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List of works by James Paton

A Nonadjuvanted Whole-Inactivated Pneumococcal Vaccine Induces Multiserotype Opsonophagocytic Responses Mediated by Noncapsule-Specific Antibodies

scientific article published in 2022

A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome

scientific article

A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli

scientific article

A recombinant probiotic for treatment and prevention of cholera

scientific article published on 01 May 2006

A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response

scientific article

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

scientific article

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

scientific article published on 16 June 2014

Acquisition of anergy to proinflammatory cytokines in nonimmune cells through endoplasmic reticulum stress response: a mechanism for subsidence of inflammation

scientific article

Action of shiga toxin type-2 and subtilase cytotoxin on human microvascular endothelial cells

scientific article

Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response

scientific article published on 26 June 2009

Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response

scientific article

BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection ⬇️

scientific article published on June 14, 2011

BiP prevents rod opsin aggregation ⬇️

scientific article published on August 1, 2012

BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER

scientific article

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

Bioengineered bugs expressing oligosaccharide receptor mimics: toxin-binding probiotics for treatment and prevention of enteric infections

scientific article

Bioengineered microbes in disease therapy.

scientific article published on 20 June 2012

Blunted activation of NF-kappaB and NF-kappaB-dependent gene expression by geranylgeranylacetone: involvement of unfolded protein response.

scientific article published on 29 October 2007

Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae

scientific article published on 19 November 2020

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier.

scientific article

Chaperone-targeting cytotoxin and endoplasmic reticulum stress-inducing drug synergize to kill cancer cells

scientific article

Characterization of a novel type IV pilus locus encoded on the large plasmid of locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli strains that are virulent for humans

scientific article

Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP.

scientific article

Cloning, expression, purification and preliminary X-ray diffraction studies of a novel AB₅ toxin

scientific article published on 27 July 2013

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma

scientific article

Comparative Characterization of Shiga Toxin Type 2 and Subtilase Cytotoxin Effects on Human Renal Epithelial and Endothelial Cells Grown in Monolayer and Bilayer Conditions

scientific article

Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin ⬇️

scientific article published on June 15, 2011

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

scientific article published on 14 April 2017

Decreased ER-associated degradation of alpha-TCR induced by Grp78 depletion with the SubAB cytotoxin

scientific article published on 20 June 2008

Designer probiotics for prevention of enteric infections.

scientific article

Detection and characterization of STEC in stool samples using PCR.

scientific article

Differential effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on chemokine and proinflammatory cytokine expression in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines

scientific article

Differential effects of short-chain fatty acids and iron on expression of iha in Shiga-toxigenic Escherichia coli

scientific article published on 14 August 2009

Direct detection and characterization of Shiga toxigenic Escherichia coli by multiplex PCR for stx1, stx2, eae, ehxA, and saa.

scientific article

Distribution of the saa gene in strains of Shiga toxin-producing Escherichia coli of human and bovine origins

scientific article

Downregulation of gap junction expression and function by endoplasmic reticulum stress

scientific article

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

scientific article published on 28 March 2013

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy

scientific article

EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit

scientific article

Effects of Escherichia coli subtilase cytotoxin and Shiga toxin 2 on primary cultures of human renal tubular epithelial cells

scientific article published on 21 January 2014

Enhanced CXC Chemokine Responses of Human Colonic Epithelial Cells to Locus of Enterocyte Effacement-Negative Shiga-Toxigenic Escherichia coli ⬇️

scientific article published on October 1, 2003

Escherichia coli 83972 expressing a P fimbriae oligosaccharide receptor mimic impairs adhesion of uropathogenic E. coli.

scientific article

Escherichia coli Subtilase Cytotoxin ⬇️

scientific article published on February 1, 2010

Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak

scientific article

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

scientific article

GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells

scientific article published on 4 January 2017

Genomic Comparison of Two O111:H- Enterohemorrhagic Escherichia coli Isolates from a Historic Hemolytic-Uremic Syndrome Outbreak in Australia

scientific article

Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly

scientific article

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

scientific article

Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment

scientific article published on 30 May 2015

In Vivo Leukocyte Changes Induced by Escherichia coli Subtilase Cytotoxin ⬇️

scientific article published on January 31, 2011

In vivo dual RNA-seq reveals that neutrophil recruitment underlies differential tissue tropism of Streptococcus pneumoniae

scientific article published on 05 June 2020

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

scientific article

Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21

scientific article

Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15

scientific article

Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response ⬇️

scientific article published on October 15, 2012

LuxS mediates iron-dependent biofilm formation, competence, and fratricide in Streptococcus pneumoniae.

scientific article published on 29 August 2011

Measuring Signaling by the Unfolded Protein Response

scientific article published on 01 January 2011

Methods for detection of STEC in humans. An overview

scientific article

Multiplex PCR for direct detection of Shiga toxigenic Escherichia coli strains producing the novel subtilase cytotoxin

scientific article

Mutation of luxS of Streptococcus pneumoniae affects virulence in a mouse model

scientific article

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

scientific article published on July 2014

Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress

scientific article published on June 26, 2011

Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin

scientific article published on 18 July 2017

Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections ⬇️

scientific article published on July 1, 1998

Pathologic changes in mice induced by subtilase cytotoxin, a potent new Escherichia coli AB5 toxin that targets the endoplasmic reticulum

scientific article

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

scientific article

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain

scientific article published on 03 January 2017

Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression

scientific article published in 2022

Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation

scientific article

Protection against Shiga-Toxigenic Escherichia coli by Non-Genetically Modified Organism Receptor Mimic Bacterial Ghosts

scientific article

Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli

scientific article

Reactivity of convalescent-phase hemolytic-uremic syndrome patient sera with the megaplasmid-encoded TagA protein of Shiga toxigenic Escherichia coli O157

scientific article

Receptor-mimic probiotics: potential therapeutics for bacterial toxin-mediated enteric diseases

scientific article published on 01 June 2010

Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea.

scientific article

Reduced virulence of an fliC mutant of Shiga-toxigenic Escherichia coli O113:H21.

scientific article

Refinement of a therapeutic Shiga toxin-binding probiotic for human trials

scientific article published on 16 April 2004

Role of Lipid Rafts and Flagellin in Invasion of Colonic Epithelial Cells by Shiga-Toxigenic Escherichia coli O113:H21 ⬇️

scientific article published on June 11, 2012

SMRT sequencing reveals differential patterns of methylation in two O111:H- Shiga toxigenicEscherichia coliisolates from a historic hemolytic uremic syndrome outbreak in Australia

article

Sab, a novel autotransporter of locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli O113:H21, contributes to adherence and biofilm formation

scientific article published on June 2009

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury

scientific article published in Scientific Reports

Selective abrogation of BiP/GRP78 blunts activation of NF-κB through the ATF6 branch of the UPR: involvement of C/EBPβ and mTOR-dependent dephosphorylation of Akt.

scientific article published on 7 February 2011

Shiga toxin 2 and flagellin from shiga-toxigenic Escherichia coli superinduce interleukin-8 through synergistic effects on host stress-activated protein kinase activation

scientific article

Shiga toxin-producing Escherichia coli strains negative for locus of enterocyte effacement

scientific article

Site of isolation determines biofilm formation and virulence phenotypes of Streptococcus pneumoniae serotype 3 clinical isolates

scientific article published on 3 December 2012

Site specific mutations of GalR affect galactose metabolism in Streptococcus pneumoniae

scientific article published on 12 October 2020

Specificity and utility of SubB2M, a new N-glycolylneuraminic acid lectin

scientific article published on 20 April 2018

Structural Basis of Subtilase Cytotoxin SubAB Assembly

scientific article

Structure, biological functions and applications of the AB5 toxins

scientific article

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

scientific article published on 29 June 2017

Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response

scientific article published on 8 December 2010

Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways

scientific article

Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes

scientific article published on 06 October 2009

Suppression of NF-kappaB by cyclosporin a and tacrolimus (FK506) via induction of the C/EBP family: implication for unfolded protein response

scientific article published in June 2009

Suppression of cytokine response by GATA inhibitor K-7174 via unfolded protein response

scientific article

Suppression of cytokine responses by indomethacin in podocytes: a mechanism through induction of unfolded protein response.

scientific article published on 17 September 2008

Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21.

scientific article published on 2 January 2017

T cell receptor-mediated signaling induces GRP78 expression in T cells: the implications in maintaining T cell viability

scientific article

Targeting GRP78 to enhance melanoma cell death.

scientific article published on 12 July 2010

The B subunit of an AB5 toxin produced by Salmonella enterica serovar Typhi up-regulates chemokines, cytokines, and adhesion molecules in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines

scientific article

The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia

scientific article

The COG Complex, Rab6 and COPI Define a Novel Golgi Retrograde Trafficking Pathway that is Exploited by SubAB Toxin

scientific article (publication date: October 2009)

The Escherichia coli Subtilase Cytotoxin A Subunit Specifically Cleaves Cell-surface GRP78 Protein and Abolishes COOH-terminal-dependent Signaling ⬇️

scientific article published on July 31, 2012

The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates

scientific article

The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

scientific article

The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment

scientific article published on 09 September 2009

The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent

scientific article

The signal sequence influences post-translational ER translocation at distinct stages

scientific article

Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome

scientific article

Tissue factor–dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli

scientific article

Treatment and prevention of enteric infections with toxin-binding probiotics

scientific article published on 01 February 2006

Unfolded Protein Response Causes a Phenotypic Shift of Inflamed Glomerular Cells toward Redifferentiation through Dual Blockade of Akt and Smad Signaling Pathways ⬇️

scientific article published on September 29, 2012

Vacuolation Activity and Intracellular Trafficking of ArtB, the Binding Subunit of an AB5 Toxin Produced by Salmonella enterica Serovar Typhi

scientific article

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