity testing of Plasmodium falciparum

scientific article

A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity

scientific article

A sporozoite-based vaccination platform against human malaria

scientific article published on 24 August 2018

A toolbox to study liver stage malaria

scientific article published on 17 October 2011

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

scientific article (publication date: 20 January 2016)

Accumulation of Plasmodium berghei-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice

scientific article published on 6 July 2010

Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection.

scientific article

Antibody recognition of rodent malaria parasite antigens exposed at the infected erythrocyte surface: specificity of immunity generated in hyperimmune mice

scientific article

Antimalarial drugs - host targets (re)visited

scientific article published on March 2006

Apoptotic Plasmodium-infected hepatocytes provide antigens to liver dendritic cells

scientific article

Assessment of dual life stage antiplasmodial activity of british seaweeds

scientific article published on 22 October 2013

Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development

scientific article published on 01 January 2019

Be in motion . . .

scientific article published on June 2006

Biology of the malaria parasite--on the special issue for the 10th BioMalPar conference

scientific article published in May 2014

Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection

scientific article published on 16 March 2007

Cerebral malaria and the hemolysis/methemoglobin/heme hypothesis: shedding new light on an old disease

scientific article published on 27 September 2008

Chemical interrogation of the malaria kinome

scientific article

Cross-species immunity in malaria vaccine development: two, three, or even four for the price of one?

scientific article

Crystal Structure of Arginase from Plasmodium falciparum and Implications for l -Arginine Depletion in Malarial Infection,

scientific article

Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy

scientific article

Developmental transition of Plasmodium sporozoites into liver-stage forms is regulated by the RNA binding protein Pumilio 2.

scientific article

Dietary alterations modulate susceptibility to Plasmodium infection

scientific article

Disrupting Plasmodium UIS3-host LC3 interaction with a small molecule causes parasite elimination from host cells

scientific article published on 19 November 2020

Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry

scientific article

Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug

scientific article

Early skin immunological disturbance after Plasmodium-infected mosquito bites

scientific article published in May 2012

Fighting for Resources: Who Started the Battle? Who Is Winning It?

scientific article published on 01 April 2018

Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds

scientific article published on 20 September 2013

Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: a new tool to study mosquito and mammalian host interactions with malaria parasites.

scientific article published in June 2001

Gene targeting in the rodent malaria parasite Plasmodium yoelii

scientific article published in April 2001

Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection.

scientific article published on 21 May 2007

Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells

scientific article

Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy

scientific article

Gold nanoparticle-based fluorescence immunoassay for malaria antigen detection

scientific article published on 17 November 2011

HGF/MET signalling protects Plasmodium-infected host cells from apoptosis.

scientific article

Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.

scientific article

Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection

scientific article published in May 2008

Hepatocyte growth factor and its receptor are required for malaria infection

scientific article published on 12 October 2003

Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes

scientific article

Host AMPK Is a Modulator of Plasmodium Liver Infection

scientific article published on 25 August 2016

Host cell autophagy contributes to Plasmodium liver development

scientific article published on 24 September 2015

Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection.

scientific article

Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events

scientific article

Host scavenger receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection

scientific article published on September 2008

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

scientific article

Host-mediated regulation of superinfection in malaria

scientific article

Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro

scientific article

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

scientific article

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria

scientific article published on 20 May 2019

Identification of the class XIV myosins Pb-MyoA and Py-MyoA and expression in Plasmodium sporozoites

scientific article published in January 2001

Imidazoquines as antimalarial and antipneumocystis agents

scientific article published on December 2009

Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

scientific article published on 17 October 2011

Improved transfection and new selectable markers for the rodent malaria parasite Plasmodium yoelii

scientific article published on 17 January 2006

In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice

scientific article published on 11 April 2012

In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection

scientific article

Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies

scientific article published on 5 January 2011

Infection by Plasmodium changes shape and stiffness of hepatic cells ⬇️

scientific article published on October 25, 2011

Infection by and protective immune responses against Plasmodium berghei ANKA are not affected in macrophage scavenger receptors A deficient mice

scientific article published on 16 August 2006

Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections

scientific article

Innate recognition of malarial parasites by mammalian hosts ⬇️

scientific article published on April 27, 2012

Interactions of the malaria parasite and its mammalian host

scientific article published on August 2008

Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis

scientific article published in 2023

Invasion of mammalian host cells by Plasmodium sporozoites

scientific article

Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection

scientific article

Liver-stage malaria parasites vulnerable to diverse chemical scaffolds

scientific article

Malaria blood stage suppression of liver stage immunity by dendritic cells

scientific article published on January 2003

Malaria infections: what and how can mice teach us.

scientific article published on 14 May 2014

Malaria liver stage susceptibility locus identified on mouse chromosome 17 by congenic mapping

scientific article

Malaria sporozoite: migrating for a living – a response

scholarly article by Maria Manuel Dias da Mota published March 2004 in Trends in Molecular Medicine

Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites

scientific article published on 18 January 2022

Microbiota, a Third Player in the Host-Plasmodium Affair

scientific article published on 29 November 2019

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

scientific article published on 19 November 2015

Migration of Plasmodium sporozoites through cells before infection.

scientific article

Migration through host cells activates Plasmodium sporozoites for infection

scientific article published on 15 October 2002

Migration through host cells by apicomplexan parasites

scientific article

Migration through host cells: the first steps of Plasmodium sporozoites in the mammalian host

scientific article

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration

scientific article

New pieces for the malaria liver stage puzzle: where will they fit?

scientific article

Nutrient sensing modulates malaria parasite virulence.

scientific article published on 5 July 2017

One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care

scientific article published on 7 August 2015

PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes

scientific article (publication date: 30 April 2002)

Parasite Sensing of Host Nutrients and Environmental Cues

scientific article published on 01 June 2018

Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection

scientific article

Parasitism: Anopheles Mosquitoes and Plasmodium Parasites Share Resources

scientific article published on 01 July 2019

Parasitology. Malaria vaccines: back to the future?

scientific article published on January 2005

Perspective: Hidden treasures from the archives

scientific article

Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility.

scientific article

Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host

scientific article

Plasmodium UIS3 sequesters host LC3 to avoid elimination by autophagy in hepatocytes.

scientific article published on 6 November 2017

Plasmodium berghei parasite transformed with green fluorescent protein for screening blood schizontocidal agents

scientific article published on March 2004

Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells

scientific article published on 03 June 2009

Plasmodium chabaudi-infected erythrocytes adhere to CD36 and bind to microvascular endothelial cells in an organ-specific way

scientific article

Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut

scientific article published on 01 August 2018

Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination

scientific article published on 22 April 2022

Plasmodium translocon component EXP2 facilitates hepatocyte invasion

scientific article published on 06 November 2020

Plasmodium yoelii: Efficient in Vitro Invasion and Complete Development of Sporozoites in Mouse Hepatic Cell Lines

article

Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016

scientific article

Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry

scientific article

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria

scientific article published on 23 May 2013

Reply to: Hepcidin in malaria superinfection: can findings be translated to humans?

article

Severe malaria increases the list of heme oxygenase-1-protected diseases

scientific article

Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation

scientific article published on 5 June 2023

Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing.

scientific article published on 31 March 2011

Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability

scientific article published on 30 September 2013

Superinfection in malaria: Plasmodium shows its iron will

scientific article published on December 2011

Survival of protozoan intracellular parasites in host cells

scientific article

Targeting Host Factors to Circumvent Anti-Malarial Drug Resistance

scientific article published on January 1, 2013

Targeting Plasmodium host cells: survival within hepatocytes

scientific article published in October 2004

Targeting liver stage malaria with metformin

scientific article published on 19 December 2019

Targeting the Liver Stage of Malaria Parasites: A Yet Unmet Goal ⬇️

scientific article published on December 21, 2011

The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens

scientific article

The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

scientific article

The next opportunity in anti-malaria drug discovery: the liver stage

scientific article

The relevance of host genes in malaria.

scientific article published on January 2007

The relevance of non-human primate and rodent malaria models for humans

scientific article

The silent path to thousands of merozoites: the Plasmodium liver stage

scientific article published on November 2006

To migrate or to invade: those are the options

scientific article

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

scientific article published on 08 July 2013

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

scientific article published on 31 March 2017

Transcriptome profile of dendritic cells during malaria: cAMP regulation of IL-6.

scientific article published on 23 February 2007

Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio

scientific article (publication date: May 2011)

Unlike the synchronous Plasmodium falciparum and P. chabaudi infection, the P. berghei and P. yoelii asynchronous infections are not affected by melatonin

scientific article

Unveiling the pathogen behind the vacuole

scientific article published on 20 July 2015

Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle

scientific article

VEGF promotes malaria-associated acute lung injury in mice

scientific article

Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging

scientific article

γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection

scientific article published on 26 April 2019

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